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Open Journal of Obstetrics and Gynecology 2014年第13期4卷 745-750页

作者： Taketo Inoue Yoshiyuki Ono Yukiko Yonezawa Junji Kishi nobuyuki emi Ono Ladies Clinic Ono Japan

The endometrial condition is a significant factor for successful pregnancy. To regulate endometrial function in fertility treatment, prednisolone (PSL) is administered for suppression of increased natural killer cells and stimulation of endometrium embryo transfer (SEET) to enhance communication between embryo and maternal tissues. We attempted to improve the endometrial condition by PSL administration and SEET during frozen–thawed blastocyst transfer (FBT). Patients took PSL (5 mg) 3 times daily for 3 days after ovulation during the FBT cycle. To analyse effects of PSL combined with SEET, we determined rates of chemical pregnancy, clinical pregnancy, foetal heart movement (FHM) and live birth. Rates of chemical pregnancy, clinical pregnancy and FHM were significantly higher in the PSL(+)/SEET(+) (57.7%, 50.0% and 46.2%, respectively) and PSL(+)/SEET(-) (53.3%, 46.7% and 46.7%, respectively) groups than in the PSL(-)/SEET(+) (30.3%, 18.2% and 18.2%, respectively) and PSL(-)/SEET(-) (22.4%, 22.4% and 18.4%;P = 0.0043, 0.0081 and 0.0055, respectively) groups. The live birth rate was significantly higher in the PSL(+)/SEET(+) group than in the PSL(+)/SEET(-), PSL(-)/SEET(+) and PSL(-)/SEET(-) groups (42.3%, 26.7%, 18.2% and 12.2%, respectively;P = 0.0237). PSL combined with SEET may be a useful adjunct to assisted reproductive technology in women who repeatedly fail to conceive by infertility treatment.

关键词： Frozen–Thawed Blastocyst Transfer Infertility Live Birth Prednisolone Stimulation of Endometrium Embryo Transfer (SEET)

Oocyte quality improvement using a herbal medicine comprising 7 crude drugs

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Open Journal of Obstetrics and Gynecology 2013年第1期3卷 195-202页

作者： Taketo Inoue Yoshiyuki Ono Yukiko Yonezawa Michinobu Oi Naomi Kobayashi Junji Kishi nobuyuki emi Herb Pharmacy Co. Ltd. Kobe Japan Ono Ladies Clinic Hyogo Japan

Maternal age is a significant factor in infertility treatment. Ovarian function and oocyte quality decrease with age, whereas the frequency of chromosomal abnormalities increases. In this study, improvement of oocyte quality and ovarian function were attempted using a herbal medicine comprising 7 crude drugs:Angelicae radix,Rehmanniae radix,Plantaginis semen,Lonicerae flos,Carthami flos,Ginseng radix, andCucurbita moschata Duch. Thirty-one women who repeatedly failed to conceive by intracytoplasmic sperm injection took the herbal medicine before breakfast and dinner from the start of menstrual cycle in the ovum pickup cycle. Average patient age was 38.5 ± 0.7 years, and the average ovum pickup frequency on the first dosage day was 7.9 ± 1.5. To analyze the effects of herbal medicine intake, the number of recovered and mature oocytes, their morphology and physical qualities, as well as the rates of fertilization, oocyte development, and pregnancy was compared before and after intake. The recovered and mature oocyte numbers, oocyte morphology and physical qualities, and fertilization rate were not significantly different before and after drug intake. However, the oocyte development rate was significantly higher(58.0%) after herbal medicine intake than before (32.5%;p = 0.0003). Moreover, the successful pregnancy rate was significantly higher after intake than before (6.9% versus 0%;p = 0.0111). Herbal medicine may constitute a useful adjunct to assisted reproductive technology in women.

关键词： Herbal Medicine Improvement of the Oocyte Development Rate Intracytoplasmic Sperm Injection Oocyte Quality Repeated Infertility Treatment Failure

Self-/conspecific discrimination and superparasitism strategy in the ovicidal parasitoid Echthrodelphax fairchildii （Hymenoptera： Dryinidae）

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Insect Science 2014年第6期21卷 741-749页

作者： emi Ito Yoshihiro Y. Yamada Insect Ecology Laboratory Graduate School of Bioresources Mie University Tsu Mie Japan

Superparasitism in solitary parasitoids results in fatal competition between the immature parasitoids, and consequently only one individual can emerge. In the semisoli- tary ovicidal parasitoid Echthrodelphaxfairchildii （Hymenoptera： Dryinidae）, 2 adults can emerge under superparasitism with a short interval （〈24 h） between the first and second ovipositions. We determined the female parasitoid＇s behavioral responses under self- and conspecific superparasitism bouts with first-to-second oviposition intervals of 〈2 h. The self- and conspecific superparasitizing frequencies increased up to an oviposition interval of 0.75 h, with the former remaining lower than the latter, particularly for oviposition intervals of _〈0.25 h, suggesting the existence of self-/conspecific discrimination. The superparasitizing frequency plateaued for oviposition intervals of _〉0.75 h, with no dif- ference between self- and conspecific superparasitism. The ovicidal-probing frequency did not differ under self- and conspecific superparasitism, and was usually 〈20%. The females exhibited no preference for the oviposition side （i.e., ovipositing on the side with or without the first progeny） and almost always laid female eggs for any oviposition in- terval under self- and conspecific superparasitism. The sex ratio was not affected by the type of superparasitism, oviposition sides, or the occurrence of ovicidal probing. These observed results about the oviposition side, ovicidal probing, and sex ratios differed from the predictions obtained assuming that the females behave optimally. Possible reasons for the discrepancies are discussed： likely candidates include the high cost of selecting oviposition sides and ovicidal probing, and, for the sex ratio, the low frequency of encountering suitable hosts before superparasitism bouts.

关键词： infanticide ovicide plant hopper self-recognition sex ratio

CD34+ dermal dendritic cells and mucin deposition in dermatomyositis

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World Journal of Dermatology 2016年第2期5卷 65-71页

作者： emi Yokoyama Yoshitaka Nakamura Tomoko Okita nobuyuki Nagai Masahiko Muto Department of Dermatology Yamaguchi University Graduate School of Medicine

Dermal mucinosis is often associated with collagen diseases such as rheumatoid arthritis, lupus erythematosus, and dermatomyositis, in addition to autoimmune thyroiditis. We report eight cases of dermal mucin deposition secondary to typical dermatomyositis with cutaneous lesions known as heliotrope rash and Gottron's papules. Striking mucin deposition was observed in both the papillary dermis and reticular dermis of all biopsy specimens. Immunohistochemical analysis showed that CD34+ dermal dendritic cells(DDCs) in the perilesional area in combination with vimentin+ cells within the mucinous lesion might be important in giving rise to abnormal deposition of dermal mucin. On the other hand, numbers of factor ⅩⅢa+ DDCs and tryptase+ mast cells were reduced within and surrounding the mucin deposition, as compared with those in the dermis of normal controls. A pathogenic mechanism of dermal mucin deposition is proposed.

关键词： Mucin deposition Dermatomyositis CD34+dermal dendritic cell

Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials

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Bioactive Materials 2023年第9期27卷 574-593页

作者： Henry F.Duncan Yoshifumi Kobayashi Michaela Kearney emi Shimizu Division of Restorative Dentistry&Periodontology Dublin Dental University HospitalTrinity College DublinUniversity of DublinLincoln PlaceDublinIreland Department of Oral Biology Rutgers School of Dental MedicineNewarkNJUSA

This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment(VPT),but also discusses the challenges in translating evidence to *** dentistry is expensive,invasive and relies on an outmoded mechanical understanding of dental disease,rather than employing a biological perspective that harnesses cell activity and the *** research has focussed on developing minimally-invasive biologically-based‘fillings’that preserve the dental pulp;research that is shifting the paradigm from expensive high-technology dentistry,with high failure rates,to smart restorations targeted at biological *** VPTs promote repair by recruiting odontoblast-like cells in a material-dependent ***,exciting opportunities exist for development of next-generation biomaterials targeted at regenerative processes in the dentin-pulp *** article analyses recent research using pharmacological-inhibitors to therapeutically-target histone-deacetylase(HDAC)enzymes in dental-pulp-cells(DPCs)that stimulate pro-regenerative effects with limited loss of ***,HDAC-inhibitors have the potential to enhance biomaterial-driven tissue responses at low concentration by influencing the cellular processes with minimal side-effects,providing an opportunity to develop a topically-placed,inexpensive bio-inductive pulp-capping *** positive results,clinical translation of these innovations requires enterprise to counteract regulatory obstacles,dental-industry priorities and to develop strong academic/industry *** aim of this opinion-led review paper is to discuss the potential role of therapeutically-targeting epigenetic modifications as part of a topical VPT strategy in the treatment of the damaged dental pulp,while considering the next steps,material considerations,challenges and future for the clinical development of epigenetic therapeutics or other‘smart’restora

关键词： Epigenetics Vital pulp treatment Histone deacetylase inhibitors Regenerative endodontics Pulp capping

Seemingly maladaptive refraining from infanticidal probing at the third parasitism attack by the semi-solitary parasitoid Echthrodelphax fairchildii （Hymenoptera： Dryinidae）

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Insect Science 2006年第3期13卷 229-233页

作者： emi ITO YOSHIHIRO Y. YAMADA Insect Ecology Laboratory Faculty of Bioresources Mie University Tsu Mie Japan

We assessed the adaptiveness of refraining from infanticidal probing at the third attack under triple parasitism in the parasitoid Echthrodelphaxfairchildii Perkins, by comparing fitness returns from the third attack with and without probing. Fitness returns were assessed in terms of the survival rate, mean developmental time, and mean adult head width of the progenies. Not probing was maladaptive under triple parasitism with oviposition intervals of 1/24 and 24/24 hours （where the numbers before and after the slash refer to the first-to-second and second-to-third oviposition intervals, respectively）, although no significant difference was detected in fitness returns for oviposition intervals of 24/1 hours. We suggest that the cost of probing （especially the decrease in the chance of future ovipositions） is a reason for the seemingly maladaptive absence of probing.

关键词： cost of reproduction Echthrodelphax fairchildii infanticide ovicide,superparasitism triple parasitism

Formation of Edge Crack in 1.4%Si Non-oriented Electrical Steel during Hot Rolling

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Journal of Iron and Steel Research International 2014年第2期21卷 269-274页

作者： Ai-hua CHEN Hai-rong GUO Hua-long LI Toshihiko emi Institute of Research of Iron and Steel Shasteel

Microstructure evolution, dynamic recrystallization, high temperature oxidation and hot ductility of 1.4 % Si non-oriented electrical steel sheets were investigated to reduce edge cracking. The causes of cracking were found to be coarse as-cast microstructure, grain boundary oxidation in reheating furnace, lack of dynamic recrystallization during hot rolling and increase of temperature, resulting in reduced hot ductility in strip edge region. Countermeas- ures against the edge crack are proposed accordingly. Lowering reheating temperature and reducing holding time re- duced oxidation and decarburization. Hot charging temperature was increased to decrease reheating temperature. And using an edger can refine microstructure in strip edge region. Finally, edge heater can be added to increase edge re- gion formability by inducing dynamic reerystallization and ductility by increasing temperature.

关键词： edge crack non-oriented electrical steel hot rolling

Identification of county-level health factors associated with COVID-19 mortality in the United States

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The Journal of Biomedical Research 2020年第6期34卷 437-445,I0014页

作者： Wei Pan Yasuo Miyazaki Hideyo Tsumura emi Miyazaki Wei Yang School of Nursing Duke UniversityDurhamNC 27710USA Department of Population Health Sciences School of MedicineDuke UniversityDurhamNC 27708USA School of Education Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA School of Community Health Sciences University of NevadaRenoNV 89557USA.

Many studies have investigated causes of COVID-19 and explored safety measures for preventing COVID-19 ***,these studies fell short to address disparities in health status and resources among decentralized communities in the United *** this study,we utilized an advanced modeling technique to examine complex associations of county-level health factors with COVID-19 mortality for all 3141 counties in the United *** results indicated that counties with more uninsured people,more housing problems,more urbanized areas,and longer commute are more likely to have higher COVID-19 *** on the nationwide population-based data,this study also echoed prior research that used local data,and confirmed that county-level sociodemographic factors,such as more Black,Hispanic,and older subpopulations,are attributed to high risk of COVID-19 *** hope that these findings will help set up priorities on high risk communities and subpopulations in future for fighting the novel virus.

关键词： COVID-19 mortality health factors health disparity hierarchical generalized linear model

Conjunctival cyst with apocrine hidrocystoma-like features:a case report

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 465-467页

作者： Takafumi Igarashi Satoru Kase Yuka Suimon emi Takakuwa Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 0608638Japan Department of Surgical Pathology Hokkaido University HospitalSapporo 0608638Japan

Dear Editor,I am Takafumi Igarashi from Hokkaido University Hospital,*** hidrocystoma is a benign cystic tumor arising in the apocrine sweat glands proposed by Mehregan^([1])in *** is likely that apocrine hidrocystoma arises in the uvula,ears,chest,and shoulders,as well as the (peri)ocular regions such as the eyelid,and sclera^([2-4]).

关键词： apo ocular likely

School health promotion:A cross-sectional study on Clean and Healthy Living Program Behavior(CHLB)among Islamic Boarding Schools in Indonesia

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International Journal of Nursing Sciences 2016年第3期3卷 291-298页

作者： Tantut Susanto Lantin Sulistyorini emi Wuri Wuryaningsih Syahroni Bahtiar Family and Community Health Nursing Department School of NursingUniversitas JemberJl.Kalimantan 37JemberEast JavaIndonesia Pediatric Nursing Department School of NursingUniversitas JemberJl.Kalimantan 37JemberEast JavaIndonesia Mental Health Nursing Department School of NursingUniversitas JemberJl.Kalimantan 37JemberEast JavaIndonesia Health Office of Jember Health Services DepartmentJl.Srikoyo 2JemberEast JavaIndonesia

Objective:This study aims to identify the knowledge,attitude,and behavior of students using eight indicators of Clean and Healthy Living Behavior(CHLB)in relation to the health education and grade levels in Islamic Boarding Schools(IBS)in Jember regency,East Java Province,***:A cross-sectional school-based survey design was *** 114 students(mean age of 13.17 years old)selected through a multi-stage random sampling completed a selfadministered questionnaire to measure the eight indicators of CHLB,such as washing hands with running water and soap,eating healthy snacks,using clean and healthy latrines,exercising regularly and measurably,eradicating mosquito larvae,not smoking at school,weighing and height measurement every 6 months,and disposing garbage *** data analyses included descriptive and comparative analyses of the difference in knowledge,attitude,and behavior toward CHLB by health education and grade ***:About 66.7% students received health *** knowledge in CHLB in relation to health education and grade was observed(P<.05),including in-depth knowledge of exercises,measurable weight and height,smoking,and healthy ***,no significant difference was observed between the attitude toward CHLB and health education in different grade ***,CHLB was associated with health education,including habitual exercise and using of clean and healthy latrines.

关键词： Health promotion Clean and Healthy Living Behavior Islamic boarding school School health