检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

装备制造业对立分异品牌策略研究

山东商业职业技术学院学报 2009年第5期9卷 1-5,11页

作者：马晓云宁夏大学经济管理学院银川750001

现阶段,我国装备制造业在参与国际竞争与分工中,一直在产业链中处于低附加价值的低端。但是一个只拥有500名员工的中国企业,在国际竞争中打破垄断,演绎了蚂蚁与大象的传奇。为探其缘由,本文由装备制造业上、下游的产业链分析入手,论证... 详细信息

现阶段,我国装备制造业在参与国际竞争与分工中,一直在产业链中处于低附加价值的低端。但是一个只拥有500名员工的中国企业,在国际竞争中打破垄断,演绎了蚂蚁与大象的传奇。为探其缘由,本文由装备制造业上、下游的产业链分析入手,论证了企业要想实现利益最大化,"品牌"是一个非常重要的局限条件。如何实现这一局限条件呢?以沈阳高压成套开关有限公司为例,从理论上验证"品类的对立分异"模型是建立品牌的关键,并对此模型做出相应的拓展分析。

关键词：选择成本品类品牌信用利益点对立分异策略

Comments on‘Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer’

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2024年第3期16卷 61-63页

作者： Xinyuan Tong ningxia Zhang Yun Xue Hongbin Ji Key Laboratory of Multi-Cell Systems Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Department of Respiratory and Critical Care Medicine The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu 322000China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China School of Life Science and Technology ShanghaiTech UniversityShanghai 200120China

Cancer plasticity is a new cancer hallmark and serves as a rising mechanism of resistance to targeted therapy(Hanahan,2022).Lung adenocarcinoma(ADC)and squamous cell carcinoma(SCC)are two distinct subtypes of non-small cell lung cancer(NSCLC),characterized by different cell origins,histopathological features,and drug ***,there is a small subtype of NSCLC termed adenosquamous cell carcinoma(AdSCC),which exhibits mixed adenomatous and squamous pathologies and frequently contains identical mutations.

关键词： squamous LKB1 lung

IL-17 induces NSCLC cell migration and invasion by elevating MMP19 gene transcription and expression through the interaction of p300-dependent STAT3-K631 acetylation and its Y705-phosphorylation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第4期32卷 625-641页

作者： WEN GE YA LI YUTING RUAN ningxia WU PEI MA TONGPENG XU YONGQIAN SHU YINGWEI WANG WEN QIU CHENHUI ZHAO Department of Immunology Nanjing Medical UniversityNanjing210000China Key Laboratory of Immunological Environment and Disease Nanjing Medical UniversityNanjing210000China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210000China Jiangsu Key Laboratory of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing210000China

The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(IL-17)can increase matrix metalloproteinases(MMPs)induction causing NSCLC cell metastasis,the underlying mechanism remains *** the study,we found that IL-17 receptor A(IL-17RA),p300,p-STAT3,Ack-STAT3,and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17.p300,STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3,Ack-STAT3 and MMP19 level as well as the cell migration and *** investigation revealed that STAT3 and p300 bound to the same region(−544 to−389 nt)of MMP19 promoter,and p300 could acetylate STAT3-K631 elevating STAT3 transcriptional activity,p-STAT3 or MMP19 expression and the cell mobility exposed to ***,p300-mediated STAT3-K631 acetylation and its Y705-phosphorylation could interact,synergistically facilitating MMP19 gene transcription and enhancing cell migration and ***,the animal experiments exhibited that the nude mice inoculated with NSCLC cells by silencing p300,STAT3 or MMP19 gene plus IL-17 treatment,the nodule number,and MMP19,Ack-STAT3,or p-STAT3 production in the lung metastatic nodules were all ***,these outcomes uncover that IL-17-triggered NSCLC metastasis involves up-regulating MMP19 expression via the interaction of STAT3-K631 acetylation by p300 and its Y705-phosphorylation,which provides a new mechanistic insight and potential strategy for NSCLC metastasis and therapy.

关键词： NSCLC cell migration and invasion IL-17 p300 STAT3 MMP19 Acetylation and phosphorylation

Synthesis and Efficiency of a SphericalMacroporous Epoxy-dicyandiamide ChelateResin for Preconcentrating and SeparatingTrace Au, Hg, Pd and Ru from Samples

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2001年第2期17卷 168-174页

作者： GONG Bo-lin, LI Xue-qiang and WANG Feng-rong (Department of Chemistry, ningxia university, yinchuan 750021, china) CHANG Xi-jun (Department of Chemistry, Lanzhou university, Lanzhou 730000, china) ningxia Univ Dept Chem Yinchuan 750021 Peoples R China Lanzhou Univ Dept Chem Lanzhou 730000 Peoples R China

A novel spherical macroporous epoxy-dicyandiamide chelate resin was synthesized simply and rapidly from epoxy resin and used for the preconcentration and separation of trace amounts of Au (Ⅲ ), Hg (Ⅱ ), Pd (Ⅳ) and Ru (Ⅲ) ions from solution samples. The analyzed ions can be quantitatively concentrated by the resin at a flow rate of 2. 0 mL/min at pH 4, and can also be desorbed with 15 mL of 4 mol/L HCl + 0. 3 g thiourea from the resin column with recoveries of 96. 5%-99. 0%. After the chelate resin was reused for 7 times, the recoveries of these ions were still over 92%, and 400-1 000 times of excess of Fe(Ⅲ ), Al(Ⅲ ), Ni( II), Mn( Ⅱ ), Cr (Ⅲ ), Cu ( Ⅱ ), Cd (Ⅱ ) and Pb (Ⅱ ) caused little interference with the determination of these ions by an inductively coupled plasma optical emission spectrometer (ICP-OES ). The capacities of the resin for the analytes are in the range of 0. 35~0. 92 mmol/g. The RSDs of the proposed method are in the range of 1. 1 % ~4. 0% for each kind of the analyzed ions. The recoveries of a standard added in real solution samples are between 96. 5% and 98. 5%, and the results for the analyzed ions in a powder sample are in good agreement with their reported values.

关键词： Concentration Separation Macroporous epoxy-dicyandiamide chelate resin Gold Mercury Palladium and ruthenium.

IRC analysis of methanol carbonylation reaction catalyzed by rhodium complex

在线全文

学校读者我要写书评

暂无评论

Science china Chemistry 2004年第1期47卷 41-49页

作者： HAO Maorong, FENG Wenlin, Jl Yongqiang & LEI MingFaculty of Science, Beijing university of Chemical Engineering, Beijing 100029, china Faculty of Chemical Engineering, ningxia university, yinchuan 750021, china 1. Faculty of Science Beijing University of Chemical Engineering 00029 Beijing China 2. Faculty of Chemical Engineering Ningxia University 750021 Yinchuan China

In the reaction cycle for methanol carbonylation catalyzed by Rh complex, the structure geometries of the reactant, intermediates, transition states and product of each elemental reaction have been studied by using the energy gradient method at HF/LANL2DZ level, and the changes of their potential profiles have also been calculated. Through IRC analyses of the transition states for each elemental reaction, it is confirmed that the various structure geometries obtained are stationary points on the cycle reaction pathway of methanol carbonylation catalyzed by Rh complex, and the changes are given in energies and structure geometries of the reactant molecules along the reaction pathway of lowest energy. It has been proposed that the geometrical conversions of intermediates play an important role during the cycle reaction. Through analyses of structure geometries, it has been suggested that, in addition to cis- and transstructure exchange linkage of catalysis reactive species, the two pathways, cis- and frans-catalyzed cycle reactions, can also be linked through geometrical conversion of intermediates, of which the activation energy is 49.79 kJ/mol. Moreover, the reductive elimination elemental reaction may be neither c/s-cycle nor trans- one, showing that the cycle reaction can be achieved through various pathways. However different the pathway, the oxidative addition elemental reaction of CH3I is the rate-controlling step.

关键词： rhodium complex catalyst, methanol carbonylation, ab initio method, homogeneous catalysis.

On　the　Approximation　by　the　Iterates　of　Stancu　Operators　and　Its　Modified　Operators

在线全文

学校读者我要写书评

暂无评论

Chinese Quarterly Journal of Mathematics 1996年第1期11卷 18-25页

作者： Xue yinchuan (Department of Mathematics, ningxia university, yinchuan )

This paper discusses the approximation of the class of function W2 and W2Lp(1

关键词： Stancu operators iterate Stancu-Kantorovic operators