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Journal of Rare Earths 2017年第11期35卷 1071-1076页

作者： Takuya Igashira Masaki Mori Go Okada noriaki kawaguchi Takayuki Yanagida Graduate School of Materials Science Nara Institute of Sdence and Technology (NAIST) 8916-5 Takayama Ikoma Nam Japan

(GdCa)(SiO)Oapatite crystals doped with different concentrations of Ce were synthesized by the Floating Zone(FZ) method, and we have evaluated the photoluminescence(PL) and radio luminescence(RL) properties. In PL, an emission band appeared around 400 nm under excitation at 300 nm due to the5 d-4 f transitions of Ce3+. The PL decay curves were approximated by a second-order exponential decay function, and the derived decay time constants ranged around 20-25 ns and 40-480 ns. Similar emission was observed in RL, but the decay time constants were much longer than those in PL. The RL afterglow was the lowest in the 1.0% Ce-doped sample. The 1.0% and 2.0% Ce-doped samples showed a full-energy peak in the pulse height spectrum measured underAm 5.5 MeV α-ray irradiation, and the absolute scintillation light yields were estimated to be around 55 and 36 ph/5.5 MeV-a, respectively.

关键词： Scintillator Apatite Ce^(3+) 5d-4f transition

Photoluminescence, scintillation and thermally-stimulated luminescence properties of Tb-doped 12CaO·7Al2O3 single crystals grown by FZ method

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Journal of Rare Earths 2017年第10期35卷 957-963页

作者： Narumi Kumamoto Daisuke Nakauchi Takumi Kato Go Okada noriaki kawaguchi Takayuki Yanagida Graduate School of Materials Science Nara Institute of Science and Technology (NAIST) 8916-5 Takayama-cho Ikoma-shi Nara 630-0192 Japan

Tb-doped 12CaO·7Al_2O_3（Tb：C12A7） crystals were synthesized by the floating zone（FZ） method and the photoluminescence（PL）, scintillation and thermally-stimulated luminescence（TSL） properties were investigated. The photoluminescence（PL） emission spectra and PL decay time profiles were investigated by using Quantaurus-tau（Hamamatsu）. The scintillation spectra and decay time profiles were measured by using our laboratory-constructed set-up under X-ray irradiation. Finally, TSL glow curve was measured by using Nanogray TL-2000 with the heating rate of 1 °C/s. In PL and scintillation, emission peaks were observed at 493, 543, 587 and 620 nm due to the 4f-4f transitions of Tb3~＋. Decay time constants of the emission by PL and scintillation appeared to be different, and the measured values were approximately 2.4 and 1.9 ms, respectively. After X-ray irradiations, the 0.5%（all Tb contents in this paper are in mole fraction） and 1.0% Tb-doped samples showed a single intense and broad glow peak around 100 oC while 1.2%–1.5% Tb-doped samples showed notable additional peak around 250 oC.

关键词： C12A7 single crystal FZ terbium scintillation photoluminescence TSL rare earths

Update on the Diagnosis and Treatment of Combined Hepatocellular Cholangiocarcinoma

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 210-217页

作者： Kai-Jian Chu Yoshikuni kawaguchi Han Wang Xiao-Qing Jiang Kiyoshi Hasegawa Biliary Surgical Department No.1 Eastern Hepatobiliary Surgical HospitalThe Naval Medical UniversityShanghaiChina Hepato-Biliary-Pancreatic Surgery Division Department of SurgeryGraduate School of MedicineThe University of TokyoTokyoJapan Department of Pathology Eastern Hepatobiliary Surgical HospitalThe Naval Medical UniversityShanghaiChina

Combined hepatocellular-cholangiocarcinoma(cHCC-CCA)is a unique type of liver tumor that contains both hepatocellular carcinoma and cholangiocarcinoma components within a single *** fifth edition of the World Health Organization classification provides a definition and diagnostic criteria for ***,the heterogeneous histomorphology and presentation resulting from variation of the proportion of each component poses challenges for clinical diagnosis and treatment.A diagnosis of cHCC-CCA may be suggested by the synchronous elevation of serum tumor markers for hepatocellular carcinoma and cholangiocarcinoma,a mixed enhancement pattern on imaging,and a discrepancy between the elevation of tumor marker and the imaging enhancement *** examination using hematoxylin and eosin staining is considered the gold standard for diagnosing cHCC-CCA,and comprehensive examination of resection or biopsy specimens is crucial for an accurate ***,there is no standard treatment for cHCC-CCA,and surgery is the *** hepatectomy with lymphadenectomy is among the recommended surgical *** role of liver transplantation in the management of cHCC-CCA is still *** chemoembolization may be effective for unresectable cHCC-CCA,particularly for hypervascular ***,the available evidence does not support systemic therapy for advanced *** prognosis of cHCC-CCA is generally poor,and there is no established staging *** research is needed to better understand the histogenesis and clinical management of *** review provides an overview of the current literature on cHCC-CCA with a focus on its clinical characteristics,pathological diagnosis,and management.

关键词： Combined hepatocellular-cholangiocarcinoma Clinical characteristics Imaging characteristics Pathological diagnosis Treatment

A comparison of the efficacy of dutasteride on reducing lower urinary tract symptoms among patients with small versus large benign prostatic hyperplasia

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Current Urology 2024年第3期18卷 199-202页

作者： Kazuyoshi Shigehara Yuki Kato Shohei kawaguchi Kouji Izumi Yoshifumi Kadono Atsushi Mizokami Department of Urology Kanazawa University Graduate School of Medical ScienceKanazawaIshikawaJapan

Background Only a few reports have currently studied the efficacy of dutasteride in patients with small benign prostatic hyperplasia(BPH).We investigated the efficacy of dutasteride on reducing lower urinary tract symptoms among *** and methods A total of 81 patients with BPH who completed 52weeks of 0.5?mg dutasteride treatment were *** patient filled out the International Prostatic Symptom Score(IPSS)and overactive bladder symptom score(OABSS)at baseline and at the 6-and 12-month follow-up *** testosterone,prostate-specific antigen,adenoma/prostate volume(PV),uroflowmetry analysis,and postvoid residual volume were evaluated at baseline and at the 12-month follow-up *** enrolled patients were divided into 2 groups according to PV at *** groups were as follows:Group A(PV≥30 mL)and Group B(PV<30 mL).Results Groups A and B had mean PVs of 52.1 and 23.6 mL and mean IPSS scores of 16.7 and 14.4,*** A had significantly higher OABSS and prostate-specific antigen levels at baseline than Group B,while no significant differences in any other baseline characteristics was *** dutasteride treatment,adenoma volume and PV decreased significantly,while testosterone level showed a significant increase in both *** A showed significant improvements in the total IPSS,voiding and storage subscore of the IPSS,OABSS,maximum flow rate,and postvoid residual *** B,on the other hand,also showed significant improvements only in the total IPSS,voiding subscore of the IPSS,and maximum flow *** The present study suggests a possible beneficial effect of dutasteride treatment on the reduction of lower urinary tract symptoms in patients with small and large ***,the effectiveness of dutasteride was limited compared to patients with large BPH(PV≥30 mL).

关键词： Benign prostatic hyperplasia Dutasteride Lower urinary tract symptoms Testosterone Voiding dysfunction

Screening for viruses in lung adenocarcinoma in China

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第3期2卷 197-199页

作者： Zhuxing Chen Peng Liang Haoxiang Xu Shengli Yang Jilong Liu Shifu Chen Ran Zhong Akira Sugimoto Wenhua Liang Jianxing He Tomoya kawaguchi Department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhouGuangdong 510120China Pulmonary Nodule Surgical Department the First People’s Hospital of FoshanFoshanGuangdong 528000China Center for Medical Research the First People’s Hospital of YulinThe Sixth Affiliated Hospital of Guangxi Medical UniversityYulinGuangxi 537000China Department of General Medicine the Second Affiliated Hospital(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou University of Chinese MedicineGuangzhouGuangdong 510120China Day Surgery Center the First People’s Hospital of FoshanFoshanGuangdong 528000China BGI Genomics BGI-ShenzhenShenzhenGuangdong 510120China HaploX Biotechnology Co.LtdShenzhenGuangdong 518000China Department of Respiratory Medicine Graduate School of MedicineOsaka Metropolitan UniversityChemotherapy CenterOsaka City University HospitalOsaka 558-8585Japan The First Clinical College Southern Medical UniversityGuangzhouGuangdong 510120China

To the Editor,Considerable numbers of cases of lung adenocarcinoma(LUAD)in non-smokers with unclear etiology have been *** and bacterial infections are the common causes of lung and respiratory diseases.1 However,whether LUAD development coexists with virus infection is still *** staining and polymerase chain reaction(PCR)are often used to detect virus in blood,sputum,and alveolar lavage fluid ***-genome sequencing(WGS)is an unbiased method with a high throughput nature that can be applied for a broader assessment of *** studies described the viral landscape in pan-cancer in The Cancer Genome Atlas(TCGA)or cohort studies;however,these studies did not include Asian ***,we sought to screen the common viral pathogens in a nationwide cohort of LUAD patients in China and further explored other potential viral pathogens by analyzing the WGS data from our single-center cohort.2 To systematically investigate the viral associations with LUAD in China,we conducted a comprehensive study that included two distinct cohorts.

关键词： adenocarcinoma lung respiratory

A Case of Warthin’s Tumor Together with IgG4-Related Sialadenitis

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Open Journal of Pathology 2024年第3期14卷 81-89页

作者： Ryogo Aoki Risa Ito Asuka Ohashi Riyoko Niwa Masashi Matsuyama Sachiko Oka Naomi kawaguchi Toshimasa Sakakima Daichi Kodama Naoki Watanabe Daisuke Okamoto Takafumi Naiki Takuji Tanaka Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP) Gifu Municipal Hospital Gifu Japan Department of Central Clinical Laboratory Gifu Municipal Hospital Gifu Japan Department of Hematology Gifu Municipal Hospital Gifu Japan

Warthin’s tumor is the second most frequent neoplasm next to pleomorphic adenoma in the salivary gland. The tumor contains the epithelial oncocyte cells with the presence of rich-mitochondria and their surrounding abundant lymphocytes. A relatively new disease entity of IgG4-related disease frequently occurs in the salivary gland. However, the coexistence of Warthin’s tumor and IgG4-related disease is scarcely observed. We have recently experienced a rare case of Warthin’s tumor with IgG4-related sialadenitis. A 51-year-old man presented to our hospital, complaining of a mass with right submandibular tenderness and spontaneous pain. A computed tomography scan of the cervical region revealed a suspicion of lymph node proliferative disease, including malignant lymphoma. Elevated serum levels of IL-2R: 1843 U/ml (reference value 122 - 496 U/ml), IgG: 3430 mg/dl (reference value 861 - 1747 mg/dl), and IgG4: 3140 mg/dl (reference value 11 - 121 mg/dl) were observed. Other laboratory data showed within normal ranges. The cervical tumor was diagnosed as Warthin’s tumor by the findings of fine-needle aspiration cytology and biopsy examination. Immunohistochemistry revealed numerous IgG4- and IgG-positive cells with fibrosis surrounding the epithelial component of Warthin’s tumor, suggesting IgG4-rerated sialadenitis. Finally, we diagnosed the cervical tumor as Warthin tumor with IgG4-related sialadenitis. This is the second report describing a case of Warthin’s tumor with possible involvement of IgG4-related sialadenitis.

关键词： Warthin’s Tumor Sialadenitis IgG4-Related Disease Immunohistochemistry

Motion Analysis of Trunk Using Simplified Human Model in Sagittal Plane

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 20-27页

作者： Masato kawaguchi Shoichiro Takehara Division of Mechanical Engineering Graduate School of Science and TechnologySophia University Department of Engineering and Applied Sciences Sophia University

The mass of very small vehicles is often comparable to that of their drivers,and thus there is a greater degree of coupling between the vehicle and the driver,compared with a case for traditional *** developing small vehicles,it is necessary to give ample consideration to the dynamics of the person who ride ***,a model of a human body riding a small personal vehicle was constructed to investigate the dynamics of the person inside such a ***,an experiment on posture maintenance by acceleration of direction of travel was conducted and the parameters for posture control were identified using agenetic *** shows that body behavior could be successfully simulated using the proposed model,and the control parameters were effective in determining the posture maintenance characteristics of the vehicle occupant.

关键词： human dynamics trunk simulation human body vehicles

Interaction between hepatitis C virus and metabolic factors

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World Journal of Gastroenterology 2014年第11期20卷 2888-2901页

作者： Yasunori kawaguchi Toshihiko Mizuta Department of Internal Medicine Saga Medical SchoolSaga 849-8501Japan

Hepatitis C virus (HCV) infection disrupts the normal metabolism processes, but is also influenced by several of the host’s metabolic factors. An obvious and significantly detrimental pathophysiological feature of HCV infection is insulin resistance in hepatic and peripheral tissues. Substantial research efforts have been put forth recently to elucidate the molecular mechanism of HCV-induced insulin resistance, and several cytokines, such as tumor necrosis factor-α, have been identified as important contributors to the development of insulin resistance in the distant peripheral tissues of HCV-infected patients and animal models. The demonstrated etiologies of HCV-induced whole-body insulin resistance include oxidative stress, lipid metabolism abnormalities, hepatic steatosis and iron overload. In addition, myriad effects of this condition have been characterized, including glucose intolerance, resistance to antiviral therapy, progression of hepatic fibrosis, development of hepatocellular carcinoma, and general decrease in quality of life. Metabolic-related conditions and disorders, such as visceral obesity and diabetes mellitus, have been shown to synergistically enhance HCV-induced metabolic disturbance, and are associated with worse prognosis. Yet, the molecular interactions between HCV-induced metabolic disturbance and host-associated metabolic factors remain largely unknown. The diet and lifestyle recommendations for chronic hepatitis C are basically the same as those for obesity, diabetes, and metabolic syndrome. Specifically, patients are suggested to restrict their dietary iron intake, abstain from alcohol and tobacco, and increase their intake of green tea and coffee (to attain the beneficial effects of caffeine and polyphenols). While successful clinical management of HCV-infected patients with metabolic disorders has also been achieved with some anti-diabetic (i.e., metformin) and anti-lipid (i.e., statins) medications, it is recommended th

关键词： Hepatitis C virus Insulin resistance Diabetes Lipid metabolism abnormality Hepatic steatosis Iron overload Oxidative stress Visceral obesity

Importance of hepatitis C virus-associated insulin resistance:Therapeutic strategies for insulin sensitization

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World Journal of Gastroenterology 2010年第16期16卷 1943-1952页

作者： Takumi kawaguchi Michio Sata Department of Digestive Disease Information & Research and Department of Medicine Kurume University School of Medicine

Insulin resistance is one of the pathological features in patients with hepatitis C virus(HCV) ***,persistence of insulin resistance leads to an increase in the risk of life-threatening complications such as cardiovascular ***,these complications are not major causes of death in patients with HCV-associated insulin ***,insulin resistance plays a crucial role in the development of various complications and events associated with HCV *** evidence indicates that HCV-associated insulin resistance may cause(1) hepatic steatosis;(2) resistance to anti-viral treatment;(3) hepatic f ibrosis and esophageal varices;(4) hepatocarcinogenesis and proliferation of hepatocellular carcinoma;and(5) extrahepatic ***,HCV-associated insulin resistance is a therapeutic target at any stage of HCV *** the risk of insulin resistance in HCV-infected patients has been documented,therapeutic guidelines for preventing the distinctive complications of HCV-associated insulin resistance have not yet been *** addition,mechanisms for the development of HCV-associated insulin resistance differ from lifestyle-associated insulin *** order to ameliorate HCV-associated insulin resistance and its complications,the eff icacy of the following interventions is discussed:a late evening snack,coffee consumption,dietary iron restriction,phlebotomy,and zinc *** is known regarding the effect of anti-diabetic agents on HCV infection,however,a possible association between use of exogenous insulin or a sulfonylurea agent and the development of HCC has recently been *** the other hand,insulin-sensitizing agents are reported to improve sustained virologic response *** this review,we summarize distinctive complications of,and therapeutic strategies for,HCVassociated insulin ***,we discuss supplementation with branched-chain amino acids as a unique insulin-sensitiz

关键词： Hepatitis C virus Diabetes mellitus Insulin resistance Complications Treatments Branched-chain amino acid

Sensitivity study of subgrid scale ocean mixing under sea ice using a two-column ocean grid in climate model CESM

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Frontiers of Earth Science 2015年第4期9卷 594-604页

作者： Meibing JIN Jennifer HUTCHINGS Yusuke kawaguchi International Arctic Research Center University of Alaska Fairbanks AK 99775 USA College of Earth Ocean and Atmospheric Sciences Oregon State University OR 97331 USA Japan Agency for Marine-Earth Science and Technology Yokosuka 237-0061 Japan

Brine drainage from sea ice formation plays a critical role in ocean mixing and seasonal variations of halocline in polar oceans. The horizontal scale of brine drainage and its induced convection is much smaller than a climate model grid and a model tends to produce false ocean mixing when brine drainage is averaged over a grid cell. A two-column ocean grid （TCOG） scheme was implemented in the Community Earth System Model （CESM） using coupled sea ice-ocean model setting to explicitly solve the different vertical mixing in the two sub- columns of one model grid with and without brine rejection. The fraction of grid with brine rejection was tested to be equal to the lead fraction or a small constant number in a series of sensitivity model runs forced by the same atmospheric data from 1978 to 2009. The model results were compared to observations from 29 ice tethered profilers （ITP） in the Arctic Ocean Basin from 2004 to 2009. Compared with the control run using a regular ocean grid, the TCOG simulations showed consistent reduction of model errors in salinity and mixed layer depth （MLD）. The model using a small constant fraction grid for brine rejection was found to produce the best model comparison with observations, indicating that the horizontal scale of the brine drainage is very small compared to the sea ice cover and even smaller than the lead fraction. Comparable to models using brine rejection parameterization schemes, TCOG achieved more improvements in salinity but similar in MLD.

关键词： climate model sea ice mixed-layer depth,ocean mixing brine drainage