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Anti-bacterial Properties of Transition Metal Complexes of Copper Metal Ion:A Mini Review

Journal of Metallic Material Research 2022年第2期5卷 27-38页

作者： Abhay Nanda Srivastva nisha saxena Netra Pal Singh Jayant Kumar Department of Chemistry Nitishwar MahavidyalayaB.R.A.Bihar UniversityMuzarrafpur842002India University Department of Chemistry B.R.A.Bihar UniversityMuzaffarpur842001India Department of Chemistry M.R.M.CollegeL.N.Mithila UniversityDarbhanga846004India Department of Chemistry D.D.U.Gorakhpur UniversityGorakhpur273009India Graduate Student Department of ZoologyNitishwar MahavidyalayaB.R.A.Bihar UniversityMuzarrafpur842002India

Bacterial infections are a major cause for impulsive deaths in human *** infections of the respiratory,gastrointestinal and central nervous system account for the majority of cases of sudden *** available drugs are getting ineffective by each passing day as the mutation is very fast in these pathogenic microbes resulting in drug *** growing resistance of bacteria necessitates the development of new and effective compounds of desired characteristics that could bar the rapid development of bacterial cell inside of the host *** with cellular resistance for clinical antibiotics,co-bacterial infections during microbial attacks(***,fungus,protozoans etc.)also demand for some novel antibacterial drugs having high efficacy and minimal side effects on human *** antibiotics should also be compatible with remedies ongoing for core microbial ***,in demand of search for effective antibacterial moieties,the scope of transition metal complexes as drug gives a good signal against the pathogenic bacteria by inhibiting their *** action of metal complexes on bacterial cell may be due to impremiablity,enzymatic interruptions,ribosomal interactions,disturbance in the path of protein synthesis,denaturing of genetic materials *** the *** in complexes may interrupt the lipophilisity through the bacterial cell *** of metal ions in organic moieties behaving as ligand delocalizeπ-electrons upon the entire chelate ring and this chelation results in overlapping of ligand orbital and partial sharing of(+)ve charge of metal ion with donor *** structural modifications in metal and organic lone pair donor species are the supposed reasons for their enhanced antimicrobial activities against pathogenic *** present review focuses on the impact of recently synthesized,well characterized mono and binuclear transition metal complexes of Cu ions that have the potential to be the drug of th

关键词： Ligands Coordination compounds Antimicrobial activity Drug resistance

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