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Dissolvable temporary barrier:a novel paradigm for flexible hydrogel patterning in organ-on-a-chip models

Bio-Design and Manufacturing 2024年第2期7卷 153-166页

作者： Ding Wang Qinyu Li Chenyang Zhou Zhangjie Li Kangyi Lu Yijun liu Lian Xuan Xiaolin Wang Department of Micro/Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Ophthalmology LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China Institute of Medical Robotics Shanghai Jiao Tong UniversityShanghai 200240China National Key Laboratory of Advanced Micro and Nano Manufacture Technology Shanghai Jiao Tong UniversityShanghai 200240China National Center for Translational medicine(shanghai)SHU Branch Shanghai UniversityShanghai 200444China

A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional(3D)tissue models in vitro,which are also known as *** hydrogel patterningwith awell-controlled spatial distribution is typically achieved by embedding sophisticated microstructures to act as a ***,these physical barriers inevitably expose cells/tissues to a less physiologically relevant microenvironment than in vivo ***,we present a novel dissolvable temporary barrier(DTB)strategy that allows robust and flexible hydrogel patterning with great freedom of design and desirable flow stimuli for cellular *** key aspect of this approach is the patterning of a water-soluble rigid barrier as a guiding path for the hydrogel using stencil printing technology,followed by a barrier-free medium perfusion after the dissolution of the *** and multiple tissue compartments with different geometries can be established using either straight or curved DTB *** effectiveness of this strategy is further validated by generating a 3D vascular network through vasculogenesis and angiogenesis using a vascularized microtumor *** a new proof-of-concept in vasculature-on-a-chip,DTB enables seamless contact between the hydrogel and the culture medium in closed microdevices,which is an improved protocol for the fabrication ofmultiorgan ***,we expect it to serve as a promising paradigm for organ-on-a-chip devices for the development of tumor vascularization and drug evaluation in the future preclinical studies.

关键词： Dissolvable temporary barrier Hydrogel patterning Microfluidics Organ-on-a-chip Vascularization

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Deep learning methods for roping defect analysis in aluminum alloy sheets: prediction and grading

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Advances in Manufacturing 2024年第3期12卷 576-590页

作者： Yuan-Zhe Hu Ru-Xue liu Jia-Peng He Guo-Wei Zhou Da-Yong Li State Key Laboratory of Mechanical Systems and Vibration Shanghai Jiao Tong UniversityShanghai200240People’s Republic of China school of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240People’s Republic of China

Roping is a severe band-like surface defect that occurs in deformed aluminum alloy *** roping prediction and rating are essential for industrial ***,the authors introduced an artificial neural network(ANN)model to efficiently forecast roping behavior across the thickness of large regions with texture *** this study,the previously proposed ANN model for roping prediction is briefly reviewed,and a few-shot learning(FSL)-based method is developed for roping grading with limited *** consider the directionality of the roping patterns,the roping dataset constructed from experimental observations is transformed into the frequency domain for more compact characterization.A transfer-based FSL method is further presented for grade roping with manifold mixup regularization and the Sinkhorn mapping algorithm.A new component-focused representation is also implemented for data-processing,exploiting the close correlation between roping and power distribution in the frequency *** ultimate FSL method achieved an optimal accuracy of 95.65%in roping classification with only five training samples per class,outperforming four typical FSL *** FSL approach can be applied to grade the roping morphologies predicted by the ANN ***,the combination of prediction and grading using deep learning provides a new paradigm for roping analysis and control.

关键词： Roping Artificial neural network(ANN) Aluminum alloys Few-shot classification Surface morphology

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GRNN与统计模型在海堤渗压监测中的应用比较

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水电能源科学 2009年第3期27卷 134-136页

作者：黄铭刘俊上海交通大学船舶海洋与建筑工程学院上海200240

为掌握海堤状态量的变化规律并进行有效预测、评判,在对海堤渗压效应量和影响因素分析的基础上,给出了监测模型的影响因子基本形式,采用统计理论和广义回归神经网络(GRNN)分别建立了分析预测模型,对两种模型的建模原理、模型中影响因素... 详细信息

为掌握海堤状态量的变化规律并进行有效预测、评判,在对海堤渗压效应量和影响因素分析的基础上,给出了监测模型的影响因子基本形式,采用统计理论和广义回归神经网络(GRNN)分别建立了分析预测模型,对两种模型的建模原理、模型中影响因素及模型效果等方面进行了比较,可为复杂的海堤状态的安全监控提供参考。

关键词：海堤渗压监测统计模型广义回归神经网络模型

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Higher ambient temperatures may worsen obstructive sleep apnea:A nationwide smartwatch-based analysis of 6.2 million person-days

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Science Bulletin 2024年第13期69卷 2114-2121页

作者： Anni Li Qingli Zhang Yuan Yao Xinlei Zhu Cong liu Yutao Guo Haidong Kan Renjie Chen school of Public Health Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology AssessmentFudan UniversityShanghai 200032China Ministry of Education-shanghai Key Laboratory of Children’s Environmental Health Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Pulmonary Vessel and Thrombotic Disease Sixth Medical CenterChinese PLA General HospitalBeijing 100048China Institute for Hospital Management Research Chinese PLA General HospitalBeijing 100048China Children’s Hospital of Fudan university National Children’s Medical CenterShanghai 201102China school of Public Health Hengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Obstructive sleep apnea(OSA)is a serious type of sleep disorder that can lead to cardiometabolic and neurocognitive *** utilized smart device-based photoplethysmography technology to collect sleep data from the Chinese population from 2019 to *** lag nonlinear models combined with a generalized nonlinear model or a linear mixed effects model were used to investigate the shortterm associations between daily temperature and indicators of OSA *** included a total of 6,232,056 d of sleep monitoring data from 51,842 participants with moderate to severe risk of OSA from 313 Chinese *** relationships between ambient temperature and OSA exacerbation,apneahypopnea index(AHI),and minimum oxygen saturation(MinSpO_(2))were almost linear and present only on the same *** temperatures were associated with a greater risk of OSA exacerbation,with an 8.4%(95%confidence interval(CI):7.6%–9.3%)increase per 10℃increase in temperature.A 10℃increase in daily temperature corresponded to an AHI increase of 0.70 events/h(95%CI:0.65–0.76)and a MinSpO_(2)decrease of 0.18%(95%CI:0.16%–0.19%).Exposure to elevated temperatures during the night can also lead to adverse *** effects of higher temperatures on OSA severity were stronger among men,participants with a body mass index24 kg/m2,those aged 45 years and older,individuals with a history of hypertension and diabetes,and during the cold *** large-scale,nationwide,longitudinal study provides robust evidence suggesting that higher ambient temperatures may immediately worsen OSA.

关键词： Obstructive sleep apnea Temperature Apnea-hypopnea index Oxygen saturation Smart device

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New signature of low mass Z'in J/ψdecays

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Chinese Physics C 2024年第8期48卷 1-5页

作者： Chao-Qiang Geng Chia-Wei liu Jiabao Zhang school of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Tsung-Dao Lee Institute&school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute of Theoretical Physics University of Chinese Academy of SciencesBeijing 100190China

We explored a new approach to search for a low-mass Z′particle through J/ψdecays by identifying its existence through parity-violating phenomena in the isospin-violating final states ofΛΣ¯^(0)and the corresponding charge conjugated states ofΛΣ¯^(0).Our investigation centered on a generation-independent and leptophobic Z′with mass below 10 *** the present experimental conditions at Beijing Spectrometer III(BESIII)and the anticipated opportunities at the Super Tau Charm Factory(STCF),we conducted Monte-Carlo simulations to predict possible events at both ***,we foresee a substantial enhancement in the precision of the lower limit estimation ofαNP as well as a reduction in statistical uncertainty with upcoming STCF ***,it is essential to highlight that a null result in the measurement ofαNP would impose stringent constraints,requiring the Z′−q−q couplings to be in the order of 10^(−2).

关键词： Z′ parity violation J/ψ

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A human-sensitive frequency band vibration isolator for heavy-duty truck seats

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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1733-1748页

作者： Qingqing liu Shenlong WANG Ge YAN Hu DING Haihua WANG Qiang SHI Xiaohong DING Huijie YU school of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechnoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China Yanfeng Adient Seating Co. Ltd.Shanghai 201315China College of Mechanical and Electrical Engineering Jiaxing Nanhu UniversityJiaxing 314001Zhejiang ProvinceChina

In this study,a human-sensitive frequency band vibration isolator(HFBVI)with quasi-zero stiffness(QZS)characteristics for heavy-duty truck seats is designed to improve the comfort of heavy-duty truck drivers on uneven ***,the analytical expressions for the force and displacement of the HFBVI are derived with the Lagrange equation and d'Alembert's principle,and are validated through the prototype restoring force ***,the harmonic balance method(HBM)is used to obtain the dynamic responses under harmonic excitation,and further the influence of pre-stretching on the dynamic characteristics and transmissibility is ***,the experimental prototype of the HFBVI is fabricated,and vibration experiments are conducted under harmonic excitation to verify the vibration isolation performance(VIP)of the proposed vibration *** experimental results indicate that the HFBVI can effectively suppress the frequency band(4-8 Hz)to which the human body is sensitive to vertical *** addition,under real random road spectrum excitation,the HFBVI can achieve low-frequency vibration isolation close to 2 Hz,providing new prospects for ensuring the health of heavy-duty truck drivers.

关键词： human-sensitive frequency band quasi-zero stiffness(QZS) heavy-duty truck seat real random road spectrum low-frequency vibration isolation

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Microbiome-driven anticancer therapy:A step forward from natural products

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mLife 2024年第2期3卷 219-230页

作者： Yunxuan Guan Di Wu Hui Wang Ning-Ning liu State Key Laboratory of Systems medicine for Cancer Center for Single‐Cell OmicsSchool of Public HealthShanghai Jiao Tong University School of MedicineShanghaiChina

Human microbiomes,considered as a new emerging and enabling cancer hallmark,are increasingly recognized as critical effectors in cancer development and *** of microbiome revitalizing anticancer therapy from natural products shows promise toward improving cancer ***,we summarize our current understanding of the human microbiome‐driven molecular mechanisms impacting cancer progression and anticancer *** highlight the potential translational and clinical implications of natural products for cancer prevention and treatment by developing targeted therapeutic strategies as adjuvants for chemotherapy and immunotherapy against *** challenges and opportunities for future investigations using modulation of the microbiome for cancer treatment are further discussed in this review.

关键词： anticancer cancer chemotherapy immunotherapy microbiota

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A layered multifunctional framework based on polyacrylonitrile and MOF derivatives for stable lithium metal anode

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Journal of Energy Chemistry 2024年第6期93卷 282-288,I0007页

作者： Fanfan liu Peng Zuo Jing Li Pengcheng Shi Yu Shao Linwei Chen Yihong Tan Tao Ma Engineering Research Center of High-frequency Soft Magnetic Materials and Ceramic Powder Materials of Anhui Province School of Chemistry and Material EngineeringChaohu UniversityHefei 238024AnhuiChina Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China school of Pharmacy Anhui University of Chinese MedicineHefei 230012AnhuiChina school of Materials and Energy Guangdong University of TechnologyGuangzhou 510006GuangdongChina Jiujiang DeFu Technology Co. Ltd.Jiujiang 332000JiangxiChina

Composite Li metal anodes based on three-dimensional(3D) porous frameworks have been considered as an effective material for achieving stable Li metal batteries with high energy ***,uneven Li deposition behavior still occurs at the top of 3D frameworks owing to the local accumulation of Li *** promote uniform Li deposition without top dendrite growth,herein,a layered multifunctional framework based on oxidation-treated polyacrylonitrile(OPAN) and metal-organic framework(MOF) derivatives was proposed for rationally regulating the distribution of Li ions flux,nucleation sites,and electrical *** from these merits,the OPAN/carbon nano fiber-MOF(CMOF) composite framework demonstrated a reversible Li plating/stripping behavior for 500 cycles with a stable Coulombic efficiency of around 99.0% at the current density of 2 mA/cm~***,such a Li composite anode exhibited a superior cycle lifespan of over 1300 h under a low polarized voltage of 18 mV in symmetrical *** the Li composite anode was paired with LiFePO_(4)(LFP) cathode,the obtained full cell exhibited a stable cycling over 500 ***,the COMSOL Multiphysics simulation was conducted to reveal the effects on homogeneous Li ions distribution derived from the above-mentioned OPAN/CMOF framework and electrical insulation/conduction *** electrochemical and simulated results shed light on the difficulties of designing stable and safe Li metal anode via optimizing the 3D frameworks.

关键词： Lithium metal anode Layered multifunctional framework Ions flux redistribution Electrical insulation/conduction structure Uniform Li deposition

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Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

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Genes & Diseases 2024年第1期11卷 218-233页

作者： Zanwen Zuo Zerong Zhou Yuzhou Chang Yan liu Yuping Shen Qizhang Li Lei Zhang Innovative Drug R&D Center College of Life SciencesHuaibei Normal UniversityHuaibeiAnhui 235000China National"111"Center for Cellular Regulation and Molecular Pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)and School of Food and Biological EngineeringHubei University of TechnologyWuhanHubei 430068China Department of Biomedical Informatics The Ohio State UniversityColumbusOH 43210USA school of Agriculture and Biology and Engineering Research Center of Cell&Therapeutic AntibodyMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Bioengineering Hunan University of Science and EngineeringYongzhouHunan425199China Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China

Ribonucleotide reductase M2(RRM2)is a small subunit in ribonucleotide reduc-tases,which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides,maintaining the dNTP pools for DNA biosynthesis,repair,and ***2 performs a critical role in the malignant biological behaviors of *** structure,regulation,and function of RRM2 and its inhibitors were ***2 gene can produce two transcripts encoding the same ***2 expression is regulated at multiple levels during the processes from transcription to ***,this gene is associated with resistance,regulated cell death,and tumor *** order to develop and design inhibitors of RRM2,appropriate strategies can be adopted based on different ***,a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis,resistance in cancer,and tumor ***,RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.

关键词： Function Inhibition Regulation Resistance RRM2

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Childhood sleep:physical,cognitive,and behavioral consequences and implications

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World Journal of Pediatrics 2024年第2期20卷 122-132页

作者： Jianghong liu Xiaopeng Ji Susannah Pitt Guanghai Wang Elizabeth Rovit Terri Lipman Fan Jiang school of Nursing University of Pennsylvania418 Curie Blvd.Room 424Claire M.Fagin HallPhiladelphiaPA 19104USA College of Health Sciences University of DelawareNewarkDE 19716USA Geisinger Commonwealth school of medicine ScrantonPA 18510USA Pediatric Translational medicine Institute Department of Developmental and Behavioral PediatricsSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Sleep problems in children have been increasingly recognized as a major public health *** research has extensively studied and presented many risk factors and potential mechanisms for children’s sleep *** this paper,we aimed to identify and summarize the consequences and implications of child sleep *** sources A comprehensive search for relevant English language full-text,peer-reviewed publications was performed focusing on pediatric sleep studies from prenatal to childhood and adolescence in a variety of indexes in PubMed,SCOPUS,and Psych Info published in the past two *** relevant data-based articles and systematic reviews are *** Many adverse consequences are associated with child sleep deficiency and other sleep problems,including physical outcomes(e.g.,obesity),neurocognitive outcomes(e.g.,memory and attention,intelligence,academic performance),and emotional and behavioral outcomes(e.g.,internalizing/externalizing behaviors,behavioral disorders).Current prevention and intervention approaches to address childhood sleep problems include nutrition,exercise,cognitive–behavioral therapy for insomnia,aromatherapy,acupressure,and *** interventions may be particularly important in the context of coronavirus disease *** research and policy strategies can target the risk factors of child sleep as well as the efficacy and accessibility of *** Given the increasing prevalence of child sleep problems,which have been shown to affect children’s physical and neurobehavioral wellbeing,understanding the multi-aspect consequences and intervention programs for childhood sleep is important to inform future research direction as well as a public health practice for sleep screening and intervention,thus improving sleep-related child development and health.

关键词： Behavior Child sleep Consequences Implications Neurocognitive Physical Prevention/intervention

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