An Experimental Study on Homoharringtonine Liposome and Glaucoma Filtration Surgery

作     者：Dawei Peng, Kerning Yu, Shujun Zeng, Yongping Li Jianxian Lin, Yuping Wu, Wenbing ZhouZhongshan Ophthalmic Center , Sun Yat-sen University of Medical Sciences , Guangzhou 510060 , China Department of Pharmacology, Sun Yat-sen University of Medical Sciences , Guangzhou 510089, China 

作者机构：Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China 

出 版 物：《眼科学报》 (Eye Science)

年 卷 期：1999年第15卷第1期

页      面：51-54,50页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：Supported by grants from the National Health Ministry(0557309) 

主　　题：滤光手术 青光眼 脂质体 

摘      要：Purpose: To observe the inhibitory action of homoharringtonine liposome during the healing process of wounds in the filtering sitesMethods: posterior sclerectomies were performed in 14 rabbits. Postoperatively one eye of each rabbit received subconjunctival injections of HH liposome and fellow eye received saline injection in a randomized masked ***; Fourteen days after operation the IOP of experimental eyes reduced significantly (P 0.01) as compared with the controlled eyes, and the number of remaining filtering blebs increased noticeably (P 0.05). Pathohistological examination revealed that the number of fibroblasts per square micron in the filtering sites and the thickness of the scars in the center of the filtering sites of the experimental eyes were less than those of the controlled eyes. No serious ocular toxic and side effects were *** : This experiment suggests that homoharringtonine liposome can markedly inhibit the scar formation of filtering sites after glaucoma