Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells

作     者：Hua Wang Benson Wui-Man Lau Ning-li Wang Si-ying Wang Qing-jun Lu Raymond Chuen-Chung Chang Kwok-fai So 

作者机构：Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical University Beijing Ophthalmology & Visual Sciences Key Laboratory Department of Rehabilitation ScienceThe Hong Kong Polytechnic University Department of AnatomyLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulam The State Key Laboratory of Brain and Cognitive SciencesThe University of Hong Kong Research Centre of HeartBrainHormone and Healthy AgingFaculty of MedicineThe University of Hong Kong Department of OphthalmologyLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulam GMH Institute of Central Nervous System RegenerationJinan University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第12期

页      面：1976-1981页

核心收录：

学科分类：0710[理学-生物学] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

主　　题：nerve regeneration traditional Chinese medicine Lycium barbarum polysaccharides Lycium barbarum (wolJberry) retinal disease neurogenesis adult neural regeneration 

摘      要：Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic ***,it remains unclear regarding the effects of Lycium barbarum polysaccharides,the main component of Lycium barbarum,on in vivo proliferation of adult ciliary body *** this study,adult rats were intragastrically administered low-and high-dose Lycium barbarum polysaccharides（1 and 10 mg/kg）for 35 days and those intragastrically administered phosphate buffered saline served as *** number of Ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups,in particular low-dose Lycium barbarum polysaccharides group,was significantly greater than that in the phosphate buffered saline ***-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic *** findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype.