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Demethylbelamcandaquinone B from Marantodes pumilum ***(Blume)Kuntze inhibits osteoclast differentiation in RAW264.7 cells

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Asian Pacific Journal of Tropical Biomedicine 2021年第12期11卷 535-542页

作者： Haryati Ahmad Hairi Jamia Azdina Jamal Nor Ashila Aladdin Khairana Husain noor Suhaili mohd Sofi Norazlina Mohamed Isa Naina Mohamed Ahmad Nazrun Shuid Department of Biochemistry Faculty of MedicineManipal University College MalaysiaJalan Batu HamparBukit Baru75150 MelakaMalaysia Faculty of Pharmacy Universiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz50300 Kuala LumpurMalaysia Department of Pharmacology Faculty of MedicinePreclinical BuildingUniversiti Kebangsaan MalaysiaJalan Yaacob LatiffBandar Tun RazakCheras56000 Kuala LumpurMalaysia Department of Pharmacology Faculty of MedicineUniversiti Teknologi MaraJalan Hospital47000 Sungai BulohSelangorMalaysia

Objective:To investigate the bone-resorbing effect of demethylbelamcandaquinone B(Dmcq B)extracted from Marantodes pumilum *** on osteoclast differentiation in RAW264.7 ***:RAW264.7 macrophages were differentiated using RANKL into osteoclast-like ***,they were treated with 10μg/mL Marantodes pumilum *** crude aqueous extract,5μg/mL dichloromethane fraction,and 0.6μg/mL Dmcq B and 0.06μg/mL ***-resistant acid phosphatase 5b(TRACP 5b)as an osteoclast phenotypic marker was determined by TRACP staining and TRACP 5b colometric assay,and bone-resorbing pits were *** gene expression of pro-inflammatory cytokines(TNF-αand IL-6)was ***,the protein expressions of pro-inflammatory cytokines(TNF-αand IL-6)and estrogen receptors were ***:Marantodes pumilum *** crude aqueous extract and Dmcq B inhibited RANKL-stimulated osteoclast differentiation as evidenced by size reduction of giant multinucleated osteoclast cells,decreased TRACP 5b activity as well as the subsiding of resorbed pit area compared with normal *** addition,they reduced the gene and protein expressions of TNF-αand *** pumilum ***,Dmcq B,and estradiol treatments increased the protein expressions of estrogen receptors alpha and beta in ***:Marantodes pumilum *** and its active compound,Dmcq B can inhibit osteoclast differentiation.

关键词： Marantodes pumilum var.alata Phytoestrogen RAW264.7 induced-osteoclast Bone-resorbing effect

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Forensic profiling of non-volatile organic compounds in soil using ultra-performance liquid chromatography:a pilot study

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Forensic Sciences Research 2022年第4期7卷 761-773页

作者： Loong Chuen Lee Ab Aziz Ishak Ameeta A/P Nai Eyan Anas Fahmi Zakaria Nurul Syahiera Kharudin Nor Azman mohd noor Program of Forensic Sciences Centre for DiagnosticTherapeutic&Investigative StudiesFaculty of Health SciencesUniversiti Kebangsaan MalaysiaBangiMalaysia Institute of IR4.0 Universiti Kebangsaan MalaysiaBangiMalaysia Makmal Forensik Polis DiRaja Malaysia(PDRM) CherasMalaysia

Soil is of particular interest to the forensic community because it can be used as valuable associative evidence to link a suspect to a victim or a crime *** chromatography is a powerful analytical tool for organic compound ***,high-performance liquid chromatography(HPLC)has proven to be an efficient method for forensic soil analysis,especially in discriminating soils from proximity ***,ultra-performance liquid chromatography(UPLC),which is much more sensitive than HPLC,has never been explored in this *** study proposed a UPLC method for profiling non-volatile organic compounds in three Malaysian soils(red,brown and yellowish-brown soils).The three soils were analysed separately to assess the effects of individual chromatographic parameters:(a)elution programme(isocratic *** gradient programmes);(b)flow rate(0.1 vs.0.2 mL/min);(c)extraction solvent(acetonitrile ***)and(d)detection wavelength(230 vs.254 nm).The injection volume and total run time were set to 5μL and 35 min,***,each soil sample gave 24 different *** showed that the most desirable chromatographic parameters were(a)isocratic elution;(b)flow rate at 0.2 mL/min and(c)acetonitrile extraction *** proposed UPLC system is expected to be a feasible method for profiling non-volatile organic compounds in soil,and is more chemical-efficient than a comparable HPLC system.

关键词： Forensic sciences soil non-volatile organic compound liquid chromatography

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Anthropogenic disturbance of aquatic biodiversity and water quality of an urban river in Penang, Malaysia

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Water Science and Engineering 2023年第3期16卷 234-242页

作者： Nur Azalina Suzianti Feisal noor Haziqah Kamaludin Muhammad Firdaus Abdullah Sani Dayang Khairulnisa Awang Ahmad mohd Azwan Ahmad Nur Faiza Abdul Razak Tengku Nilam Baizura Tengku Ibrahim Department of Environmental Health Faculty of Health SciencesMAHSA UniversityBandar Saujana Putra42610 JenjaromMalaysia Center of Environmental Health&Safety Faculty of Health SciencesUniversiti Teknologi MARA42300 Puncak AlamMalaysia NaturePRO Services Port Dickson71000 Negeri SembilanMalaysia Department of Environmental Health Faculty of Health SciencesUniversiti Teknologi MARACawangan Pulau PinangKampus Bertam13200 Pulau PinangMalaysia

Malaysia's rapid economic and demographic development have placed negative pressure on its water supplies and the quality of the Juru River, which is close to the nation's capital and its major source of water. Healthy aquatic ecosystems are supported by physicochemical properties and biological diversity. This study evaluated the anthropogenic impacts on aquatic biodiversity, especially plankton, fish, and macrobenthos, as well as the water quality of the Juru River in the Penang area. Aquatic biodiversity and river water parameters were collected from ten sampling stations along the Juru River. Seven variables were used to assess the physicochemical environment: pH, temperature, total suspended solids (TSS), salinity, dissolved oxygen (DO), biochemical oxygen demand (BOD), and chemical oxygen demand. At each sampling station, the total number of plankton, fish, and macrobenthic taxa were counted and analyzed. The relationships between the physicochemical parameters and aquatic biodiversity were investigated with biotypological analysis, principal component analysis, hierarchical cluster analysis, and linear regression analysis. These analyses showed that the richness and diversity indices were generally influenced by salinity, temperature, TSS, BOD, and pH. The data obtained in this study supported the bioindicator concept. The findings, as they related to scientifically informed conservation, could serve as a model for Juru River management, as well as for river management throughout Malaysia and other tropical Asian countries.

关键词： Anthropogenic disturbance Aquatic biodiversity River water quality Urban river Hierarchical cluster analysis

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Synthesis and Characterization of Co/Mo Bimetallic Nanocatalysts

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材料科学与工程（中英文A版） 2011年第3X期1卷 390-397页

作者： Sardar Ali noor Asmawati mohd Zabidi Duvvuri Subbarao Department of Chemical Engineering Universiti Teknologi PETRONAS Bandar Seri lskandar Tronoh 31750 Perak Malaysia Department of Fundamental and Applied Sciences Universiti Teknologi PETRONAS Bandar Seri lskandar Tronoh 31750 Perak Malaysia

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Effects of Pressure on the Performance of CNTs-Supported Catalyst in a Fischer-Tropsch Reaction

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材料科学与工程（中英文B版） 2014年第2期4卷 28-33页

作者： noor Asmawati mohd Zabidi Sardar Ali Duvvuri Subbarao Department of Fundamental and Applied Sciences Universiti Teknologi PETRONAS Bandar Seri Iskandar Tronoh 31750 PerakMalaysia Department of Chemical Engineering Universiti Teknologi PETRONAS Bandar Seri Iskandar Tronoh 31750 Perak Malaysia

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Effect of a Novel Approach of Sintering on Physical Properties of Carbonated Hydroxyapatite

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材料科学与工程（中英文B版） 2011年第2期1卷 157-163页

作者： Yanny-Marliana Baba Ismail Ahmad-Fauzi mohd noor School of Materials and Mineral Resources Engineering Universiti Sains Malaysia Engineering Campus Nibong Tebal 14300Penang Malaysia

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Establishment of Human Neuroblastoma Cell-Line (SK-N-SH) as an In Vitro Model of Morphine Addiction

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Journal of Pharmacy and Pharmacology 2021年第3期9卷 115-121页

作者： noor Azuin Suliman noor Azlina Abu Bakar Mohamad Aris mohd Moklas Che Norma Mat Taib Faculty of Medicine and Health Science Universiti Sultan Zainal Abidin(UniSZA)Kampus KotaJalan Sultan MahmudKuala Terengganu20400Malaysia Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia

Morphine is a schedule II-controlled substance that used to allow the diminution of intra-operative, post-operative orchronic pain. However, its usage is limited due to addiction and overdose liabilities. Morphine was observed to cause tolerance,dependence and withdrawal in human. Justification: to date lack of scientific evidence of morphine addiction was carried out byusing specific single human neuroblastoma cell-line (SK-N-SH). Therefore, this study was performed to establish the morphineaddiction model in this cell line. The cells were exposed to morphine for 24 hrs before treatment with methadone, as ananti-withdrawal drug for subsequence 24 hours. The cytosolic fraction of the cell was used in different objectives including receptoraffinity, withdrawal properties, endocytic machinery, desensitisation or internalisation and cellular adaptation. The result shows thatmorphine and methadone bind to the μ-opioid receptor. The morphine-treated cells were observed to increase the expression ofaddiction markers, have a low rate of the endocytic machinery, cause desensitisation of receptor and reduce cellular *** changes by morphine were normalised by the treatment of methadone. As a whole, it is postulated that neuroblastoma cell line,SK-N-SH, can be used as an in-vitro model to demonstrate morphine addiction before animal and human testing.

关键词： Morphine addiction receptor affinity withdrawal properties endocytic machinery desensitisation internalisation cellular adaptation methadone.

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Production of Amylase Enzyme through Solid State Fermentation by Aspergillus niger

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Journal of Chemistry and Chemical Engineering 2010年第11期4卷 23-26页

作者： Sharifah Soplah Syed Abdullah Zuriani Randeran mohd Azizan mohd noor Department of BioEngineering Technology University Kuala Lumpur-MICET Alor Gajah 78000 Melaka Malaysia

Traditionally, coconut dregs will be used as animal feed after the extraction of coconut oil and coconut milk from the copra. This study was carried out to discover the commercial value of coconut dregs as a solid substrate in the production of amylase through solid state fermentation （SSF） since this agro-waste is fairly rich in nutrients, providing the necessary nutrients supplementation for better microbial activity to produce enzymes. In this study, amylase is to be produced from coconut dregs by Aspergillus niger through solid state fermentation （SSF）. Three parameters were covered, which are incubation time, initial moisture content of substrate and inoculum sizes. SSF was carried out by using incubator at 37 ~C to test for enzyme activity at these following parameters： incubation time： 24, 48, 72, 96 and 120 hours; substrate moisture content： 64, 66, 68, 70 and 72% （w/w）; inoculum sizes： 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 mL spore suspension （5.5 × 10^6 spores/mL）. Enzyme activities were measured through the estimation of liberated reducing sugars after the assay of amylase enzyme by using DNS （3, 5 dinitrosalicylic acid） method. Highest enzyme activities were obtained at these following parameters： incubation time： 72 hours （31.76 U/gds）; initial moisture content ofsubstrate： 66% （26.66 U / gds） and inoculum sizes： 2.0 mL （30.56 U/gds）.

关键词： Amylase solid state fermentation Aspergillus niger.

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Higher Order OAM Mode Generation Using Wearable Antenna for 5G NR Bands

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Computer Systems Science & Engineering 2023年第10期47卷 537-551页

作者： Shehab Khan noor Arif Mawardi Ismail mohd Najib mohd Yasin Mohamed Nasrun Osman Thennarasan Sabapathy Shakhirul Mat Salleh Ping Jack Soh Ali Hanafiah Rambe Nurulazlina Ramli Advanced Communication Engineering(ACE) Centre of ExcellenceFaculty of Electronic Engineering&TechnologyUniversiti Malaysia PerlisKangarPerlisMalaysia Faculty of Engineering Technology(FTK) Department of Electronic Engineering TechnologyUniversiti Malaysia Perlis(UniMAP)Unicity Alam Campus02100Padang BesarPerlisMalaysia Centre for Wireless Communications(CWC) University of Oulu90570OuluFinland Department of Electrical Engineering Universitas Sumatera UtaraMedan20155Indonesia Centre for Advanced Electrical and Electronic System(CAEES)Faculty of Engineering Built Environment and Information TechnologySEGi University SelangorMalaysia

This paper presents a flexible and wearable textile array antenna designed to generate Orbital Angular Momentum(OAM)waves with Mode+2 at 3.5 GHz(3.4 to 3.6 GHz)of the sub-6 GHz fifth-generation(5G)New Radio(NR)*** proposed antenna is based on a uniform circular array of eight microstrip patch antennas on a felt textile *** contrast to previous works involving the use of rigid substrates to generate OAM waves,this work explored the use of flexible substrates to generate OAM waves for the first *** than that,the proposed antenna was simulated,analyzed,fabricated,and tested to confirm the generation of OAMMode+*** the same design,OAM Mode−2 can be generated readily simply by mirror imaging the feed *** that the proposed antenna operated at the desired frequency of 3.5 GHz with an overall bandwidth of 400 MHz in free ***,mode purity analysis is carried out to verify the generation of OAM Mode+2,and the purity obtained was 41.78%at free space flat ***,the effect of antenna bending on the purity of the generated OAM mode is also ***,the influence of textile properties on OAM modes is examined to assist future researchers in choosing suitable fabrics to design flexible OAM-based *** a comprehensive analysis considering different factors related to wearable applications,this paper demonstrates the feasibility of generating OAMwaves using textile ***,as per the obtained Specific Absorption Rate(SAR),it is found that the proposed antenna is safe to be *** findings of this work have a significant implication for body-centric communications.

关键词： Wearable antenna OAM vortex waves 5G textile antenna microstrip patch antenna specific absorption rate(SAR)

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Application of Crude Protease from Cheap and Local Raw Material as a Biopesticide for the Disruption of Pomacea Canaliculata Eggs

Application of Crude Protease from Cheap and Local Raw Mater...

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作者： noor Hasyierah mohd Salleh Dachyar Arbain School of Bioprocess Engineering University Malaysia Perlis

The application of crude protease of Aspergillus oryzae to suppress the hatchability of Pomacea canaliculata eggs is highlighted. The enzyme was produced through solid state fermentation(SSF) using cassava, which is cheap and abundantly available. It was found that the enzyme suppressed the hatchability of P. canaliculata eggs as much as 30% and 20% at 20.8U/ml enzyme for 3 and 9 days old eggs respectively. The ANOVA result revealed that the hatchability was significantly affected by both protease concentration as well as egg’s age. The LC for 3 and 9 days old eggs were 3.29 U/ml and 3.54 U/ml, respectively;while LC for 3 and 9 days old eggs were 19.11 U/ml and 20.09 U/ml respectively. It is proposed that the crude protease propagated from SSF using locally available and cheap material should be considered as an alternative biopesticide to suppress the hatchability of P. canaliculata eggs.

关键词： Aspergillus oryzae pomacea canaliculata hatchability eggs

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