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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 59-60页

作者： Nomura I. Abe J. noma s. D. Y. M. Leung 王经纬 Natl. Jewis. Med. and R es. Center Department of Pediatrics 1400 Jackson Street Denver CO 80206 United StatesDr.

Kawas.ki dis.as. (KD) is.an acute inflammatory dis.rder of children frequently as.ociated with the development of coronary artery abnormalities. Although a gr eat deal is.known about inflammatory and immune res.ons.s.in acute KD, the mecha nis.s.linking the immune res.ons. to vas.ular changes.are not known. To gain fur ther ins.ght into this.proces., we performed a microarray gene expres.ion analys.is.on RNA is.lated from the peripheral blood mononuclear cells.of four patients.with KD during both their acute and convales.ent phas.s. Fortys.ven genes.of 712 9 genes.examined s.owed an increas.d expres.ion in three or all four patients.in the acute compared with the convales.ent phas. of KD. Fourteen of thes. genes.w ere s.gnificantly (p s.veral inflammatory res. ons. genes.(e. g. s.100 A9 protein) and als. anti-inflammatory genes.(e. g. Ts.G-6). Of greates. interes., the adrenomedullin (ADM) gene, known to be as.ociat ed with coronary artery vas.dilation, was.up-regulated in the acute phas. of KD (p = 0.024). Up-regulation of ADM in the acute phas. of KD was.confirmed in p eripheral blood mononuclear cells.of 11 additional KD patients.by revers. trans. riptas.-PCR (p s.lated blood monocytes.but not lymphocytes.were demo ns.rated by real-time PCR to have increas.d ADM mRNA (p = 0.01). Plas.a ADM pr otein level in 32 additional KD patients.was.als. confirmed to be higher in acut e KD compared with convales.ent KD (p s.interes.ing that from mic roarray res.lts. other molecules.known to be as.ociated with coronary dilation, including nitric oxide, pros.acyclin, acetylcholine, bradykinin, s.bs.ance P, an d s.rotonin, were not elevated in acute KD. Our current s.udy s.gges.s.that ADMe xpres.ing monocytes.that infiltrate the coronary vas.ular wall may be the caus. of coronary dilation in the acute phas. of KD.

关键词：川崎病肾上腺髓质激素基因表达冠状动脉扩张急性期前列腺环素冠状动脉血管炎症反应免疫反应缓激肽

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Clus.er Modulation: A Generalized Modulation s.heme Leading to noma or Adaptive Modulation

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Journal of Computer and Communications 2024年第7期12卷 12-22页

作者： Jamal s. Rahhal s.liman J. Rahhal Electrical Engineering Department The University of Jordan Amman Jordan Invenco Co. Tampa USA

The need for higher data rate and higher s.s.ems.capacity leads.to s.veral s.lutions.including higher cons.ellation s.ze, s.atial multiplexing, adaptive modulation and Non-Orthogonal Multiple Acces. (noma). Adaptive Modulation makes.us. of the us.r’s.location from his.bas. s.ation, s.ch that, clos.r us.rs.get bigger cons.ellation s.ze and hence higher data rate. A s.milar idea of adaptive modulation that makes.us. of the us.r’s.locations.is.the noma technique. Here the bas. s.ation trans.its.compos.te s.gnals.each for a different us.r at a different dis.ance from the bas. s.ation. The trans.itted s.gnal is.formed by s.mming different us.r’s.cons.ellations.with different weights. The clos.r the us.rs.the les. average power cons.ellation is.us.d. This.will allow the clos.r us.r to the bas. s.ation to dis.inguis. his.cons.ellation and others.cons.ellation. The far us.r will only dis.inguis. his.cons.ellation and other us.r’s.data will appear as.a s.all interference added to his.s.gnal. In this.paper, it is.s.own that the Adaptive modulation and the noma are s.ecial cas.s.of the more general Clus.er Modulation technique. Therefore, a general frame can be s.t to des.gn both modulation s.hemes.and better unders.anding is.achieved. This.leads.to des.gning a multi-level noma and/or flexible adaptive modulation with combined channel coding.

关键词： Clus.er Modulation Adaptive Modulation noma

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Expanding the Boundaries.of the Chemical s.ace of DNA Methyltrans.eras. 1 Modulators

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Computational Molecular Bios.ience 2024年第1期14卷 1-16页

作者： Mas.yel s. Martínez-Cortés.Diana L. Prado-Romero Jos. L. Medina-Franco DIFACQUIM Res.arch Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyltrans.eras. 1 (DNMT1), one of the main epigenetic targets. is.involved in the duplication of the DNA methylation pattern during replication, and it is.es.ential for proper mammalian development. s.all molecule DNMT1 modulators.are attractive for biochemical epigenetic s.udies.and have the potential to become drugs. s. far, more than five hundred s.all molecules.have been reported as.DNMT1 inhibitors. However, only a limited number of DNMT1 activators.have been dis.los.d becaus., at leas. in part, DNMT1 activators.are typically regarded as.negative data in virtual s.reening campaigns.or optimization projects. This.manus.ript aims.to report the chemical s.ructures.and biological activity of s.all molecules.that increas. the enzymatic activity of DNMT1. Res.lts.of the biochemical experimental as.ays.are dis.us.ed. It was.found that s.all molecule activators.have a large variety of chemical s.affolds.but s.are pharmacophore features. Vis.al analys.s.of the chemical s.ace and multivers. bas.d on molecular fingertips.s.pported that activators.are s.ructurally divers.. This.is.the firs. report of eight s.all molecules.that increas. the enzymatic activity of DNMT1 by more than 400% in an enzymatic-bas.d as.ay. The outcome warrants.further inves.igation of the epigenetic activity of the compounds.in a counter-s.reen as.ay, e.g., cell-bas.d and in vivo context.

关键词： Chemical Multivers. Chemoinformatics Epigenetics Pharmacophore Hypothes.s s.all Molecules

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Early Phas.s.of s.ar Formation: Tes.ing Chemical Tools

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Res.arch in As.ronomy and As.rophys.cs 2024年第1期24卷 96-118页

作者： N.C.Martinez s.Paron CONICET-Univers.dad de Buenos.Aires.Ins.ituto de As.ronomía y Fís.ca del Es.acio Ciudad Universitaria(C1428EGA)Ciudad Autónoma de Buenos AiresArgentina

s.ar-forming proces.es.s.rongly influence the Is. ***,many high-quality databas.s.are available at millimeter *** them,it is.pos.ible to carry out s.udies.that review and deepen previous.*** thes. s.udies.involve large s.mples.of s.urces.it is.preferred to us. direct tools.to s.udy the molecular *** the aim of tes.ing thes. tools.s.ch as.the us. of the HCN/HNC ratio as.a thermometer,and the us. of H^(13)CO^(+),HC_(3)N,N_(2)H^(+) and C_(2)H as."chemical clocks." we pres.nt a molecular line s.udy toward 55 s.urces.repres.nting mas.ive young s.ellar objects.at different evolutionary s.ages.infrared dark clouds.IRDCs.,highmas. protos.ellar objects.HMPOs.,hot molecular cores.HMCs. and ultracompact H II *** found that the us. of the HCN/HNC ratio as.a univers.l thermometer in the Is. s.ould be taken with care becaus. the HCN optical depth is.a big is.ue that can affect the ***,this.tool s.ould be utilized only after a careful analys.s.of the HCN s.ectrum,checking that no line,neither the main nor the hyperfine ones.pres.nts.abs.rption *** point out that the analys.s.of the emis.ion of H^(13)CO^(+),HC_(3)N,N_(2)H^(+) and C_(2)H could be us.ful to trace and dis.inguis. regions.among IRDCs.HMPOs.and *** molecular line widths.of thes. four s.ecies.increas. from the IRDC to the HMC s.age,which can be a cons.quence of the gas.dynamics.related to the s.arforming proces.es.taking place in the molecular *** res.lts.not only contribute with more s.atis.ics.acting as.a probe of s.ch chemical tools.us.ful to obtain information in large s.mples.of s.urces.but als. complement previous.works.through the analys.s.of other types.of s.urces.

关键词： s.ars.formation Is.:molecules Is.:clouds

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Morphometry and Mineral Content in the s.eds.and s.il of Two s.ecies.of Argemone L.(Papaveraceae)in the Central Part of the Chihuahuan Des.rt

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 371-386页

作者： Perla Patricia Ochoa-García Jaime s.nchez-s.las.Ricardo Trejo-Calzada Jes.s.Jos.fathQuezada-Rivera Fabián García-González Unidad Regional Univers.taria de Zonas.ridas BermejilloUniversidad Autónoma ChapingoDurango35230México Facultad de Ciencias.Biológicas Universidad Juárez del Estado de DurangoGómez PalacioDurango35010México

The genus.Argemone L.(Papaveraceae)is.found widely dis.ributed in Mexico’s.Chihuahuan Des.rt(CD).s.me s.ecies.of this.genus.are of phytochemical or ethnobotanical *** are inedible plants.cons.dered as.*** date they have not been broadly s.udied;thus.their ecology is.to our knowledge,*** pres.nt work was.centered around carrying out a morphometric analys.s.and the determination of minerals.in the s.il and s.eds.of the wild populations.of Argemone at s.tes.belonging to two ecoregions.of the CD in *** April 2021 and April 2022,s.eds.of Argemone s.p.,and s.il s.mples.were collected at 10 s.tes.of the *** s.eds.were s.lected under a randomized des.gn,and weight,length,diameter,thicknes.,buoyancy,and mineral content were *** s.il s.mples.were obtained under the Mexican regulation NOM-021-RECNAT-2000,and determinations.of mineral content,electrical conductivity,apparent dens.ty,and s.luble anions.were *** information obtained was.grouped by variable,s.ecies.and place of *** s.atis.ical tes.s.cons.s.ed of an ANOVA,Tukey means.tes.s.cons.dering p≤0.05,and a Principal Components.*** pleiacantha exhibited differences.in terms.of weight(F=54.79,p=0.001),length(F=90.83,p=0.001),thicknes.(F=104.89,p=0.001),and diameter(F=155.82,p=0.001),and the differences.in Argemone mexicana were in weight(F=46.71,p=0.001),thicknes.(F=187.49,p=0.001),length(F=191.56,p=0.001),and diameter(F=215.83,p=0.001).The evaluated s.eds.reached their maximal imbibition velocity at 24 h of *** content of the micro-and macro-nutrients.analyzed in the s.eds.and s.il s.gges. a tight relation with the morphometric characteris.ics.of the s.eds.

关键词： Micronutrients agricultural area s.miarid zone ecoregion buoyancy

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Male genitourinary s.his.os.mias.s.related s.mptoms.among long-term Wes.ern African migrants.in s.ain: a pros.ective population-bas.d s.reening s.udy

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贫困所致传染病(英文) 2024年第2期13卷 29-38页

作者： Roure s.lvia Vallès.Xavier Pérez-Quílez Olga López-Mu?oz Is.ael Chamorro Anna Abad Elena Valerio Lluís.s.ldevila Laura Es.a?a s.rgio Hegazy Alaa H. A. Fernández-Rivas.Gema Gorriz Es.er Herena Dolores.Oliveira Mário Miralles.Maria Carme Conde Carmen Montero-Alia Juan Jos. Fernández-Pedregal Elia Miranda-s.nchez Jos. Llibre Jos.p M. Is.ard Mar Bonet Jos.p Maria Es.rada Oriol Prat Núria Clotet Bonaventura The s.his.o-s.op s.udy group International Health Program (PROs.Cs. Barcelona North Metropolitan Territorial Directorate for Infectious Diseases Catalan Institute for Health CAP La Salut Passatge dels Encants S/N Badalona Spain Fundació Lluita contra les.Infeccions c/Can Ruti s/n Badalona Spain Infectious.Dis.as.s.Department Hospital Universitari Germans Trias i Pujol c/Can Ruti s/n Badalona Spain Germans.Trias.i Pujol Res.arch Ins.itute c/Can Ruti s/n Badalona Spain Microbiology Department Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Department of Genetics.and Microbiology Universitat Autònoma de Barcelona c/Can Ruti s/n Badalona Spain Faculty of Medicine University of Asyut El Fateh Assiut Governorate Egypt Department of Urology Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Canovelles.Primary Health Care Unit Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Indústria Canovelles Spain Primary Health Care Unit Mataró-(Rocafonda-Palau) Barcelona North Metropolitan Health Directorate Catalan Institute for Health Camí Ral el Ravalet Mataró Barcelona Spain Barcelona North Metropolitan Primary Care Directorate Catalan Institute for Health Ctra. de Barcelona Sabadell Barcelona Spain Directorate for Innovation and Interdis.iplinary Cooperation Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain Irs.Caixa-AIDs.Res.arch Ins.itute Hospital Universitari Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Infectious.Dis.as.s.Directorate Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain

Background s.his.os.mias.s.is.highly endemic in s.b-s.haran Africa and frequently imported to Europe. Male urogenital manifes.ations.are often neglected. We aimed to as.ertain the prevalence of genitourinary clinical s.gns.and s.mptoms.among long-term African migrants.in a non-endemic European country us.ng a s.rology *** We carried out a pros.ective, community-bas.d cros.-s.ctional s.udy of adult male migrants.from s.b-s.haran Africa living in *** s.rology tes.s.and micros.opic urine examinations.were carried out, and clinical data were obtained from an electronic medical record s.arch and a s.ructured *** We included 388 adult males. mean age 43.5 years.[s.andard Deviation (s.) = 12.0, range: 18–76]. The median time s.nce migration to the European Union was.17 [Interquartile range (IQR): 11–21] years. The mos. frequent country of origin was.s.negal (N = 179, 46.1%). Of the 338, 147 (37.6%) tes.ed pos.tive fors.his.os.ma. Paras.te eggs.were pres.nt in the urine of only 1.3%. Nine genitourinary clinical items.were s.gnificantly as.ociated with pos.tives.his.os.ma s.rology res.lts. pelvic pain (45.2%;OR = 1.57, 95%CI: 1.0–2.4), pain on ejaculation (14.5%;OR = 1.85, 95%CI: 1.0–3.5), dys.areunia (12.4%;OR = 2.45, 95%CI: 1.2–5.2), erectile dys.unction (9.5%;OR = 3.10, 95%CI: 1.3–7.6), s.lf-reported epis.des.of infertility (32.1%;OR = 1.69, 95%CI: 1.0–2.8), haematuria (55.2%;OR = 2.37, 95%CI: 1.5–3.6), dys.ria (52.1%;OR = 2.01, 95%CI: 1.3–3.1), undiagnos.d s.ndromic s.Is.(5.4%), and orchitis.(20.7%;OR = 1.81, 95%CI: 1.0–3.1). Clinical s.gns.tended to *** Urogenital clinical s.gns.and s.mptoms.are prevalent among male African long-term migrants.with a pos.tives.his.os.ma s.rology res.lts. Genital involvement can be frequent even among thos. with long periods.of non-res.dence in their s.b-s.haran African countries.of origin. Further res.arch is.needed to develop diagnos.ic tools.and validate therapeutic approaches.to

关键词： s.his.os.mias.s Chronic s.his.os.mias.s Urogenital s.his.os.mias.s Male genital s.his.os.mias.s Longterm migrant

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Renewable Polymers.in Biomedical Applications.From the Bench to the Market

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Journal of Renewable Materials 2024年第4期12卷 643-666页

作者： Rauany Cris.ina Lopes.Tamires.Nos.a Wilton Rogério Lus.ri Gabriel Lombardo Maria Inés.Errea Eliane Trovatti Department of Health and Biological s.iences University of Araraquara—UNIARAAraraquara14801-340Brazil Laboratory of Materials.LabMat)and Laboratory of Biopolymers.LaBioPol) Federal Institute of EducationScience and Technology of São Paulo Campus Itapetininga(IFSP)Itapetininga18.202‑000Brazil Ins.ituto Tecnológico de Buenos.Aires Cidade Autônoma de Buenos AiresC1437FBCArgentina Cons.lho Nacional de Pes.uis.s.Científicas.e Técnicas.CONICET) Cidade Autônoma de Buenos AiresC1425FQBArgentina Tecnologia YPF(Y-TEC) BerissoBuenos Aires1923Argentina

Polymers.from renewable res.urces.have been us.d for a long time in biomedical applications.and found an irreplaceable role in s.me of *** us.s.have been increas.ng becaus. of their attractive properties.contributing to the improvement of life quality,mainly in drug releas. s.s.ems.and in regenerative *** us.ng natural polymer,nano and micros.ale particles.preparation,compos.tes.blends.and chemical modification s.rategies.have been us.d to improve their properties.for clinical *** many s.udies.have been carried out with thes. natural polymers.the way to reach the market is.long and only very few of them become commercially *** cellulos.,bacterial cellulos.,chitos.n,poly(lactic acid)and s.arch can be found among the mos. s.udied polymers.for biological applications.s.me with s.veral derivatives.already es.ablis.ed in the market,and others.with potential for *** this.s.enario this.work aims.to des.ribe the properties.and potential of thes. renewable polymers.for biomedical applications.the routes.from the bench to the market,and the pers.ectives.for future developments.

关键词： Polymers renewable biomedical applications market

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Meas.ring Impact of Lean Manufacturing Tools.for Continuous.Improvement on Economic s.s.ainability

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Journal of s.s.ems.s.ience and s.s.ems.Engineering 2024年第4期33卷 452-474页

作者： Luis.Javier Márquez Figueroa Jorge Luis.García-Alcaraz Ahmed I.Os.an Alfons. Jes.s.Gil López Yas.ar Aryanfar Mika s.llanpää Mamdouh El Haj As.ad Department of Electrical Engineering and Computer s.ience Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico Department of Indus.rial Engineering and Manufacturing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico s.hool of Chemis.ry and Chemical Engineering Queens UniversityBelfastNorthern IrelandUK Department of Economic and Managerial s.iences University of La RiojaLa RiojaSpain Department of Chemical Engineering University of JohannesburgJohannesburgSouth Africa Department of s.s.ainable and Renewable Energy Engineering University of SharjahSharjahUAE

Us.ng Lean Manufacturing(LM)tools.in production proces.es.is.crucial for companies.economic,environmental,and s.cial s.s.ainability *** s.udy s.ows.a s.ructural equation model(s.M)that s.ows.the relations.ip between LM Tools.like Kaizen(KAI),Gemba(GEM),Value s.ream Mapping(Vs.)and Key Performance Indicator(KPI)with Economic s.s.ainability(ECs..s.ven hypothes.s.were evaluated with data from 179 res.ons.s.to a ques.ionnaire about the Mexican maquiladora indus.ry,s.owing that thes. variables.are *** a 95%confidence level,the model was.evaluated us.ng the partial leas. s.uares.*** findings.indicate that the relations.ips.between KAI and GEM and KAI and Vs. have the s.ronges. relations.ip,followed by Vs. and ECs.however,Vs. has.the s.ronges. effect on *** on thes. findings.it is.recommended that managers.adopt a continuous.improvement(KAI)approach bas.d on working directly on the s.op floor(GEM and Vs.)to s.pport their decis.ons.regarding economic growth(ECs..

关键词： Lean manufacturing economic s.s.ainability s.ructural equation model quality improvement

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The firs. record of dermochelyid turtles.in the Eocene of Tierra del Fuego:new ins.ghts.on the evolution of the Weddellian faunas

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Advances.in Polar s.ience 2024年第1期35卷 63-77页

作者： Paula BONA Juliana s.ERLI Marcelo s.úl de la FUENTE Eduardo OLIVERO Marta s.FERNÁNDEZ Marcelo REGUERO Divis.ón Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina Cons.jo Nacional de Inves.igaciones.Científicas.y Técnicas.CONICET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Mus.o Paleontológico Egidio Feruglio Trelew U9100Argentina Ins.ituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina Centro Aus.ral de Inves.igaciones.Científicas.CONICET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina Divis.ón Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fos.il record has.been the key to recons.ructing the evolution of the Weddellian s.a and final dis.emberment of s.uthern *** this.context,Eocene marine vertebrates.from s.ymour(Marambio)Is.and have provided valuable *** pres.nt the firs. Eocene record of marine reptiles.from the s.uthern Atlantic Coas. of s.uth *** corres.onds.to s.veral pos.cranial turtle remains.repres.nted by a proximal end of the right humerus.three caudal and one thoracic vertebrae,a fragment of the left pubis.and ten os.icles.of the dors.l carapace,coming from the Leticia Formation(late-mid Eocene)at Cabo Tiburones.Tierra del Fuego,*** materials.s.ow s.veralfeatures.s.ch as.the s.ze and general morphology of the humerus.and vertebrae,and the pres.nce of relatively s.all,irregular,s.ooth,and unkeeled os.icles.which allow us.to as.ign them to Dermochelyidae *** are a cos.opolitan group ofcryptodiran turtles.regis.ered from the late Cretaceous.up to the recent,with s.me phys.ological-biological peculiarities.e.g.,endothermy and an exclus.ve jellyfis.-bas.d diet)and characterized by the pres.nce of an os.eous.carapace formed by *** new finding from the Leticia Formation is.an addition to the s.arce and extremely fragmentary record of Eocene dermochelyids.from the s.uthern s.as.like thos. from the La Mes.ta and s.bmes.ta formations.Antarctica)and the Waihao and Burns.de formations.New Zealand).This.new information allows.us.to dis.us. the pres.nce of thes. turtles.in s.ch high latitudes.in the pas. and its.implication in the evolution of the Weddellian fauna.

关键词： marine reptiles s.a turtles Dermochelyidae Paleogene La Mes.ta Formation s.bmes.ta Formation Leticia Formation

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Development of s.rgical Treatment for Vitreous.Dis.as.

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s.rgical s.ience 2012年第11期3卷 507-513页

作者： Tats.ya Mimura Hidetaka noma Hideharu Funats. Department of Ophthalmology Tokyo Women’s Medical University Medical Center East Tykyo Japan Department of Ophthalmology Yachiyo Medical Center Tokyo Women’s Medical University Yachiyo Japan

Vitreous.s.rgery has.improved remarkably with various.advances.in s.rgical ins.ruments.and techniques. The two mos. important breakthrough in recent years.have been the introduction of s.all-gauge pars.plana vitrectomy (PPV) s.s.ems.and new illumination devices. Compared with traditional 20-gauge PPV, s.tureles. s.all-gauge PPV appears.to be s.fer, with a s.orter operating time, les. pos.operative inflammation, les. patient dis.omfort, and more rapid recovery of vis.al acuity. This.article reviews.recent progres. in the s.rgical management of vitreous.dis.as. with a his.orical pers.ective.

关键词： Review Vitrectomy 25 Gauge

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