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Long-term Efficacy of Trabeculectomy on Chinese Patients with Pigmentary Glaucoma： A Prospective Case Series Observational Study

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Chinese Medical Journal 2016年第11期129卷 1268-1272页

作者： Guo-Ping Qing ning-li wang Tao wang Hong Chen Da-Peng Mou Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing 100730 China

Background： Though trabeculectomy is often performed on patients with medically refractive pigmentary glaucoma （PG）, the clinical outcomes of surgical treatment on PG remain unknown. The aim of this study was to summarize the long-term efficacy and safety of trabeculectomy on PG. Methods： This was a prospective case series observational study. Eighteen consecutive PG patients were followed up for 8 years after trabeculectomy from May 2006 to April 2007. Visual acuity （VA）, best-corrected visual acuity （BCVA）, slit lamp biomicroscopy, intraocular pressure （lOP） measurement, Humphrey visual field analysis （VFA）, and stereoscopic funduscopy were performed on admission and every 6 months after the surgery. Postoperative lOP, VA, BCVA, VFA, adjunctive anti-glaucoma medication, treatment-related side-effects, changes in blebs, and main clinical findings in the anterior segment of PG were recorded and compared with the baseline. Results： Eighteen PG eyes from 18 patients, with average preoperative IOP of 34.5±4.7 mmHg （range： 21 47 mmHg, 1 mmHg=0.133 kPa） were enrolled in this study. All enrolled patients completed the follow-up visits and required examinations. Eight years after trabeculectomy, all surgical eyes （18/18） had satisfactory IOP control with an average of 13.7 -~ 2.5 mmHg （range： 9-19 mmHg）, which was significantly lower than baseline （P - 0.001 ）. Majority （15/18） of the PG eyes had stable VA, BCVA, VFA, and optic disc cupping parameters. Functional blebs still existed in 12/18 of the PG eyes at the last follow-up visit. Unanimously, pigmentation in the anterior segment attenuated with time after surgical treatment. No severe side-effects were recorded in any of the surgical eyes. Conclusions： All surgical PG eyes in this study had satisfactory lOP control 8 years after the surgery with well-preserved visual function. The long-term efficacy and safety of trabeculectomy are promising in PG patients.

关键词： Pigment Dispersion Syndrome Pigmentary Glaucoma Trabeculectomy

Neuronal changes in the retinal ganglion cell layer following recombinant human interleukin-2 intravitreal injection in a rat model of chronically elevated intraocular pressure

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Neural Regeneration Research 2010年第24期5卷 1888-1894页

作者： ning li Jing wang Xuan Zou Juanlian Cui Xuanchu Duan Department of Ophthalmology Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

Intraperitoneal injection of recombinant human interleukin-2（rhIL-2）inhibits neuronal apoptosis in the chronic ocular hypertension retinal ganglion cell *** injection was performed on retinal ganglion cells in a Wistar rat model of chronically elevated intraocular pressure to observe the effects of LY294002 and AG490 on retinal ganglion cell survival,macrophage activation,and PI3K/Akt and JAK/STAT *** number of retinal ganglion cells in the rhIL-2 treatment group was much greater than in the normal control and phosphate-buffered saline *** blot analysis revealed low Akt and STAT3 protein expression in the retina after 3-hour intravitreous injections of ***,protein expression was increased at 12 hours,but decreased again at 24 hours,with very low expression at 96 ***294002 and AG490,which are inhibitors of the PI3K/Akt and JAK/STAT3 signal pathways,prevented upregulation of Akt and STAT3 protein expression in the retina,*** injection of rhIL-2 exhibited neuroprotective effects by decreasing retinal ganglion cell layer damage in a rat model of chronic *** results suggest that intravitreal injection of rhIL-2 could induce the PI3K/Akt and JAK/STAT3 signaling pathways to protect retinal ganglion cells in chronically elevated intraocular pressure models.

关键词： glaucoma neuroprotection signal pathway recombinant human interleukin-2 retinal ganglion cells

Effects of sleep deprivation on gamma oscillation of waking human EEG

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Progress in Natural Science:Materials International 2008年第12期18卷 1533-1537页

作者： ning li~a Yan wang~a Mingshi wang~a Haiying liu~(a,b) a College of Precision Instrument and Opto-Electronics Engineering,Tianjin University,Tianjin 300072,China b Department of Radiology University of Minnesota,Minneapolis,MN 55455,USA [a]College of Precision Instrument and Opto-Electronics Engineering Tianjin University Tianjin 300072 China [b]Department of Radiology University of Minnesota Minneapolis MN 55455 USA

This study compares and evaluates the effect of sleep deprivation (SD) on human brain cognition by analyzing the recorded EEG data under normal and 24 h sleep deprived *** auditory event-related potentials were collected from 14 healthy volunteers,and the statistical values of wavelet-transformed EEG in gamma band were decomposed by parallel factor analysis (PARAFAC) to identify where the differences appeared in the time,frequency and spatial *** results showed that the changes of brain states caused by SD appeared around 40 Hz at about 400 ms after stimulation on prefrontal and frontal *** effects of SD on neuronal activity and oscillation were *** analysis of the EEG data by the wavelet transform and PARAFAC can be an integrated way to estimate the change of brain states in the three domains.

关键词： Gamma oscillation Sleep deprivation Event-related potential Wavelet transform Parallel factor Neuronal activity

Assessment on Dietary Melamine Exposure from Tainted Infant Formula

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Biomedical and Environmental Sciences 2009年第2期22卷 100-103页

作者： XU-DONG JIA ning li ZHU-TIAN wang YUN-FENG ZHAO YONG-ning WU AND WEI-XING YAN Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To estimate the dietary melamine exposure in Chinese infants and young children from the consumption of melamine adulterated Sanlu infant formula. Methods Four age groups of infants and young children （3, 6, 12, and 24 months） were chosen as the assessed subjects and the maximum amount of infant formula consumption was estimated based on the recommended usage level in the package insert of Sanlu infant formula and other brands. Melamine was analyzed in 111 Sanlu infant fbrmula samples collected from the markets in Beijing and Gansu province using the LC-MS-MS with a limit of quantification of 0.05 mg/kg. Four levels of melamine concentration were chosen to estimate the dietary intakes, including the mean, median, 90th percentile, and maximum. Results The infants of 3 months had the highest intake of melamine, and with the increase of the age （inonth）, the intake decreased. Based on the median melamine concentration （1 000 mg/kg） as an example, the melamine intakes fur the infants of 3, 6, 12, and 24 months were 23.4, 21.4, 15.0, and 8.6 mg/kg bw/d, respectively. Conclusion Dietary melamine intakes from tainted Sanln infant formula significantly exceeded the TDI level （0.2 mg/kg bw/d） recommended by the WHO Expert Meeting in 2008. However, the present assessment has some limitations including the poor representative samples, the varied melamine concentrations in the adulterated Sanlu infant formula, and other brand infant formula possibly consumed by these infants.

关键词： Dietary exposure assessment Melamine Infant formula

Pd/Sulfated Alumina: a Novel Catalyst for Selective Catalytic Reduction of NO with Methane

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催化学报 2003年第11期24卷 809-810页

作者： li ning, wang Aiqin, ZHENG Mingyuan, wang Xiaodong, ZHANG Tao (Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 11 6023, liaoning, China) Dalian Institute of Chemical Physics The Chinese Academy of Sciences 辽宁 Dalian 116023

Recently, much attention has been directed to the selective catalytic reduction (SCR) of NO with methane as reductant. Pd-based catalysts have been found to be active for the reactions. However, the performance of the Pd-based catalysts for this reaction depends strongly on the nature of the supports. So far, only acidic zeolites and acidic zirconia have been shown to be the effective supports for the Pd-based catalysts. In contrast, Pd/γ-Al_2O_3, which is one of the most widely used three-way catalysts at present, exhibits very low activity in the SCR of NO with methane. In this work, the SCR of NO with methane was carried out over a series of Pd-loaded sulfated alumina (SA) catalyst samples, and the effect of Pd content on the performance of the catalyst was investigated.

关键词： Pd /Al2(S04)3 钯硫酸铝催化剂选择性催化还原 NO 甲烷 CH4 一氧化氮

The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing ning Shi Lv Qian wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

Safety and Efficiency of Trabectome-mediated Trabecular Meshwork Ablation for Chinese Glaucoma Patients： A Two-year, Retrospective, Multicentre Study

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Chinese Medical Journal 2018年第4期131卷 420-425页

作者： Ya-Long Dang Yu-Jie Cen Ying Hong Ping Huang ning-li wang Chao wang Chun Zhang Department of Ophthalmology Peking University Third Hospital Beijing 100191 China Department of Ophthalmology Beijing Tongren Hospital Capital Medical Univerty Beijing 100005 China Department of Ophthalmology University of Pittsburgh Pittsburgh Pennsylvania 15213 USA

Background： The aim of the study was to evaluate the long-term safety and efficacy of the Trabectome for Chinese glaucoma patients. Methods： This was a multicenter, retrospective, observational study. Glaucoma patients, except those with neovascular glaucoma, with/without a visually significant cataract were enrolled. The patients received Trabectome or a combined surgery with phacoemulsification and intraocular lens implantation. The primary outcome evaluation was a reduction in intraocular pressure （IOP）, and the secondary outcomes were a reduction in glaucoma medication, the 2-year success percentages, and complications. Success was defined as an IOP 〈21 mmHg and at least a 20% IOP reduction from baseline after 3 months for any two consecutive visits, without additional glaucoma surgery. The data were processed using the R Stats Package version 3.0.0. The Wilcoxon test was used to compare the postoperative IOP and the number of glaucoma medications with baselines. The Kaplan–Meier test was used to calculate the 2-year success percentage. The risk factors related to Trabectome failure were determined by logistic regression. Results： A total of 120 glaucoma patients were enrolled. The Trabectome efficiently reduced the IOP from a baseline of 22.8 ± 1.34 mmHg to 17.6 ± 0.96 mmHg, and the use of glaucoma medications from 2.2 ± 0.17 mmHg to 1.4 ± 0.21 in a 2-year follow-up （both, P 〈 0.01）. The overall success percentage was 80%. No risk factor related to Trabectome failure was identified. No vision-threatening complication was observed. Ten patients, who required secondary glaucoma surgery, all reached the target IOP. Conclusions： In a 2-year follow-up, Trabectome was an efficient and safe procedure for Chinese glaucoma patients.

关键词： Glaucoma Intraocular Pressure Minimally Invasive Surgical Procedures Trabecular Meshwork

Reduction on OFF-responses of Electroretinogram in Monkeys with Long-term High Intraocular Pressure

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Chinese Medical Journal 2017年第22期130卷 2713-2719页

作者： Ke-Gao liu Xiao-Yan Peng Zheng Zhang Hua Sun Di-Ya Yang ning-li wang Department of Ophthalmology Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key Lab Beijing Tongren Hospital Capital Medical University Beijing 100730 China Beijing Tongren Eye Center Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Background： There are ON- and OFF-pathways in the normal vertebrate retina. Short- and long-flash electroretinogram （ERG） are suitable methods to observe the function of ON- and OFF-pathways in vivo, respectively. It is clear that high intraocular pressure （IOP） might cause dysfunction of cone-dominated photopic negative response （PhNR） in monkeys with high lOP in ON-pathway. However, whether cone-dominated OFF-responses are also affected is less known. The aim of this study was to observe photopic OFF-responses of ERG in monkeys with high lOP. Methods： Nine monkeys were involved in the experiment from January 2006 to December 2016. High IOP was induced in the right eye by laser coagulation of the mid-trabecular meshwork in five monkeys. Six years after the laser coagulation, both short- and long-flash of the photopic ERG were recorded. Stimulus light was red flashes superimposed on a blue background. Four normal monkeys were examined under the same ERG protocols as controls. Paired t-test was used to compare the difference of each ERG parameter between the lasered eye and the fellow eye. Analysis of variance （ANOVA） with Tukey adjustment was adopted to calculate the differences among the lasered eye, the fellow eye, and the eyes of normal monkeys. Results： The mean amplitude of a-wave （11.73 ± 2.05） and PhNR （8.67 ± 2.44） in lasered eyes was significantly lower than that of a-wave （21.47 ±3.15） and PhNR （22.05 ± 3.42） in fellow eyes （P = 0.03 and P 0.01, respectively） in response to short flash. The mean amplitude old-wave （ 1.60 ± 0.59） and/-wave （3.13± 0.64） was significantly reduced in the lasered eyes than that of d-wave （4.01 ± 0.56） and/-wave （8.79 ± 1.75） in the fellow eyes （P =0.02 and P = 0.02, respectively） in response to long flash. Conclusions： Reduced OFF-responses are recorded in monkeys with high IOP when dysfunction ofphotoreceptor is involved. The reduced OFF-responses to long-flash stimulus show evidence of anomalous retinal circuitry in glaucomat

关键词： Electroretinogram OFF-responses Monkey liatraocular Pressure Retinal Pathway

Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells

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Neural Regeneration Research 2015年第12期10卷 1976-1981页

作者： Hua wang Benson Wui-Man Lau ning-li wang Si-ying wang Qing-jun Lu Raymond Chuen-Chung Chang Kwok-fai So Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical University Beijing Ophthalmology & Visual Sciences Key Laboratory Department of Rehabilitation Science The Hong Kong Polytechnic University Department of Anatomy Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulam The State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong Research Centre of Heart BrainHormone and Healthy AgingFaculty of MedicineThe University of Hong Kong Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulam GMH Institute of Central Nervous System Regeneration Jinan University

Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic ***,it remains unclear regarding the effects of Lycium barbarum polysaccharides,the main component of Lycium barbarum,on in vivo proliferation of adult ciliary body *** this study,adult rats were intragastrically administered low-and high-dose Lycium barbarum polysaccharides（1 and 10 mg/kg）for 35 days and those intragastrically administered phosphate buffered saline served as *** number of Ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups,in particular low-dose Lycium barbarum polysaccharides group,was significantly greater than that in the phosphate buffered saline ***-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic *** findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype.

关键词： nerve regeneration traditional Chinese medicine Lycium barbarum polysaccharides Lycium barbarum (wolJberry) retinal disease neurogenesis adult neural regeneration