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An effective initial polytherapy for children with West syndrome

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Neural Regeneration Research 2013年第17期8卷 1623-1630页

作者： Feiyong Jia Huiyi Jiang Lin Du Ning Li Ji Sun Chunbo niu Department of Pediatorehabilitation Second Part of First Hospital Jilin University Department of Pathology China-Japan Union Hospital of Jilin University

Adrenocorticotropic hormone is recommended worldwide as an initial therapy for infantile spasms. However, infantile spasms in about 50% of children cannot be fully controlled by adrenocorticotropic hormone monotherapy, seizures recur in 33% of patients who initially respond to adrenocorticotropic hormone monotherapy, and side effects are relatively common during adrenocorticotropic hormone treatment. Topiramate, vitamin B6, and immunoglobulin are effective in some children with infantile spasms. In the present study, we hypothesized that combined therapy with adrenocorticotropic hormone, topiramate, vitamin B6, and immunoglobulin would effectively treat infantile spasms and have mild adverse effects. Thus, 51 children newly diagnosed with West syndrome including infantile spasms were enrolled and underwent polytherapy with the four drugs. Electroencephalographic hypsarrhythmia was significantly improved in a majority of patients, and these patients were seizure-free, had mild side effects, and low recurrence rates. The overall rates of effective treatment and loss of seizures were significantly higher in cryptogenic children compared with symptomatic children. The mean time to loss of seizures in cryptogenic children was significantly shorter than in symptomatic patients. These findings indicate that initial polytherapy with adrenocorticotropic hormone, topiramate, vitamin Be, and immunoglobulin effectively improves the prognosis of infantile spasms, and its effects were superior in cryptogenic children to symptomatic children.

关键词： neural regeneration brain injury West syndrome spasm etiology polytherapy adrenocorticotropichormone topiramate vitamin B6 intravenous immunoglobulin seizure-free electroencephalograph neuroregeneration

Human insulin-like growth factor 1-transfected umbilical cord blood neural stem cell transplantation improves hypoxic-ischemic brain injury

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Neural Regeneration Research 2011年第19期6卷 1445-1451页

作者： Dengna Zhu Yanjie Jia Jun Wang Boai Zhang Guohui niu Yazhen Fan Rehabilitation and Treatment Center for Children with Cerebral Palsy of Henan Province Third Affiliated Hospital of Zhengzhou University Zhengzhou 450052 Henan Province China Department of Neurology First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 Henan Province China

Human insulin-like growth factor 1-transfected umbilical cord blood neural stem cells were transplanted into a hypoxic-ischemic neonatal rat model via the tail vein. BrdU-positive cells at day 7 post-transplantation, as well as nestin- and neuron specific enolase-positive cells at day 14 were increased compared with those of the single neural stem cell transplantation group. In addition, the proportion of neuronal differentiation was enhanced. The genetically modified cell-transplanted rats exhibited enhanced performance in correctly crossing a Y-maze and climbing an angled slope compared with those of the single neural stem cell transplantation group. These results showed that human insulin-like growth factor 1-transfected neural stem cell transplantation promotes the recovery of the leaming, memory and motor functions in hypoxic-ischemic rats.

关键词： human insulin-like growth factor 1 neural stem cell hypoxic-ischemic brain damage transplantation neural regeneration

Mine-hoist fault-condition detection based on the wavelet packet transform and kernel PCA

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Journal of China University of Mining and Technology 2008年第4期18卷 567-570页

作者： XIA Shi-xiong niu Qiang ZHOU Yong ZHANG Lei School of Computer Science ＆ Technology China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

A new algorithm was developed to correctly identify fault conditions and accurately monitor fault development in a mine hoist. The new method is based on the Wavelet Packet Transform (WPT) and kernel PCA (Kernel Principal Compo- nent Analysis, KPCA). For non-linear monitoring systems the key to fault detection is the extracting of main features. The wavelet packet transform is a novel technique of signal processing that possesses excellent characteristics of time-frequency localization. It is suitable for analysing time-varying or transient signals. KPCA maps the original input features into a higher dimension feature space through a non-linear mapping. The principal components are then found in the higher dimen- sion feature space. The KPCA transformation was applied to extracting the main nonlinear features from experimental fault feature data after wavelet packet transformation. The results show that the proposed method affords credible fault detection and identification.

关键词： kernel method PCA KPCA fault condition detection

The electron structure and photocatalytic activity of Ti(IV) doped Bi_2O_3

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Science China Chemistry 2011年第1期54卷 180-185页

作者： YIN LiFeng niu JunFeng SHEN ZhenYao SUN Ying State Key Laboratory of Water Environment Simulation School of Environment Beijing Normal University Beijing 100875 China College of Science China Agricultural University Beijing 100193 China

Density functional theory （DFT） plays a significant role in the development of visible light responsive photocatalysts. Based on the first-principles plane-wave ultrasoft pseudopotential （USPP） method, the crystal structures of α,β,γ, and 5-Bi2O3 were optimally calculated for the total density of states （TDOS） and the partial density of states （PDOS） of Bi, O atoms. The calculation for Ti（IV） doped Bi2O3 supercell was carried out. The effects of Ti（IV）-doping on the electron structures and light absorption properties of various Bi2O3 were analyzed. The results showed that Ti 3d orbital appeared in the forbidden band of Bi2O3 and hybridized with O 2p, Bi 6p orbitals. The narrowed band gap （Eg） and red-shift of light absorption edge are responsible for the enhanced photoeatalytic activity of Bi2O3. The Ⅱ-Bi2O3 and Ti-doped β-Bi2O3 were prepared by a hydrotherrnal synthesis method. The improvement of the photoeatalytic activity of Bi2O3 has also been verified by the characteristics of the UV-vis diffuse reflection spectrum and the experimental evaluation of the photocatalytic degradation of crystal violet in aqueous solution.

关键词： Ti(IV) doping Bi2O3 electron structure visible light photocatalytic activity density functional theory

Lattice Boltzmann Simulation of Nanoparticle Transport and Attachment in a Microchannel Heat Sink

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Fluid Dynamics & Materials Processing 2021年第2期17卷 301-317页

作者： Xiaokang Tian Kai Yue Yu You Yongjian niu Xinxin Zhang School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing100083China Shunde Graduate School of University of Science and Technology Beijing Shunde528399China

The heat transfer performances of a microchannel heat sink in the presence of a nanofluid can be affected by the attachment of nanoparticle(NP)on the microchannel *** this study,the mechanisms underlying NP transport and attachment are comprehensively analyzed by means of a coupled double-distribution-function lattice Boltzmann model combined with lattice-gas *** this approach,the temperature distribution and the two-phase flow pattern are obtained for different values of the influential *** results indicate that the number of attached NPs decrease exponentially as their diameter and the fluid velocity *** increase in the wall temperature leads to an increase of the attached NPs,e.g.,the Al_(2)O_(3) NPs attached on the CuO microchannel wall increases by 105.8%in the range between 293 K and 343 *** are more attached NPs in microchannels with an irregular *** tendency of SiO2 NP to attach to the PDMS(polydimethylsiloxane),Fe and Cu walls is less significant than that for Al_(2)O_(3) and CuO NP;Moreover,NPs detach from the PDMS microchannel wall more easily than from the Cu and Fe microchannel *** SiO2 attachment layer has the greatest influence on the heat transfer performance although its thickness is thinner than that for Al_(2)O_(3) and CuO NPs under the same conditions.

关键词： Double-distribution-function lattice Boltzmann method lattice gas automata microchannel nanoparticle(NP) attachment

Effects of Ce addition on microstructure, mechanical properties and corrosion resistance of as-cast AZ80 magnesium alloy

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China Foundry 2014年第3期11卷 157-162页

作者： Wang Wei Xu Chunxiang Zhang Jinshan Cheng Weili niu Xiaofeng College of Materials Science and Engineering Taiyuan University of Technology

In this study, Ce was introduced into the AZ80 alloy and the effects of Ce addition on the microstructure, mechanical properties and corrosion resistance of the as-cast AZ80 magnesium alloy were investigated. The results show that the addition of Ce into the AZ80 alloy can not only refine the microstructure, but also result in the formation of the needle-like Al4Ce phase. These tiny Al4Ce phases are homogeneously distributed at grain boundaries and within grains. An appropriate Ce addition can also change the β-Mg17Al12 phase at the grain boundaries from continuous network to small island-like. At the same time, with the increase of Ce content from 0 to 2.0wt.%, the macro-hardness of the as-cast alloy is enhanced linearly, while impact toughness, tensile strength and elongation all firstly increase and then decrease. The AZ80 alloy containing 1.0wt.% Ce exhibits the optimal properties. Its macro-hardness, impact toughness, tensile strength and elongation are 61.90 HB, 15.50 J·cm-2, 171.80 MPa and 3.35%, increase by 9.95%, 63%, 13.3% and 36.7%, respectively compared with the base alloy. In addition, Ce can enhance the corrosion resistance of the AZ80 magnesium alloy.

关键词： Ce AZ80 magnesium alloy microstructure mechanical properties corrosion resistance

信迪利联合靶向治疗中晚期原发性肝癌的临床研究

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肝脏 2024年第9期29卷 1068-1073页

作者：董燕兵牛猛罗月宾闻听亮阜南县人民医院肿瘤科安徽236300 阜南县人民医院感染科安徽236300

目的探究对原发性肝癌(PLC)中晚期患者予以信迪利联合靶向治疗的临床效果。方法 2019年9月—2023年6月阜南县人民医院及北区诊治的PLC患者84例,通过随机数字法均分为两组。对照组(42例)予以信迪利,观察组(42例)实施信迪利联合贝伐珠治... 详细信息

目的探究对原发性肝癌(PLC)中晚期患者予以信迪利联合靶向治疗的临床效果。方法 2019年9月—2023年6月阜南县人民医院及北区诊治的PLC患者84例,通过随机数字法均分为两组。对照组(42例)予以信迪利,观察组(42例)实施信迪利联合贝伐珠治疗。用药3个周期后,用酶联免疫吸附法测定血管生成及肿瘤相关血清指标,流式细胞仪测定免疫指标。Kapkan-Meier进行生存分析。结果治疗后,与对照组相比,观察组疾病控制率(76.19%vs92.86%)和客观缓解率(42.86%vs64.29%)较高,死亡率(47.62%vs23.81%)较低(P<0.05)。观察组CEA、AFP、CA19-9、DCP水平[分别为(16.7±3.3)ng/mL、(138.7±27.7)ng/mL、(142.7±20.3)U/mL、(30.5±4.3)mAU/mL]均显著低于对照组[分别为(21.4±4.2)ng/mL、(176.2±35.2)ng/mL、(165.6±23.6)U/mL、(35.2±5.1)mAU/mL](P<0.05)。观察组CD3^(+)、CD4^(+)/CD8^(+)水平[分别为(72.9±4.8)%、(1.7±0.4)]均显著高于对照组[分别为(68.4±4.5)%、(1.4±0.3)](P<0.05)。观察组VEGF、MMP-9、Ang-2水平[分别为(22.5±4.3)ng/mL、(40.5±5.2)mg/L、(21.6±3.6)μg/L]均显著低于对照组[分别为(26.4±5.1)ng/mL、(44.6±5.5)mg/L、(25.1±4.2)μg/L](P<0.05)。结论信迪利联合贝伐珠单抗用于中晚期PLC疗效显著,患者肿瘤标志物及血管生成相关因子水平均下降,免疫功能及生存率均提高,且用药安全。

关键词：原发性肝癌中晚期信迪利单抗贝伐珠单抗临床疗效

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Biodegradable Materials as Nanocarriers for Drugs and Nutrients

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Journal of Renewable Materials 2021年第7期9卷 1189-1211页

作者： Xingran Kou Qixuan Zhao Wenwen Xu Zuobing Xiao Yunwei niu Kai Wang Key Laboratory of Textile Science&Technology Ministry of EducationCollege of TextilesDonghua UniversityShanghai201620China School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai201418China R&D Center of China Tobacco Yunnan Industrial Co. Ltd.Kunming650231China

Several important drugs and nutritional supplements are limited by their lack of *** display unique beneficial properties that might help improve the bioavailability of drugs and nutritional supple***,nanomaterials produced from synthetic polymers and metals may have similar difficulties with bioavailability and *** occurring biopolymers are biodegradable and non-toxic and are adaptable to the synthesis of *** and other substances can be encapsulated or embedded in such particles with an increase in *** search for biodegradable nanomaterials is an active research *** review summarizes the research on nanocrystalline cellulose,starch,lignin,and other biological and environment-friendly nanocomposites which are commonly used as nanocarriers for drugs and ***,prospects for the use of biodegradable nanomaterials in targeted therapy,including environmentally responsive therapy,are discussed.

关键词： Nanomaterials biodegradation classification application

Dynamics and Control of a Novel 3-DOF Parallel Manipulator with Actuation Redundancy

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Machine Intelligence Research 2013年第6期10卷 552-562页

作者： Xue-Mei niu Guo-Qin Gao Xin-Jun Liu Zhi-Da Bao School of Electrical and Information Engineering Jiangsu University Department of Mechanical Engineering Tsinghua University

This paper deals with the dynamics and control of a novel 3-degrees-of-freedom(DOF)parallel manipulator with actuation *** to the kinematics of the redundant manipulator,the inverse dynamic equation is formulated in the task space by using the Lagrangian formalism,and the driving force is optimized by utilizing the minimal 2-norm *** on the dynamic model,a synchronized sliding mode control scheme based on contour error is proposed to implement accurate motion tracking ***,an adaptive method is introduced to approximate the lumped uncertainty of the system and provide a chattering-free *** simulation results indicate the efectiveness of the proposed approaches and demonstrate the satisfactory tracking performance compared to the conventional controller in the presence of the parameter uncertainties and un-modelled dynamics for the motion control of manipulators.

关键词： Parallel manipulator redundant actuation dynamics modelling sliding mode control weighed integral gain reaching law