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The antiangiogenic phloroglucinol hyperforin inhibits the secretion of proMMP-2, proMMP-9 and VEGF-A during apoptosis of primary acute myeloid leukemia cells

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 588-603页

作者： Faten Merhi Ruoping Tang Ollivier Legrand Florence nguyen-khac Santos A.Susin Brigitte Bauvois Centre de Recherche des Cordeliers INSERMSorbonne UniversitéUSPCUniversitéParis DescartesUniversitéParis DiderotParis F-75006France Department of Life&Earth Sciences Faculty of Sciences(I)Lebanese UniversityBeirutLebanon Assistance Publique-Hôpitaux de Paris Groupe Hospitalier Saint-AntoineService d’Hématologie CliniqueParis F-75012France Service Génétique des Tumeurs Département de Biologie et de Pathologie MédicaleGustave Roussy Cancer CamusVillejuif F-94805France Assistance Publique-Hôpitaux de Paris Groupe Hospitalier Pitié-SalpêtrièreService d’Hématologie BiologiqueParis F-75013France.

Aim:Angiogenesis is observed in acute myeloid leukemia(AML).AML cells abnormally proliferate and are resistant to *** regulators of angiogenesis,VEGF-A and matrix metalloproteinases(MMPs)2 and 9 are markers of disease status in *** natural phloroglucinol hyperforin(HF)displays antitumoral properties of potential pharmacological ***,we investigated the effects of HF on MMP-2/9 and VEGF-A expression and survival of primary AML ***:Blood and bone marrow samples were collected in 45 patients with distinct subtypes defined by French American British classification,i.e.,M0,M1,M2,M3,M4,and *** of MMPs and VEGF-A in leukemic blood cells and culture supernatants were determined by RT-PCR,ELISA,and gelatin zymography(MMPs).The balance between cell death and survival was assessed by flow cytometry with analysis of phosphatidylserine externalization and caspase-3 ***:The administration of HF promoted a caspase-associated apoptosis in primary AML blasts(from blood and bone marrow),but not normal blood cells and *** addition,HF inhibited the levels of secreted proMMP-2,proMMP-9,and VEGF-A without altering *** induction of apoptosis by HF significantly paralleled the inhibition of MMP-2/9 and VEGF-A release by *** differences were seen in response to the deleterious effects of HF between AML cells of distinct ***:Our results suggest that HF,through its proapoptotic and potential antiangiogenic properties(by inhibiting MMP-2/9 and VEGF-A)on primary AML cells,might be a useful experimental agent,in combination with existing drugs,for new therapeutic approaches in the treatment of this incurable disease.

关键词： Acute myeloid leukemia apoptosis hyperforin matrix metalloproteinase VEGF secretion

One-step hydrothermal synthesis of Sn-doped α-Fe_(2)O_(3) nanoparticles for enhanced photocatalytic degradation of Congo red

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Journal of Semiconductors 2022年第12期43卷 22-31页

作者： Van Nang Lam Thi Bich Vu Quang Dat Do Thi Thanh Xuan Le Tien Dai nguyen T-Thanh-Bao nguyen Hoang Tung Do Thi Tu Oanh nguyen Department of Natural Sciences Hoa Lu UniversityNinh NhatNinh Binh CityViet Nam Institute of Theoretical and Applied Research Duy Tan UniversityHanoi 100000Viet Nam Faculty of Natural Sciences Duy Tan UniversityDa Nang 550000Vietnam Institute of Physics Vietnam Academy of Science and Technology10 Dao TanBa DinhHanoiVietnam Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCaugiayHanoiVietnam

We report on the synthesis of Sn-doped hematite nanoparticles(Sn-α-Fe_(2)O_(3) NPs)by the hydrothermal *** prepared Sn-α-Fe_(2)O_(3) NPs had a highly pure and well crystalline rhombohedral phase with an average particle size of 41.4 *** optical properties of as-synthesizedα-Fe_(2)O_(3) NPs show a higher bandgap energy(2.40-2.57 eV)than that of pure bulkα-Fe_(2)O_(3)(2.1 eV).By doping Sn intoα-Fe_(2)O_(3) NPs,the Sn-doped hematite was observed a redshift toward a long wavelength with in-creasing Sn concentration from 0%to 4.0%.The photocatalytic activity of Sn-dopedα-Fe_(2)O_(3) NPs was evaluated by Congo red(CR)dye *** degradation efficiency of CR dye using Sn-α-Fe_(2)O_(3) NPs catalyst is higher than that of pureα-Fe_(2)O_(3) *** highest degradation efficiency of CR dye was 97.8%using 2.5%Sn-dopedα-Fe_(2)O_(3) NPs catalyst under visible-light *** results suggest that the synthesized Sn-dopedα-Fe_(2)O_(3) nanoparticles might be a suitable approach to develop a photocatalytic degradation of toxic inorganic dye in wastewater.

关键词： α-Fe_(2)O_(3)nanoparticles Sn Congo red photocatalytic properties photodegradation

A Chance–Constrained Data Envelopment Analysis Approach to Problem Provincial Productivity Growth in Vietnamese Agriculture from 1995 to 2007

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Open Journal of Statistics 2011年第3期1卷 217-235页

作者： nguyen khac Minh Pham Van Khanh 不详

This study employs a chance-constrained data envelopment analysis (CDEA) approach with two models (model A and model B) to decompose provincial productivity growth in Vietnamese agriculture from 1995 to 2007 into technological progress and efficiency change. The differences between the chance - constrained programming model A and model B are assumptions imposed on the covariance matrix. The decomposition allows us to identify the contributions of technical change and the improvement in technical efficiency to productivity growth in Vietnamese production. Sixty-one provinces in Vietnam are classified into Mekong - technology and other -technology categories. We conduct a Mann-Whitney test to verify whether the two samples, the Mekong technology province sample and the other technology sample, are drawn from the same productivity change populations. The result of the Mann-Whitney test indicates that the differences between the Mekong technology category and the other technology category from two models are more significant. Two important questions are whether some provinces in the samples could maintain their relative efficiency rank positions in comparison with the others over the study period and how to further examine the agreements between the two models. The Kruskal - Wallis test statistic shows that technical efficiency from both models for some provinces are higher than those of them in the study period. The Malmquist results show that production frontier has contracted by around 1.3 percent and 0.31 percent from chance-constrained model A and model B, respectively, a year on average over the sample period. To examine the agreements or disagreements in the total factor productivity indexes we compute the correlation between Malmquist indexes, which is positive and not very high. Thus there is a little discrepancy between the two Malmquist indexes, estimated from the chance - constrained models A and B.

关键词： Total Factor Productivity Technical Efficiency Change Technological Progress Chance-Constrained Programming

Forecasting the Convergence State of per Capital Income in Vietnam

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American Journal of Operations Research 2013年第6期3卷 487-496页

作者： nguyen khac Minh Pham Van Khanh Military Technical Academy Hanoi Vietnam National Economics University Hanoi Vietnam

Convergence problem of an economic variable represents an underlying forecast of neoclassical economic growth model. This paper aims to analyze the convergence of provincial per capita GDP stability in Vietnam over the period of 1991-2007. This can be done by two approaches including bias data-based regression method for testing convergence and Markov chain model for describing features of long-term tendency of per capita income in Vietnam growth in provinces. The regression method results in the signs of convergence. To apply Markov process, we divide total pattern into 5 per capita income classes. Result estimated from the Markov chain model shows the poor convergence.

关键词： Convergence Regression Method Markov Proces

Control of Nonlinear Systems with Output Tracking Error Constraints

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Journal of Measurement Science and Instrumentation 2010年第3期1卷 217-223页

作者： khac Duc Do Dang Binh nguyen Anh Duc nguyen School of Mechanical Engineering University of Western Australia WA 6009 Australia Rectoral Office Thainguyen University of Technology Thainguyen Vietnam Department of Electrical Engineering Thainguyen University of Technology Thainguyen Vietnam

A constructive method is presented to design controllers that force the output of nonlinear systems in a strict feedback form to track a bounded and sufficient smooth reference trajectory *** suitable condition with the initial output tracking error,the proposed controllers guarantee the output tracking error within a symmetric or an asymmetric pre-specified limit range,and boundedness of all signals of the closed loop system.A transformation is introduced to take care of the output tracking error *** and/or p-times differentiable step functions are proposed and incorporated in the output tracking error transformation to overcome difficulties due to the asymmetric limit range on the output tracking *** a result,there are no switchings in the proposed controllers despite of the asymmetric limit range.

关键词：跟踪误差控制输出非线性系统限制范围控制器参考轨迹济南大学输出跟踪

Impacts of Exchange Rate Volatility and FDI on Technical Efficiency—A Case Study of Vietnamese Agricultural Sector

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American Journal of Operations Research 2015年第4期5卷 317-325页

作者： nguyen khac Minh Pham Van Khanh nguyen Viet Hung Economics and Management Faculty Thang Long University Hanoi Vietnam Institute of Economics and Corporate Group Hanoi Vietnam Faculty of Economics National Economics University Hanoi Vietnam

The objective of this research is to examine impacts of exchange rate volatility and FDI on efficiency of the Vietnamese agricultural sector at the provincial level for the period 1998-2011. Due to the characteristic of high uncertainty in agricultural production, the chance-constrained programming model would be used to estimate efficiency of the agricultural production sector. In order to study impacts of exchange rate volatility and FDI, we employ the two-stage model. In the first stage, we use the chance-constrained programming model to measure technical efficiency and ARIMA model to quantify exchange rate volatility. In the second stage, we use the fixed effect model to evaluate impacts of exchange rate volatility and FDI on efficiency of agricultural production in poor and rich provinces. The estimated results show that fluctuation in exchange rate volatility would reduce efficiency in agricultural production but FDI has an insignificant impact on the efficient production in Vietnam agricultural sector.

关键词： Chance-Constrained Programming DEA Exchange Rate Volatility FDI Technical Efficiency

Taxonomic notes of three tea-plants(Camellia ***)recently described in Vietnam

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Beverage Plant Research 2022年第1期2卷 174-176页

作者： nguyen Trung Thanh Luong Van Dung Le Nguyet Hai ninh Quang Cuong Truong Shixiong Yang Faculty of Biology VNU University of Science334 Nguyen TraiHanoi 100000Vietnam Faculty of Biology Dalat UniversityPhu Dong ThienVuong str.01Dalat66106Lam DongVietnam Faculty of Nong Lam Hoa Lu UniversityNinh Binh 40000Vietnam Bidoup Nui Ba National Park Tran Hung Dao str.5EDalat66116Lam DongVietnam CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina

Camellia sinensis *** is a heterotypic synonym of *** *** flosculora and *** were excluded from ***.

关键词： notes Vietnam Camellia

Nonlinear Control of Magnetic Bearings

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Journal of Measurement Science and Instrumentation 2010年第1期1卷 10-16页

作者： khac Duc Do Dang Hoe nguyen Thanh Binh nguyen School of Mechanical Engineering University of Western Australia WA 6009 Australia Vice-Rectoral Office Thainguyen University of Technology Thainguyen Vietnam Dept. of Human Resource University ofThainguyen Thainguyen Vietnam

In this paper,recent results controling nonlinear systems with output tracking error constraints are applied to the design of new tracking controllers for magnetic *** proposed controllers can force the rotor to track a bounded and sufficiently smooth reference trajectory asymptotically and guarantee non-contactedness between the rotor and the stator of the magnetic *** results are included to illustrate the effectiveness of the proposed controllers.

关键词：非线性控制磁悬浮轴承控制器设计跟踪误差非线性系统参考轨迹仿真结果磁轴承

The Optimal Stopping Time for Selling an Asset When It Is Uncertain Whether the Price Process Is Increasing or Decreasing When the Horizon Is Infinite

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American Journal of Operations Research 2018年第2期8卷 82-91页

作者： nguyen khac Minh nguyen Thanh Trung Pham Van Khanh Thang Long Institute of Mathematics and Applied Science Hanoi Vietnam Faculty of Fundamental Science Military Academy of Logistics Hanoi Vietnam

Assume that we want to shell an asset with unknown drift but known that the drift is a two value random variable, and the initial distribution can be estimated. As time goes by, this distribution is updated and base on the probability of the drift takes the small one gives us the stopping rule. Research results show that the optimal strategy to sell the asset is if the initial probability that the drift receives a small value greater than a certain threshold then liquidates the asset immediately, otherwise the asset holder will wait until the probability of the drift receives a small value passing a certain threshold, it is the optimal time to liquidate the asset.

关键词： Optimal Stopping Time Incomplete Information Probability Process