Human insulin-like growth factor 1-transfected umbilical cord blood neural stem cell transplantation improves hypoxic-ischemic brain injury

作     者：Dengna Zhu Yanjie Jia Jun Wang Boai Zhang Guohui Niu Yazhen Fan 

作者机构：Rehabilitation and Treatment Center for Children with Cerebral Palsy of Henan Province Third Affiliated Hospital of Zhengzhou University Zhengzhou 450052 Henan Province China Department of Neurology First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 Henan Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第19期

页      面：1445-1451页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：the National Natural Science Foundation of China  No.30770758  81071114 

主　　题：human insulin-like growth factor 1 neural stem cell hypoxic-ischemic brain damage transplantation neural regeneration 

摘      要：Human insulin-like growth factor 1-transfected umbilical cord blood neural stem cells were transplanted into a hypoxic-ischemic neonatal rat model via the tail vein. BrdU-positive cells at day 7 post-transplantation, as well as nestin- and neuron specific enolase-positive cells at day 14 were increased compared with those of the single neural stem cell transplantation group. In addition, the proportion of neuronal differentiation was enhanced. The genetically modified cell-transplanted rats exhibited enhanced performance in correctly crossing a Y-maze and climbing an angled slope compared with those of the single neural stem cell transplantation group. These results showed that human insulin-like growth factor 1-transfected neural stem cell transplantation promotes the recovery of the leaming, memory and motor functions in hypoxic-ischemic rats.