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Coconut Oil Reduces Visceral Adipocyte Size and Improves the Metabolic Profile of Rats Fed a High-Carbohydrate Diet

Journal of Pharmacy and Pharmacology 2019年第3期7卷 98-109页

作者： Valéria Schoffen Romao-Carrascoza Rosangela Fernandes Garcia Lorena Lima Garo Maria Montserrat Diaz Pedrosa nilton de almeida brito Clairce Luzia Salgueiro-Pagadigorria Márcia do Nascimento brito Department of Physiological Sciences State University of MaringáMaringá87020900PRBrazil Department of Medicine State University of MaringáMaringá87020900PRBrazil

This work aimed to evaluate the effects of the food supplementation with coconut oil(CO)on biometric and metabolic parameters in an animal model of *** rats fed a high-carbohydrate diet(HCD rats)develop metabolic disorders very similar to those found in human metabolic syndrome,including increased adiposity,insulin resistance(IR),non-alcoholic fatty liver disease(NAFLD)and *** HCD rats had normal fasting glycemia,they developed IR as revealed by Homa-IR index and,after glucose overload,exhibited higher peaks of insulinemia and *** alterations were accompanied by a higher formation of advanced glycated end products(AGEs).The supplementation with CO improved IR,reduced AGEs formation and reverted *** effects could be due to CO action of reducing visceral adipocyte size and take place without undesirable collateral effects on lipid profile,placing CO as an adjuvant in the treatment of the metabolic syndrome.

关键词： Adipocyte hypertrophy metabolic syndrome insulin resistance NAFLD coconut oil

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Agnuside Reduces Visceral Adipocyte Size,Improves Insulin Sensitivity and Reverses Hepatic Steatosis in Ovariectomized Rats

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Journal of Pharmacy and Pharmacology 2019年第4期7卷 133-147页

作者： Franciele Neves Moreno Eduardo Hideo Gilglioni Rosangela Fernandes Garcia Naiara Cristina Lucredi Sandra Mara Ferreira nilton almeida brito Marcia do Nascimento brito Emy Luiza Ishii-Iwamoto Clairce Luzia Salgueiro-Pagadigorria Laboratory of Experimental Steatosis Department of BiochemistryState University of MaringaMaringa 87020-900PRBrazil Laboratory of Biological Oxidations Department of BiochemistryState University of MaringaMaringa 87020-900PRBrazil Department of Physiological Sciences State University of MaringaMaringa 87020-900PRBrazil Laboratory of Biological oxidations Department of BiochemistryFederal University of Santa CatarinaFlorianopolis 88040-900SCBrazil Department of Structural and Functional Biology Institute of BiologyState University of Campinas(UNICAMP)Campinas 13083-970SPBrazil

This study aimed to investigate the effects of agnuside(AGN),a phytoestrogen in Vitex agnus-castus,on cellular and metabolic alterations induced by ovariectomy in ***(OVX)Wistar rats were used as an animal model of postmenopausal metabolic *** visceral and subcutaneous adipocyte sizes,the peripheral insulin sensitivity and the occurrence of nonalcoholic fatty liver disease(NAFLD)and liver oxidative damage were *** results were compared with those obtained from control rats(sham-operated)and OVX rats treated daily with *** OVX rats exhibited visceral adipocyte hypertrophy and developed glucose intolerance,hyperinsulinemia,NAFLD and *** exerted beneficial effects on several metabolic parameters in OVX rats,including the improvement in glucose intolerance,hyperinsulinemia and ***,AGN promoted a general improvement in the liver redox *** the reduction of the mesenteric adipocyte size is very likely to be an important mode of action of AGN,some actions of AGN could also involve the interaction with estrogen receptors.

关键词： Metabolic syndrome ovariectomized rats adipocyte size NAFLD agnuside

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