Role of Small Extracellular Vesicles in Liver Diseases:Pathogenesis,Diagnosis,and Treatment

作     者：Tingmao Xue Judy Wai Ping Yam 

作者机构：Department of Hepatobiliary Surgery IIZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of PathologySchool of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChinaReceived 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2022年第10卷第6期

页      面：1176-1185页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Natural Science Foun-dation of China General Program(Grant numbers:81872340 and 82072626) 

主　　题：Small extracellular vesicles Liver injury Liver fibrosis Liver fail-ure Hepatocellular carcinoma Biomarkers. 

摘      要：Extracellular vesicles(EVs)are vesicular bodies that bud off from the cell membrane or are secreted virtually by all cell *** EVs(sEVs or exosomes)are key mediators of cell-cell communication by delivering their cargo,including proteins,lipids,or RNAs,to the recipient cells where they induce changes in signaling pathways and phenotypic *** findings have revealed the pivotal involve-ment of sEVs in the pathogenesis of various *** the bright side,they are rich sources of biomarkers for diag-nosis,prognosis,treatment response,and disease *** have high stability,biocompatibility,targetability,low toxicity,and are immunogenic in *** intrinsic properties make sEVs an ideal delivery vehicle to be loaded with cargo for therapeutic *** diseases are a major global health *** review aims to focus on the roles and mechanisms of sEVs in the pathogenesis of liver diseases,liver injury,liver failure,and liver *** are released not only by hepatocytes but also by stromal and immune cells in the *** detection of liver disease determines the chance for cura-tive treatment and high survival of *** review focuses on the potential of circulating sEV cargo as specific and sensitive noninvasive biomarkers for the early detection and prognosis of liver *** addition,the therapeutic use of sEVs derived from various cell types is ***-though sEVs hold promise for clinical applications,there are still challenges to be overcome by further research to bring utilization of sEVs into clinical practice.