A comparison of the efficacy of dutasteride on reducing lower urinary tract symptoms among patients with small versus large benign prostatic hyperplasia
作者机构:Department of UrologyKanazawa University Graduate School of Medical ScienceKanazawaIshikawaJapan
出 版 物:《Current Urology》 (当代泌尿学(英文))
年 卷 期:2024年第18卷第3期
页 面:199-202页
学科分类:1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学]
主 题:Benign prostatic hyperplasia Dutasteride Lower urinary tract symptoms Testosterone Voiding dysfunction
摘 要:Background Only a few reports have currently studied the efficacy of dutasteride in patients with small benign prostatic hyperplasia(BPH).We investigated the efficacy of dutasteride on reducing lower urinary tract symptoms among *** and methods A total of 81 patients with BPH who completed 52weeks of 0.5?mg dutasteride treatment were *** patient filled out the International Prostatic Symptom Score(IPSS)and overactive bladder symptom score(OABSS)at baseline and at the 6-and 12-month follow-up *** testosterone,prostate-specific antigen,adenoma/prostate volume(PV),uroflowmetry analysis,and postvoid residual volume were evaluated at baseline and at the 12-month follow-up *** enrolled patients were divided into 2 groups according to PV at *** groups were as follows:Group A(PV≥30 mL)and Group B(PV30 mL).Results Groups A and B had mean PVs of 52.1 and 23.6 mL and mean IPSS scores of 16.7 and 14.4,*** A had significantly higher OABSS and prostate-specific antigen levels at baseline than Group B,while no significant differences in any other baseline characteristics was *** dutasteride treatment,adenoma volume and PV decreased significantly,while testosterone level showed a significant increase in both *** A showed significant improvements in the total IPSS,voiding and storage subscore of the IPSS,OABSS,maximum flow rate,and postvoid residual *** B,on the other hand,also showed significant improvements only in the total IPSS,voiding subscore of the IPSS,and maximum flow *** The present study suggests a possible beneficial effect of dutasteride treatment on the reduction of lower urinary tract symptoms in patients with small and large ***,the effectiveness of dutasteride was limited compared to patients with large BPH(PV≥30 mL).