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Rieger Syndrome

眼科学报 1998年第1期14卷 52-56页

作者： Juan Deng, ningli wangZhongshan ophthalmic {2., sun yat-sen University of medical sciences, guangzhou 510060, china Zhongshan ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Purpose: To discuss the clinic features of Rieger syndrome, the reasons of making wrong diagnosis , the way of treatment, and the research progress of its molecular characterization and gene mapping of this ***: Two cases of Rieger syndrome which affected a patient and his daughter were studied. Multiple clinical examinations including photography of anterior segment, go-nioscopy and fundus, Humphrey perimetry, A-scan ultrasonography, multiple tonometry in a day and chromosome examination were performed. Most importantly, ultrasonic biomicro-scope(UBM) was first used to show the abnormalities of anterior segment in this syndrome. Results: Gonioscopic examination revealed many mesoderm tissues remained and some parts of the iris adhered to cornea . In addition to hypoplasia of cornea, iris and chamber angle, UBM showed that there was also hypoplasia of ciliary body. The result of the chomosome examination indicated ***: Rieger syndrome is an autosomal-dominated disorder with

关键词：眼病染色体异常分了生物学 Riegr综合症超生波生物显微镜 ubm

Ultrasound Biomicroscopic Dark Room Provocative Test

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眼科学报 1997年第3期13卷 116-119页

作者： mingying lai , {2., Wengbing Zhou, Xiuqi ChenZhongshan ophthalmic center, sun Hat-sen University of Medicial sciences, guangzhou 510060, china Zhongshan ophthalmic center Sun Yat-sen University of Medicial Sciences Guangzhou 510060 China

Purpose : To compare the clinical application value of Ultrasound biomicrsocpic dark room provocative test with the traditional dark room test in screening primary angle closure glaucoma (PACG).Methods: 2. eyes with PACG in prodromal stage and 30 eyes with deep anterior chamber and wide angle of 15 normal persons were observed in this trail. All 52.eyes were performed traditional dark room provocative test and ultrasound biomicorosopic darkroom test respectively. With different positive diagnostic criteria, the sensitivity of the two methods were compared using chi-squared *** : After staying in the dark room for 2.hours, In case group, IOP in 10 of 2. eyes rose more than 1. 07kPa(1kPa = 7.5mmHg), in 12.eyes less than 1.07kPa or had no changes; appositional angle closure were found by Goldmann gonioscopy in 8 eyes : 3 eyes in two quadrants, 5 eyes in more than two quadrants; the appositional angle closure was found by UBM in 15 eyes; 3 eyes in one quadrants, 5 eyes in two quadrants, 7

关键词：暗里试验多频生物显微结构闭角型青光眼

Phacoemulsification in Patients with Secondary Glaucoma Caused by Uveitis

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Eye Science 2001年第1期17卷 8-10页

作者： Mingkai Lin, Jian Ge, Yizhi Liu, Yuqing Lan, Yehong zhouzhongshan ophthalmic {2., sun yat-sen University of medical sciences. guangzhou, 510060, china Zhongshan ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Purposes: To evaluate the effect of phacoemulsification in the patients with uveitis,secondary glaucoma and complicated cataract.Methods: Phacoemulsification and implantation of a foldable intraocular len was performed in 12.patients(13 eyes) with uveitis, secondary glaucoma and complicated cataract. The complications, intraocular pressures (IOP), and visual acuity were observed postoperatively.Results: No severe complication was found in the patients postoperatively or within the operation procedure. The visual acuity was improved after the operation ( P ＜ 0.05) .The intraocular pressures and/or the number of antiglaucoma medications reduced in 3months of the follow-up time.Conclusion: phacoemulsification is the best way to treat the patients with secondary glaucoma and complicated cataract caused by uveitis. Eye Science 2.01; 17: 8 ～ 10.

关键词：晶状体囊炎青光眼并发症葡萄膜炎病因

An Experimental Study on Homoharringtonine Liposome and Glaucoma Filtration Surgery

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眼科学报 1999年第1期15卷 51-54,50页

作者： Dawei Peng, Kerning Yu, Shujun Zeng, Yongping Li Jianxian Lin, Yuping Wu, wenbing zhouzhongshan {2. center , sun yat-sen University of medical sciences , guangzhou 510060 , china Department of Pharmacology, sun yat-sen University of medical sciences , guangzhou 510089, china Zhongshan ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Purpose: To observe the inhibitory action of homoharringtonine liposome during the healing process of wounds in the filtering sitesMethods: posterior sclerectomies were performed in 14 rabbits. Postoperatively one eye of each rabbit received subconjunctival injections of HH liposome and fellow eye received saline injection in a randomized masked ***; Fourteen days after operation the IOP of experimental eyes reduced significantly (P center of the filtering sites of the experimental eyes were less than those of the controlled eyes. No serious ocular toxic and side effects were *** : This experiment suggests that homoharringtonine liposome can markedly inhibit the scar formation of filtering sites after glaucoma

关键词：滤光手术青光眼脂质体

Studies of Primary Angle Qosure Glaucoma in china

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眼科学报 1997年第3期13卷 120-124页

作者： ningli wang, wenbin Zhou, Tiancai Ye, Qiang Yu,{2., Meihua LeZhongshan ophthalmic center, sun yat-sen University of medical sciences, guangzhou 510060,{12.

The resent researches on primary angle closure glaucoma (PACG) in china were reviewed. The prevalence of PACG (0.41%) in chinese is between the Caucasian and Eskimos, and chronic type is the dominant type in PACG. However, with the economic development and {2. care improvements, the prevalence condition of PACG may change; several researches discovered that the mechanism of PACG, especially the chronic type, is not only because of pupil-blocking but also closely related to the mechanism of crowding of peripheral iris and the anterior location of the ciliary body. We supposed that PACG can be divided into several subtypes based on this machnism. Also, we believe that the use of ultrasound biomicroscopy (UBM) and ophthalmic laser in china has promoted the research of PACG and improved the level of prevention and treatment of PACG. Eye Science 1997; 13 : 12.- 12..

关键词：闭角型青光眼初期中国多频生物显微

Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues

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Protein & Cell 2024年第8期15卷 594-611页

作者： Jian Wu Chaoye wang Shuhui sun Tianmin Ren Lijie Pan Hongyi Liu Simeng Hou Shen Wu Xuejing Yan Jingxue Zhang Xiaofang Zhao Weihai Liu Sirui Zhu Shuwen Wei Chi Zhang Xu Jia Qi Zhang Ziyu Yu Yehong Zhuo Qi Zhao Chenlong Yang {2. Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China State Key Laboratory of Oncology in South china Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Department of Neurosurgery Peking University Third HospitalCenter for Precision Neurosurgery and Oncology of Peking University Health Science CenterBeijing 100191China Spencer center for Vision Research Byers Eye InstituteSchool of MedicineStanford UniversityPalo AltoCA 94304USA

The progressive degradation in the trabecular meshwork(TM)is related to age-related ocular diseases like primary open-angle ***,the molecular basis and biological significance of the aging process in TM have not been fully ***,we established a dynamic single-cell transcriptomic landscape of aged macaque TM,wherein we classified the outflow tissue into 12.cell subtypes and identified mitochondrial dysfunction as a prominent feature of TM ***,we divided TM cells into 13 clusters and performed an in-depth analysis on cluster O,which had the highest aging score and the most significant changes in cell proportions between the two ***,we found that the APOE gene was an important differentially expressed gene in cluster O during the aging process,highlighting the close relationship between cell migration and extracellular matrix regulation,and TM *** work further demonstrated that silencing the APOE gene could increase migration and reduce apoptosis by releasing the inhibition on the PI3K-AKT pathway and downregulating the expression of extracellular matrix components,thereby increasing the aqueous outflow rate and maintaining intraocular pressure within the normal *** work provides valuable insights for future clinical diagnosis and treatment of glaucoma.

关键词： single-cell transcriptomic atlas macaque trabecular meshwork ocular outflow tissue aging

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超声生物显微镜暗室激发试验

中华眼科杂志 1998年第3期34卷 183-186,I012页

作者：王宁利赖铭莹陈秀琦叶天才中山医科大学中山眼科中心

目的比较超声生物显微镜（ｕｌｔｒａｓｏｕｎｄｂｉｏｍｉｃｒｏｓｃｏｐｙ，ＵＢＭ）暗室激发试验与传统暗室激发试验在闭角型青光眼筛选中的应用价值。方法选择２２例（２２只眼）先兆期闭角型青光眼作为患者组，１５例（３０只眼）... 详细信息

目的比较超声生物显微镜（ｕｌｔｒａｓｏｕｎｄｂｉｏｍｉｃｒｏｓｃｏｐｙ，ＵＢＭ）暗室激发试验与传统暗室激发试验在闭角型青光眼筛选中的应用价值。方法选择２２例（２２只眼）先兆期闭角型青光眼作为患者组，１５例（３０只眼）深前房正常者作为对照组，分别进行传统暗室试验和ＵＢＭ暗室试验。比较两种暗室试验前后房角的变化与眼压差，采用统计学χ２检验比较两者的阳性率。结果两种暗室试验结果显示，闭角型青光眼组２２只眼中，１０只眼试验前后眼压差＞１．０７ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ），１２只眼试验前后眼压差＜１．０７ｋＰａ或无变化。ＵＢＭ暗室试验发现，１５只眼出现房角功能关闭，其中３只眼１个象限关闭，５只眼２个象限关闭，７只眼超过２个象限关闭。传统暗室试验结合Ｇｏｌｄｍａｎｎ房角镜检查发现８只眼房角关闭；其中３只眼２个象限关闭，５只眼２个以上象限关闭。对照组３只眼试验前后眼压差＞１．０７ｋＰａ，ＵＢＭ及Ｇｏｌｄｍａｎｎ房角镜检查均未发现房角功能关闭。以两种暗室试验下诱发的房角关闭为判断标准，ＵＢＭ暗室试验诊断的敏感性为６８．２％，特异性为１００．０％；传统暗室试验的阳性率为３１．８％，两者间敏感性差异有显著性。结论研究结果?

关键词：暗室激发试验超声生物显微镜诊断青光眼.闭角型

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原发性先天性青光眼眼前段活体结构观察

眼科学报 1998年第2期14卷 83-86页

作者：王宁利欧阳洁中山医科大学中山眼科中心广州510060

目的:观察先天性青光眼的超声生物显微镜(UBM)图像特征并探讨先天性青光眼的发病机制。方法:采用高频、高分辨率的超声生物显微镜对6例先天性青光眼患者10只眼的房角、虹膜、睫状体等进行扫描和分析,并与7例正常人或无相关疾病患者的7... 详细信息

目的:观察先天性青光眼的超声生物显微镜(UBM)图像特征并探讨先天性青光眼的发病机制。方法:采用高频、高分辨率的超声生物显微镜对6例先天性青光眼患者10只眼的房角、虹膜、睫状体等进行扫描和分析,并与7例正常人或无相关疾病患者的7只眼进行比较。结果:超声生物显微镜检查显示出原发性先天性青光眼的房角、虹膜、睫状体及巩膜突发育不良,虹膜基质薄,睫状体细小,巩膜突解剖特征不明显。原发性先天性青光眼组的虹膜厚度及睫状体大小的测量和统计学比较均明显小于正常对照组。结论:超声生物显微镜可以观察到常规眼科检查观察不到的部位,如睫状体、房角隐窝、虹膜后表面等等。原发性先天性青光眼具有虹膜基质薄、睫状体细小、巩膜突解剖特征不明显等特征,提示原发性先天性青光眼除了房角发育异常外,尚合并存在虹膜、睫状体巩膜突发育不良。其中虹膜、睫状体发育不良可能是先天性青光眼相对比较重要的发病机制。眼科学报1998;14:83—86。

关键词： UBM 先天性青光眼病理青光眼活体结构

Discovery of a normal-tension glaucoma-suspect rhesus macaque with craniocerebral injury:Hints of elevated translaminar cribrosa pressure difference

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Chinese medical Journal 2024年第4期137卷 484-486页

作者： Jian Wu Qi Zhang Xu Jia Yingting Zhu Zhidong Li Shu Tu Ling Zhao Yifan Du Wei Liu Jiaoyan Ren Liangzhi Xu Hanxiang Yu Fagao Luo Wenru Su ningli wang Yehong Zhuo State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceSun Yat-sen UniversityGuangzhouGuangdong 510060China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing 100730China School of Food sciences and Engineering South China University of TechnologyGuangzhouGuangdong 510641China guangzhou Huazhen Biosciences GuangzhouGuangdong 510920China

To the Editor:Normal-tension glaucoma(NTG)is a progressive optic neuropathy characterized by irreversible blindness with statistically normal intraocular pressure(IOP)(≤2. mmHg),^([1,2.)which makes early-stage diagnosis in the clinical practice *** pathways underlying NTG include vascular dysregulation,toxic metabolite accumulation,and elevated translaminar cribrosa pressure difference(TLCPD).^([3])Although various small animal models have provided evidence of different pathophysiological mechanisms,the complicated clinical phenotype cannot be fully imitated by secondary disease models,and the gap between rodents and humans weakens their translational ***,the pathological changes associated with NTG remain unclear.

关键词： elevated glaucoma diagnosis