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Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong nobuo Funao Yuuichi Sakurai Jessica D.Eisner Li Xie Minhu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CI<0%)was also *** 12 weeks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

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Garenoxacin Prophylaxis for Febrile Neutropenia after Chemotherapy in Hematological Malignancies

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Open Journal of Internal Medicine 2016年第4期6卷 128-138页

作者： Nobuhiko Nakamura Takeshi Hara Soranobu Ninomiya Yuhei Shibata Takuro Matsumoto Hiroshi Nakamura Junichi Kitagawa Yasuhito Nannya Masahito Shimizu nobuo murakami Hisashi Tsurumi Department of Hematology Gifu University Graduate School of Medicine Gifu Japan

Background: Febrile neutropenia is one of the most serious adverse events in patients with hematological malignancies and chemotherapy. The routine use of fluoroquinolone prophylaxis in patients with hematological malignancies is controversial. Therefore, we prospectively evaluated the efficacy and safety of prophylactic use of garenoxacin for febrile neutropenia. Patients and Methods: Consecutive adult patients with hematological malignancies who were at risk for chemotherapy-induced neutropenia lasting more than seven days were eligible for present study. They received oral garenoxacin (400 mg daily) from the neutrophil count decreased to less than 1000/μl and continued until the neutropenia had resolved. The primary endpoint was incidence of febrile neutropenia, and the secondary endpoints were the type and incidence of adverse events. Results: We enrolled 46 consecutive patients (median age, 59 years). The underlying diseases comprised acute myeloid leukemia (n = 17), acute lymphoblastic leukemia (n = 3), malignant lymphoma (n = 23), and multiple myeloma (n = 3). There were 23 febrile neutropenia episodes and 2 episodes of bacteremia. There were no grade 3 or 4 adverse events;however serum creatinine levels were significantly elevated after garenoxacin administration. The overall prophylactic efficacy of garenoxacin was 50%, and there were no infection-related deaths. Conclusions: Prophylactic use of garenoxacin is effective and safe in patients with hematological malignancies. (Clinical trial registration number: UMIN000004979).

关键词： Febrile Neutropenia Prophylaxis Garenoxacin Hematological Malignancies

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Goblet cell carcinoid of the appendix:Six case reports

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World Journal of Clinical Cases 2024年第22期12卷 5217-5224页

作者： Toshiaki Toshima Ryo Inada Shinya Sakamoto Eri Takeda Takahiro Yoshioka Kento Kumon Naoki Mimura nobuo Takata Motoyasu Tabuchi Kazuyuki Oishi Takuji Sato Kenta Sui Takehiro Okabayashi Kazuhide Ozaki Toshio Nakamura Yuichi Shibuya Manabu Matsumoto Jun Iwata Department of Gastroenterological Surgery Kochi Health Sciences CenterKochi 781-8555Japan Department of Diagnostic Pathology Kochi Health Sciences CenterKochi 781-8555Japan

BACKGROUND Goblet cell carcinoid(GCC)of the appendix is a rare tumor characterized by neuroendocrine and adenocarcinoma *** preoperative diagnosis is very difficult,with most patients complaining mainly of abdominal *** tomography shows swelling of the appendix,so diagnosis is usually made incidentally after appendectomy based on a preoperative diagnosis of *** if a patient undergoes preoperative colonoscopy,accurate endoscopic diagnosis is very difficult because GCC shows a submucosal growth pattern with invasion of the appendiceal *** SUMMARY Between 2017 and 2022,6 patients with GCC were treated in our *** presenting complaint for 5 of these 6 patients was abdominal *** 5 patients underwent appendectomy,including 4 for a preoperative diagnosis of appendicitis and the other for diagnosis and treatment of an appendiceal *** sixth patient presented with vomiting and underwent ileocecal resection for GCC diagnosed from preoperative *** 2 patients with GCC underwent colonoscopy,no neoplastic changes were *** of the six patients showed lymph node metastasis on pathological *** of the last followup(median:15 mo),all cases remained alive without *** As preoperative diagnosis of GCC is difficult,this possibility must be considered during surgical treatments for presumptive appendicitis.

关键词： Goblet cell carcinoid Appendix Preoperative diagnosis Endoscopic diagnosis Surgical treatment Case report

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Influence of synovia constituents on tribological behaviors of articular cartilage

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Friction 2013年第2期1卷 150-162页

作者： Teruo murakami Seido YARIMITSU Kazuhiro NAKASHIMA Yoshinori SAWAE nobuo SAKAI Research Center for Advanced Biomechanics Kyushu University744 MotookaNishi-kuFukuoka819-0395Japan Department of Mechanical Engineering Faculty of EngineeringKyushu University744 MotookaNishi-kuFukuoka819-0395Japan Department of Applied Science for Integrated System Engineering Graduate School of EngineeringKyushu Institute of Technology1-1SensuichoTobata-kuKitakyushu804-8550Japan

The extremely low friction and minimal wear in natural synovial joints appear to be established by effective lubrication mechanisms based on appropriate combination of articular cartilage and synovial *** complex structure of cartilage composed of collagen and proteoglycan with high water content contributes to high load-carrying capacity as biphasic materials and the various constituents of synovial fluid play important roles in various lubrication ***,the detailed differences in functions of the intact and damaged cartilage tissues,and the interaction or synergistic action of synovia constituents with articular cartilage have not yet been *** this study,to examine the roles of synovia constituents and the importance of cartilage surface conditions,the changes in friction were observed in the reciprocating tests of intact and damaged articular cartilage specimens against glass plate lubricated with lubricants containing phospholipid,protein and/or hyaluronic acid as main constituents in synovial *** effectiveness of lubricant constituents and the influence of cartilage surface conditions on friction are *** addition,the protectiveness by synovia constituents for intact articular cartilage surfaces is evaluated.

关键词： articular cartilage synovial fluid synovial joint lubrication biotribology

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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

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Biomimetic artificial cartilage:fibre-reinforcement of PVA hydrogel to promote biphasic lubrication mechanism

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Biosurface and Biotribology 2019年第1期5卷 13-19页

作者： nobuo Sakai Seido Yarimitsu Yoshinori Sawae Mochimitsu Komori Teruo murakami Integrated Systems Engineering Kyushu Institute of TechnologyKitakyushuJapan Intelligent Mechanical Systems System DesignTokyo Metropolitan UniversityTokyoJapan Mechanical Engineering Kyushu UniversityFukuokaJapan Research Center for Advanced Biomechanics Kyushu UniversityFukuokaJapan Medical Technology Teikyo UniversityOmutaJapan

The fibre-reinforced structure in synovial articular cartilage plays an important role in enhancing the fluid load support in the biphasic lubrication ***(vinyl alcohol)(PVA)hydrogel is a potential biomimetic articular cartilage *** this study,PVA hydrogel was reinforced with PVA fibres to improve its frictional *** computational analysis,the position of the PVA fibre layer was examined with a migrating contact condition to reduce the friction *** improve the fibre reinforcement,a method for fibre placement was developed to retain the initial strain of the fibre in the hydrogel *** experimental results showed that the fibre-reinforced PVA hydrogel with a surface fibre layer had a low friction coefficient of 0.031 in pure *** fibre-reinforced PVA hydrogel successfully reduced friction coefficient.

关键词： mechanism. material. fibre

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Identifying visual sensitive areas:an evaluation of view corridors to support nature-culture heritage conservation in Chiang Mai historic city

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Built Heritage 2022年第4期6卷 15-34页

作者： Janjira Sukwai nobuo Mishima Nattasit Srinurak Graduate School of Science and Engineering Saga University1 Honjo-machiSaga 840-8502Japan. Urban Design and Environmental Studies Center SRIChiang Mai University239 SuthepChiang Mai 50230Thailand.

The visual integrity of mountains contributing to cultural landscapes as nature-culture attributes is often obscured by the vertical intrusive built environment,especially in bufer areas of protected heritage ***,this study argued that even low/medium-rise buildings that inappropriately appear in the horizontal visual plane could be a factor increasing sensitivity to this panoramic *** integrative tool–visual sensitivity assessment–consists of Viewshed and Skyline analysis considering the pedestrian’s visual limitation in identifying the sensitive areas of the mountain view corridor in the historic city of Chiang *** visible mountain areas(VMAs)were determined as a baseline,and their relationship with the visible building areas(VBAs)was then examined using statistical correlation to defne a strong negative relationship as the visual sensitive areas in fve *** results showed that the bufer zone was found to have more areas with visual sensitivity values,but this varies depending on the characteristics of buildings and the assessment from the view ***,in height-restricted areas,such as historic area zone 5,there are some concerns about the visual intrusion,which necessitates continuous monitoring using the assessment result as a *** the results into implementation could support cultural landscape conservation in Chiang Mai *** method is applicable in historic cities with similar settings to produce the baseline for the built environment that is harmonious with the cultural and historical characteristics of the city and with respect to its broader setting.

关键词： Nature-culture heritage conservation Mountain view corridor Visual sensitivity assessment Intrusive built environment Visual integrity

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Transitional behaviour between biphasic lubrication and soft elastohydrodynamic lubrication of poly(vinyl alcohol)hydrogel using microelectromechanical system pressure sensor

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Biosurface and Biotribology 2018年第1期4卷 24-33页

作者： nobuo Sakai Seido Yarimitsu Yoshinori Sawae Mochimitsu Komori Teruo murakami Integrated System Engineering Kyushu Institute of TechnologyKitakyushuJapan Intelligent Mechanical Systems System DesignTokyo Metropolitan UniversityTokyoJapan Mechanical Engineering Kyushu UniversityFukuokaJapan Research Center for Advanced Biomechanics Kyushu UniversityFukuokaJapan Medical Technology Teikyo UniversityOmutaJapan

The soft hydrogel material is expected for a candidate material as biomimetic artificial cartilage with synergisticfunctionalities of adaptive multimode *** boundary lubrication mode of hydrogel material,the biphasiclubrication mechanism cooperatively exerts its *** hydrodynamic lubrication mode,it is preferable that thelubricating surfaces be impermeable to trap the fluid pressure in contact surfaces,whereas the actual biphasic materiallike a hydrogel is a permeable material with surface *** is indicated that the interstitial fluid pressurisation inthe permeable biphasic material can contribute to significant fluid load support under lower sliding speed ***,the authors examined how the contrary fluid pressure effect appears in the transition from the boundarylubrication mode to soft elastohydrodynamic lubrication *** the experiment,a small pressure sensor was utilisedto measure the in-situ fluid pressure in sliding *** the experimental condition of this study wasselective,the result showed a possibility of the negative effect of the biphasic surface,in which the permeable surfacediminished the hydrodynamic fluid *** means that one should manage and enhance the biphasic lubricationabilities in wide operation range when the hydrogel material was used as a load bearing material.

关键词： hydrogel behaviour synergistic

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Serrated flow accompanied with dynamic type transition of the Portevin-Le Chatelier effect in austenitic stainless steel

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Journal of Materials Science & Technology 2023年第2期133卷 154-164页

作者： Seung-Yong Lee Sita Chettri Ritupan Sarmah Chikako Takushima Jun-ichi Hamada nobuo Nakada Department of Materials Science and Engineering Tokyo Institute of Technology4259 Nagatsuta-choMidori-kuYokohama-shiKanagawa-ken 226-8503Japan Department of Physics Tezpur UniversityNappamTezpur 784028India Research and Development Center Nippon Steel Stainless Steel CorporationHikari 743-8550Japan

In order to further understand high-temperature deformation behavior and its-related mechanical prop-erties,the Portevin-Le Chatelier(PLC)effect in an Fe-19Cr-13Ni-0.2C austenitic stainless steel was in-vestigated using high-temperature digital image correlation(DIC)*** the tensile testing at temperatures from 473 to 623 K,different types of serrated flow appeared even at a constant applied strain rate,and the type transition took place dynamically in a certain order with deformation *** analysis revealed that the dynamic type transition of the serrated flow obeys the PLC band propagation behavior,and that the transition of the PLC band propagation behavior could be attributed to the PLC band nucleation *** modeling also proved that the nucleation manner of PLC band nu-cleation is determined by the spatial-temporal coupling effect.

关键词： Dynamic strain aging(DSA) Austenitic stainless steel(γ-STS) Portevin-Le Chatelier(PLC)effect Digital image correlation(DIC) Local strain distribution

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价值认知与实践决策——工业建筑遗产更新中当代建筑师的话语思考

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建筑遗产 2024年第1期 8-16页

作者：赵子杰徐苏斌田甜 [日]青木信夫天津大学建筑学院天津300072 天津大学中国文化遗产保护国际研究中心太原理工大学建筑学院

遗产的价值认知与保护是一个多维度的议题,受到不同认知主体背景差异的影响,可能引发争议,进而影响保护决策的制定。作为工业建筑遗产更新实践的直接策划者与执行者,建筑师的价值认知与实践决策会直接影响实践效果。文章旨在从建筑师的... 详细信息

遗产的价值认知与保护是一个多维度的议题,受到不同认知主体背景差异的影响,可能引发争议,进而影响保护决策的制定。作为工业建筑遗产更新实践的直接策划者与执行者,建筑师的价值认知与实践决策会直接影响实践效果。文章旨在从建筑师的价值认知视角出发,记录这一群体对价值认知与保护决策的思考,以探究建筑师群体对于遗产保护与再利用的当代思考。文章发现,建筑师群体普遍认为工业建筑遗产要走入当代生活,并对工业建筑遗产及其环境的保护利用和干预持正面态度。

关键词：工业建筑遗产更新建筑师价值认知

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