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Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism

World Journal of Stem Cells 2016年第10期8卷 306-315页

作者： Taylor C Peak nora m haney William Wang Kenneth J DeLay Wayne J Hellstrom Department of Urology School of MedicineTulane University

The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation.

关键词： Stem cell therapy Leydig cells Primary hypogonadism Stem Leydig cells Testosterone Bone marrow-derived stem cells Adipose-derived mesenchymal stem cells

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Friction and wear performance of polyether ether ketone(PEEK)polymers in three lubrication regimes

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Friction 2024年第4期12卷 670-682页

作者： Davide mASSOCCHI nora LECIS marco LATTUADA Davide SCAGLIA Steven CHATTERTON Paolo PENNACCHI Department of mechanical Engineering Politecnico di MilanoMilan 20156Italy Eni SpA Downstream product R&DLombardia 20097Italy Eurobearings S.R.L. Lombardia 29016Italy

This experimental study investigates the friction and wear of three coatings commonly used in industrial applications,particularly in hydrodynamic *** three materials under investigation were Babbitt,polyether ether ketone(PEEK)reinforced with 15%carbon fibers,and PEEK reinforced with 20%carbon *** first polymer material was extruded,while the other was produced by fused deposition modelling(FDm).The materials were subjected to sliding tests in a pin-on-disc configuration,with a steel ball serving as the counter *** tests were conducted at room temperature,with a load of 10 N and under three different lubrication conditions:dry,grease,and *** linear speed was set at 0.3 m/s for the dry and semi-solid lubrication tests,while for the oil tests,the speed was set at 0.25 m/*** greases used had consistency grades of NGLI 000 and NGLI *** ISO VG 68 circulation oil was used for the oil lubrication ***,thermodynamic analyses were performed under the most severe conditions(i.e.,dry)to investigate the steel-Babbitt and steel-PEEK contact.

关键词： hydrodynamic bearings polyether ether ketone(PEEK)polymers additive manufacturing grease lubrication sliding oil lubrication ball-on-disk tribology

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Inhibition of autophagy rescues HT22 hippocampal neurons from erastin-induced ferroptosis

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Neural Regeneration Research 2023年第7期18卷 1548-1552页

作者： nora Hanke Abdelhaq Rami Institut für Experimentelle Neurobiologie(Anatomie Ⅱ) Klinikum der Johann Wolfgang von Goethe-UniversitätTheodor-Stern-Kai 760590 Frankfurt/MainGermany

Ferroptosis is a regulated form of cell death which is considered an oxidative iron-dependent *** lipid hydroperoxidase glutathione peroxidase 4 prevents the iron(Fe2+)-dependent formation of toxic lipid reactive oxygen *** emerging evidence indicates that inhibition of glutathione peroxidase 4 as a hallmark of ferroptosis in many cancer cell lines,the involvement of this biochemical pathway in neuronal death remains largely ***,we investigate,first whether the ferroptosis key players are involved in the neuronal cell death induced by *** second objective was to examine whether there is a cross talk between ferroptosis and *** third main was to address neuron response to erastin,with a special focus on ferritin and nuclear receptor coactivator 4-mediated *** test this in neurons,erastin(0.5-8μm)was applied to hippocampal HT22 neurons for 16 *** addition,cells were cultured with the autophagy inhibitor,3-methyladenin(10 mm)and/or ferroptosis inhibitors,ferrostatin 1(10-20μm)or deferoxamine(10-200μm)before exposure to *** this study,we demonstrated by immunofluorescence and western blot analysis,that erastin downregulates dramatically the expression of glutathione peroxidase 4,the sodium-independent cystine-glutamate antiporter and nuclear receptor coactivator *** protein levels of ferritin and mitochondrial ferritin in HT22 hippocampal neurons did not remarkably change following erastin *** addition,we demonstrated that not only the ferroptosis inhibitor,ferrostatin1/deferoxamine abrogated the ferroptotic cell death induced by erastin in hippocampal HT22 neurons,but also the potent autophagy inhibitor,*** conclude that(1)erastin-induced ferroptosis in hippocampal HT22 neurons,despite reduced nuclear receptor coactivator 4 levels,(2)that either nuclear receptor coactivator 4-mediated ferritinophagy does not occur or is of secondary importance in this model,(3)that ferroptos

关键词： erastin ferritin ferritinophagy ferroptosis glutathione peroxidase 4 HT22 neurons nuclear receptor coactivator 4

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Improved mPPT Control Strategy for PV Connected to Grid Using IncCond-PSO-mPC Approach

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 1008-1020页

作者： nora Kacimi Abdelhakim Idir Said Grouni mohamed Seghir Boucherit Laboratoire de Commande de Processus ENP AlgerAlgiersAlgeria Electrical Engineering Department University of M’silaBP 28000M’silaAlgeria Boumerdes University Boumerdes35000BoumerdesAlgeria.He is now with the Tamaghasset UniversityAlgeria

This paper proposes a new hybrid maximum power point tracking(mPPT)control strategy for grid-connected solar systems based on Incremental conductance—Particle Swarm Optimization and model Predictive Controller(IncCond-PSOmPC).The purpose of the suggested method is to create as much power as feasible from a PV system during environmental changes,then transfer it to the power *** accomplish this,a hybrid combination of incremental conductance(IncCond)and particle swarm optimization(PSO)is proposed to locate maximum power,followed by model predictive control(mPC)to track maximum power and control the boost converter to achieve high performance regardless of parameter variations.A two-level inverter,likewise,controlled by model Predictive Control,is employed to inject the PV power *** this application,the mPC is based on minimizing the difference between the reference and prediction powers,which is computed to select the switching state of the *** proposed system is simulated and evaluated in a variety of dynamic conditions using matlab/*** reveal that the proposed control mechanism is effective at tracking the maximum power point(mPP)with fewer power oscillations.

关键词： DC/DC boost converter grid-connected PV incremental conductance particle swarm optimization and model predictive controller(IncCond-PSO-mPC) maximum power point tracking(mPPT) photovoltaic(PV)

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Actinidia deliciosa as a complemental therapy against nephropathy and oxidative stress in diabetic rats

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Food Science and Human Wellness 2023年第6期12卷 1981-1990页

作者： Ali Y.Naoom Wenyi Kang nora F.Ghanem mohamed m.Abdel-Daim Fatma m.El-Demerdash Department of medical Laboratory Techniques Imam Ja'afar Al-Sadiq UniversityAl-Muthanna 66002Iraq National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Department of Zoology Faculty of ScienceKafr ElSheikh UniversityKafr El Sheikh 33516Egypt Department of Pharmaceutical Sciences Pharmacy ProgramBatterjee Medical CollegeJeddah 21442Saudi Arabia Pharmacology Department Faculty of Veterinary MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Environmental Studies Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria 21526Egypt

This study aimed to evaluate the anti-hyperglycemic and antioxidant role of Actinidia deliciosa(kiwifruits)aqueous extract in streptozotocin-treated *** were distributed into;control,*** aqueous extract(ADAE;1 g/kg orally),streptozotocin(STZ;50 mg/kg,i.p,single dose),and STZ plus ADAE,*** showed that ADAE had high antioxidant and radical scavenging *** in blood sugar level,lipid peroxidation(LPO),kidney function biomarkers,and perturbations in hematological parameters were observed in diabetic ***,enzymatic and non-enzymatic antioxidants,protein content,and alkaline phosphatase(ALP)activity ***,histological,immunohistochemical alpha-smooth muscle actin immunoreactivity(α-SmA-ir)and histochemical(collagen,total protein,DNA,and RNA)alterations were observed in rat ***,STZ produced upregulation of inflammatory associated genes(tumor necrosis factor-alpha;TNF-αand transforming growth factorβ1;TGF-β1)and triggered apoptosis by upregulating apoptotic related gene[Bcl2-associated X protein(Bax)]and downregulating anti-apoptotic related gene B-cell lymphoma-2(Bcl-2)based on real-time PCR ***,diabetic rats administered with ADAE showed significant restoration in LPO,antioxidant status,and biochemical indices besides tissue architecture,and genes improvement regarding STZ ***,*** has a valuable ameliorative infl uence and can restore glucose levels and improve kidney dysfunction in diabetic rats.

关键词： Diabetes mellitus Actinidia deliciosa Inflammation Apoptosis Oxidative stress Nephropathy

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Incremental Learning Framework for mining Big Data Stream

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Computers, materials & Continua 2022年第5期71卷 2901-2921页

作者： Alaa Eisa nora E.L-Rashidy mohammad Dahman Alshehri Hazem m.El-bakry Samir Abdelrazek Information Systems Department Faculty of Computers and InformationMansoura UniversityMansoura35516Egypt machine Learning and Information Retrieval Department Faculty of Artificial IntelligenceKafrelsheikh UniversityKafr El-SheikhEgypt Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

At this current time,data stream classification plays a key role in big data analytics due to its enormous *** of the existing classification methods used ensemble learning,which is trustworthy but these methods are not effective to face the issues of learning from imbalanced big data,it also supposes that all data are *** weakness of current methods is that it takes a long evaluation time when the target data stream contains a high number of *** main objective of this research is to develop a new method for incremental learning based on the proposed ant lion fuzzy-generative adversarial network *** proposed model is implemented in spark *** each data stream,the class output is computed at slave nodes by training a generative adversarial network with the back propagation error based on fuzzy bound *** method overcomes the limitations of existing methods as it can classify data streams that are slightly or completely unlabeled data and providing high scalability and *** results show that the proposed model outperforms stateof-the-art performance in terms of accuracy(0.861)precision(0.9328)and minimal mSE(0.0416).

关键词： Ant lion optimization(ALO) big data stream generative adversarial network(GAN) incremental learning renyi entropy

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Picomolar antimalarial agent from a Chinese medicinal plant

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Science China Chemistry 2022年第1期65卷 82-86页

作者： Bin Zhou Flavia m.Zimbres Joshua H.Butler Cheng-Hui Xu Reagan S.haney Yan Wu maria B.Cassera Jian-min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Biochemistry and molecular Biology Center for Tropical and Emerging Global Diseases(CTEGD)University of GeorgiaAthensGeorgia 30602United States

In our long-term efforts searching for antimalarial agents from Chinese medicinal plants,seven novel dimeric sesquiterpenoids(1–7)with significant antimalarial activity were isolated and characterized from the whole plants of Sarcandra glabra *** by solid data acquired by diverse *** them,compound 3 with an EC50 value of 4.3 pm against the chloroquine-resistant Plasmodium falciparum is the most potent antimalarial agent reported hitherto,about 1,000-fold stronger than *** article further consolidates and refines our previously delineated structure-activity relationship for this antimalarial compound class.

关键词： medicinal plants dimeric sesquiterpenoids antimalarial agent structure-activity relationship

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Hamstring autograft utilization in reconstructing anterior cruciate ligament:Review of harvesting techniques,graft preparation,and different fixation methods

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World Journal of Orthopedics 2022年第10期13卷 876-890页

作者： Waleed Albishi Baraa Baltow nora Albusayes Ameer A Sayed Hamza m Alrabai Department of Orthopedic Surgery College of MedicineKing Saud UniversityRiyadh 11362Saudi Arabia Department of Orthopedic Surgery AlHada Armed Forces HospitalMinistry of DefenseAlHada 26792Saudi Arabia Department of Orthopedic Surgery King Fahad Armed Forces HospitalMinistry of DefenseJeddah 23311Saudi Arabia

Rupture of the anterior cruciate ligament(ACL)is a common orthopedic *** graft options are available for the reconstruction of ruptured *** the hamstring muscle as an autograft was first described in 1934,and it remains a commonly harvested graft for ACL *** autografts can be harvested using the traditional anteromedial approach or the newer posteromedial *** isolated semitendinosus tendon can be used or combined with the gracilis *** are numerous methods for graft fixation,such as intra-tunnel or extra-tunnel *** comprehensive review discusses the different hamstring muscle harvesting techniques and graft preparation options and fixation *** provides a comprehensive overview for choosing the optimal surgical technique when treating patients.

关键词： Anterior cruciate ligament Anterior cruciate ligament reconstruction Graft fixation Hamstring autograft Infrapatellar nerve injury Patient reported outcomes

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metabolic regulation of immune responses to cancer

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Cancer Biology & medicine 2022年第11期19卷 1528-1542页

作者： Jannis WiBfeld Anke Werner Xin Yan nora ten Bosch Guoliang Cui Helmholtz Institute for Translational Oncology(HI-TRON) Mainz 55131Germany T Cell metabolism Group(D192) German Cancer Research Center(DKFZ)Heidelberg 69120Germany Faculty of Biosciences Heidelberg UniversityHeidelberg 69120Germany

The tumor microenvironment is an ecosystem composed of multiple types of cells, such as tumor cells, immune cells, and cancerassociated fibroblasts. Cancer cells grow faster than non-cancerous cells and consume larger amounts of nutrients. The rapid growth characteristic of cancer cells fundamentally alters nutrient availability in the tumor microenvironment and results in reprogramming of immune cell metabolic pathways. Accumulating evidence suggests that cellular metabolism of nutrients, such as lipids and amino acids, beyond being essential to meet the bioenergetic and biosynthetic demands of immune cells, also regulates a broad spectrum of cellular signal transduction, and influences immune cell survival, differentiation, and anti-tumor effector function. The cancer immunometabolism research field is rapidly evolving, and exciting new discoveries are reported in high-profile journals nearly weekly. Therefore, all new findings in this field cannot be summarized within this short review. Instead, this review is intended to provide a brief introduction to this rapidly developing research field, with a focus on the metabolism of two classes of important nutrients-lipids and amino acids-in immune cells. We highlight recent research on the roles of lipids and amino acids in regulating the metabolic fitness and immunological functions of T cells, macrophages, and natural killer cells in the tumor microenvironment. Furthermore, we discuss the possibility of “editing” metabolic pathways in immune cells to act synergistically with currently available immunotherapies in enhancing anti-tumor immune responses.

关键词： Lipids amino acids cancer anti-tumor immunity T cells NK cells metabolism immunometabolism

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Using immune cell-based bioactivity assays to compare the inflammatory activities of oil sands process-affected waters from a pilot scale demonstration pit lake

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Journal of Environmental Sciences 2023年第6期128卷 55-70页

作者： Dustin m.E.Lillico nora A.S.Hussain Yemaya Y.Choo-Yin Rui Qin Zuo Tong How mohamed Gamal El-Din James L.Stafford Department of Biological Sciences University of AlbertaAlberta T6G 2E9Canada Department of Civil and Environmental Engineering University of AlbertaAlberta T6G 2E9Canada

In this study,we provide evidence that oil sands process-affected waters(OSPW)contain factors that activate the antimicrobial and proinflammatory responses of immune ***,using the murine macrophage RAW 264.7 cell line,we establish the bioactivity of two different OSPW samples and their isolated ***,we directly compared the bioactivity of two pilot scale demonstration pit lake(DPL)water samples,which included expressed water from treated tailings(termed the before water capping sample;BWC)as well as an after water capping(AWC)sample consisting of a mixture of expressed water,precipitation,upland runoff,coagulated OSPW and added *** inflammatory(*** activating)bioactivity was associated with the AWC sample and its organic fraction(OF),whereas the BWC sample had reduced bioactivity that was primarily associated with its inorganic fraction(IF).Overall,these results indicate that at non-toxic exposure doses,the RAW 264.7 cell line serves as an acute,sensitive and reliable biosensor for the screening of inflammatory constituents within and among discrete OSPW samples.

关键词： OSPW Oil sands Tailings ponds Remediation macrophages Bioactivity Bioindicator Immunoecotoxicology

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