检索结果-南通市图书馆

Downregulation of miR-4772-3p promotes enhanced regulatory T cell capacity in malignant pleural effusion by elevating Helios levels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2019年第22期132卷 2705-2715页

作者： Wen-Qing Yu ning-fei ji Cheng-jing Gu Zhi-Xiao Sun Zheng-Xia Wang Zhong-Qi Chen Yuan Ma Zhen-Zhen Wu Yan-Li Wang Chao-jie Wu Ming-Dong Ding Gui-Hong Dai Juan Yao Rong-Rong jin Mao Huang Ming-Shun Zhang Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Infectious Diseases Taizhou People's Hospital Affiliated to Nantong UniversityTaizhouJiangsu 225300China Department of Pharmacy Taizhou People's Hospital Affiliated to Nantong UniversityTaizhouJiangsu 225300China Department of Pathology Taizhou People's Hospital Affiliated to Nantong UniversityTaizhouJiangsu 225300China Department of Oncology Taizhou People's Hospital Affiliated to Nantong UniversityTaizhouJiangsu 225300China Department of Immunology Nanjing Medical UniversityNanjingJiangsu 210029China

Background:Malignant pleural effusion(MPE)is a complicated condition of patients with advanced *** dissecting the microenvironment of infiltrated immune cells and malignant cells are warranted to understand the immune-evasion mechanisms of tumor development and ***:The possible involvement of microRNAs(miRNAs)in malignant pleural fluid was investigated using small RNA *** T cell(Treg)markers(CD4,CD25,forkhead box P3),and Helios(also known as IKAROS Family Zinc Finger 2[IKZF2])were detected using flow *** expression levels of IKZF2 and miR-4772-3p were measured using quantitative real-time reverse transcription polymerase chain *** interaction between miR-4772-3p and Helios was determined using dual-luciferase reporter *** effects of miR-4772-3p on Helios expression were evaluated using an in vitro *** assays between miR-4772-3p and functional molecules of Tregs were ***:Compared with non-malignant controls,patients with non-small cell lung cancer had an increased Tregs frequency with Helios expression in the MPE and peripheral blood mononuclear *** verified downregulation of miR-4772-3p was inversely related to the Helios*Tregs frequency and Helios expression in the *** of miR-4772-3p could inhib让Helios expression in in vitro ***,ectopic expression of Helios in induced Tregs reversed the effects induced by miR-4772-3p ***,miR-4772-3p could regulate Helios expression by directly targeting IKZF2 ***:Downregulation of miR-4772-3p,by targeting Helios,contributes to enhanced Tregs activities in the MPE microenvironment.

关键词： Helios IKAROS family zinc finger 2 Lung cancer Malignant pleural effusion MiR-4772-3p Regulatory T cells

Occluded Gait Emotion Recognition Based on Multi-Scale Suppression Graph Convolutional Network

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 1255-1276页

作者： Yuxiang Zou ning He jiwu Sun Xunrui Huang Wenhua Wang Beijing Key Laboratory of Information Service Engineering Beijing Union UniversityBeijing100101China College of Smart City Beijing Union UniversityBeijing100101China

In recent years,gait-based emotion recognition has been widely applied in the field of computer ***,existing gait emotion recognition methods typically rely on complete human skeleton data,and their accuracy significantly declines when the data is *** enhance the accuracy of gait emotion recognition under occlusion,this paper proposes a Multi-scale Suppression Graph ConvolutionalNetwork(MS-GCN).TheMS-GCN consists of three main components:Joint Interpolation Module(ji Moudle),Multi-scale Temporal Convolution Network(MS-TCN),and Suppression Graph Convolutional Network(SGCN).The ji Module completes the spatially occluded skeletal joints using the(K-Nearest Neighbors)KNN interpolation *** MS-TCN employs convolutional kernels of various sizes to comprehensively capture the emotional information embedded in the gait,compensating for the temporal occlusion of gait *** SGCN extracts more non-prominent human gait features by suppressing the extraction of key body part features,thereby reducing the negative impact of occlusion on emotion recognition *** proposed method is evaluated on two comprehensive datasets:Emotion-Gait,containing 4227 real gaits from sources like BML,ICT-Pollick,and ELMD,and 1000 synthetic gaits generated using STEP-Gen technology,and ELMB,consisting of 3924 gaits,with 1835 labeled with emotions such as“Happy,”“Sad,”“Angry,”and“Neutral.”On the standard datasets Emotion-Gait and ELMB,the proposed method achieved accuracies of 0.900 and 0.896,respectively,attaining performance comparable to other ***,on occlusion datasets,the proposedmethod significantly mitigates the performance degradation caused by occlusion compared to other methods,the accuracy is significantly higher than that of other methods.

关键词： KNN interpolation multi-scale temporal convolution suppression graph convolutional network gait emotion recognition human skeleton

芍药苷对血管紧张素Ⅱ诱导心肌成纤维细胞纤维化的保护作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第25期29卷 5382-5389页

作者：纪雅琼宁忠平上海中医药大学上海市201203 上海健康医学院附属周浦医院心血管内科上海市201318

背景:研究表明芍药苷对肝、肾等器官纤维化具有改善作用,尤其是在肝纤维化中表现出突出优势,但芍药苷对于血管紧张素Ⅱ诱导的心肌纤维化的保护作用尚不明确。目的:探讨芍药苷对血管紧张素Ⅱ诱导的心肌成纤维细胞的保护作用及分子机制。... 详细信息

背景:研究表明芍药苷对肝、肾等器官纤维化具有改善作用,尤其是在肝纤维化中表现出突出优势,但芍药苷对于血管紧张素Ⅱ诱导的心肌纤维化的保护作用尚不明确。目的:探讨芍药苷对血管紧张素Ⅱ诱导的心肌成纤维细胞的保护作用及分子机制。方法:在分离培养的SD大鼠乳鼠心肌成纤维细胞中加入血管紧张素Ⅱ(1μmol/L)干预48 h作为模型组;芍药苷低、高剂量组给予不同剂量的芍药苷(50,100μmol/L)预处理2 h,再用血管紧张素Ⅱ处理48 h;SIRT1抑制剂组先用10μmol/L SIRT1抑制剂EX527处理2 h,再用100μmol/L芍药苷处理2 h,最后用血管紧张素Ⅱ处理48 h。采用CCK-8法检测细胞活力,Transwell检测细胞迁移能力,用DHA荧光探针检测细胞内活性氧水平,用试剂盒检测氧化应激标志物水平,Western blot检测纤维化相关基因的蛋白表达,qRT-PCR检测细胞外基质和纤维化相关基因的mRNA表达。结果与结论:①与对照组相比,血管紧张素Ⅱ干预后心肌成纤维细胞的增殖、迁移能力明显提高,细胞内活性氧和丙二醛水平升高,超氧化物歧化酶和过氧化氢酶活性降低,α-平滑肌肌动蛋白、Ⅰ型胶原蛋白、Ⅲ型胶原蛋白、纤维连接蛋白、结缔组织生长因子、基质金属蛋白酶9的mRNA表达增加;与模型组相比,芍药苷剂量依赖性抑制上述效应改变(P<0.01);②与模型组相比,芍药苷剂量依赖性上调SIRT1的蛋白表达(P<0.001);③与芍药苷高剂量组相比,SIRT1抑制剂组细胞迁移数量、α-平滑肌肌动蛋白、Ⅰ型胶原蛋白、Ⅲ型胶原蛋白表达水平显著增加(P<0.01)。结果表明,芍药苷可能通过上调SIRT1的表达,有效减轻了血管紧张素Ⅱ诱导的心肌成纤维细胞纤维化改变,剂量依赖性地抑制了心肌成纤维细胞氧化应激和细胞外基质沉积,对于心肌成纤维细胞纤维化具有保护作用。

关键词：芍药苷心肌成纤维细胞血管紧张素Ⅱ 细胞外基质纤维化氧化应激

MULTIPLE DIMENSION COLLABORATIVE OPERATION TECHNIQUES AND NETWORKING FOR AIR-SPACE-GROUND INTEGRATED SYSTEM:TECHNOLOGIES AND APPLICATIONS

在线全文

学校读者我要写书评

暂无评论

China Communications 2021年第9期18卷 I0003-I0004页

作者： Qinyu Zhang Xuejun Sha fei ji ning Ge Harbin Institute of Technology(Shenzhen) system of MOE China communication research center Electronic Engineering South China University of Technology Department of Electronics Engineering at Tsinghua University

Along with the swift growth of communication services,various networks have undergone multidimensional technical evolution,*** transmission speed and large bandwidth for ground cellular network,high mobility for aviation network,and wide-area coverage for satellite *** the industry demands for joint operation arise,an integrated space-air-ground collaboration network will be formed.

关键词： network SPACE aviation

Application of New Empirical Models Based on Mathematical Statistics in the Through-Flow Analysis

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2021年第6期30卷 2087-2098页

作者： fei Teng ji Lucheng School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China

The through-flow analysis is an important part in the compressor design *** this part,lots of empirical models are used to predict the compressor aerodynamic *** models are all based on the early experimental results of low-load and low-speed compressors;so,they may not be suitable for modern compressor performance *** this study,several empirical models were reviewed,and two new models to estimate the minimum blade profile loss and minimum-loss deviation angle were established using mathematical ***,the original models with poor accuracy were replaced by these two models in through-flow ***,three compressors(Rotor 67,Stage 35,and a 4-stage repeating stage)were simulated using both the original and new *** final results show that the new models have better accuracy in estimating the performance parameters than the original *** indicates that it is feasible to use mathematical statistical methods to establish the empirical models,and this method provides an idea for the improvement of other empirical models in through-flow program.

关键词： through-flow analysis empirical models blade loss deviation regression analysis

考虑场地效应的多点地震动作用下边坡永久位移分析

在线全文

学校读者我要写书评

暂无评论

岩土工程学报 2025年第1期47卷 65-75页

作者：宋健潘驭航陆朱汐姬建张飞高玉峰河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210024 河海大学土木与交通学院江苏南京210024

地震动引起的边坡土层非线性动力响应可能导致坡体不同位置的地震动加速度时程不一致,从而对整个滑动体的极限平衡状态及之后的地震累积永久位移产生影响。为了研究场地效应对边坡地震永久位移的影响,基于极限平衡条分法,通过对不同土... 详细信息

地震动引起的边坡土层非线性动力响应可能导致坡体不同位置的地震动加速度时程不一致,从而对整个滑动体的极限平衡状态及之后的地震累积永久位移产生影响。为了研究场地效应对边坡地震永久位移的影响,基于极限平衡条分法,通过对不同土条赋予不同的水平和竖向地震动时程,推导出一种考虑场地效应的圆弧和任意形状滑面的多点地震作用下边坡永久位移分析方法。通过与有限差分软件FLAC的数值模拟结果进行对比,验证了该方法能够合理考虑地震动的场地效应。通过研究不同分布形式的多点地震动及竖向地震动对边坡永久位移的影响,结果表明:场地效应引起的水平地震动放大以及多点地震动不同分布模式会导致整个滑体平均地震惯性力作用位置发生改变,从而影响地震作用下滑动体沿滑面的永久变形量,竖向地震动对边坡地震位移影响较小。将方法应用于Lexington土石坝震后变形案例分析,计算得到的坝坡地震永久位移与实际震后观测值相吻合,证明了考虑场地效应的重要性及本文方法的合理性。

关键词：地震边坡稳定性场地效应永久位移极限平衡条分法多点地震动

Flow structures of gaseous jets injected into water for underwater propulsion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2011年第4期27卷 461-472页

作者： jia-ning Tang ning-fei Wang Wei Shyy School of Aerospace Engineering Beijing Institute of Technology 100081 Beijing China Department of Aerospace Engineering University of Michigan Ann Arbor MI 48109 USA

Gaseous jets injected into water are typically found in underwater propulsion, and the flow is essentially unsteady and turbulent. Additionally, the high water-to-gas density ratio can result in complicated flow structures; hence measuring the flow structures numerically and experimentally remains a challenge. To investigate the performance of the underwater propulsion, this paper uses detailed NavierStokes flow computations to elucidate the gas-water interactions under the framework of the volume of fluid （VOF） model. Furthermore, these computations take the fluid compressibility, viscosity, and energy transfer into consideration. This paper compares the numerical results and experimental data, showing that phenomena including expansion, bulge, necking/breaking, and back-attack are highlighted in the jet process. The resulting analysis indicates that the pressure difference on the rear and front surfaces of the propul- sion system can generate an additional thrust. The strong and oscillatory thrust of the underwater propulsion system is caused by the intermittent pulses of the back pressure and the nozzle exit pressure. As a result, the total thrust in underwater propulsion is not only determined by the nozzle geometry but also by the flow structures and associated pressure distri- butions.

关键词： Gaseous jets - Underwater propulsion Highdensity ratio Gas-water interactions

T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases:A meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第10期16卷 1258-1266页

作者： Cheng, jia-fei ning, Yue-ji Zhang, Wei Lu, Zong-Hai Lin, Lin Nanjing Med Univ Dept Gastroenterol Affiliated Hosp 1 Nanjing 210029 Jiangsu Prov Peoples R China

AIM:To evaluate the association of the autophagy- related 16-like 1 (ATG16L1 ) T300A polymorphism (rs2241880) with predisposition to inflammatory bowel diseases (IBD) by means of ***: Publications addressing the relationship between rs2241880/T300A polymorphism of ATG16L1 and Crohn's disease (CD) and ulcerative colitis (UC) were selected from the MEDLINE and EMBASE data-bases. To make direct comparisons between the data collected in these studies, the individual authors were contacted when necessary to generate a standardized set of data from these studies. From these data, odds ratio (OR) with 95% confidence interval (CI) were ***: Twenty-five studies of CD were analyzed, 14 of which involved cases of UC. The variant G allele of ATG16L1 was positively associated with CD (OR=1.32, 95% CI: 1.26-1.39, P<0.00001) and UC (OR =1.06, 95% CI:1.01-1.10, P=0.02). For child-onset IBD, a higher G allele frequency was found for cases of CD (OR=1.35, 95% CI: 1.16-1.57, P=0.0001) than for cases of UC (OR = 0.98, 95% CI: 0.81-1.19, P = 0.84) relative to ***: The ATG16L1 T300A polymorphism contributes to susceptibility to CD and UC in adults, but different in children, which implicates a role for autophagy in the pathogenesis of IBD.

关键词： ATG16L1 Inflammatory bowel diseases Crohn’s disease Ulcerative colitis Meta-analysis

Guidance Laws Based on H_∞ Observer Considering Measurement Noises

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2016年第3期29卷 642-656页

作者： LIAO fei ji Haibo Department of Automation University of Science and Technology of China

Since in practice the line-of-sight(LOS)rate is difficult for a pursuer to measure accurately,the robust nonlinear H∞observer is applied to estimate it using LOS azimuths without any priori information of target maneuvers or its estimate in the presence of measurement noise.A threedimensional guidance law is implemented by replacing the LOS rate with their estimates using only relative range,speed,and LOS *** stability analyses and performed simulations results show that the presented approach is effective.

关键词： Guidance law H∞ observer measurement noise.