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Diagnosis and management of autoimmune pancreatitis:Experience from China

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World Journal of Gastroenterology 2008年第4期14卷 601-606页

作者： Yang Song Quan-Da Liu ning-xin zhou Wen-Zhi Zhang Dian-Jun Wang Emergency Department Chinese PLA GeneralHospital 28^th Fuxing Road Beijing 100853 China Institute of Hepatobiliary Surgery Chinese'PLA General Hospital Beijing100853 China Department of Pathology Chinese PLA GeneralHospital Beijing 100853 China

AIM： To determine the clinical, radiographic and pathologic characteristics, diagnostic and treatment modalities in patients with autoimmune pancreatitis （AIP）. METHODS： In this retrospective study, the data of patients with diagnosed chronic pancreatitis （CP） between 1995 and 2006 in Chinese PLA General Hospital were included to screen for the cases with AIP, according to the following diagnostic criteria：（1） diagnostic histopathologic features, and abound IgG4-positive plasma cells on pancreatic tissues; （2） characteristic imaging on computed tomography and pancreatography, together with increased serum IgG, y-globulin levels or presence of autoantibodies; （3） response to steroid therapy. The clinical, radiographic and pathologic characteristics, diagnostic and treatment modalities, and outcome of AIP cases were reviewed. RESULTS： Twenty-five （22 male, 3 female; mean age 54 years, 36-76 years） out of 510 CP patients were diagnosed as AIP, which accounted for 49% （21/43） of CP population undergoing surgical treatment in the same period. The main clinical manifestations included intermittent or progressive jaundice in 18 cases （72%）, abdominal pain in 11 （44%）, weight loss in 10 （40%）, and 3 cases had no symptoms. The imaging features consisted of pancreatic enlargement, especially in the head of pancreas （18 cases）, strictures of main pancreatic duct and intrapancreatic bile duct. Massive lymphocytes and plasma cells infiltration in pancreatic tissues were showed on pathology, as well as parenchymal fibrosis. Twenty-three patients were misdiagnosed as pancreaticobiliary malignancy, and 21 patients underwent exploratory laparotomy, theremaining 4 patients dramatically responded to steroid therapy. No pancreatic cancer occurred during a mean 46-mo follow-up period. CONCLUSION： AIP patients always are subjected to mistaken diagnosis of pancreatic cancer and an unnecessary surgical exploration, due to its similarity in clinical features with pancreatic cancer. The dif

关键词： Autoimmune pancreatitis Pancreatic neoplasms Differential diagnosis Steroid therapy

hFXYD6反义核酸对胆管癌细胞体外增殖和侵袭能力的影响

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世界华人消化杂志 2007年第9期15卷 929-935页

作者：窦春青岳鑫周宁新中国人民解放军总医院全军肝胆外科研究所北京市100853 北京大学神经科学研究所北京市100083

目的:研究hFXYD6基因反义核酸对人胆管癌QBC939细胞体外增殖和侵袭能力的影响.方法:构建hFXYD6基因反义核酸真核表达载体pcDNA3.1(-)/hFXYD6(-)并转染人胆管癌QBC939细胞,同时设pcDNA3.1(-)空载体对照组和空白对照组.SYBR GreenⅠ荧光定... 详细信息

目的:研究hFXYD6基因反义核酸对人胆管癌QBC939细胞体外增殖和侵袭能力的影响.方法:构建hFXYD6基因反义核酸真核表达载体pcDNA3.1(-)/hFXYD6(-)并转染人胆管癌QBC939细胞,同时设pcDNA3.1(-)空载体对照组和空白对照组.SYBR GreenⅠ荧光定量RT- PCR和免疫组化分别检测hFXYD6 mRNA及蛋白表达;MTT、平板克隆形成实验检测细胞体外增殖活性:流式细胞仪检测细胞周期;Transwell侵袭小室模型检测细胞体外侵袭能力.结果:与空白组和空载组比较,反义组细胞hFXYD6 mRNA及蛋白表达量降低;细胞群体倍增时间增加(46.8 h vs 34.5 h,35.3 h),细胞克隆形成率降低(24.3%±5.3% vs 61.0%±8.5%,58.0%±5.6%,P<0.001);细胞周期中G1期细胞比例明显升高(66.4%±2.9% vs 33.5%±2.3%,39.4%±3.7%,P<0.001),S期比例明显减少(18.6%±1.6% vs 36.2%±2.1%,34.1%±1.6%,P<0.001);Transwell侵袭小室中24 h穿膜细胞数无显著改变.空白组和空载组细胞间均无明显差异.结论:hFXYD6反义核酸抑制人胆管癌QBC939细胞体外增殖能力,但对其侵袭能力无明显作用.

关键词： FXYD6 反义核酸胆管癌增殖侵袭荧光定量RT—PCR 免疫组化流式细胞术

A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei Kang zhou xin Huang xing zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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腹腔镜超声在肝癌射频消融治疗中的临床应用

世界华人消化杂志 2009年第2期17卷 205-208页

作者：王峰牟培源周宁新周丁华白媛媛中国人民解放军二炮总医院肝胆胃肠病研究所北京市100088

目的:探讨腹腔镜超声技术在肝癌射频消融(radiofrequency ablation,RFA)治疗中的临床应用.方法:2007-09/2008-04我院对15例肝癌患者的20个肝内肿瘤实施了腹腔镜超声引导下RFA治疗,肿瘤直径2.5-7.3(平均4.5)***(+)10例,HCV(+)1例,合并有... 详细信息

目的:探讨腹腔镜超声技术在肝癌射频消融(radiofrequency ablation,RFA)治疗中的临床应用.方法:2007-09/2008-04我院对15例肝癌患者的20个肝内肿瘤实施了腹腔镜超声引导下RFA治疗,肿瘤直径2.5-7.3(平均4.5)***(+)10例,HCV(+)1例,合并有不同程度肝硬化11例,胆囊结石9例.其中1个癌灶12例,2个癌灶1例,3个癌灶2例.术后采用超声检查及螺旋CT增强扫描评价RFA疗效.结果:12例顺利完成腹腔镜下射频消融治疗,其中8例同时行胆囊切除术,单个肿瘤平均射频治疗时间40.2±12.3min,平均总手术时间98.7±28.5min,平均总出血量145.3±82.8mL.患者术中、后均未出现严重并发症.术后随访4-12mo,4例射频治疗部位复发,1例发现肝内新病灶,均采用经皮射频消融进行治疗.其中有2例患者第3次定期复查时,CT诊断原发性肝癌复发,外科医生建议行肝移植术,其余13例随访至今均存活.结论:在RFA治疗肝癌过程中,腹腔镜超声引导技术已成为协助外科医生顺利完成手术必不可少的手段之一.

关键词：肝脏腹腔镜超声射频消融肝癌

腹腔镜超声和经皮超声在肝癌射频消融治疗中的联合应用

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世界华人消化杂志 2009年第7期17卷 720-723页

作者：王峰牟培源周宁新周丁华白媛媛辽宁医学院院外硕士培养点中国人民解放军北京二炮总医院北京市100088 中国人民解放军二炮总医院全军肝胆胃肠病医学专科中心北京市100088

目的:探讨腹腔镜超声和经皮超声在肝癌射频消融治疗中的联合应用.方法:2007-09/2008-11我院对25例肝癌患者的43个肝内肿瘤在腹腔镜超声和经皮超声引导下行射频消融治疗.肿瘤直径2.7-7.5(平均3.8)cm.本组中,HBV(+)14例,HCV(+)2例,合并有... 详细信息

目的:探讨腹腔镜超声和经皮超声在肝癌射频消融治疗中的联合应用.方法:2007-09/2008-11我院对25例肝癌患者的43个肝内肿瘤在腹腔镜超声和经皮超声引导下行射频消融治疗.肿瘤直径2.7-7.5(平均3.8)cm.本组中,HBV(+)14例,HCV(+)2例,合并有不同程度肝硬化16例,胆囊结石13例.其中1个癌灶14例,2个癌灶3例,3个癌灶4例,4例多发.术后采用超声检查及螺旋CT增强扫描评价RFA疗效.结果:25例患者顺利完成腹腔镜超声引导下射频消融治疗,有4例射频治疗部位复发和3例肝内新发病灶又采取经皮超声引导下射频消融治疗.全部病例中,11例同时行胆囊切除术,在腹腔镜超声引导下,单个肿瘤平均射频治疗时间为39.3±12.1min,平均总手术时间95.5±25.8min,平均总出血量148.5±84.3mL.在经皮超声引导下,单个肿瘤平均射频治疗时间28.3±10.3min,平均总手术时间50.2±11.5min,治疗后超声检查肝周、腹腔未见明确积液.患者术中、后均未出现严重并发症.术后随访,有3例CT提示原发性肝癌复发,外科医生建议行肝移植,其余22例随访至2008-11均存活.结论:腹腔镜超声和经皮超声在肝癌射频消融治疗中的联合应用,使患者的远期疗效比较满意.

关键词：肝脏腹腔镜超声经皮超声射频消融肝癌

腹腔镜超声在机器人辅助腹部肿瘤微创治疗中的应用

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世界华人消化杂志 2016年第12期24卷 1926-1930页

作者：高楠牟培源白媛媛周宁新辽宁医学院研究生院辽宁省锦州市121001 中国人民解放军火箭军总医院全军肝胆胃肠病专科中心北京市100088

目的:探讨腹腔镜超声在机器人辅助腹部肿瘤微创治疗中的临床应用.方法:对41例患者(肝门部胆管癌16例,肝占位15例,胰腺占位9例,腹膜后占位1例)行腹腔镜超声引导机器人辅助腹部肿瘤微创治疗.肿瘤治疗前经腹腔镜超声全面探查肿瘤精确部位... 详细信息

目的:探讨腹腔镜超声在机器人辅助腹部肿瘤微创治疗中的临床应用.方法:对41例患者(肝门部胆管癌16例,肝占位15例,胰腺占位9例,腹膜后占位1例)行腹腔镜超声引导机器人辅助腹部肿瘤微创治疗.肿瘤治疗前经腹腔镜超声全面探查肿瘤精确部位、数量及其与邻近组织关系,术中实时引导肿瘤治疗路径,治疗后即刻经腹腔镜超声初步评价疗效.术后用超声、增强CT/MRI及血生化等进行临床疗效评价.结果:41例患者在腹腔镜超声引导下均成功完成机器人辅助腹部肿瘤微创治疗,手术成功率100%.其中10例患者在腹腔镜超声扫查下发现术前未预期病情,改变原手术方式,手术方式纠正率24.39%(10/41).围手术期无死亡病例,术后超声、增强CT/MRI均未见异常改变,生化指标趋于正常,术中及术后均未见严重并发症,患者生活质量改善,生存状况满意.结论:腹腔镜超声在机器人辅助腹部肿瘤微创治疗中不仅可引导手术方式选择,而且有助于提高术中安全性、减少术后并发症并延长无瘤生存时间,从而更利于提高机器人微创手术的临床疗效.

关键词：腹腔镜超声机器人微创肿瘤

Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： Song Jiang Congwen Zhu ning Jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen xin-ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia zhou Bo Ma Yan Luan xin Wang xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells