检索结果-南通市图书馆

Pegylated interferon alfa-2b plus ribavirin for treatment of chronic hepatitis C

World Journal of Hepatology 2014年第7期6卷 520-526页

作者： PN Rao Abraham Koshy Jacob Philip Narayanan Premaletha Joy Varghese Krishnasamy Narayanasamy Samir Mohindra nitin vikas pai Manoj Kumar Agarwal Ashokna Konar Hasmukh B Vora Department of Gastroenterology Asian Institute of Gastroenterology Hyderabad 500082 India Department of Hepatology Lakeshore Hospital Kochi 682040 India Department of Gastroenterology Cosmopolitan Hospital Thiruvananthapuram 695004 India Department of Gastroenterology Medical College Thiruvananthapuram 695011 India Department of Hepatology Global Hospitals and Health City Chennai 600100 India Department of Hepatology GGHand MMC Chennai 600003 India Department of Gastroenterology SGPGIMS Lucknow 226014 India Department of Gastroenterology Pai Clinic and Diagnostic Center Pune 411005 India Department of Gastroenterology Belle Vue Clinic Kolkata 700017 India Department of Gastroenterology PeerlessHospital and B.K. Roy Research Center Kolkata 700094 India Department of Gastroenterology Alka Hospital Ahmedabad 380019 India

AIM: To study the safety and efficacy of pegylated interferon alfa-2b, indigenously developed in India, plus ribavirin in treatment of hepatitis C virus(HCV). METHODS: One-hundred HCV patients were enrolled in an open-label, multicenter trial. Patients were treated with pegylated interferon alfa-2b 1.5 μg/kg per week subcutaneously plus oral ribavirin 800 mg/d for patients with genotypes 2 and 3 for 24 wk. The same dose of peginterferon plus weight-based ribavirin(800 mg/d for ≤ 65 kg; 1000 mg/d for > 65-85 kg; 1200 mg/d for > 85-105 kg; 1400 mg/d for > 105 kg body weight) was administered for 48 wk for patients with genotypes 1 and 4. Serological and biochemical responses of patients were ***: Eighty-two patients(35 in genotypes 1 and 4 and 47 in 2 and 3), completed the study. In genotype 1, 25.9% of patients achieved rapid virologic response(RVR): while the figures were 74.1% for early virologic response(EVR) and 44.4% for sustained virologic response(SVR). For genotypes 2 and 3, all patients bar one belonged to genotype 3, and of those, 71.4%, 87.5%, and 64.3% achieved RVR, EVR, and SVR, respectively. In genotype 4, 58.8%, 88.2%, and 52.9% of patients achieved RVR, EVR, and SVR, respectively. The majority of patients attained normal levels of alanine aminotransferase by 4-12 wk of therapy. Most patients showed a good tolerance for the treatment, although mild-to-moderate adverse events were exhibited; only two patients discontinued the study medication due to serious adverse events(SAEs). Eleven SAEs were observed in nine patients; however, only four SAEs were related to study ***: Peginterferon alfa-2b, which was developed in India, in combination with ribavirin, is a safe and effective drug in the treatment of HCV.

关键词： Hepatitis C virus Genotype Peginterferon alfa-2b Ribavirin Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Randomized, double-blind, comparative study of dexrabeprazole 10 mg versus rabeprazole 20 mg in the treatment of gastroesophageal reflux disease

引用

World Journal of Gastroenterology 2007年第30期13卷 4100-4102页

作者： vikas pai nitin pai pai Clinic Pune Abhinav Apts 778/B-1 Shivajinagar Pune 411005 India

AIM：TO compare the efficacy and safety of dexrabe-prazole 10 mg versus rabeprazole 20 mg in the treatment of gastroesophageal reflux disease （GERD）.METHODS： This was a randomized, double-blind clinical study. Fifty patients with GERD were randomly assigned to receive dexrabeprazole 10 mg or rabeprazole 20 mg once daily. Efficacy was assessed by evaluating improvement in visual analog scale （VAS） scores of heart-burn and regurgitation and safety was assessed by recording incidence of any adverse drug reactions. Laboratory investigations and upper gastro-intestinal endoscopy was conducted at baseline and after 28 d of therapy.RESULTS： A total of 50 patients （n = 25 in dexrabeprazole group and rabeprazole group each） completed the study. There were no significant differences in the baseline characteristics between the two groups. The VAS score （mean 4. SD） of heartburn and regurgitation in dexrabeprazole （64.8±5.1 and 64 ± 8.1, respectively） and rabeprazole （64.4 ± 8.7 and 57.6 ± 9.7, respectively） groups significantly reduced （P 〈 0.0001） to 30 ± 11.5, 24 ± 10 and 32 ± 9.5, 29.2±11.9, respectively on d 28. A significantly higher （P = 0.002） proportion of patients showed ≥ 50% improvement in regurgitation with dexrabeprazole 10 mg （96%） compared to rabeprazole 20 mg （60%）. Onset of symptom improvement was significantly earlier with dexrabeprazole than with rabeprazole （1.8 ± 0.8 d vs 2.6 ± 1.4 d; P 〈0.05）. The incidences of esophagitis in the dexrabeprazole group and rabeprazole group before therapy were 84% and 92%, respectively （P = 0.38）. The incidence of improvement/healing of esophagitis after therapy was more （P = 0,036） in the dexrabeprazole group （95.2%） compared to the rabeprazole group （65.2%）. No adverse drug reaction was seen in either group.CONCLUSION： In the treatment of GERD, efficacy of dexrabeprazole 10 mg is better than rabeprazole 20 mg, with regards to improvement/healing of endoscopic lesions and relief from symptoms of regurgitation.

关键词： Dexrabeprazole/R(+) rabeprazole Gastroesophageal reflux disease Efficacy Safety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease

引用

World Journal of Gastroenterology 2006年第37期12卷 6017-6020页

作者： vikas G pai nitin V pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram pai Clinic Pune India Thacker’s Clinic Sukh Sagar 4th Floor NS Patkar Marg Mumbai India Surya Hospital Pune India Inlaks & Budhrani Hospital Pune India Sharada Clinic Karad India

AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of ***: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equa

关键词： Gastro-esophageal reflux disease Pantoprazole Efficacy Tolerability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cryogenic and conventional milling of AZ91 magnesium alloy

引用

Journal of Magnesium and Alloys 2024年第6期12卷 2503-2519页

作者： vikas Marakini Srinivasa pai P Gururaj Bolar Bhaskara P Achar Department of Mechanical Engineering Nitte(Deemed to be University)NMAM Institute of Technology(NMAMIT)Nitte 574110India Department of Mechanical and Industrial Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipal 576104India

Use of magnesium is the need of the hour due to its low density as well as its high strength-to-weight and stiffness-to-weight ratio *** study focuses on the effectiveness of liquid nitrogen(LN_(2))assisted cryogenic machining on the surface integrity(SI)characteristics of AZ91 magnesium *** milling using uncoated carbide inserts have been performed under liquid nitrogen(LN_(2))assisted cryogenic condition and compared with conventional(dry)*** are performed using machining parameters in terms of cutting speeds of 325,475,625 m/min,feed rates of 0.05,0.1,0.15 mm/teeth and depth of cuts of 0.5,1,1.5 mm *** significant surface integrity characteristics such as surface roughness,microhardness,microstructure,and residual stresses have been *** of SI characteristics with respect to milling parameters have been identified using statistical technique such as ANOVA and signal-to-noise(S/N)ratio ***,the multi criteria decision making(MCDM)techniques such as additive ratio assessment method(ARAS)and complex proportional assessment(COPRAS)have been utilized to identify the optimal conditions for milling AZ91 magnesium alloy under both dry and cryogenic *** of LN_(2)during machining,resulted in reduction in machining temperature by upto 29%with a temperature drop from 251.2℃under dry condition to 178.5℃in cryogenic *** showed the advantage of performing cryogenic milling in improving the surface integrity to a significant *** machining considerably minimized the roughness by upto 28%and maximised the microhardness by upto 23%,when compared to dry *** speed has caused significant impact on surface roughness(95.33%-dry,92.92%-cryogenic)and surface microhardness(80.33%-dry,82.15%-cryogenic).Due to the reduction in machining temperature,cryogenic condition resulted in compressive residual stresses(maximumσ║=-113 MPa)on the alloy *** indicate no

关键词： Magnesium alloy Cryogenic machining Roughness Microhardness Microstructure Residual stress Multi criteria decision making

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimization of Cognitive Radio System Using Self-Learning Salp Swarm Algorithm

引用

Computers, Materials & Continua 2022年第2期70卷 3821-3835页

作者： nitin Mittal Harbinder Singh vikas Mittal Shubham Mahajan Amit Kant Pandit Mehedi Masud Mohammed Baz Mohamed Abouhawwash Department of Electronics&Communication Engineering Chandigarh UniversityMohali140413India School of VLSI Design and Embedded Systems National Institute of TechnologyKurukshetra136119India School of Electronics&Communication Engineering Shri Mata Vaishno Devi UniversityKatra182320India Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Computer Engineering College of Computer and Information TechnologyTaif UniversityTaif21994Saudi Arabia Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA

CognitiveRadio(CR)has been developed as an enabling technology that allows the unused or underused spectrum to be used dynamically to increase spectral *** improve the overall performance of the CR systemit is extremely important to adapt or reconfigure the *** Decision Engine is a major module in the CR-based system that not only includes radio monitoring and cognition functions but also responsible for parameter *** meta-heuristic algorithms offer numerous advantages compared to traditional mathematical approaches,the performance of these algorithms is investigated in order to design an efficient CR system that is able to adapt the transmitting parameters to effectively reduce power consumption,bit error rate and adjacent interference of the channel,while maximized secondary user ***-Learning Salp Swarm Algorithm(SLSSA)is a recent meta-heuristic algorithm that is the enhanced version of SSA inspired by the swarming behavior of *** this work,the parametric adaption of CR system is performed by SLSSA and the simulation results show that SLSSA has high accuracy,stability and outperforms other competitive algorithms formaximizing the throughput of secondary *** results obtained with SLSSA are also shown to be extremely satisfactory and need fewer iterations to converge compared to the competitive methods.

关键词： Cognitive radio meta-heuristic algorithm cognitive decision engine salp swarm algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Federated Learning on Internet of Things:Extensive and Systematic Review

引用

Computers, Materials & Continua 2024年第5期79卷 1795-1834页

作者： Meenakshi Aggarwal vikas Khullar Sunita Rani Thomas AndréProla Shyama Barna Bhattacharjee Sarowar Morshed Shawon nitin Goyal Chitkara University Institute of Engineering and Technology Chitkara UniversityRajpuraPunjab140401India Department of CSE&IT BPS Mahila VishwavidyalayaKhanpur KalanSonipatHaryana131305India Engineering Research&Innovation Group Universidad Europea del AtlánticoC/Isabel Torres 21Santander39011Spain Department of Project Management Universidad Internacional IberoamericanaAreciboPR00613USA Department of Project Management Universidade Internacional do CuanzaEstrada Nacional 250Bairro KaluapandaCuito-BiéAngola Department of Computer Science and Engineering University of Science and Technology Chittagong(USTC)Chattogram4202Bangladesh Deptartment of EEE University of Science and Technology Chittagong(USTC)Chattogram4202Bangladesh Department of Computer Science and Engineering School of Engineering and TechnologyCentral University of HaryanaMahendragarhHaryana123031India

The proliferation of IoT devices requires innovative approaches to gaining insights while preserving privacy and resources amid unprecedented data ***,FL development for IoT is still in its infancy and needs to be explored in various areas to understand the key challenges for deployment in real-world *** paper systematically reviewed the available literature using the PRISMA guiding *** study aims to provide a detailed overview of the increasing use of FL in IoT networks,including the architecture and challenges.A systematic review approach is used to collect,categorize and analyze FL-IoT-based *** was performed in the IEEE,Elsevier,Arxiv,ACM,and WOS databases and 92 articles were finally *** measures were published in English and with the keywords“FL”and“IoT”.The methodology begins with an overview of recent advances in FL and the IoT,followed by a discussion of how these two technologies can be *** be more specific,we examine and evaluate the capabilities of FL by talking about communication protocols,frameworks and *** then present a comprehensive analysis of the use of FL in a number of key IoT applications,including smart healthcare,smart transportation,smart cities,smart industry,smart finance,and smart *** key findings from this analysis of FL IoT services and applications are also ***,we performed a comparative analysis with FL IID(independent and identical data)and non-ID,traditional centralized deep learning(DL)*** concluded that FL has better performance,especially in terms of privacy protection and resource *** is excellent for preserving privacy becausemodel training takes place on individual devices or edge nodes,eliminating the need for centralized data aggregation,which poses significant privacy *** facilitate development in this rapidly evolving field,the insights presented are intended to help practitioners and re

关键词： Internet of Things federated learning PRISMA framework of FL applications of FL data privacy communication

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effectiveness of massage therapy on post-operative outcomes among patients undergoing cardiac surgery:A systematic review

引用

International Journal of Nursing Sciences 2015年第3期2卷 304-312页

作者： C.Ramesh Vasudev Baburaya pai nitin Patil Baby S.Nayak Anice George Linu Sara George Elsa Sanatombi Devi Manipal College of Nursing Manipal UniversityManipalIndia Kasturba Medical College Manipal UniversityManipalIndia

The incidence and prevalence of cardiovascular disease(CVD)are increasing rapidly in developing *** patients with CVD do not respond to medical treatment and have to undergo cardiac *** highly stressful experience results in increased levels of anxiety for *** objective of this review was to evaluate the efficacy of massage therapy on postoperative outcomes among patients undergoing cardiac surgery.A comprehensive literature search was made on PubMed-Medline,CINAHL,Science Direct,Scopus,Web of Science and the Cochrane library databases for original research articles published between 2000 and *** articles that reported the efficacy of massage therapy in patients undergoing cardiac surgery were *** Cochrane data extraction form was used to extract data.A total of 297 studies were identified in the literature ***,only seven studies were eligible for *** the seven studies,six studies demonstrated the effects of massage therapy on improving postoperative outcomes of patients,while one study found no evidence of *** the methods varied considerably,most of the studies included in this review reported positive ***,there is some evidence that massage therapy can lead to positive postoperative *** of the effectiveness of massage therapy in patients undergoing cardiac surgery remains *** research is needed to provide a strong evidence base for the use of massage therapy to improve post-operative outcomes and recovery among cardiac surgery patients.

关键词： Anxiety Heart surgery Massage pain Post-operative period

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Efficient and Rapid Synthesis of 2-amino-4-arylthiazoles Employing Microwave Irradiation in Water

引用

Green and Sustainable Chemistry 2011年第2期1卷 35-38页

作者： Kishor S. Jain Jitender B. Bariwal Muthu K. Kathiravan vikas K. Raskar Gajanan S. Wankhede nitin A. Londhe Satish N. Dighe 不详

A facile, high yielding green chemical synthetic protocol adaptable to the parallel synthesis of a library of potentially bioactive 2-amino-4-arylthiazoles is reported herein. The methodology involves the condensation of various aracyl bromides with N-arylthioureas under MWI using water as solvent, to yield pure products (81%-97%) in very short reaction times (1-20 min).

关键词： Green Chemical Synthesis MWI Water 2-amino-4-arylthiazoles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy and Safety of PDM011011 Capsules as Compared to Metformin in Subjects with Type-2 Diabetes Mellitus: An Open-Label, Randomized, Active-Controlled, Multicentric, Phase III Study

引用

Journal of Diabetes Mellitus 2016年第1期6卷 38-48页

作者： Ashish C. Suthar vikas G. pai Yogesh Kadam Aniruddha Tongaonkar Shailaja Kale Atul B. Deshpande Sharat Kolke Snehal Tanna Shrikant V. Deshpande Purvi Chawla Debjit Biswas Somesh Sharma Piramal Enterprises Limited Mumbai India pai Clinic and Diagnostic Center Pune India Poona Diabetes Centre Pune India Tongaonkar Hospital Pune India Orange Diabetes Clinical Research Unit Pune India Ethika Clinical Research Centre Prakruti Hospital Thane India Kolkes Clinic Mumbai India Clinic De Care Thane India Ashirwad Hospital and Medical Research Centre Thane India

Context: Bitter melon (Momoradica charantia) is one of the well-known plants used for lowering blood glucose since antiquity. Aims: To compare the efficacy and safety of PDM011011 capsule (1200 mg/day) with Metformin (1000 mg/day) in a 15 weeks study using mean change in fasting plasma glucose (FPG) and Hb1Ac% in subjects with type 2 diabetes mellitus (T2DM). Settings and Design: This is an open-label, randomized, active-controlled, multicentric, phase III study. Methods and Material: A total of 123 eligible patients were randomized in 2:1 ratio in PDM011011 and Metformin arm. Total 83 subjects received PDM011011 capsule (1200 mg/day) and 40 subjects received Metformin (1000 mg/day) in their respective arms for 15 weeks. Subjects were analyzed for FPG and Hb1Ac% at baseline and during treatment visits (Visit 3 to Visit 7). Safety assessments were carried out. Results: In this study, the significant reduction in mean FPG level was observed after treatment with PDM011011 capsule and Metformin in T2DM patients. The mean change from baseline to week 15 in FPG was 14.52 mg/dL (95% CI: 6.36, 22.67) in the PDM011011-treated subjects and 28.34 mg/dL (95% CI: 21.35, 35.32) in the Metformin-treated subjects. At week 15, the mean change from baseline in HbA1c levels was 0.27% (95% CI: 0.06, 0.47) in the PDM011011 arm and 0.62% (95% CI: 0.40, 0.83) in the Metformin arm. Conclusion: PDM011011 capsule (1200 mg/day) exhibited the modest efficacy and safety as compared to Metformin (1000 mg/day) in type 2 diabetes patients.

关键词： Momoradica charantia Glycebal Diabetes mellitus Anti-Diabetic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：