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Bacteriological Profile of Effusion Fluids Infections at Charles De Gaulle University Pediatric Hospital from 2017 to 2020

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Open Journal of Medical Microbiology 2024年第2期14卷 146-163页

作者： Kambiré Dinanibè Ouédraogo Oumarou Tiendrebéogo Salam Tondé Issa Tamboura Mamadou Zida Sylvie Kpoda Dissinviel Sagna Tani Compaoré T. Rebeca Zouré Abdou-Azaque Soubeiga R. Serge Théophile Sawadogo Stanislas Ilboudo Maïmouna Rouamba Hortense Ouédraogo Wenkouni Henri Gautier Ouédraogo-Traoré Rasmata Sanou Mahamoudou Institut de Recherche en Sciences de la Sant Ouagadougou Burkina Faso Centre Hospitalier Universitaire Pdiatrique Charles De Gaulle Ouagadougou Burkina Faso Centre Universitaire de Ziniar Ziniar Burkina Faso Universit Joseph Ki-Zerbo Ouagadougou Burkina Faso Universit Ouaga 3S Ouagadougou Burkina Faso Centre Mdical Urbain de Samandin Ouagadougou Burkina Faso

Introduction: Microbiology of effusion fluids in children in Burkina Faso is characterized by the scarcity of data. This work aimed to study the bacteriological and antibiotics susceptibility profile of bacteria involved in effusion fluid infections in paediatrics in order to improve the choice of probabilistic antibiotics therapy. Methods: A cross-sectional, descriptive study was used in children aged 0 to 15 years from 2017 to 2020 at the Charles De Gaulle Pediatric University Hospital Center (CHUP-CDG) in Ouagadougou. Classical bacteriology methods such as macroscopy, Gram staining, identification galleries and antibiotics susceptibility testing were used. Results: Of 231 samples, 64 bacteria were isolated. The most common bacterial strains of pleural fluid were Staphylococcus aureus (25%) and 40% for Enterobacteriaceae. Of the peritoneal fluid, 77% were Enterobacteriaceae with 57% Escherichia coli;and from joint fluid, 33% were S. aureus and 22% for P. aeruginosa. The overall susceptibility profile showed 29% extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL), 10% methicillin-resistant S. aureus (MRSA), and 8% carbapenemases. Conclusion: Bacteriological profile is characterized by ESBL-producing Enterobacteriaceae and MRSA. The most active antibiotics were macrolides, aminoglycosides, and cefoxitin (methicillin) for Gram-positive cocci, carbapenems, and aminoglycosides for Gram-negative bacilli. Then, the monitoring of antibiotics resistance must be permanent.

关键词： Bacteriological Profile Effusion Fluid Infections

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Role of Small Extracellular Vesicles in Liver Diseases:Pathogenesis,Diagnosis,and Treatment

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1176-1185页

作者： Tingmao Xue Judy Wai Ping yam Department of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChinaReceived

Extracellular vesicles(EVs)are vesicular bodies that bud off from the cell membrane or are secreted virtually by all cell *** EVs(sEVs or exosomes)are key mediators of cell-cell communication by delivering their cargo,including proteins,lipids,or RNAs,to the recipient cells where they induce changes in signaling pathways and phenotypic *** findings have revealed the pivotal involve-ment of sEVs in the pathogenesis of various *** the bright side,they are rich sources of biomarkers for diag-nosis,prognosis,treatment response,and disease *** have high stability,biocompatibility,targetability,low toxicity,and are immunogenic in *** intrinsic properties make sEVs an ideal delivery vehicle to be loaded with cargo for therapeutic *** diseases are a major global health *** review aims to focus on the roles and mechanisms of sEVs in the pathogenesis of liver diseases,liver injury,liver failure,and liver *** are released not only by hepatocytes but also by stromal and immune cells in the *** detection of liver disease determines the chance for cura-tive treatment and high survival of *** review focuses on the potential of circulating sEV cargo as specific and sensitive noninvasive biomarkers for the early detection and prognosis of liver *** addition,the therapeutic use of sEVs derived from various cell types is ***-though sEVs hold promise for clinical applications,there are still challenges to be overcome by further research to bring utilization of sEVs into clinical practice.

关键词： Small extracellular vesicles Liver injury Liver fibrosis Liver fail-ure Hepatocellular carcinoma Biomarkers.

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Symmetry-driven half-integer conductance quantization in Cobalt–fulvalene sandwich nanowire

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npj Computational Materials 2023年第1期9卷 314-321页

作者： Zhuoling Jiang Kah-Meng yam Yee Sin Ang Na Guo Yongjie Zhang Hao Wang Chun Zhang Department of Physics and Centre for Advanced 2D Materials National University of SingaporeSingapore 117551Singapore Science Mathematics and Technology(SMT)ClusterSingapore University of Technology and DesignSingapore 487372Singapore Department of Chemistry National University of SingaporeSingapore 117543Singapore National University of Singapore Chongqing Research Institute 401123 ChongqingChina

Precise manipulation and monitoring spin transport in one-dimensional (1D) systems is a long-sought goal in the field of nano-spintronics. Based on first-principles calculations, we report the observation of half-integer conductance quantization in the Cobalt-fulvalene sandwich nanowire. Compared with a pure monatomic Cobalt wire, the introduction of fulvalene molecules leads to threeimportant features: Firstly, the strong coupling between the fulvalene and the Cobalt prevents the contamination of the ambientair, ensuring both chemical and physical stabilities;Secondly, the fulvalene symmetry-selectively filters out most of the d-typeorbitals of the Cobalt while leaving a single d-type orbital to form an open spin channel around the Fermi level, which offers amechanism to achieve the observed half-integer conductance;Thirdly, it maintains a superexchange coupling between adjacent Coatoms to achieve a high Curie temperature. Spin transport calculations show that this half-metallic nanowire can serve as a perfectspin filter or a spin valve device, thus revealing the potential of Cobalt-fulvalene sandwich nanowire as a promising building blockof high-performance spintronics technology.

关键词： sandwich coupling transport

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Ferroptosis:From Basic Research to Clinical Therapeutics in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 207-218页

作者： Ziyue Huang Haoming Xia Yunfu Cui Judy Wai Ping yam Yi Xu Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Pathology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Key Laboratory of Myocardial Ischemia Harbin Medical UniversityMinistry of EducationHarbinHeilongjiangChina

Hepatocellular carcinoma(HCC)is one of the most common and highly heterogeneous malignancies *** the rapid development of multidisciplinary treatment and personalized precision medicine strategies,the overall survival of HCC patients remains *** limited survival benefit may be attributed to difficulty in early diagnosis,the high recurrence rate and high tumor ***,a novel mode of cell death driven by iron-dependent lipid peroxidation,has been implicated in the development and therapeutic response of various tumors,including *** this review,we discuss the regulatory network of ferroptosis,describe the crosstalk between ferroptosis and HCCrelated signaling pathways,and elucidate the potential role of ferroptosis in various treatment modalities for HCC,such as systemic therapy,radiotherapy,immunotherapy,interventional therapy and nanotherapy,and applications in the diagnosis and prognosis of HCC,to provide a theoretical basis for the diagnosis and treatment of HCC to effectively improve the survival of HCC patients.

关键词： Hepatocellular carcinoma Ferroptosis Sorafenib Cancer therapy Molecular targets

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Viscosity behavior of magnetic suspensions in fluid-assisted finishing

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Progress in Natural Science:Materials International 2008年第1期18卷 91-96页

作者： yam Yeung China Department of Mechanical and Automation Engineering The Chinese University of Hong Kong New Territories Shatin

Magnetic fluid-assisted finishing has been verified both theoretically and experimentally as an effective fabrication technology for opti- cal mirrors and *** purpose of this paper is to introduce a novel design of polishing tool and demonstrate the possible applica- tions of this *** work includes studying the viscosity of the magnetic suspensions of micrometer-sized Carbonyl iron particles under the influence of a magnetic *** the cases of magnetizable suspension with and without abrasive cerium oxide par- ticles are studied for their ensuing polishing *** of material removal function is conducted using a Wyko Nat1100 *** to reduce surface roughness with the proposed tool are also performed using a K9 mirror as the *** show that the surface accuracy is improved over three times to less than 0.5 nm after two cycles of polishing.

关键词： Surface roughness Micro-structure Super-smooth Fluid-assisted finishing Material removal rate

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Impact of climate change on agricultural production: A case of Rasuwa District, Nepal

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Regional Sustainability 2022年第2期3卷 122-132页

作者： Binod DAWADI Anjula SHRESTHA Ram Hari ACHARYA yam Prasad DHITAL Rohini DEVKOTA Central Department of Hydrology and Meteorology Tribhuvan UniversityKirtipur Kathmandu44613Nepal Kathmandu Centre for Research and Education Chinese Academy of Sciences-Tribhuvan UniversityKirtipur Kathmandu44613Nepal Central Department of Environmental Science Tribhuvan UniversityKirtipur Kathmandu44613Nepal Department of Meteorology Tri-Chandra Multiple CampusTribhuvan UniversityGhantaghar Kathmandu44600Nepal College of Water Resources and Architectural Engineering Shihezi UniversityShihezi832000China Southern Downs Regional Council Queensland4350Australia University of Southern Queensland Toowoomba Queensland4350Australia

Climate change is expected to threaten the developing countries the most. Nepal is considered one of the five countries most vulnerable to climate change in the world. The mountainous area such as Rasuwa District in Nepal is more vulnerable due to complex topography, human activity(tourism), and climate change. In this context, we carried out this study to assess the climate change and its impact on agriculture production as well as people’s perceptions on the impact of climate change. The long-term(1980–2014) observed climate data(temperature and precipitation) and field-based survey data on people’s perceptions were analyzed. Mann-Kendall trend test and Sen’s slope estimation were used to analyze the temperature and precipitation trends. Furthermore, key informant interviews(KIIs) and focal group discussions(FGDs) were conducted to understand people’s perceptions of the impact of climate change on agricultural production. Further, ERA5 and Asian Precipitation-Highly Resolved Observational Data Integration Towards Evaluation of Water Resources(APHRODITE) datasets were used to compare the in situ climate data. The maximum temperature and total precipitation in summer monsoon(June–September) were found increasing significantly at rates of 0.07℃/a and 19.89 mm/a, respectively. But the minimum winter temperature and winter precipitation were found decrease by 0.05℃/a and 4.89 mm/a, respectively. Moreover, a large number of respondents reported a decrease in millet and wheat productions while an increase in potato production over the considered time duration(1990–2014). It is noteworthy that the respondents from the mid-elevation regions perceived an increasing trend in crop production compared to those from the low elevation regions. In recent years, people living in the high elevation regions of Rasuwa District have started to shift their cropping calendar to increase agricultural production. This study will provide useful information for policymakers in formulating a

关键词： Mountainous areas Climate change Temperature Precipitation Agriculture production Nepal

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Linear-scaling computation of excited states in time-domain

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Science China Chemistry 2014年第1期57卷 70-77页

作者： yam ChiYung CHEN GuanHua Department of Chemistry The University of Hong Kong Beijing Computational Science Research Center

The applicability of quantum mechanical methods is severely limited by their poor *** circumvent the problem,linearscaling methods for quantum mechanical calculations had been *** physical basis of linear-scaling methods is the locality in quantum mechanics where the properties or observables of a system are weakly influenced by factors spatially far *** the substantial efforts spent on devising linear-scaling methods for ground state,there is also a growing interest in the development of linear-scaling methods for excited *** review gives an overview of linear-scaling approaches for excited states solved in real time-domain.

关键词： linear-scaling methods,quantum chemistry,time-domain,density matrix

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Rainfall erosivity and sediment dynamics in the Himalaya catchment during the Melamchi flood in Nepal

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Journal of Mountain Science 2023年第10期20卷 2993-3009页

作者： Binod BANIYA TANG Qiu-hong Bhupati NEUPANE XU Xi-meng HE Li Tirtha Raj ADHIKARI Seyed Rashid Fallah SHAMSI yam Prasad DHITAL Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 1oo101China Department of Environmental Science Patan Multiple CampusInstitute of Science and TechnologyTribhuvan UniversityKathmandu44613Nepal State Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesInstitute of Tibetan Plateau ResearchChine se Academy of SciencesBeijing 100101China Central Department of Hydrology and Meteorology Tribhuvan UniversityKathmandu 44613Nepal College of Applied Science Tribhuvan UniversityKathmandu 44613Nepal Department of Natural Resource and Environment College of AgricultureShiraz UniversityShiraz 71345Iran College of Water Resources and Architectural Engineering Shihezi UniversityShihezi 832000China

Rainfall erosivity is an indicator of rainfall potential to cause soil *** Melamchi extreme flood occurred on June-15 and recurred on July-31,2021 in *** these flooding events,a large volume of sediments were eroded,transported and deposited due to the high rainfall erosivity of the *** this study,the temporal and the spatial distribution of rainfall erosivity within the Melamchi River Basin was estimated and further linked to sediment discharge and concentration at various sites along the river *** daily rainfall data for the event year 2021 of the entire basin were *** was performed by post-flooding grain size *** result showed that rainfall and rainfall erosivity exhibit pronounced intensity within the Melamchi River basin,particularly at Sermathang and Tarkeghang,both located in the middle section of the *** average annual rainfall in the Melamchi region was 3140.39 mm with an average annual erosivity of 18302.06(MJ mm)/(ha h yr).The average daily erosivity of the basin was 358.67(MJ mm)/(ha h)during the first event and 1241(MJ mm)/(ha h)for the second *** the upper section of sampling,the sediment size ranged from 0.1 mm to>8 mm and was poorly ***,the lower region had smaller sediment ranging from 0.075 mm to>4.75 mm and also well *** smaller size(100 mm)sediments were passed relatively higher from the Kiwil(8.20%)and Ambathan(8.39%)river *** premonsoon and monsoon seasons,the highest sediment concentration was found to be 563.8 g/L and 344.3 g/L in Bhimtar and the lowest was 238.5 g/L and 132.1 g/L at the Ambathan,*** sediment concentration during the pre-monsoon was found to be higher than the sediment concentration during the monsoon season in the Melamchi *** more erosive regions in the basin were associated with the presence of highly

关键词： Rainfall erosivity Sediment Extreme flood Melamchi Nepal

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Bending,Compression and Bonding Performance of Cross-Laminated Timber(CLT)Made from Malaysian Fast-Growing Timbers

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Journal of Renewable Materials 2022年第11期10卷 2851-2869页

作者： Norshariza Mohamad Bhkari Lum Wei Chen Anis Azmi Muhammad Shaiful Nordin Norman Wong Shew yam Zakiah Ahmad Lee Seng Hua Institute for Infrastructure Engineering and SustainableManagement(IIESM) Universiti TeknologiMARAShah Alam40450Malaysia School of Civil Engineering College of EngineeringUniversiti Teknologi MARAShah Alam40450Malaysia Sapulut Forest Development Sdn.Bhd. Kota Kinabalu88400Malaysia Institute of Tropical Forestry and Forest Products(INTROP) Universiti Putra Malaysia UPMSerdang43400Malaysia

This study investigated the bending,compression as well as the bonding performance of CLT panels made from fast-growing timber species,i.e.,Laran(Neolamarckia cadamba)and Batai(Paraserianthes falcataria).The variables studied were timber species(Laran and Batai),layers of lamination(3-layer and 5-layer),loading direction in bending(in-plane and out-of-plane),loading direction in compression(x-,y-,and z-axis)and different treatment conditions for bonding performance *** desired outputs of this study were bending and compression properties(strength and stiffness)as well as bonding performance(block shear strength,wood failure percentage and delamination value).The bending and compression test were conducted according to EN16351:2015 and EN408:2012,*** the other hand,the bonding performance test was determined by block shear and delamination test based on EN16351:2015 and EN14374:2004,*** to block shear test,the samples were subjected to three different treatment *** results showed that CLT made from 3-layer Laran timber,loaded at out-of-plane direction exhibited the highest bending ***,CLT made from 5-layered Batai timber,loaded at in-plane direction showed the lowest bending *** samples for compression loaded at x-axis exhibited the best compressive ***,Laran CLT showed greater bonding performance determined by shear test compared to Batai CLT for both 3-and 5-layer *** the contrary,delamination results showed that Batai CLT demonstrated better bonding performance compared to Laran *** terms of bonding performance measured by wood failure percentage(WFP),most samples under various treatment conditions showed WFP≥80%except for samples under wet condition with WFP≤60%.

关键词： Cross-laminated timber plantation timber flexural performance bonding performance

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Rational design of platinum(Ⅱ)complexes with orthogonally oriented triazolyl ligand with emission enhancement characteristics for cancer chemotherapy in vivo

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Science China Chemistry 2023年第10期66卷 2878-2884页

作者： Yeye Ai Zherui Zhang Yuexuan Fei Ruirong Ye Angela Sin-Yee Law Zong-Wan Mao Junqiu Liu Yongguang Li Vivian Wing-Wah yam Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Institute of Molecular Functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong KongChina School of Chemistry Sun Yat-Sen UniversityGuangzhou 510275China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China

The mitochondria are essential for tumorigenesis and have been regarded as important targets in cancer ***,the mitochondria-targeted platinum(Ⅱ)complexes have been *** introduction of the triazole group with larger steric hindrance through post-click reaction converts the hybridization of carbon from sp to sp^(2),endowing the complexes with an orthogonally oriented ligand with restricted rotation and emission enhancement *** of the triazolyl ligand has led to platinum(Ⅱ)complexes that can efficiently enter cancer cells and selectively accumulate in mitochondria,leading to significant enhancement in *** vivo anti-cancer investigations have demonstrated their distinct antitumor efficacy in substantial inhibition of tumor growth in breast cancer mice through dissipation of mitochondrial membrane potential,inducing apoptosis of tumor cell with negligibly systemic cytotoxicity.

关键词： platinum(Ⅱ)complexes post-click reaction emission enhancement mitochondria-targeting antitumor

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