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Multi-exponential model to describe pressure-dependent p-and s-wave velocities and its use to estimate the crack aspect ratio

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 385-395页

作者： Mihály Dobróka norbert péter s.abó Tünde Edit Dobróka Mátyás Krisztián Baracza Department of Geophysics University of MiskolcMiskolc-Egyetemváros3515Hungary MTA-ME Geoengineering Research Group University of MiskolcMiskolc-Egyetemváros3515Hungary Research Institute of Applied Earth sciences University of MiskolcMiskolc-Egyetemváros3515Hungary

We present new quantitative model describing the pressure dependence of acoustic p-and s-wave *** that a variety of individual mechanisms or defects(such as cracks,pore collapse and grain crushing)can contribute to the pressure-dependent change of the wave velocity,we order a characteristic pressure to all of them and allow a series of exponential terms in the description of the(pand s-waves)velocity-pressure *** estimate the parameters of the multi-exponential rock physical model in inversion procedures using laboratory measured p-and s-wave velocity *** is known,the conventional damped least squares method gives acceptable results only when one or two individual mechanisms are *** the number of exponential terms leads to highly nonlinear ill-posed inverse *** to this reason,we develop the spectral inversion method(sIM)in which the velocity amplitudes(the spectral lines in the characteristic pressure spectrum)are only considered as *** characteristic pressures(belonging to the velocity amplitudes)are excluded from the set of inversion unknowns,instead,they are defined in a set of fixed positions equidistantly distributed in the actual interval of the independent variable(pressure).Through this novel linear inversion method,we estimate the parameters of the multi-exponential rock physical model using laboratory measured p-and s-wave velocity *** characteristic pressures are related to the closing pressures of cracks which are described by well-known rock mechanical relationships depending on the aspect ratio of elliptical *** gives the possibility to estimate the aspect ratios in terms of the characteristic pressures.

关键词： Multi-exponential rock physical model spectral inversion method(sIM) Crack aspect ratio Characteristic pressures

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Insulin is necessary for the hypertrophic effect of cholecystokinin-octapeptide following acute necrotizing experimental pancreatitis

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World Journal of Gastroenterology 2004年第15期10卷 2275-2277页

作者： péter Hegyi Zoltán RakonczayJr Réka sári László Czakó norbert Farkas Csaba Góg József Németh János Lonovics Tamás Takács First Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary School of Cell and Molecular BiosciencesMedical SchoolUniversity of NewcastleNewcastle upon TyneNE2 4HHUnited Kingdom First Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary Jr.School of Cell and Molecular BiosciencesMedical SchoolUniversity of NewcastleNewcastle upon TyneNE2 4HHUnited Kingdom First Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary

AIM:In previous experiments we have demonstrated that by administering low doses of cholecystokinin-octapeptide (CCK-8),the process of regeneration following L-arginine (Arg)-induced pancreatitis is *** rats that were also diabetic(induced by streptozotocin,sTZ),pancreatic regeneration was not *** aim of this study was to deduce whether the administration of exogenous insulin could in fact restore the hypertrophic effect of CCK-8 in diabetic-pancreatitic rats. METHODs:Male Wistar rats were used for the experiments. Diabetes mellitus was induced by administering 60mg/kg body mass of sTZ intraperitoneally(i.p.),then,on d 8, pancreatitis was induced by 200mg/100 g body mass Arg *** at an interval of 1 *** animals were injected subcutaneously twice daily(at 7 *** 7 p.m.)with 1 μg/kg of CCK-8 and/or 2 IU mixed insulin(300g/L short- action and 700g/L intermediate-action insulin) for 14 d after pancreatitis *** this the animals were killed and the serum amylase,glucose and insulin levels as well as the plasma glucagon levels,the pancreatic mass/body mass ratio(pm/bm),the pancreatic contents of DNA,protein,amylase,lipase and trypsinogen were *** tissue samples were examined by light microscopy on paraffin-embedded sections. REsULTs:In the diabetic-pancreatitic rats treatment with insulin and CCK-8 significantly elevated pw/bm and the pancreatic contents of protein,amylase and lipase vs the rats receiving only CCK-8 ***-8 administered in combination with insulin also elevated the number of acinar cells with mitotic activities,whereas CCK-8 alone had no effect on laboratory parameters or the mitotic activities in diabetic-pancreatitic rats. CONCLUsION:Despite the hypertrophic effect of CCK-8 being absent following acute pancreatitis in diabetic-rats, the simultaneous administration of exogenous insulin restored this *** results clearly demonstrate that insulin is necessary for the hypertrophic ef

关键词： Animals Diabetes Mellitus, Experimental Hypoglycemic Agents Insulin Male pancreatitis, Acute Necrotizing Rats Rats, Wistar Regeneration Research support, Non-U.s. Gov't sincalide

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Cluster Analysis Assisted Float-Encoded Genetic Algorithm for a More Automated Characterization of Hydrocarbon Reservoirs

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Intelligent Control and Automation 2013年第4期4卷 362-370页

作者： norbert péter s.abó Mihály Dobróka Réka Kavanda Department of Geophysics University of Miskolc Miskolc Hungary kavreka@***

A genetic algorithm-based joint inversion method is presented for evaluating hydrocarbon-bearing geological formations. Conventional inversion procedures routinely used in the oil industry perform the inversion processing of borehole geophysical data locally. As having barely more types of data than unknowns in a depth, a set of marginally over-determined inverse problems has to be solved along a borehole, which is a rather noise sensitive procedure. For the reduction of noise effect, the amount of overdetermination must be increased. To fulfill this requirement, we suggest the use of our interval inversion method, which inverts simultaneously all data from a greater depth interval to estimate petrophysical parameters of reservoirs to the same interval. A series expansion based discretization scheme ensures much more data against unknowns that significantly reduces the estimation error of model parameters. The knowledge of reservoir boundaries is also required for reserve calculation. Well logs contain information about layer-thicknesses, but they cannot be extracted by the local inversion approach. We showed earlier that the depth coordinates of layerboundaries can be determined within the interval inversion procedure. The weakness of method is that the output of inversion is highly influenced by arbitrary assumptions made for layer-thicknesses when creating a starting model (i.e. number of layers, search domain of thicknesses). In this study, we apply an automated procedure for the determination of rock interfaces. We perform multidimensional hierarchical cluster analysis on well-logging data before inversion that separates the measuring points of different layers on a lithological basis. As a result, the vertical distribution of clusters furnishes the coordinates of layer-boundaries, which are then used as initial model parameters for the interval inversion procedure. The improved inversion method gives a fast, automatic and objective estimation to layer-boundari

关键词： Hierarchical Cluster Analysis Genetic Algorithm Well-Logging Interval Inversion

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symbiotic nitrogen fixation in black locust (Robinia pseudoacacia L.) seedlings from four seed sources

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Journal of Forestry Research 2011年第4期22卷 689-692页

作者： Alireza Moshki norbert p. Lamersdorf Büsgen-Institut Soil Science of Temperate and Boreal Ecosystems Faculty of Forest Sciences and Forest Ecology University of Goettingen Büsgenweg 2 37077 Goettingen Germany

We conducted a greenhouse experiment to investigate the role of seed source in growth and symbiotic nitrogen fixation of black locust （Robinia pseudoacacia L）. seeds from different sources were planted in the same environmental conditions and inoculated with a suspension of mixed Rhizobium. We used the modified ^15N isotope dilution method to estimate biological nitrogen fixation of Robinia trees. Different Robinia seed sources differed significantly in terms of tissue dry weight （50.6-80.1 g）, total N （1.31-2.16 g） and proportion of nitrogen derived from the atmosphere （ 0-51%）. A higher nitrogen fixation rate of Robinia trees was associated with higher dry weight. Moreover, the leaves of Robinia proved to adequately represent the nitrogen fixation capacity of entire plants. Our results confirmed that assessment of seed sources is a useful way to improve the nitrogen fixation capacity and therefore the growth rate of Robinia.

关键词： Robinia pseudoacacia seed source ^15N dilution method symbiotic nilxogen fixation

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Cholesterol crystal binding of biliary immunoglobulin A: visualization by fluorescence light microscopy

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World Journal of Gastroenterology 2001年第2期7卷 198-202页

作者： Frank Lammert stefan südfeld norbert Busch siegfried Matern Department of Medicine III University of Technology (RWTH) AachenGermany

AIM: To assess potential contributions of biliary IgA for crystal agglomeration into gallstones, we visualized cholesterol crystal binding of biliary IgA. METHODs: Crystal binding biliary proteins were extracted from human gallbladder bile using lectin affinity *** IgA was isolated from the bound protein fraction by immunoaffinity chromatography. pure cholesterol monohydrate crystals were incubated with biliary IgA and fluoresceine isothiocyanate (FITC)conjugated anti IgA at 37 degree. samples were examined under polarizing and fluorescence light microscopy with digital image processing. REsULTs: Binding of biliary IgA to cholesterol monohydrate crystals could be visualized with FITC conjugated anti IgA *** fluorescence occurred at crystal edges and dislocations. Controls without biliary IgA or with biliary IgG showed no significant fluorescence. CONCLUsION: Fluorescence light microscopy provided evidence for cholesterol crystal binding of biliary IgA. Cholesterol crystal binding proteins like IgA might be important mediators of crystal agglomeration and growth of cholesterol gallstones by modifying the evolving crystal structures in vivo.

关键词： Crystallization Bile Cholelithiasis Cholesterol Chromatography, Affinity Fluorescent Antibody Technique Humans Image processing, Computer-Assisted Immunoglobulin A, secretory Microscopy, Fluorescence Research support, Non-U.s. Gov't

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Research and development of VUV optical coatings for micro mirror applications

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光学精密工程 2005年第4期13卷 465-470页

作者： Alexandre Gatto norbert Kaiser Fraunhofer IOF Albert-Einstein-Str. 7 D-07745 Jena GermanyFraunhofer IOF Albert-Einstein-Str. 7 D-07745 Jena Germany

This paper deals with vacuum UV optical coatings for micro mirror applications. High reflecting low-stress optical coatings have been developed for the next-generation of micro mechanical mirrors. The optimized metal systems are applicable in the VUV spectral region and can be integrated in the technology of MOEMs, such as spatial light modulators (sLM) and micro scanning mirrors.

关键词： VUV 光学涂覆技术微镜技术薄膜调节器

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Tests of gravitational symmetries with radio pulsars

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science China(physics,Mechanics & Astronomy) 2016年第9期59卷 10-32页

作者： LiJing shao norbert Wex Max planck Institute for Gravitational physics (Albert Einstein Institute) Potsdam-Golm D-14476 Germany school of physics and state Key Laboratory of Nuclear physics and Technology Peking University Beijing 100871 China Max-planck-Institut fur Radioastronomie Bonn D-53121 Germany

symmetries play important roles in modern theories of physical laws. In this paper, we review several experimental tests of important symmetries associated with the gravitational interaction, including the universality of free fall for self-gravitating bodies,time-shift symmetry in the gravitational constant, local position invariance and local Lorentz invariance of gravity, and spacetime translational symmetries. Recent experimental explorations for post-Newtonian gravity are discussed, of which, those from pulsar astronomy are highlighted. All of these tests, of very different aspects of gravity theories, at very different length scales, favor to very high precision the predictions of the strong equivalence principle(sEp) and, in particular, general relativity which embodies sEp completely. As the founding principles of gravity, these symmetries are motivated to be promoted to even stricter tests in future.

关键词： gravitation radio pulsars spacetime symmetry

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A NOVEL DEsIGN OF COMpOsITE WAter TURBINE UsING CFD

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Journal of Hydrodynamics 2012年第1期24卷 11-16页

作者： pIECHNA Janusz MLLER norbert Turbomachinery Laboratory Department of Mechanical EngineeringMichigan State UniversityEast LansingUSA

This paper presents computational investigation of a novel design of composite material axial water turbine using Computational Fluid Dynamics（CFD）.Based on three-dimensional numerical flow analysis,the flow characteristics through the water turbine with nozzle,wheel and diffuser are *** extract power and torque of a composite water turbine at different rotating speeds were calculated and analyzed for a specific flow *** simulation results show that using nozzle and diffuser can increase the pressure drop across the turbine and extract more power from available water *** results provide a fundamental understanding of the composite water turbine,and this design and analysis method is used in the design process.

关键词： water turbine composite material Computational Fluid Dynamics(CFD) extracted power

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pivotal Role of pGE_2 and IL-10 in the Cross-Regulation of Dendritic Cell-Derived Inflammatory Mediators

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Cellular & Molecular Immunology 2006年第4期3卷 271-277页

作者： Hedi Harizi norbert Gualde CNRs UMR 5540 Bordeaux Université Bordeaux 2France

Exposure to pathogens induces antigen-presenting cells （ApC） such as macrophages and dendritic cells （DC） to produce various endogenous mediators, including arachidonic acid （AA）-derived eicosanoids, cytokines, and nitric oxide （NO）. Many secreted products of activated ApC can act by themselves in an autocrine manner and modulate their function. Moreover, the cross-interaction between endogenous bioactive molecules regulates the function of professional ApC with important consequences for their ability to activate and sustain immune and inflammatory responses, and to regulate immune homeostasis. Although neglected for many years when compared to their role in cardiovascular homeostasis, cancer and inflammation, the importance of eicosanoids in immunology is becoming more defined. The role of prostaglandin （pG） E2 （pGE2）, one of the best known and most well studied eicosanoids, is of particular interest. It modulates the activities of professional DC by acting on their differentiation, maturation and their ability to secrete cytokines. Uniquely among haematopoietic cytokines, interleukin-10 （IL-10） is a pleiotropic molecule that displays both immunostimulatory and immunoregulatory activities. IL-10 has attached much attention because of its anti-inflammatory properties. It modulates expression of cytokines, soluble mediators and cell surface molecules by cells of myeloid origin, particularly macrophages and DC. We previously reported that pGE2 is a potent inducer of IL-10 in bone marrow-derived DC （BM-DC）, and pGE2-induced IL-10 is a key regulator of the BM-DC pro-inflammatory phenotype. BM-DC may be considered as an important model to study complex interactions between endogenous mediators, and autocrine IL-10 plays a pivotal role in the crossregulation of AA-derived lipid mediators, cytokines, and NO, with critical effects on immune and inflammatory responses.

关键词： BM-DC IL-10 pGE2 feed-back regulation cytokine inflammation

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Experimental study on polarization holographic storage in genetic mutant BR-D96N film

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science China(physics,Mechanics & Astronomy) 2004年第3期47卷 284-292页

作者： MENKE Neimule norbert HAMpp state Key Laboratory of Transient Optics Technology Xi'n Institute of Optics and Precision Mechanics Chinese Academy of Sciences Xi'n 710068 ChinaInstitute of Physical Chemistry University of Marburg D-35032 Marburg Germany

Recording with both parallel and orthogonal linearly polarized lights, polarization holographic storage in genetic mutant BR-D96N film is reported with both transmission type geometry and reflection type geometry. polarization properties of diffraction light and scattering light are discussed for two different cases, parallel polarization recording and orthogonal polarization recording. It shows that, compared with recording with parallel polarization lights, orthogonal polarization holography can separate the diffraction light from the scattering noise, therefore improving the signal-to-noise ratio. It also shows that, compared with reconstruction with reference light, reconstruction with phase conjugated wave of the reference light can improve the signal-to-noise ratio of the reconstructed diffraction image, and also the wave-front aberration of the object light introduced by irregular phase object in the optical pass-way can also be corrected effectively, which ensures that the reconstructed diffraction image has a better fidelity. The preliminary angle-multiplexed volume holographic storage multiplexed by transmission type geometry and reflection type geometry is demonstrated in the BR-D96N film. Experiment shows that there is no cross-talk between the two pages of images except for some scattering noises.

关键词： polarization holography, BR-D96N, photochromism, phase conjugation, photo-induced anisot-ropy.

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