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Long-term survival of more than 3 years among patients with advanced non-small cell lung cancer treated with chemotherapy

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World Journal of Respirology 2013年第3期3卷 110-115页

作者： Rieko Kaira Kyoichi Kaira Takehito Shukuya Hirotsugu Kenmotsu Akira Ono Haruyasu Murakami Asuka Tsuya Yukiko Nakamura Tateaki Naito Masahiro Endo nobuyuki Yamamoto Toshiaki Takahashi Division of Thoracic Oncology Shizuoka Cancer Center Sunto-gun Shizuoka 411-8777 Japan Division of Diagnostic Radiology Shizuoka Cancer Center Sunto-gun Shizuoka 411-8777 Japan

AIM: To evaluate the prognostic factors of long-term survival of more than 3 years in patients with advanced non-small cell lung cancer(NSCLC). METHODS: We retrospectively analyzed the records of 474 patients with advanced ⅢB/Ⅳ NSCLC who received chemotherapy as initial treatment between September 2002 and March ***: The median survival time(MST) was 12.5 mo and the 3 year and 5 year survival rates were 14.6% and 5.3%, respectively. Long-term survival of more than 3 and 5 years was observed in 65 and 16 patients, respectively. The MST for the 65 patients was61.5 mo(range, 60.1-81.0 mo). In the 474 patients, a good performance status(PS), female sex, non-smoking status and adenocarcinoma histology were significantly associated with a favorable outcome. Furthermore, female sex, a good PS, non-smoking status and adenocarcinoma histology were significantly correlated with longterm survival of more than 3 years and most of these patients(89.2%, 58/65) received epidermal growth factor receptor-tyrosine kinase inhibitors as any line treatment. Survival analysis of long-term survivors showed that a PS of 0 was an independent prognostic factor for predicting favorable outcomes. CONCLUSION: Our results suggest that a good PS and adenocarcinoma histology play an important role in long-term survival of more than 3 years. A PS of 0 was an independent prognostic factor for predicting favorable outcomes in patients with advanced NSCLC who survived for more than 3 years.

关键词： Non-small cell lung cancer Long-term survivor Chemotherapy Performance status Epidermal growth factor receptor-tyrosine kinase inhibitors

Usefulness of the Guglielmi detachable coil for embolization of a systemic venous collateral after Fontan operation:A case report

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World Journal of Radiology 2012年第9期4卷 418-420页

作者： Tetsuo Sonomura Akira Ikoma nobuyuki Kawai Tomohiro Suenaga Takashi Takeuchi Hiroki Minamiguchi Shunji Uchita Motoki Nakai Hiroyuki Suzuki Kazushi Kishi Morio Sato Department of Radiology Wakayama Medical University811-1 KimiideraWakayama 641-8510Japan Department of Pediatrics Wakayama Medical University811-1 KimiideraWakayama 641-8510Japan Department of Thoracic and Cardiovascular Surgery Wakayama Medical University811-1 KimiideraWakayama 641-8510Japan

Embolization of collateral veins is often treated with rigid coils(Gianturco and interlocking detachable coils type).However,when dealing with tortuous and dilated collateral veins,there is a high risk for technical failure and coil migration due to inflexibility of the *** safely and successfully solve this problem,Guglielmi detachable coils(GDC) can be used for *** flexibility allows for easy navigation in tortuous veins,low risk of unintended coil release or coil migration,and safe deployment.A 12-year-old girl with a single ventricle had severe cyanosis and a low exercise tolerance 5 years after Fontan *** symp-toms were caused by a tortuous and dilated collateral from the left phrenic vein into the left pulmonary vein,forming a right-to-left *** collateral,which had a large diameter and high flow,and therefore a high risk of coil migration,was successfully embolized with 8 *** were no complications such as coil migration or cerebral *** embolization increased her systemic oxygen saturation from 81%-84% to 94%-95%,and increased her ability to *** embolization procedure using flexible GDC was low risk compared with other rigid coil embolization techniques when performing embolization of tortuous and dilated collateral veins.

关键词： Pediatric intervention Embolization Systemic venous collateral Fontan operation Guglielmi detachable coil

日本JFE开发的建筑结构件用高强度厚壁钢管

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四川冶金 2011年第5期33卷 71-76,65页

作者： SUEISHI nobuyuki[日] ARAKAWA Takekazu[日] OHMORI Akio[日] 齐殿威

介绍了为应对近几年来对更高强度较厚壁厚钢管的需求,日本JFE制钢公司开发的抗拉强度490～780 MPa、屈服强度385～630 MPa系列钢管产品,阐述了由于这些钢管产品都是采用高性能厚板制造,所以钢管的力学性能,尤其是屈服强度(YS)和屈服比(... 详细信息

介绍了为应对近几年来对更高强度较厚壁厚钢管的需求,日本JFE制钢公司开发的抗拉强度490～780 MPa、屈服强度385～630 MPa系列钢管产品,阐述了由于这些钢管产品都是采用高性能厚板制造,所以钢管的力学性能,尤其是屈服强度(YS)和屈服比(YR)性能更适用于建筑构架的建造。另外,根据各种设计的不同要求,JFE制钢公司通过控制制造钢管所用厚板的力学性能和制管工艺,既能制造低屈服比(YR)钢管,又能制造高屈服比(YR)钢管两种类型的建筑结构件用钢管。

关键词： JFE制钢公司高强度厚壁钢管建筑结构件

Complex Valued BP NN和Real BP NN应用于图像复原的比较

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计算机工程与应用 2005年第11期41卷 72-73,227页

作者：宋芬郁春江松井申之苏州大学计算机科学与技术学院苏州215006 日本姬路工业大学智能工学科

该文首先探讨了将ComplexValuedBP神经网络(NeuralNetwork)和RealBP神经网络用于图像复原的优势比较。其次,用图像数据训练网络,再利用训练好的网络实现不同图像的复原。最后,对图像进行像素空间分布的分析来寻找原因。

关键词： Complex Valued BP Real BP 像素空间

用醋酸锌去除脂肪以测定糙米中有机磷农药残留的简便分析方法

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世界农药 1986年第1期 43-45页

作者： Kazuhiko Adachi nobuyuki Ohokuni Takao Mitsuhashi 陆贻通日本兵库县公共卫生研究所日本兵库县公共卫生研究所日本兵库县公共卫生研究所

在气相色谱分析方法出现之前,人们就已开发了液液分配和柱层析分离法来进行各种食物样品中有机氯和有机磷农药残留的提取、净化和测定。Bertuzzi 和 Burke 等人确定,用含水35％的乙腈溶液萃取低水份植物样品中的残留农药,可获得较高的... 详细信息

在气相色谱分析方法出现之前,人们就已开发了液液分配和柱层析分离法来进行各种食物样品中有机氯和有机磷农药残留的提取、净化和测定。Bertuzzi 和 Burke 等人确定,用含水35％的乙腈溶液萃取低水份植物样品中的残留农药,可获得较高的提取效果。Wheeler 等人进一步证明,乙腈作为非脂肪性食物的提取剂,其提取效果随其含水量的增加而提高,乙腈-水混合提取液的最佳含水量为40～50％。近期的研究表明,这些提取剂也能有效地提取糙米中的有机磷农药。

关键词：有机磷农药活性炭吸附剂脂肪乙酸锌醋酸锌异丙稻瘟净有机磷杀菌剂异稻瘟净苯硫磷对硫磷乐戈乐果糙米

房颤患者中充血性心力衰竭的发生率和死亡风险:一项超过20年的社区研究

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 23-24页

作者： miyasaka Y. Barnes M.E. Gersh B.J. T.S.M.Tsang 苏畅 Division of Cardiovascular Disease and Internal Medicine Mayo Clinic200 First Street SWRochesterMN 55905United States

Aims: We sought to determine whether the incidence of and survival following congestive heart failure(CHF) in patients with atrial fibrillation(AF) have changed over time. Methods and results: Olmsted County, Minnesota residents diagnosed with first AF during 1980-2000 were identified and followed in medical records to 2004. The trends of incidence and survival of CHF over time were assessed. Of the 3288 subjects(mean age 71±15 years) diagnosed with first AF and without CHF prior to or at AF diagnosis, 790(24%) developed a first CHF during a mean follow-up of 6.1±5.2 years(unadjusted incidence, 44 per 1000 person years). Age-and sex-adjusted CHF incidence was unrelated to calendar year of AF diagnosis(P=0.86). The age-and sex-adjusted mortality risk following CHF was higher than that in patients without CHF(hazard ratio 3.4, 95%confidence interval 3.1-3.8, P< 0.0001). There were no detectable changes over time with respect to the absolute(P=0.94) or the relative(P=0.68) mortality risk after CHF diagnosis. Conclusion: In this study spanning two decades, there appeared to have been no significant reduction in terms of the incidence and mortality risk of CHF following first AF diagnosis.

关键词：充血性心力衰竭死亡风险房颤患者发生率社区研究时间变化平均年龄 CHF

An Evans Syndrome Case Expressing Anti-Jk<sup>a</sup>Autoantibody under Condition of Primary IgA Immunodeficiency

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International Journal of Clinical Medicine 2015年第7期6卷 496-499页

作者： Takeshi Sugimoto Ayumi Tani Ikuyo Hayakawa Makoto Hashimoto Tomoko Yanai Ikuko Kubokawa Takeshi Mori Takeshi Kato Satoshi Hirase nobuyuki Yamamoto Hironobu Minami Akira Hayakawa Department of Hematology and Oncology Kita-Harima Medical Center Ono Japan Department of Blood Transfusion Kobe University Hospital Kobe Japan Institute of Biomedical Research and Innovation Kobe Japan Department of Pediatric Medicine Kobe University Hospital Kobe Japan

Autoimmune haemolytic anaemia is a haemolytic disease resulting from an autoimmune reaction to the surface of red blood cells. A part of autoantibody is known to react with the blood type antigen. This is the case of a 14 years old female with Evans syndrome in which autoimmune haemolysis may cause from anti-Jka autoantibody reaction. As this case is complicated with primary IgA immunodeficiency syndrome, anti-Jka autoantibody may occur under the condition of primary immunodeficiency status, in which autoantibody production is accelerated. Considering the co-occurrence of autoimmune haemolytic anaemia and primary IgA immunodeficiency syndrome, analysis focusing on specificity for red blood cells antigens will be required in IgA immunodefi-ciency syndrome patients.

关键词： Anti-Jka Autoantibody Evans Syndrome IgA Immunodeficiency

两性离子氨基酸钝化氧化镍实现高效钙钛矿太阳能电池

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两性离子氨基酸钝化氧化镍实现高效钙钛矿太阳能电池

Efficacy and Tolerability of Second-Line Metronidazole Triple Therapy Using Vonoprazan for Helicobacter pylori Eradication in Japan—Comparative Study: Vonoprazan vs. Proton Pump Inhibitors

第十一届新型太阳能材料科学与技术学术研讨会

作者：王宪钊姜军刘子嫣李爱军 Tsutomu miyasaka 王晓峰吉林大学吉林大学新型电池物理与技术教育部重点实验室桐荫横滨大学工学研究科

为了解决氧化镍空穴传输层的低电导率、高密度缺陷等问题,我们在氧化镍/钙钛矿界面引入了一种中性氨基酸-色氨酸。作为一种两性离子,色氨酸分子同时带有带负电的羧基以及带正电的铵基,可以分别钝化界面两侧的阳离子缺陷及阴离子缺陷。... 详细信息

为了解决氧化镍空穴传输层的低电导率、高密度缺陷等问题,我们在氧化镍/钙钛矿界面引入了一种中性氨基酸-色氨酸。作为一种两性离子,色氨酸分子同时带有带负电的羧基以及带正电的铵基,可以分别钝化界面两侧的阳离子缺陷及阴离子缺陷。色氨酸修饰后,导电性更高、更偏p型的三价镍比例提高,从而提升了薄膜整体导电性,改善了界面的能级排列,促进了空穴萃取。同时,色氨酸的存在调控了钙钛矿层的生长,生成了尺寸更大、晶界更小的钙钛矿晶粒,结晶度更高的钙钛矿薄膜。在对氧化镍及钙钛矿薄膜的双重优化下,钙钛矿太阳能电池的效率由19.58%提升至了23.79%,长期稳定性也有显著提升,未封装器件在50%-60%相对湿度的空气中存放1600小时后效率仍保持在80%以上。此外,我们还将色氨酸与酸性氨基酸-精氨酸和碱性氨基酸-谷氨酸进行了对比,后两者仅带有一种带电基团。经比较,色氨酸与氧化镍和钙钛矿的相互作用最为强烈,钝化效果最为优异。本研究充分展示了两性离子在钙钛矿太阳能电池中的应用潜力。

关键词：两性离子氧化镍界面修饰钙钛矿太阳能电池

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Open Journal of Gastroenterology 2018年第1期8卷 27-38页

作者： Masahiko Ohtaka Mika Miura Mitsuhiko Hanawa Yuichi Hirose Atsuko Kitahashi Naoki Imamura Ikko Watanabe Kazuhiko Takaso Naoki Shimura Yoshioki Yoda Ichiro Takayama Mitsuharu Fukasawa nobuyuki Enomoto Yamanashi Koseiren Health Care Center Yamanashi Japan First Department of Internal Medicine Graduate School of Medical and Engineering Science University of Yamanashi Yamanashi Japan Health Care Center University of Yamanashi Yamanashi Japan

Aim: To investigate the efficacy and tolerability of second-line metronidazole triple therapy with vonoprazan (VPZ) for Helicobacter pylori (H. pylori). Methods: We retrospectively reviewed medical records of patients who experienced clarithromycin triple therapy failure and were treated with second-line (20 mg VPZ (n = 274)/30 mg lansoprazole (n = 323) or 10 mg rabeprazole (n = 141) twice daily, 750 mg amoxicillin twice daily, 250 mg metronidazole twice daily for 7 days) eradication therapies. Successful eradication rates were compared between two groups: those receiving VPZ and those receiving a proton pump inhibitor (PPI). Adverse events were also investigated. Results: Successful second-line eradication rates according to ITT analysis and PP analysis, respectively, were 79.9% and 92.4% for VPZ therapy and 83.6% and 93.3% for PPI therapy. There were no significant differences between treatment groups. The eradication rates in those who had received first-line VPZ therapy previously according to ITT and PP analysis were 75.2% and 88.1%, respectively;in contrast, values were 82.5% and 95.4%, respectively, for those who had received first-line PPI therapy previously. In second-line therapy, the overall adverse event rate for VPZ therapy was the same as for PPI therapy. Conclusions: The efficacy and tolerability of metronidazole-containing second-line triple therapy with VPZ or a PPI were equivalent.

关键词： Vonoprazan Metronidazole Proton Pump Inhibitor Second-Line Eradication Helicobacter pylori