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Hidden army within:Harnessing the microbiome to improve cancer treatment outcomes

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World Journal of Clinical Cases 2024年第28期12卷 6159-6164页

作者： Ippokratis Messaritakis Georgios Vougiouklakis Asimina Koulouridi Aris P Agouridis nikolaos spernovasilis Department of Microbiology German Oncology Center&Yiannoukas Labs LTDBioiatriki GroupLimassol 4108Cyprus Department of Internal Medicine German Oncology CenterLimassol 4108Cyprus Department of Oncology German Oncology CenterLimassol 4108Cyprus School of Medicine European University CyprusNicosia 2404Cyprus Department of Infectious Diseases German Oncology CenterLimassol 4108Cyprus

The gut microbiome has emerged as a critical player in cancer pathogenesis and treatment ***,an imbalance in the gut microbial community,impacts tumor initiation,progression,and therapy *** bacterial species have been associated with either promoting or inhibiting tumor growth,offering potential targets for therapeutic *** gut microbiome in-fluences the efficacy and toxicity of conventional treatments and cutting-edge immunotherapies,highlighting its potential as a therapeutic target in cancer ***,translating microbiome research into clinical practice requires addres-sing challenges such as standardizing methodologies,validating microbial bio-markers,and ensuring ethical ***,we provide a comprehensive overview of the gut microbiome's role in cancer highlighting the need for on-going research,collaboration,and innovation to harness its full potential for im-proving patient outcomes in *** current editorial aims to explore these insights and emphasizes the need for standardized methodologies,validation of microbial biomarkers,and interdisciplinary collaboration to translate microbiome research into clinical ***,it underscores ethical consider-ations and regulatory challenges surrounding the use of microbiome-based ***,this article advocates for ongoing research,collaboration,and innovation to realize the full potential of microbiome-guided oncology in impro-ving patient care and outcomes.

关键词： Gut microbiome Cancer treatment Immunotherapy Microbiome-based interventions Dysbiosis Precision oncology

COVID-19 in pregnancy:Perinatal outcomes and complications

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World Journal of Virology 2024年第4期13卷 62-73页

作者： Karolina Akinosoglou Georgios Schinas Evangelia Papageorgiou Theodoros Karampitsakos VasilikiDimakopoulou Eleni Polyzou Argyrios Tzouvelekis Markos Marangos Despoina Papageorgiou nikolaos spernovasilis George Adonakis Department of Medicine University of PatrasPatras 26504Greece Department of Obstetrics and Gynecology University General Hospital of PatrasPatras 26504Greece Department of Pneumonology University General Hospital of PatrasPatras 26504Greece Department of Infectious Diseases German Oncology CenterLimassol 4108LimassolCyprus

BACKGROUND The risk of severe coronavirus disease 2019(COVID-19)in pregnant women is *** To examine the outcomes of pregnant women with COVID-19 and report perinatal outcomes and complications,while providing a brief review of current *** The study included pregnant women presenting from April 2020 to February 2022 to the emergency department(ED)of a tertiary *** retrospectively recorded the maternal and perinatal files,including patient epidemiological and clinical characteristics,laboratory values,outcomes,treatment modalities and associations were *** Among the 60 pregnant women,25%required hospitalization,all of whom were *** delivery occurred in 30%of *** percent of neonates required admission to the neonatal intensive care unit,and 5%were classified as small for their gestational *** mothers survived COVID-19 and pregnancy,with 6.6%requiring invasive mechanical *** delivery rates did not differ between hospitalized and non-hospitalized pregnant women;composite unfavorable perinatal outcomes,including stillbirth,small for gestational age,or neonatal intensive care unit(ICU)admission,did not significantly increase in the cases hospitalized for COVID-19(P=0.09).The odds of hospitalization increased 2.3-fold for each day of delayed ED presentation[***(95%CI:1.46-3.624),P<0.001].Comorbidity status was an independent predictor of hospitalization,albeit with marginal significance[***=16.13(95%CI:1.021-255.146),P=0.048].No independent predictors of adverse fetal outcome(composite)were identified,and eventual hospitalization failed to reach statistical significance by a slight margin(P=0.054).CONCLUSION Delayed ED presentation and comorbidities increase hospitalization *** study highlights the importance of continuous and specific guidance for managing pregnant COVID-19 patients,including timely and appropriate interventions to minimize maternal and perinatal morbidity an

关键词： SARS-CoV-2 COVID-19 Pregnancy Maternal outcomes Preterm delivery

Acute acalculous cholecystitis due to infectious causes

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World Journal of Clinical Cases 2021年第23期9卷 6674-6685页

作者： Ioulia Markaki Afroditi Konsoula Lamprini Markaki nikolaos spernovasilis Marios Papadakis Department of Emergency General Hospital of Kythira“Trifyllio”Kythira 80200Greece Department of Emergency General Hospital of Mytilene"Vostaneio"Lesvos 81132Greece Department of Pediatrics "Agia Sofia"Children's HospitalAthens 11527Greece School of Medicine University of CreteHeraklion 71003Greece Department of Surgery II University of Witten-HerdeckeWuppertal 40235NRWGermany

Acute acalculous cholecystitis(AAC)is an inflammation of the gallbladder not associated with the presence of *** usually occurs in critically ill patients but it has also been implicated as a cause of cholecystitis in previously healthy *** this subgroup of patients,infectious causes comprise the primary ***,herein,discuss the pathophysiological mechanisms involved in AAC,focusing on the infectious *** associated with critical medical conditions is caused by bile stasis and gallbladder *** mechanisms are reported to be involved in AAC in patients without underlying critical illness including direct invasion of the gallbladder epithelial cells,gallbladder vasculitis,obstruction of the biliary tree,and *** emphasize that multiple pathogenic mechanisms may concurrently contribute to the development of AAC in varying *** of the implicated pathogens is essential since it will allow a more focused examination of the histopathological *** conclusion,additional research and a high degree of clinical suspicion are needed to clarify the complex spectrum of mechanisms that are involved in the pathogenesis of AAC.

关键词： Cholecystitis Infectious causes Vasculitis Sequestration Epstein-Barr virus

Transition beyond the acute phase of the COVID-19 pandemic: Need to address the long-term health impacts of COVID-19

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World Journal of Clinical Cases 2022年第27期10卷 9967-9969页

作者： Constantinos Tsioutis Andreas Tofarides nikolaos spernovasilis School of Medicine European University CyprusNicosia 2404Cyprus State Health Services Organisation Nicosia General HospitalNicosia 2029Cyprus Infectious Diseases Department German Oncology CenterLimassol 4108Cyprus

Despite gaps in knowledge,long-term sequelae of coronavirus disease 2019(COVID-19)infections are globally acknowledged and thus require special attention by public health organizations and ***,it is necessary to suppo... 详细信息

关键词： Pandemic COVID-19 Long-term Long-covid Post-covid Post-acute COVID-19 syndrome

In vitro study on the transmission of multidrug-resistant bacteria from textiles to pig skin

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World Journal of Experimental Medicine 2023年第5期13卷 134-141页

作者： Pavlina Lena Spyridon Karageorgos Maria Liatsou Aris P Agouridis nikolaos spernovasilis Demetris Lamnisos Panagiotis Papageorgis Constantinos Tsioutis Mpn Unilab Clinical Laboratory Nicosia 1066Cyprus Department of Health Sciences School of SciencesEuropean University CyprusNicosia 2404Cyprus First Department of Pediatrics “Aghia Sophia”Children’s HospitalNational and Kapodistrian University of AthensAthens 11527Greece School of Medicine European University CyprusNicosia 2404Cyprus Infectious Diseases German Oncology CenterLimassol 4108Cyprus Department of Life Sciences School of SciencesEuropean University CyprusNicosia 2404Cyprus

BACKGROUND The survival of microorganisms on textiles and specifically on healthcare profes-sionals’(HCP)attire has been demonstrated in several *** ability of microorganisms to adhere and remain on textiles for up to hours or days raises questions as to their possible role in transmission from textile to skin via HCP to *** To evaluate the presence,survival and transmission of different multidrug-resistant bacteria(MDRB)from HCP attire onto *** Three MDRB[methicillin-resistant Staphylococcus aureus(MRSA);vancomycin-resistant Enterococcus faecium(VRE);carbapenem-resistant Klebsiella pneumoniae,(CRKP)]were inoculated on textiles from scrubs(60%cotton-40%polyester)and white coat(100%cotton)at concentrations of 108 colony-forming units(CFU),105 CFU,and 103 CFU per *** inoculation of swatches was divided in time intervals of 1 min,5 min,15 min,30 min,1 h,2 h,3 h,4 h,5 h,and 6 *** the end of each period,textiles were imprinted onto pig skins and each skin square was inverted onto three different selective chromogenic *** from the pig skin squares was recorded for the 3 MDRB at the three above concentrations,for the whole length of the 6-h *** MRSA was recovered from pig skins at all concentrations for the whole duration of the 6-h *** was recovered from the concentration of 108 CFU/mL for 6 h and from 105 CFU/mL for up to 3 h,while showing no growth at 103 CFU/*** was recovered from 108 CFU/mL for 6 h,up to 30 min from 105 CFU/mL and for 1 min from the concentration of 103 CFU/*** Evidence from the current study shows that MRSA can persist on textiles and transmit to skin for 6 h even at low *** fact that all MDRB can be sustained and transferred to skin even at lower concentrations,supports that textiles are implicated as vectors of bacterial spread.

关键词： Textiles Attire Multidrug-resistant bacteria Methicillin-resistant Staphylococcus aureus Vancomycin-resistant Enterococcus faecium Extended-spectrum b-lactamase Pig skin Skin Transmission