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C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 279-287页

作者： Hritik Rathod Ritu m.Soni Jigna S.shah Department of Pharmacology Institute of Pharmacy Nirma UniversityAhmedabadGujaratIndia

Objective:To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s ***:C-phycocyanin(50 mg/kg,i.p.,daily)was administered to rotenone(30 mg/kg,p.o.,daily)treated mice for 28 *** studies(Y-maze,rotarod,round beam walk,and wire-hang tests)were carried out to assess neurobehavioral *** and malondialdehyde were determined in both serum and striatal *** proteins(AKT,AmPK,NF-κB,BDNF,and alpha-synuclein)in the striatum were estimated using *** analyses(hematoxylin and eosin stainning as well as Nissl staining)were carried out to assess structural abnormalities in the ***:C-phycocyanin significantly increased BDNF levels and decreased alpha-synuclein *** also slightly upregulated AmPK and AKT levels without significant difference compared with the rotenone ***,rotenone-induced elevated oxidative stress and structural abnormalities in the striatum were markedly mitigated by ***:C-phycocyanin might have potential neuroprotective effects against Parkinson’s *** studies are warranted to verify its efficacy and to understand the molecular mechanisms behind the neuroprotective effects of C-phycocyanin in Parkinson’s disease.

关键词： Parkinson’s disease C-phycocyanin Alphasynuclein BDNF Oxidative stress Rotenone

Twinning aspects and their efficient roles in wrought mg alloys:A comprehensive review

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Journal of magnesium and Alloys 2024年第6期12卷 2201-2230页

作者： S.S.A.shah manping Liu Azim Khan Farooq Ahmad m.R.Abdullah Xingquan Zhang Shiwei Xu Zhen Peng School of materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of mechanical Engineering Anhui University of TechnologyMáanshan 243002China College of mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China

Twinning is widely recognized as an effective and cost-efficient method for controlling the microstructure and properties of wrought magnesium(mg)***,twins play a crucial role in initiating dynamic recrystallization(DRX),while twin regions experience rapid recrystallization during static recrystallization(SRX).The activation of twinning can lead to changes in lattice orientation,significantly impacting the final texture in mg *** active roles of twinning are influenced by various factors during the activation process,and the mobility of twin boundaries(TB)can be amplified by stress effects,dislocation interactions,and thermal ***,annealing treatments that involve proper segregation or precipitation on TBs serve to stabilize them,restraining their *** such as segregation may also alter the twinning propensity in magnesium-rare earth(mg-RE)***{10-11}contraction twins(CT)and{10-11}-{10-12}double twins(DT)can promote dynamic recrystallization(DRX),they also pose a risk as potential sources of voids and ***,understanding the nucleation and growth mechanisms of twinning is crucial,and these aspects are briefly reviewed in this *** the factors mentioned above,this article summarizes the recent research progress in this field,shedding light on advancements in recent eras.©2024 Chongqing *** services provided by Elsevier *** behalf of KeAi Communications ***.

关键词： mg alloys Twinning Recrystallization Texture mechanical properties

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Ir single atoms on NiFeZn-LDH matrix for exceptional oxygen evolution reaction

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Nano Research 2024年第8期17卷 7039-7044页

作者： muhammad Israr muhammad Humayun Jiaqi Zhang Khadim shah Xin Tan Chen Chen Yadong Li Department of Chemistry Tsinghua UniversityBeijing 100084China Energy Water and Environment LabCollege of Humanities and SciencePrince Sultan UniversityRiyadh11586Saudi Arabia

To address the sluggish kinetics of the oxygen evolution reaction(OER),a potential approach is to rationally design and fabricate extremely effective single atom catalysts(SACs).Using an appropriate matrix to stabilize single-atom active centers with optimal geometric and electronic structures is crucial for enhancing catalytic ***,we report the design and fabrication of Ir single atoms on NiFeZn layered double hydroxide(Ir-SAC/NiFeZn-LDH)electrocatalyst for highly efficient and stable *** is investigated that the NiFeZn support exhibits abundant defect sites and unsaturated coordination *** sites function to anchor and stabilize single Ir single atoms on the *** strong synergetic electronic interaction between the Ir single atoms and the NiFeZn matrix resulted in remarkable OER performance of the as-fabricated Ir-SAC/NiFeZn *** a loading Ir content of 1.09 wt.%,this catalyst demonstrates a highly stable OER activity,with an overpotential of 196 mV at 10 mA·cm^(−2)and a small Tafel slope of 35 mV·dec^(−1)for the OER in a 1 m KOH *** results significantly surpass the performance of the commercially available IrO_(2)catalyst.

关键词： Ir single atoms layered double hydroxides rational design geometric optimization oxygen evolution reaction

Enhancing mild Cognitive Impairment Detection through Efficient magnetic Resonance Image Analysis

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Computers, materials & Continua 2024年第8期80卷 2081-2098页

作者： Atif mehmood Zhonglong Zheng Rizwan Khan Ahmad Al Smadi Farah shahid shahid Iqbal mutasem K.Alsmadi Yazeed Yasin Ghadi Syed Aziz shah mostafa m.Ibrahim Department of Computer Science and Technology Zhejiang Normal UniversityJinhua321002China Zhejiang Institute of Photoelectronics&Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua321004China Department of Data Science and Artificial Intelligence Zarqa UniversityZarqa13100Jordan School of Chemical and Environmental Engineering College of ChemistryChemical Engineering andMaterials ScienceSoochow UniversitySuzhou215123China Department of management Information Systems College of Applied Studies and Community ServiceImam Abdulrahman Bin Faisal UniversityDammam32244Saudi Arabia Department of Computer Science Al Ain UniversityAbu Dhabi999041United Arab Emirates Department of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61519Egypt Healthcare Technology and Innovation Theme Faculty Research Centre for Intelligent HealthcareCoventry UniversityCoventryCV48BWUK

Neuroimaging has emerged over the last few decades as a crucial tool in diagnosing Alzheimer’s disease(AD).mild cognitive impairment(mCI)is a condition that falls between the spectrum of normal cognitive function and ***,previous studies have mainly used handcrafted features to classify mCI,AD,and normal control(NC)*** paper focuses on using gray matter(Gm)scans obtained through magnetic resonance imaging(mRI)for the diagnosis of individuals with mCI,AD,and *** improve classification performance,we developed two transfer learning strategies with data augmentation(i.e.,shear range,rotation,zoom range,channel shift).The first approach is a deep Siamese network(DSN),and the second approach involves using a cross-domain strategy with customized *** performed experiments on the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset to evaluate the performance of our proposed *** experimental results demonstrate superior performance in classifying the three binary classification tasks:NC ***,NC ***,and mCI ***,we achieved a classification accuracy of 97.68%,94.25%,and 92.18%for the three cases,*** study proposes two transfer learning strategies with data augmentation to accurately diagnose mCI,AD,and normal control individuals using Gm *** findings provide promising results for future research and clinical applications in the early detection and diagnosis of AD.

关键词： Alzheimer’s disease mild cognitive impairment normal control transfer learning classification augmentation

Al3+ doped CeO2 for proton conducting fuel cells

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International Journal of minerals,metallurgy and materials 2024年第10期31卷 2253-2262页

作者： Sarfraz shahzad Rasool muhammad Khalid m.A.K.Yousaf shah Bin Zhu Jung-Sik Kim muhammad Imran Asghar Nabeela Akbar Wenjing Dong Jiangsu Provincial Key Laboratory of Solar Energy Science and Technology/Energy Storage joint Research Center School of Energy and Environment Southeast University Sino-French Engineer School/School of General Engineering Beihang University Renewable Energy Technologies Group Faculty of Engineering and Natural Sciences Tampere University School of microelectronics Hubei University

Developing high ionic conducting electrolytes is crucial for applying proton-conducting fuel cell （PCFCs） *** current study investigates the effect of alumina on the structural,morphological,electrical,and electrochemical properties of *** oxygen vacancies are induced in CeO2by a general doping concept that enables fast ionic conduction at low-temperature ranges（300–500°C） for *** refinement of the X-ray diffraction （XRD） patterns established the pure cubic fluorite structure of Aldoped CeO2（ADC） samples and confirmed Al ions’fruitful integration in the *** electronic structure of the alumina-doped ceria of the materials （10ADC,20ADC,and 30ADC） has been *** a result,it was found that the best composition of 30ADC-based electrolytes induced maximum lattice oxygen *** corresponding PCFC exhibited a maximum power output of 923 mW/cm2at 500°***,the investigation proves the proton-conducting ability of alumina-doped ceria-based fuel cells by using an oxide ion-blocking layer.

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Toward a comprehensive hypothesis of oxygen-evolution reaction in the presence of iron and gold

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Journal of Energy Chemistry 2024年第2期89卷 172-183,I0005页

作者： Negah Hashemi Jafar Hussain shah Cejun Hu Subhajit Nandy Pavlo Aleshkevych Sumbal Farid Keun Hwa Chae Wei Xie Taifeng Liu Junhu Wang mohammad mahdi Najafpour Department of Chemistry Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Center for Advanced mössbauer Spectroscopy Mössbauer Effect Data CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Key Lab of Advanced Energy materials Chemistry(ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityTianjin 300071China Advanced Analysis Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Institute of Physics Polish Academy of SciencesWarsaw 02-668Poland National and Local Joint Engineering Research Center for Applied Technology of Hybrid Nanomaterials Henan UniversityKaifeng 475004HenanChina Center of Climate Change and Global Warming Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Research Center for Basic Sciences&modern Technologies(RBST) Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran

This study investigates the effects of Fe on the oxygen-evolution reaction(OER)in the presence of *** distinct areas of OER were identified:the first associated with Fe sites at low overpotential(~330 mV),and the second with Au sites at high overpotential(~870 mV).Various factors such as surface Fe concentration,electrochemical method,scan rate,potential range,concentration,method of adding K_(2)Fe O_(4),nature of Fe,and temperature were varied to observe diverse behaviors during OER for Fe O_(x)H_(y)/*** amounts of Fe ions had a significant impact on OER,reaching a saturation point where the activity did not increase *** electronic interaction between Fe and Au ions was indicated by X-ray photoelectron spectroscopy(XPS)and electron paramagnetic resonance(EPR)*** situ visible spectroscopy confirmed the formation of Fe O_(4)^(2-)during *** situ mossbauer and surfaceenhanced Raman spectroscopy(SERS)analyses suggest the involvement of Fe-based species as intermediates during the rate-determining step of OER.A lattice OER mechanism based on Fe O_(x)H_(y)was proposed for operation at low *** functional theory(DFT)calculations revealed that Fe oxide,Fe-oxide clusters,and Fe doping on the Au foil exhibited different activities and stabilities during *** study provides insights into the interplay between Fe and Au in OER,advancing the understanding of OER mechanisms and offering implications for the design of efficient electrocatalytic systems.

关键词： DFT calculation Fe/Au electrocatalysis mechanism Oxygen evolution Water oxidation

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An arrow in the quiver: evaluating the performance of Hyptis suaveolens(L.) Poit. in different light levels

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Ecological Processes 2024年第2期 130-147页

作者： Kanhaiya shah Gyan Prakash Sharma R.Sagar Department of Environmental Studies University of Delhi Department of Botany Banaras Hindu University

Background Hyptis suaveolens（L.） Poit.,native to the American tropics,is a pantropical annual plant and a major invasive species throughout *** was anticipated that the availability of sunlight,coupled with its superior reproductive potential,persistent propagule bank,and dispersal ability,could lead to an increase in the growth and spread of this invader,thus potentially impeding herbaceous growth and diversity in non-native *** its ecological fitness and competitive performance will be useful to manage the spread of *** in natural ecosystems that are facing a wide range of anthropogenic *** The present study is a three-tier *** the first tier,a field study was conducted to assess the patterns of *** abundance and herbaceous species diversity in response to light availability(sun,842-1072μmol m-2s-1and shade 253-341 μmol m-2S-1) in the tropical dry deciduous ecosystems in the Vindhyan highlands,***,the impact of *** abundance on the resident native and non-native species abundance and diversity was also *** the second tier,a randomized common garden experiment was conducted to understand the trait fitness of *** in sun(940 μmol m-2s-1) and shade(300 μmol m-2s-1) *** the third tier,a plant growth chamber experiment with high-light(940 μmol m-2s-1) and low-light(300 μmol m-2s-1)treatments was done to learn how *** partitions its biomass between aboveground and belowground plant *** The field study indicated that the sunlit areas had a higher abundance of *** and a lower diversity of resident herbaceous species than the shaded *** common garden experiment showed that sun-dwelling *** individuals performed better in germinative,vegetative,eco-physiological,and reproductive traits than the shade-dwelling *** growth chamber experiment exhibited that plants grown in high-light environment had greater seed germi

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SImAP500: A novel risk score to identify recipients at higher risk of hepatocellular carcinoma recurrence following liver transplantation

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World Journal of Transplantation 2024年第3期14卷 132-143页

作者： Amr Alnagar Nekisa Zakeri Konstantinos Koilias Rosemary E Faulkes Rachel Brown Owen Cain m Thamara P R Perera Keith J Roberts Rebeca Sanabria-mateos David C Bartlett Yuk Ting ma Shivan Sivakumar Shishir Shetty Tahir shah Bobby V m Dasari Department of HBP and Liver Transplantation Surgery Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Centre for Liver Research Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom Department of Hepatology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Department of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Department of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

BACKGROUND Recurrence of hepatocellular carcinoma(HCC)following liver transplantation(LT)has a devastating influence on recipients’survival;however,the risk of recur-rence is not routinely *** stratification is vital with a long LT waiting time,as that could influence the recurrence despite strict listing *** This study aims to identify predictors of recurrence and develop a novel risk pre-diction score to forecast HCC recurrence following *** A retrospective review of LT for HCC recipients at University Hospitals Bir-mingham between July 2011 and February *** and multivariate analyses were performed to identify recurrence predictors,based on which the novel SImAP500(satellite nodules,increase in size,microvascular invasion,AFP>500,poor differentiation)risk score was *** 234 LTs for HCC were performed with a median follow-up of 5.3 *** developed in 25 patients(10.7%).On univariate analyses,RETREAT score>3,α-fetoprotein(AFP)at listing 100-500 and>500,bridging,increased tumour size between imaging at the listing time and explant histology,increase in the size of viable tumour between listing and explant,presence of satellite nodules,micro-and macrovascular invasion on explant and poor differentiation of tumours were significantly associated with recurrence,based on which,the SImAP500 risk score is *** SImAP500 demonstrated an excellent predictive ability(c-index=0.803)and outper-formed the RETREAT score(c-index=0.73).SImAP500 is indicative of the time to disease *** SImAP500 risk score identifies the LT recipients at risk of HCC *** stratification allows patient-centric post-transplant surveillance *** validation of the score is recommended.

关键词： Liver transplantation Hepatocellular carcinoma Recurrence Survival

Effect of Cu/Zn Substitution in mgO Nanostructures for Tuning the Optical Bandgap and Structural Properties

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Journal of Wuhan University of Technology(materials Science) 2022年第6期37卷 1035-1040页

作者： ATIF Dawar S NASEEm shah m ASIF Siddiqui YASmEEN Bibi Department of Physics Federal Urdu University of ArtsScience and TechnologyKarachiPakistan Department of Chemistry Federal Urdu University of ArtsScience and TechnologyKarachiPakistan

Low cost co-precipitation method was used to synthesize Cu(0-0.05)doped mgO samples with fixed concertation of Zn=0.01.X-ray diffraction(XRD)spectra confirmed the phase purity of the samples for 0≤Cu≤0.03 doping *** secondary phase for 0.04≤Cu≤0.05 exhibited the formation of mixed metal *** crystallite size was found to increase from 17.5 to 23.5 nm for 0≤Cu≤0.03 and then decreased from 22 to 18.5 nm for 0.04≤Cu≤*** estimated bandgap first reduced from 5.48 to 4.88 eV and then increased from 5.21 to 5.36 *** morphology of the samples transformed from spheroidal shape to star-like *** obtained results reveal that the structural and optical property are in good agreement with the morphological *** peak shifting towards the lower values of vibrational frequency from 694 to 579 cm^(-1) confirms the incorporation of Cu/Zn in mg-O *** tuning of optical bandgap and structural properties with varying dopant concentration in mgO nanomaterials can be used for multifunctional modern energy storage and optoelectronic devices.

关键词： Cu/Zn doping mgO optical bandgap morphology vibrational modes

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