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5-fluorouracil,Methotrexate,Leucovorin,CDDP and Epirubicin（FEPMTX）:A Wide-Spectrum Regimen of Salvage Chemotherapyfor High- Grade Advanced Gastric Cancer

5-fluorouracil,Methotrexate,Leucovorin,CDDP and Epirubicin（...

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2000全国肿瘤学术大会

作者： Kazuo Kinoshita Yutaka Yonemura Toshiharu Sawa Tatsukazu Miyata Hiroshi Sakuma nobuo matsuki Sigehiro Tanaka Sachio Fushida Takashi Fujimura Young Jae Mok Byung Sik Kim Jong In Lee Dong Wook Choi Young Jin Song Doo Hyun Yang Sung Joon Kwon Itsuo Miyazaki Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Korea University Hospital M.D. Ulsan University Hospital M.D. Korean Cancer Center Hospital M.D. Korean Cancer Center Hospital M.D. Chungbuk National University Hospital M.D. Chonbuk National University Hospital M.D. Hanyang University Hospital Korea M.D. Department of Surgery Ⅱ School of medicine Kanazawa University13-1 Takara-machiKanazawaJapan M.D.

＜正＞Twenty-one patients with primary high-grade advanced gastric cancer in whom the presence of stage ? was con- firmed by preoperative diagnostic imaging,were treated with a wide-spectrum regimen,designated as FEPMTX therapy to establish an effective salvage *** therapy consisted of 5-fluorouracil（5-FU）and the triple biochemical modulators;methotrexate（MTX）,calcium leucovorin（LV）,cisplatin（CDDP）,and in addition of epiru- bicin（EPI）.The schedule comprised 3 days continuous administration of 5-FU（350 mg/m2/day）and MTX（35 mg/ m2）on day 1,LV（30 mg/m2）on the day 2,LV（30 mg/m2）and CDDP（30 mg/m2）and EPI（20 mg/m2）on day *** treatment was performed two or more courses with 2 weeks interval in *** partial responses（PR）, five no changes（NC）and five progressive diseases（PD）were obtained,and the response rate was 52%.Ten patients （PR 7,NC 2,PD 1）were received gastrectomy（resectability rate 48%）.The survival in all cases resulted in median survival of 184 days and one-year survival rate of 23%.While there is no significant difference insurvival between the cases with or without the resection of the primary lesion,the survival of responders was significantly longer than that of non-responders（median survival time;responder 356days,non-responder 152days）.Adverse effects such as myelo- suppression and anorexia and fatigue sometimes occurred,but were mild and all the patients well *** therapy is thought to be an effective regimen for neoadjuvant chemotherapy with longer survival and little toxic for patients with stage?gastric cancer.

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ELASTOMERIC SEISMIC-PROTECTION ISOLATORS FOR BUILDINGS AND BRIDGES

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Chinese Journal of Polymer Science 2013年第1期31卷 50-57页

作者： Toshio Nishi nobuo Murota International Division Tokyo Institute of Technology Department of Seismic Isolation &Vibration Control Development

A giant earthquake of magnitude 9.0 occurred in Pacific Ocean off of Tohoku District Japan on March 11,2011. The highest seismic intensity of 7 in JMA scale was recorded in Miyagi. In the Tohoku district, around 230 buildings are seismically isolated （hereafter, SI） mainly by elastomeric isolators （seismic rubber bearings）. According to the official survey reports by several organizations （for example）, the records of those buildings have verified the effectiveness of the seismic isolation. The response acceleration of the SI buildings was reduced by 30% to 50% of the input ground acceleration. Additionally, the difference of the conditions inside the room between SI and the fixed-base buildings was obvious as well as the damage in main structures of the buildings. The displacements of the isolators by the earthquake were around 200 mm according to the records of the instruments. As a result, the performance of SI buildings and the elastomeric isolators in the Tohoku District -- Off the Pacific Ocean Earthquake 2011 were excellent, and the efficiency of the seismic isolation was verified by the records of many buildings in wide area.

关键词： Elastomeric isolator Seismic isolation Rubber bearing.

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Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases

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Acta Pharmacologica Sinica 2007年第3期28卷 439-445页

作者： nobuo MURATA Tatsuo YAMAKAWA Department of Surgery Mini-invasive surgery CenterTeikyo University Mizonokuchi HospitalKawasaki 213-8507Japan

Aim:To provide experimental data for further research on the signal transductionof apoptosis in lung adenocarcinoma cells,we examined the effects of exogenousC2-ceramide administration on several members of the mitogen-activated proteinkinase(MAPK)superfamily and caspase-3 in A549 ***:Cell viabilityand apoptosis were analyzed by cell counting kit-8 assay and flow *** MAPK and caspase-3 proteins were detected by Western ***:C2-ceramide selectively altered the phosphorylation state &members ofthe MAPK superfamily,causing hyperphosphorylation ofmitogen-activated pro-tein kinase kinase(MEK)1/2 and the p38 MAPK,but not affecting the phosphory-lation ofextracellular signal-regulated kinase 1/2 and the c-Jun N-terminal ***-203580(a p38 MAPK inhibitor)and p38 siRNA,but not U0126(a MEKinhibitor),partially rescued cell death induced by C2-ceramide.C2-ceramide promoted theactivation of ***:Exogenous C2-ceramide induced apoptosisin human lung adenocarcinoma A549 *** activation of MAPK and caspase-3were involved in the mechanisms ofC2-ceramide-induced apoptosis in A549 cells.

关键词： ceramide apoptosis mitogen-activated protein kinases A549 cells

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Recent Advancement in Optical Fiber Sensing for Aerospace Composite Structures

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Photonic Sensors 2013年第4期3卷 345-354页

作者： Shu MINAKUCHI nobuo TAKEDA Graduate School of Frontier Sciences The University of Tokyo 5-1-5 Kashiwanoha Kashiwa-shi Chiba 277-8561Japan

Optical fiber sensors have attracted considerable attention in health monitoring of aerospace composite structures. This paper briefly reviews our recent advancement mainly in Brillouin-based distributed sensing. Damage detection, life cycle monitoring and shape reconstruction systems applicable to large-scale composite structures are presented, and new technical concepts, ＂smart crack arrester＂ and ＂hierarchical sensing system＂, are described as well, highlighting the great potential of optical fiber sensors for the structural health monitoring （SHM） field.

关键词： Carbon fiber reinforced plastic (CFRP) Brillouin-based system fiber Bragg grating (FBG)

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Analysis of Sparse Quasi-Newton Updates with Positive Definite Matrix Completion

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Journal of the Operations Research Society of China 2014年第1期2卷 39-56页

作者： Yu-Hong Dai nobuo Yamashita State Key Laboratory of Scientific and Engineering Computing Institute of Computational Mathematics and Scientific/Engineering ComputingAcademy of Mathematics and Systems ScienceChinese Academy of SciencesP.O.Box 2719Beijing 100080People’s Republic of China Department of Applied Mathematics and Physics Graduate School of InformaticsKyoto UniversityKyoto 606-8501Japan

Based on the idea of maximum determinant positive definite matrix completion,Yamashita(Math Prog 115(1):1–30,2008)proposed a new sparse quasi-Newton update,called MCQN,for unconstrained optimization problems with sparse Hessian *** exchange of the relaxation of the secant equation,the MCQN update avoids solving difficult subproblems and overcomes the ill-conditioning of approximate Hessian ***,local and superlinear convergence results were only established for the MCQN update with the DFP *** this paper,we extend the convergence result to the MCQN update with the whole Broyden’s convex *** results are also reported,which suggest some efficient ways of choosing the parameter in the MCQN update the Broyden’s family.

关键词： Quasi-Newton method Large-scale problems Sparsity Positive definite matrix completion Superlinear convergence

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A method for estimating the fraction of mineral dust in particulate matter using PM2.5-to-PM10 ratios

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Particuology 2016年第5期14卷 114-120页

作者： nobuo Sugimoto Atsushi Shimizu Ichiro Matsui Masataka Nishikawa Center for Environmental Measurement and Analysis National Institute for Environmental Studies 16-20nogawa Tsukuba 305-8506 Japan Tokyo University of Science Environmental Safety Center 1-3 Kagurazaka Shinjuku-ku Tokyo 162-8601Japan

A simple method for estimating the contributions of mineral dust to PM2.5, PM10, or TSP is presented. The method is based on the assumption of external mixing of two types of particles with different PM2.5/PM10 ratios, The method was applied to local and transported dust events observed in Tsukuba, Japan, and was compared with collocated polarization lidar measurements. The method was then applied to three dust events that occurred in Oki, Rishiri, and Ochiishi,Japan, in 2012. The results showed that the method was useful for detecting mineral dust and for qualitatively describing the mixing of dust with anthropogenic aerosols.

关键词： Mineral dust PM2.5 dust fraction PM2.5 to PM10 ratio Atmospheric mixing Lidar Depolarization ratio

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Proposal of Japanese Vocabulary Difficulty Level Dictionaries for Automated Essay Scoring Support System Using Rubric

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Journal of the Operations Research Society of China 2020年第4期8卷 601-617页

作者： Megumi Yamamoto nobuo Umemura Hiroyuki Kawano School of Contemporary International Studies Nagoya University of Foreign StudiesIwasaki-choNisshin 470-0197Japan School of Media and Design Nagoya University of Arts and SciencesNagoya 470-0196Japan Faculty of Science and Engineering Nanzan UniversityNagoya 466-8673Japan

We are developing a Moodle plug-in,which is an AES(automated essay scoring)support system for the basic education of university *** system evaluates essays based on rubric,which has five evaluation viewpoints“Contents,Structure,Evidence,Style,and Skill”.Vocabulary level is one of the scoring items of *** is calculated using Japanese Language Learners’Dictionaries constructed by Sunakawa et *** this does not fully cover the words used in the student-level essays,we found that there is a problem with the accuracy of the vocabulary level *** this paper,we propose to construct comprehensive Japanese vocabulary difficulty level dictionaries using Japanese Wikipedia as the *** apply Latent Dirichlet Allocation(LDA)to the Wikipedia corpus and find the word appearance probability as one of the indexes of word *** use the TF-IDF value instead of the LDA value of the words,which rarely *** a result,we constructed highly comprehensive Japanese vocabulary difficulty level *** confirmed that the vocabulary level can be scored for all words in the test dataset by using the constructed dictionaries.

关键词： Automated essay scoring Vocabulary level Dictionary Wikipedia Corpus LDA Rubric

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Lidar Methods for Observing Mineral Dust

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Journal of Meteorological Research 2014年第2期28卷 173-184页

作者： nobuo SUGIMOTO HUANG Zhongwei 黄忠伟 National Institute for Environmental Studies College of Atmospheric Sciences Lanzhou University

Lidar methods for observing mineral dust aerosols are *** methods include Mie scattering lidars,polarization lidars,Raman scattering lidars,high-spectral-resolution lidars,and fluorescence *** of the lidar systems developed by the authors and the results of the observations and applications are *** largest advantage of the lidar methods is that they can observe vertical distribution of aerosols continuously with high temporal and spatial *** of ground-based lidars provide useful data for understanding the distribution and movement of mineral dust and other *** lidar network data are actually used for validation and assimilation of dust transport models,which can evaluate emission,transport,and deposition of mineral *** lidar methods are also useful for measuring the optical characteristics of aerosols that are essential to assess the radiative effects of *** of the lidar data analysis methods for aerosol characterization is also *** from space and ground-based networks are two important approaches with the lidar methods in the studies of the effects of mineral dust and other aerosols on climate and the *** of the researches with lidar methods in the near future are discussed.

关键词： lidar mineral dust Mie scattering lidar Raman lidar high-spectral-resolution lidar fluorescence lidar

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Principle and basic techniques in urinary tract surgery

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畜牧与兽医 2012年第S2期44卷 1-3页

作者： nobuo Sasaki Nippon Institute for Biological Science The University of Tokyo

Among the disease of the urinary tract in dogs and cats,the most common diseases requiring surgery are urinary bladder and *** this article,the principles of diagnosis,strategy of treatments and basic techniques for these diseases are discussed.1 Urinary bladder In dogs,most common bladder diseases are cystitis,cystic calculi,cystic trauma due to car accident and bladder *** patients often show abnormal urination such as incontinence,pollakiuria and *** urine or he-

关键词： bladder urinary cystitis incontinence requiring urethral trauma suture radiography ureter

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Endoplasmic reticulum stress transducer old astrocyte specifically induced substance contributes to astrogliosis after spinal cord injury

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Neural Regeneration Research 2018年第3期13卷 536-540页

作者： Atsushi Takazawa Naosuke Kamei nobuo Adachi Mitsuo Ochi Department of Orthopaedic Surgery Graduate School of Biomedical & Health Sciences Hiroshima University Medical Center for Translational & Clinical Research Hiroshima University Hospital

Old astrocyte specifically induced substance （OASIS） is an endoplasmic reticulum （ER） stress transducer specifically expressed in astrocytes and osteoblasts. OASIS regulates the differentiation of neural precursor cells into astrocytes in the central nervous system. This study aimed to elucidate the involvement of ER stress responses stimulated via OASIS in astrogliosis following spinal cord injury. In a mouse model of spinal cord contusion injury, OASIS mRNA and protein expression were evaluated at days 7 and 14. A significant increase in OASIS mRNA on day 7 and an increase in protein on days 7 and 14 was observed in injured spinal cords. Immunostaining on day 7 revealed co-localization of OASIS and astrocytes in the periphery of the injury site. Furthermore, anti-OASIS small interfering RNA （siRNA） was injected at the injury sites on day 5 to elucidate the function of OASIS. Treatment with anti-OASIS siRNA caused a significant decrease in OASIS mRNA on day 7 and protein on days 7 and 14, and was associated with the inhibition of astrogliosis and hindlimb motor function recovery. Results of our study show that OASIS expression synchronizes with astrogliosis and is functionally associated with astrogliosis after spinal cord injury.

关键词： unfolded protein response cAMP-response element binding protein/activating transcription factor protein family C57BL/6 contusion injury reactive astrocyte functional recovery real-time polymerase chain reaction western blot immunohistochemistry glial fibrillary acidic protein

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