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七年制临床医学专业课程设置的改革与实践

山西医科大学学报（基础医学教育版） 2007年第5期9卷 590-593页

作者：陈培刚程牛亮都文霞秦小兵山西医科大学教务处

随着七年制临床医学专业教学管理科学化与培养目标的科学定位,就七年制临床医学专业教育中课程设置的改革与实践,课程整体优化及培养实践中存在的某些问题进行了探讨,旨在和兄弟院校、同行学者共同探讨,积极稳妥进行七年制临床医学教育... 详细信息

随着七年制临床医学专业教学管理科学化与培养目标的科学定位,就七年制临床医学专业教育中课程设置的改革与实践,课程整体优化及培养实践中存在的某些问题进行了探讨,旨在和兄弟院校、同行学者共同探讨,积极稳妥进行七年制临床医学教育改革发展。

关键词：课程设置七年制实践

Efficient and robust missing key tag identification for large-scale RFID systems

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Digital Communications and Networks 2023年第6期9卷 1421-1433页

作者： Chu Chu Guangjun wen Jianyu niu School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu611731China Research Institute of Trustworthy Autonomous Systems Southern University of Science and TechnologyShenZhen518055China School of Engineering The University of British ColumbiaKelownaV1V 1V7BCCanada

Radio Frequency Identification(RFID)technology has been widely used to identify missing *** many applications,rapidly pinpointing key tags that are attached to favorable or valuable items is *** realize this goal,interference from ordinary tags should be avoided,while key tags should be efficiently *** many previous studies,how to rapidly and dynamically filter out ordinary tags when the ratio of ordinary tags changes has not been ***,how to efficiently verify missing key tags in groups rather than one by one has not been explored,especially with varying missing *** this paper,we propose an Efficient and Robust missing Key tag Identification(ERKI)protocol that consists of a filtering mechanism and a verification ***,the filtering mechanism adopts the Bloom filter to quickly filter out ordinary tags and uses the labeling vector to optimize the Bloom filter's performance when the key tag ratio is ***,the verification mechanism can dynamically verify key tags according to the missing rates,in which an appropriate number of key tags is mapped to a slot and verified at ***,we theoretically analyze the parameters of the ERKI protocol to minimize its execution *** numerical results show that ERKI can accelerate the execution time by more than 2.14compared with state-of-the-art solutions.

关键词： RFID Missing key tag identification Time efficiency Robust

Influence of transient intraocular pressure elevation during laser in situ keratomileusis on rabbit retina thickness

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1089-1093页

作者： Hai-xia Zhao Hui Liu Chun-Mei niu wen-Ying Guan Department of Ophthalmology the Affiliated Hospital of Inner Mongolia Medical University

AIMTo utilize tissue micro measurement to study the effect of transient high intraocular pressure (IOP) induced by different durations of suction during laser in situ keratomileusis (LASIK) on rabbit retina *** healthy New Zealand white rabbits were randomly divided into a control group, and 3 negative-pressure suction groups (20s group, 45s group, and 3min group) and each group was comprised of 15 rabbits (30 eyes); the latter 3 groups were the transient high IOP models. The retinal tissue around the papilledema was separated. Hematoxylin and eosin (HE) staining was carried out to generate slices for light microscopy. The changes in the retina thickness values of each layer were measured for all animals in each group at different postoperative recovery periods and compared with the values recorded for the animals in the control group. The thickness of the retinal tissue showed a normal distribution. The ANOVA was performed by using SPSS13.0 statistic *** the comparison between the 20s and 45s negative-pressure suction groups and the control group, no significant differences were observed, except at 14d. Significant difference was observed between the 3min negative-pressure suction group and the control group, and the retina thickness value of each layer reached a peak at 14d after *** negative suction during LASIK may not lead to significant changes in retinal tissue thickness; however, if the suction duration is increased to 3min, it will cause significant changes in retinal tissue thickness.

关键词： laser in situ keratomileusis transient high intraocular pressure retina thickness

Magnetoresistance retraction behaviour of Ag/p-Ge:Ga/Ag device under pulsed high magnetic field

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Journal of Materials Science & Technology 2022年第19期114卷 1-6页

作者： Xiong He Zhengcai xia Haoyu niu Zhuo Zeng Wuhan National High Magnetic Field Center Huazhong University of Science and TechnologyWuhan 430074China School of Physics Huazhong University of Science and TechnologyWuhan 430074China

In non-magnetic semiconductor materials,unsaturated magnetoresistance(MR)effect has attracted lots of attention due to its physical interests and potential applications in electronic *** the ex-tremely high magnetic field,the stability and reliability of MR effects based on the non-ohmic transport has been rarely *** this paper,the transport properties of non-magnetic Ag/p-Ge:Ga/Ag devices under 45 T pulsed high magnetic field at 300 K are *** is found that in ohmic conduction re-gion(I<5 mA)where the single dominant carrier is hole,the MR values increase with increasing the applied magnetic field,presenting a conventional unsaturated *** the two non-ohmic regions(5 mA≤I≤100 mA)where the transport is dominated by bipolar(electrons and holes),a MR retraction has been obviously observed under pulsed high magnetic *** the Hall measurement results and calculation of Hall effect with bipolar-driven transport model,the mechanism of the MR retraction is analysed,in which the MR retraction may be related to the strong regulation of electron-to-hole den-sity ratio by pulsed high magnetic *** work provides a reference for evaluating the stability and reliability of the properties of non-magnetic semiconductor based MR devices under the interference of strong magnetic pulses.

关键词： Germanium-based device Magnetoresistance Bipolar transport Retraction behavior Pulsed high magnetic field

Quench characteristics and mechanical responses during quench propagation in rare earth barium copper oxide pancake coils

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Applied Mathematics and Mechanics(English Edition) 2021年第2期42卷 235-250页

作者： Mengdie niu Jing xia Huadong YONG Youhe ZHOU Key Laboratory of Mechanics on Disaster and Environment in Western China The Ministry of Education of ChinaLanzhou UniversityLanzhou 730000China Department of Mechanics and Engineering Sciences College of Civil Engineering and MechanicsLanzhou UniversityLanzhou 730000China Institute of Applied Physics and Computational Mathematics Beijing 100094China

Quench and mechanical behaviors are critical issues in high temperature superconducting(HTS)*** this paper,the quench characteristics in the rare earth barium copper oxide(REBCO)pancake coil at 4.2K are analyzed,and a two-dimensional(2D)axisymmetric electro-magneto-thermal model is *** effects of the constituent materials,background field,and coil size are *** elastoplastic mechanical model is used to study the corresponding mechanical responses during the quench *** variations of the temperature and strain in superconducting layers are *** results indicate that the radial strain evolutions can reflect the transverse quench propagation and the tensile hoop and radial stresses in superconducting layers increase with the quench *** possible damages are discussed with the consideration of the effects of the background field and coil *** is concluded that the high background field significantly increases the maximum tensile hoop and radial stresses in quenching coils and local damage may be caused.

关键词： rare earth barium copper oxide(REBCO)pancake coil hoop stress quench characteristic mechanical response radial stress

Thyroid Nodules in Type 2 Diabetes Mellitus

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Current Medical Science 2019年第4期39卷 576-581页

作者： Hong-mei ZHANG Qi-wen FENG Yi-xin niu Qing SU xia WANG Department of Endocrinology Xinhua HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200092China The George Institute for Global Health and Royal Prince Alfred Hospital the University of SydneySydneyNSW 2050Australia

The present analysis aims to investigate the prevalence of thyroid nodules in type 2 diabetes mellitus (T2DM) *** searched PubMed,EMBASE,and Web of Science from inception to the March 1,*** studies were selected to estimate the prevalence of thyroid nodules in T2DM subjects and to compare the prevalence of thyroid nodules in different glucose tolerance *** random effects model was used,and the outcome was presented as a pooled prevalence proportion with 95% confidence interval (95% CI) or a summary odds ratio (OR) with 95% *** the end,9 studies met the inclusion criteria and were included in the *** pooled prevalence of thyroid nodules was 60%(95% CI:0.52,0.68) for T2DM 2 diabetes patients,50%(95% CI:0.4& 0.51) for pre-diabetes,and 43%(95% CI:0.34,0.52) for normal glucose tolerance *** with patients without diabetes,diabetes subjects are more likely to develop thyroid nodules,adjusted OR for thyroid nodule was 1.78 (95% CI:1.25,2.55).Insulin resistance might be involved in thyroid nodule development.

关键词： thyroid nodule diabetes insulin resistance

Stroma-epithelium crosstalk in prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 28-35页

作者： Yi-Nong niu Shu-Jie xia Department of Urology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China Department of Urology Shanghai First People＇s Hospital Shanghai Jiao Tong University Shanghai 200080 China

The critical role played by stroma-epithelium crosstalk in carcinogenesis and progression of prostate cancer has been increasingly recognized. These interactions are mediated by a variety of paracrine factors secreted by cancer cells and/or stromal cells. In human prostate cancer, reactive stroma is characterized by an increase in myofibroblasts and a corresponding amplification of extracellular matrix production and angiogenesis. Permanent genetic mutations have been reported in stromal cells as well as in tumour cells. Transforming growth factor-J3, vascular endothelial growth factor, platelet-derived growth factor and fibroblast growth factor signalling pathways are involved in the process of angiogenesis, whereas hepatocyte growth factor, insulin-like growth factor-l, epidermal growth factor, CXC12 and Interleukin-6 play active roles in the progression, androgen-independent conversion and distal metastasis of prostate cancer. Some soluble factors have reciprocal interactions with androgens and the androgen receptor （AR）, and can even activate AR in the absence of the androgen ligand. In this article, we review the complex interactions between cancer cells and the surrounding microenvironment, and discuss the potential therapeutic targets in the stromal compartment of prostate cancer.

关键词： angiogenesis metastasis paracrine growth factors prostate prostatic neoplasm stroma

Cost-benefit analysis of esophageal cancer endoscopic screening in high-risk areas of China

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World Journal of Gastroenterology 2012年第20期18卷 2493-2501页

作者： Juan Yang wen-Qiang wei Jin niu Zhi-Cai Liu Chun-xia Yang You-Lin Qiao Department of Epidemiology West China School of Public Health Sichuan University Chengdu 610041 Sichuan Province China Department of Epidemiology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China Department of Thoracic-Surgery Linzhou Cancer Institute Linzhou 456550 Henan Province China

AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer(EC)in high-risk areas of China. METHODS:Markov model-based analyses were conducted to compare the net present values(NPVs)and the benefit-cost ratios(BCRs)of 12 EC endoscopic screening *** varied according to the targeted screening age,screening frequencies,and follow-up *** parameters were collected from population-based studies in China,published literatures,and surveillance data. RESULTS:Compared with non-screening outcomes,all strategies with hypothetical 100 000 subjects saved life *** five dominant strategies determined by the incremental cost-effectiveness analysis,screening once at age 50 years incurred the lowest NPV(international dollar-I$55 million)and BCR(2.52).Screening six times between 40-70 years at a 5-year interval[i.e., six times(40)f-strategy]yielded the highest NPV(I$99 million)and BCR(3.06).Compared with six times(40)fstrategy,screening thrice between 40-70 years at a 10-year interval resulted in relatively lower NPV,but the same BCR. CONCLUSION:EC endoscopic screening is cost-beneficial in high-risk areas of ***-makers should consider the cost-benefit,population acceptance,and local economic status when choosing suitable screening strategies.

关键词： Cost-benefit analysis Esophageal cancer Endoscopy Screening High-risk area

Modeling tuberous sclerosis complex with human induced pluripotent stem cells

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World Journal of Pediatrics 2024年第3期20卷 208-218页

作者： Weibo niu Benjamin Siciliano Zhexing wen Department of Psychiatry and Behavioral Sciences Emory University School of MedicineWhitehead Research Building 447615 Michael StreetAtlantaGA 30322USA The Graduate Program in Molecular and Systems Pharmacology Laney Graduate SchoolEmory UniversityAtlanta.GA 30322.USA Department of Cell Biology Emory University School of MedicineWhitehead Research Building 447615 Michael StreetAtlantaGA30322USA Department of Neurology Emory University School of MedicineWhitehead Research Building 447.615 Michael StreetAtlantaGA 30322USA

Background Tuberous sclerosis complex(TSC)is an autosomal dominant genetic disorder with a birth incidence of I:6000 in the United States that is characterized by the growth of non-cancerous tumors in multiple organ systems including the brain,kidneys,lungs,and ***,TSCis also associated with signicant neurological manifestations including epilepsy TSC-associated neuropsychiatric disorders,intellectual disabilities,and autism spectrum *** in the TSCI or TSC2 genes are well-established causes of TSC,which lead to TSC1/TSC2 deficiency in organs and hyper-activation of the mammalian target of rapamycin signaling *** models have been widely used to study the effect of TSCl/2 genes on the development and function of the *** considerable progress in understanding the molecular mechanisms underlying TSC in animal models,a human-specific model is urgently needed to investigate the effects of TSCl/2 mutations that are unique to human *** sources Literature reviews and research articles were published in PubMed-indexed *** Human-induced pluripotent stem cells(iPSCs),which capture risk alleles that are identical to their donors and have the capacity to differentiate into virtually any cell type in the human body,pave the way for the empirical study of previously inaccessible biological systems such as the developing human *** In this review,we present an overview of the recent progress in modeling TSC with human iPSC models,the existing limitations,and potential directions for future research.

关键词： Induced pluripotent stem cells Three-dimensional cultures Tuberous sclerosis complex Two-dimensional cultures