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A Well Productivity Model for Multi-Layered Marine and Continental Transitional Reservoirs with Complex Fracture Networks

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Fluid Dynamics & Materials Processing 2024年第6期20卷 1313-1330页

作者： Huiyan Zhao Xuezhong chen Zhijian Hu Man chen bo Xiong Jianying Yang Sichuan Changning Natural Gas Development Company Limited PetroChina Southwest Oil and Gas Field CompanyYibin644399China Sichuan Shale Gas Exploration and Development Company Limited PetroChina Southwest Oil and Gas Field CompanyNeijiang641100China New Energy Division PetroChina Southwest Oil and Gas Field CompanyChengdu610051China

Using the typical characteristics of multi-layered marine and continental transitional gas reservoirs as a basis,a model is developed to predict the related well production *** model relies on the fractal theory of tortuous capillary bundles and can take into account multiple gas flow mechanisms at the micrometer and nanometer scales,as well as the flow characteristics in different types of thin layers(tight sandstone gas,shale gas,and coalbed gas).Moreover,a source-sink function concept and a pressure drop superposition principle are utilized to introduce a coupled flow model in the reservoir.A semi-analytical solution for the production rate is obtained using a matrix iteration method.A specific well is selected for fitting dynamic production data,and the calculation results show that the tight sandstone has the highest gas production per unit thickness compared with the other types of ***,desorption and diffusion of coalbed gas and shale gas can significantly contribute to gas production,and the daily production of these two gases decreases rapidly with decreasing reservoir ***,the gas production from fractures exhibits an approximately U-shaped distribution,indicating the need to optimize the spacing between clusters during hydraulic fracturing to reduce the area of overlapping fracture *** coal matrix water saturation significantly affects the coalbed gas production,with higher water saturation leading to lower production.

关键词： Marine-continental transitional reservoir multi-layered reservoir seepage mechanisms apparent permeability hydraulic horizontal well productivity model

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Mitochondrial-Oriented Injectable Hydrogel Microspheres Maintain Homeostasis of Chondrocyte Metabolism to Promote Subcellular Therapy in Osteoarthritis

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Research 2024年第3期7卷 775-790页

作者： Li chen Jianye Yang Zhengwei Cai Yanran Huang Pengcheng Xiao Hong chen Xiaoji Luo Wei Huang Wenguo Cui ning Hu Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityOrthopedic Laboratory of Chongqing Medical UniversityChongqing 400016China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai 200025China.

Subcellular mitochondria serve as sensors for energy metabolism and redox balance, and the dynamic regulation of functional and dysfunctional mitochondria plays a crucial role in determining cells' fate. Selective removal of dysfunctional mitochondria at the subcellular level can provide chondrocytes with energy to prevent degeneration, thereby treating osteoarthritis. Herein, to achieve an ideal subcellular therapy, cartilage affinity peptide (WYRGRL)-decorated liposomes loaded with mitophagy activator (urolithin A) were integrated into hyaluronic acid methacrylate hydrogel microspheres through microfluidic technology, named HM@WY-Lip/UA, that could efficiently target chondrocytes and selectively remove subcellular dysfunctional mitochondria. As a result, this system demonstrated an advantage in mitochondria function restoration, reactive oxygen species scavenging, cell survival rescue, and chondrocyte homeostasis maintenance through increasing mitophagy. In a rat post-traumatic osteoarthritis model, the intra-articular injection of HM@WY-Lip/UA ameliorated cartilage matrix degradation, osteophyte formation, and subchondral bone sclerosis at 8 weeks. Overall, this study indicated that HM@WY-Lip/UA provided a protective effect on cartilage degeneration in an efficacious and clinically relevant manner, and a mitochondrial-oriented strategy has great potential in the subcellular therapy of osteoarthritis.

关键词： spheres remove thereby

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Comparison of Combustion Characteristics of Tars Produced with Tobacco Stem Biomass Gasification

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Journal of Renewable Materials 2024年第1期12卷 119-129页

作者： bo chen Mingjun Wang bo Liu Chunping Lu Guohai Jia Yong Chao Chao Zhong School of Mechanical Engineering Hunan Institute of EngineeringXiangtan411104China School of Automotive Engineering Xiangtan Institute of TechnologyXiangtan411100China School of Electrical and Information Engineering Hunan Institute of EngineeringXiangtan411104China China Metallurgic Jingcheng(Xiangtan)Heavy Industry Equipment Co. Ltd.Xiangtan411100China Hunan Shuanghuan Fiber Molding Machinery Co. Ltd.Xiangtan411100China

In order to study the combustion characteristics of tar in biomass gasifier inner wall and gasification gas,“tobacco stem semi-tar inside furnace”,“tobacco stem tar inside furnace”and“tobacco stem tar out-of-furnace”were subjected to thermogravimetric experiments,and the combustion characteristics and kinetic characteristics were *** result shows that“tobacco stem semi-tar inside furnace”has the highest value and“tobacco stem tar out-of-furnace”is has the lowest value on ignition characteristics,combustion characteristics and combustible stability;“tobacco stem semi-tar inside furnace”has the lowest value and“tobacco stem tar outside furnace”has the highest value on burnout characteristics;“tobacco stem tar outside furnace”has the highest value and“tobacco stem tar inside furnace”has the lowest value on integrated combustion characteristics.

关键词： Tobacco stem tar gasifier combustion characteristics

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Catalytic Asymmetric Diastereodivergent Synthesis of 2-Alkenylindoles Bearing both Axial and Central Chirality

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Precision Chemistry 2024年第5期2卷 208-220页

作者： Shuang Yang Jia-bo Huang Da-Hua Wang ning-Yi Wang Yu-Yu chen Xin-Yan Ke Hao chen Shao-Fei Ni Yu-chen Zhang Feng Shi Research Center of Chiral Functional Heterocycles School of Chemistry and Materials ScienceJiangsu Normal UniversityXuzhou 221116China Department of Chemistry Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China Department of Otolaryngology Xuzhou First People’s HospitalAffiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhou 221002China School of Petrochemical Engineering Changzhou UniversityChangzhou 213164China

The catalytic asymmetric diastereodivergent synthesis of axially chiral 2-alkenylindoles was established via chiral phosphoric acid-catalyzed addition reactions of C3-unsubstituted 2-alkenylindoles with o-hydroxybenzyl alcohols under different reaction *** this strategy,two series of 2-alkenylindoles bearing both axial and central chirality were synthesized in a diastereodivergent fashion with moderate to high yields and good stereoselectivities(up to 99%yield,95:5 er,>95:5 dr).Moreover,theoretical calculations were performed on the key transition states leading to different stereoisomers,which provided an in-depth understanding of the origin of the observed stereoselectivity and diastereodivergence of the products under different reaction *** importantly,these 2-alkenylindoles were utilized in asymmetric catalysis as chiral organocatalysts and in medicinal chemistry for evaluation of their cytotoxicity,which demonstrated their potential *** study has not only established the catalytic atroposelective synthesis of axially chiral 2-alkenylindoles,but also provided an efficient strategy for catalytic asymmetric diastereodivergent construction of indole-based scaffolds bearing both axial and central chirality.

关键词： 2-Alkenylindole Axial chirality Central chirality Diastereodivergent synthesis Chiral phosphoric acid

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Application of nanoscale metal–organic frameworks in tumor immunotherapy

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Rare Metals 2024年第10期43卷 4867-4883页

作者： Xiao-Xuan Zeng Jing-Sheng Lu Dong-Wei Ma Yu-Ting Huang Ling chen Gang Wang Qing chen ning Lin College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine Center of Engineering and Technology

Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor recurrence. However, due to the poor efficacy of the monotherapy in tumor immunotherapy, combination therapies are needed to enhance their efficacy,such as chemodynamic therapy/immunotherapy, photodynamic therapy/immunotherapy, sonodynamic therapy/immunotherapy and so on. Nanoscale metal–organic frameworks(nMOFs) are widely used for drug delivery because of their rich and variable composition, high drug loading capacity and good biodegradability. Compared with other conventional drug delivery systems(DDSs),nMOFs play more advantageous role in inducing immune cell death of tumor cells and combination therapies. This article focuses on the application of n MOFs in tumor immunotherapy in terms of their use as gatekeepers, supplementary agents and drug carriers, respectively, with the aim of providing some ideas and references for the design of smart nanoscale DDS for tumor immunotherapy.

关键词： Drug delivery system Immunotherapy Metal–organic frameworks Tumor

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High-resolution remote thermometry based on Bi^(3+)-doped 0D zinc halide hybrids

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Science China Chemistry 2024年第8期67卷 2599-2605页

作者： Cui-Mi Shi Shu-Hua Xue Jin-Yun Wang Liang-Jin Xu Zhong-ning chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science Technology Innovation Laboratory for Optoelectronic Information of ChinaFuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China

Developing highly sensitive optical thermometers is of great significance due to their capability to enable remote and non-contact temperature measurements, rendering them highly applicable in diverse and harsh environments. Herein we report a temperature-dependent phosphor of 0D metal halide hybrid by incorporating Bi^(3+)into the(MePPh_(3))_(2)ZnCl_(4) matrix. Through Bi^(3+)doping,the initially non-luminescent(MePPh_(3))_(2) ZnCl_(4) matrix exhibits a deep-blue emission centered at 453 nm, with a photoluminescence quantum yield(PLQY) of 5.71% and a Stokes shift of 75 nm at room temperature. Experimental characterization demonstrates that exciton-like luminescence of Bi^(3+)is mainly responsible for the blue emission. Single crystals of Bi^(3+)-doped(MePPh_(3))_(2)ZnCl_(4) show an unusual correlation between photoluminescence(PL) lifetime and temperature. Particularly, the dependence of luminescence lifetime on temperature is most remarkable in the temperature range of 80 to 100 K with an exceptional sensitivity up to 0.09 K^(-1), representing one of the best levels for thermometry based on PL decay lifetime. Our work not only provides a viable strategy for designing a novel, environmentally friendly, and stable blue emitter, but also paves the way for precise thermometric application at low temperature.

关键词： lead-free hybrids Bi^(3+)doping blue emission temperature sensing

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Development of a high-repetition-rate lumped-inductance kicker magnet prototype for the beam switchyard of SHINE

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Nuclear Science and Techniques 2024年第2期35卷 20-31页

作者： Yong-Fang Liu Rui-Ping Wang Jin Tong bo Zhang Si chen Qi-Bing Yuan Hai-Xiao Deng Ming Gu bo Liu Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201412People’s Republic of China

The Shanghai high-repetition-rate X-ray free-electron laser and extreme light facility(SHINE)operates at a maximum repetition rate of 1 *** magnets are key components that distribute electron bunches into three different undulator lines in a bunch-by-bunch *** kicker field width must be less than the time interval between bunches.A lumpedinductance kicker prototype was developed using a vacuum chamber with a single-turn *** full magnetic field strength was 0.005 *** paper presents the requirements,design considerations,design parameters,magnetic field calculations,and measurements of the kicker *** relevant experimental results are also *** pulse width of the magnetic field was approximately 600 ns,and the maximum operation repetition rate was 1 *** developed kicker satisfies the requirements for the SHINE ***,numerous recommendations for the future optimization of kicker magnets are provided.

关键词： X-ray free-electron laser Kicker magnet Beam switchyard High repetition rate Ni-Zn ferrites

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A Post-Quantum Cross-Domain Authentication Scheme Based on Multi-Chain Architecture

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Computers, Materials & Continua 2024年第2期78卷 2813-2827页

作者： Yi-bo Cao Xiu-bo chen Yun-Feng He Lu-Xi Liu Yin-Mei Che Xiao Wang Ke Xiao Gang Xu Si-Yi chen Information Security Center State Key Laboratory ofNetworking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China Information Center of China North Industries Group Corporation Beijing100089China School of Information Science and Technology North China University of TechnologyBeijing100144China

Due to the rapid advancements in network technology,blockchain is being employed for distributed data *** the Internet of Things(IoT)scenario,different participants manage multiple blockchains located in different trust domains,which has resulted in the extensive development of cross-domain authentication ***,the emergence of many attackers equipped with quantum computers has the potential to launch quantum computing attacks against cross-domain authentication schemes based on traditional cryptography,posing a significant security *** response to the aforementioned challenges,our paper demonstrates a post-quantum cross-domain identity authentication scheme to negotiate the session key used in the cross-chain asset exchange ***,our paper designs the hiding and recovery process of user identity index based on lattice cryptography and introduces the identity-based signature from lattice to construct a post-quantum cross-domain authentication ***,our paper utilizes the hashed time-locked contract to achieves the cross-chain asset exchange of blockchain nodes in different trust ***,the security analysis reduces the security of the identity index and signature to Learning With Errors(LWE)and Short Integer Solution(SIS)assumption,respectively,indicating that our scheme has post-quantum *** but not least,through comparison analysis,we display that our scheme is efficient compared with the cross-domain authentication scheme based on traditional cryptography.

关键词： Cross-domain identity authentication lattice-based cryptography blockchain hashed time-locked contract

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Enhancing thermoelectric performance in P-type Mg_(3)Sb_(2)-based Zintls through optimization of band gap structure and nanostructuring

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Journal of Materials Science & Technology 2024年第3期170卷 25-32页

作者： Yi-bo Zhang Ji-Sheng Liang chengyan Liu Qi Zhou Zhe Xu Hong-bo chen Fu-cong Li Ying Peng Lei Miao Guangxi Key Laboratory of Information Material Engineering Research Center of Electronic Information Materials and DevicesMinistry of EducationSchool of Material Science and EngineeringGuilin University of Electronic TechnologyGuilin 541004China Guangxi Key Laboratory for Relativity Astrophysics Center on Nanoenergy ResearchGuangxi Key Laboratory of Processing for Nonferrous Metal and Featured MaterialsSchool of Physical Science&TechnologyGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Precision Navigation Technology and Application Guilin University of Electronic TechnologySchool of Information and CommunicationGuilin 541004China

P-type Mg_(3)Sb_(2)-based Zintls have attracted considerable interest in the thermoelectric(TE)field due to their environmental friendliness and low ***,compared to their n-type counterparts,they show relatively low TE performance,limiting their application in TE *** this work,we simultaneously introduce Bi alloying at Sb sites and Ag doping at Mg sites into the Mg_(3)Sb_(2)to coopera-tively optimize the electrical and thermal properties for the first time,acquiring the highest ZT value of∼0.85 at 723 K and a high average ZT of 0.39 in the temperature range of 323-723 K in sample Mg_(2.94)Ag_(0.06)Sb_(1.9)Bi_(0.1).The first-principle calculations show that the codoping of Ag and Bi can shift the Fermi level into the valence band and narrow the band gap,resulting in the increased carrier concentration from 3.50×10^(17)cm^(-3)in the reference Mg 3 Sb 0.9 Bi 0.1 to∼7.88×10^(19)cm^(-3)in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi *** a result,a remarkable power factor of∼778.9μW m^(-1)K^(-2)at 723 K is achieved in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi ***,a low lattice thermal conductivity of∼0.48 W m^(-1)K^(-1)at 723 K is also obtained with the help of phonon scattering at the distorted lattice,point defects,and nano-precipitates in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi *** synergistic effect of using the multi-element co-doping/-alloying to optimize electrical properties in Mg_(3)Sb_(2)holds promise for further improving the TE performance of Zintl phase materials or even others.

关键词： Thermoelectric materials Band engineering Nanostructuring P-type Mg_(3)Sb_(2) Ag and Bi Co-doping

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Applications of single-cell RNA sequencing in spermatogenesis and molecular evolution

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Zoological Research 2024年第3期45卷 575-585页

作者： Wen-bo chen Meng-Fei Zhang Fan Yang Jin-Lian Hua College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China

Spermatogenic cell heterogeneity is determined by the complex process of spermatogenesis ***,effectively revealing the regulatory mechanisms underlying mammalian spermatogenic cell development and differentiation via traditional methods is *** in technology have led to the emergence of many single-cell transcriptome sequencing protocols,which have partially addressed these *** this review,we detail the principles of 10x Genomics technology and summarize the methods for downstream analysis of single-cell transcriptome sequencing ***,we explore the role of single-cell transcriptome sequencing in revealing the heterogeneity of testicular ecological niche cells,delineating the establishment and disruption of testicular immune homeostasis during human spermatogenesis,investigating abnormal spermatogenesis in humans,and,ultimately,elucidating the molecular evolution of mammalian spermatogenesis.

关键词： Single-cell RNA sequencing(scRNA-seq) Spermatogenesis Molecular evolution Sertoli cell

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