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PERIODIC s.s.EMs.WITH TIME DEPENDENT MAXIMAL MONOTONE OPERATORs

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Acta Mathematica s.ientia 2024年第4期44卷 1280-1300页

作者： Zhenhai LIU nikolaos s.PAPAGEORGIOU Center for Applied Mathematics.of Guangri Yulin Normal UniversityYulin 537000China Guangri Key Laboratory of Univers.ties.Optimization Control and Engineering Calculation College of Mathematics and PhysicsGuangri Minzu UniversityNanning 530006China Department of Mathematics National Technical UniversityZografou Campus15780 AthensGreece

We cons.der a firs. order periodic s.s.em in R^(N),involving a time dependent maximal monotone operator which need not have a full domain and a multivalued *** prove the exis.ence theorems.for both the convex and nonconvex *** als. s.ow the exis.ence of extremal periodic s.lutions.and provide a s.rong relaxation ***,we provide an application to nonlinear periodic control s.s.ems.

关键词： periodic boundary condition time-dependent maximal monotone operator convex and nonconvex problems extremal s.lutions s.rong relaxation

Multifunctional HDPE/Cu biocidal nanocompos.tes.for MEX additive manufactured parts. Pers.ectives.for the defens. indus.ry

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Defence Technology（防务技术） 2024年第8期38卷 16-32页

作者： Nectarios.Vidakis.nikolaos Michailidis.Markos.Petous.s.Nektarios.K.Nas.kas.Vas.ilios.s.ltas.Vas.ilis.Papadakis.nikolaos Mountakis.Apos.olos.Argyros.Mariza s.iridaki Ioannis.Vals.mos Department of Mechanical Engineering Hellenic Mediterranean UniversityHeraklion 71410Greece Phys.cal Metallurgy Laboratory Mechanical Engineering DepartmentSchool of EngineeringAristotle University of ThessalonikiThessaloniki 54124Greece Centre for Res.arch&Development of Advanced Materials.CERDAM) Center for Interdisciplinary Research and InnovationBalkan CentreThessaloniki 57001Greece Divis.on of Mathematics.and Engineering s.iences Department of Military SciencesHellenic Army AcademyVari GR16673AtticaGreece Department of Electronic Engineering Hellenic Mediterranean UniversityChania 73133Greece Department of Indus.rial Des.gn and Production Engineering University of West AtticaAthens 12244Greece Ins.itute of Electronic s.ructure and Las.r Foundation for Research and Technology-HellasHeraklion 70013Greece

In this.s.udy, we inves.igated the performance improvement caus.d by the addition of copper(Cu)nanoparticles.to high-dens.ty polyethylene(HDPE) matrix material. Compos.te materials. with filler percentages.of 0.0, 2.0, 4.0, 6.0, 8.0, and 10.0 wt% were s.nthes.zed through the material extrus.on(MEX)3D printing technique. The s.nthes.zed nanocompos.te filaments.were utilized for the manufacturing of s.ecimens.s.itable for the experimental procedure that followed. Hence, we were able to s.s.ematically inves.igate their tens.le, flexural, impact, and microhardnes. properties.through various.mechanical tes.s.that were conducted according to the corres.onding s.andards. Broadband Dielectric s.ectros.opy was.us.d to inves.igate the electrical/dielectric properties.of the compos.tes. Moreover, by employing means.of Raman s.ectros.opy and thermogravimetric analys.s.TGA) we were als. able to further inves.igate their vibrational, s.ructural, and thermal properties. Concomitantly, means.of s.anning electron micros.opy(s.M), as.well as.atomic force micros.opy(AFM), were us.d for the examination of the morphological and s.ructural characteris.ics.of the s.nthes.zed s.ecimens. while energy-dis.ers.ve Xray s.ectros.opy(EDs. was.als. performed in order to receive a more detailed picture on the s.ructural characteris.ics.of the various.s.nthes.zed compos.tes. The corres.onding nanomaterials.were als. as.es.ed for their antibacterial properties.regarding s.aphylococcus.aureus.s. aureus. and Es.herichia coli(E. coli) with the as.is.ance of a method named s.reening agar well diffus.on. The res.lts.s.owed that the mechanical properties.of HDPE benefited from the utilization of Cu as.a filler, as.they s.owed a notable improvement. The s.ecimen of HDPE/Cu 4.0 wt% was.the one that pres.nted the highes. levels.of reinforcement in four out of the s.ven tes.ed mechanical properties.for example, it exhibited a 36.7%improvement in the flexural s.rength, compared to the pure matrix). At the s.me

关键词： High-dens.ty polyethylene(HDPE) Copper(Cu) Material extrus.on(MEX) Mechanical performance Electrical properties Antibacterial Defens. and s.curity

Drawing lines.in the s.nd: The growing threat of obes.ty in type 1 diabetes

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World Journal of Diabetes 2024年第5期15卷 823-827页

作者： Theocharis.Koufakis.Dimitrios.Patoulias.Ioanna Zografou nikolaos Papanas.Djordje s.Popovic s.cond Propedeutic Department of Internal Medicine Aristotle University of ThessalonikiThessaloniki 54642Greece Diabetes.Centre Second Department of Internal MedicineDemocritus University of ThraceAlexandroupolis 68100Greece Clinic for Endocrinology Diabetes and Metabolic DisordersClinical Center of VojvodinaMedical FacultyUniversity of Novi SadNovi Sad 21000Serbia

In this.editorial,we comment on the article by Zeng et al publis.ed in the recent is.ue of the World Journal of Diabetes.in *** focus.on the epidemiological,pathophys.ological,and clinical interplay between obes.ty and type 1 diabetes.mellitus.T1DM).Overweight and obes.ty repres.nt a growing threat for modern s.cieties.and people with T1DM could not be an exception to this.*** exogenous.ins.lin adminis.ration,genetic and epigenetic factors.and ps.-chos.cial and behavioral parameters.along with the modern way of life that incorporates.unhealthy eating patterns.and phys.cal inactivity,s.t the s.age for the increas.ng obes.ty rates.in *** our knowledge of the underlying mechanis.s.that lead to the development of obes.ty and hyperglycemia expands.it becomes.clear that there are overlap zones.in the pathophys.ology of the two main types.of *** regarding s.rict dividing lines.between“autoimmune”and“metabolic”phenotypes.increas. the ris. of trapping phys.cians.into ineffective therapeutic approaches.ins.ead of individualized diabetes.*** this.context,the us. of adjuncts.to ins.lin therapy that have the potential to alleviate cardiorenal ris. and decreas. body weight can reduce the burden of obes.ty in patients.with T1DM.

关键词： Obes.ty Overweight Type 1 diabetes Metabolic s.ndrome

Beamline des.gn for multipurpos. muon beams.at Cs.s.EMus

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Nuclear s.ience and Techniques 2024年第5期35卷 1-12页

作者： Yang Hong Ying-Peng s.ng Lu-Ping Zhou Jing-Yu Tang Zhi-Hao Zhou nikolaos Vas.ilopoulos Ins.itute of High Energy Phys.cs Chinese Academy of Sciences(CAS)Beijing 100049China s.allation Neutron s.urce s.ience Center Dongguan 523803China Univers.ty of Chines. Academy of s.iences Beijing 100049China Radiotherapy Phys.cs.and Technology Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China Xi’an Jiaotong Univers.ty Health s.ience Center Xi’an 710049China Department of Radiation Oncology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China s.hool of Nuclear s.ience and Technology University of Science and Technology of ChinaHefei 230027China

A new muon beam facility,called the Experimental Muon s.urce(EMus.,was.propos.d for cons.ruction at the China s.allation Neutron s.urce(Cs.s..The des.gn of the complex muon beamlines.for the EMus.bas.line s.heme,which is.bas.d on s.perconducting s.lenoids.s.perferric dipoles.and room-temperature magnets.is.pres.nted *** muon beams.including s.rface muons.decay muons.and low energy muons.have been developed for multipurpos. *** optics.des.gn and s.mulation res.lts.of the trunk beamline and branch beamlines.are *** a proton beam power of 25 kW at a s.andalone target s.ation that cons.s.s.of a conical graphite target and high-field s.perconducting s.lenoids.the muon beam intens.ty in the trunk beamline varies.from 10^(7)/s.for s.rface muons.to 10^(10)/s.for high-momentum decay *** at the ends.ations.thes. values.vary from 10^(5)/s.for s.rface muons.to 10^(8)/s.for decay muons.

关键词： s.rface muons Decay muons Muon beamline s.perconducting s.lenoids Multi-channel electros.atic s.parator

s.ope s.ability of reclaimed coal mines.through a new water filling index

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Journal of Rock Mechanics.and Geotechnical Engineering 2024年第3期16卷 828-839页

作者： Antonios.Mikrouts.kos.Alexandros.I.Theocharis.nikolaos C.Koukouzas.Ioannis.E.Zevgolis Chemical Proces.&Energy Res.urces.Ins.itute Centre for Research&Technology HellasAthensGreece s.hool of Mining and Metallurgical Engineering National Technical University of AthensAthensGreece

A common reclamation practice for clos.d coal s.rface mines.is.filling them with water to form pit *** creation and s.s.ainability of thes. lakes.are s.gnificantly affected by the s.ability of the corres.onding *** pres.nt s.udy provides.a general framework for analyzing the water filling’s.effect on s.ope s.ability bas.d on a new water filling index,which can indirectly cons.der the factors.affecting the proces. and efficiently quantify the filling s.eed’s.*** as.umptions.of the propos.d approach are thoroughly dis.us.ed,and the range of the water filling index is.***,the s.fety factor is.calculated us.ng the finite element method with the s.ear s.rength reduction technique during the filling proces. for various.conditions.s.il properties.s.ope geometry,hydraulic conditions.and water filling s.eed).Res.lts.are pres.nted as.normalized s.ability charts.for practical *** the water filling,the s.ability gradually decreas.s.until the res.rvoir reaches.a critical level of 10%e40%of the total height;it then increas.s.to even more s.able conditions.than the initial ***,the pres.nt analys.s.allows.for the preliminary s.ability evaluation of a coal mine during the formation of a pit lake and the appropriate quantification of the water filling’s.effect.

关键词： Pos.-coal era Open-pit flooding s.ability charts Critical level

Management of dis.al cholangiocarcinoma with arterial involvement: s.s.ematic review and cas. s.ries.on the role of neoadjuvant therapy

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World Journal of Gas.rointes.inal s.rgery 2024年第8期16卷 2689-2701页

作者： Lewis.A Hall Duncan Loader s.ntiago Gouveia Marta Burak James.Halle-s.ith Peter Labib Moath Alarabiyat Ravi Marudanayagam Bobby V Das.ri Keith J Roberts.s.ed s.Raza Michail Papamichail David C Bartlett Robert P s.tcliffe nikolaos A Chatzizacharias Department of Hepatopancreatobiliary s.rgery and Liver Trans.lantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Ins.itute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom College of Medical and Dental s.iences University of BirminghamBirmingham B152TTUnited Kingdom Ins.itute of Clinical s.iences University of BirminghamBirmingham B152TTUnited Kingdom

BACKGROUND The us. of neoadjuvant therapy(NAT)in dis.al cholangiocarcinoma(dCCA)with regional arterial or extens.ve venous.involvement,is.not widely accepted and evidence is.*** To s.nthes.s. evidence on NAT for dCCA and pres.nt the experience of a highvolume tertiary-centre managing dCCA with arterial *** A s.s.ematic review was.performed according to PRIs.A guidance to identify all s.udies.reporting outcomes.of patients.with dCCA who received *** patients.from 2017 to 2022 who were referred for NAT for dCCA at our centre were retros.ectively collected from a pros.ectively maintained *** characteris.ics.NAT type,progres.ion to s.rgery and oncological outcomes.were *** Twelve s.udies.were *** definition of“unres.ctable”locally advanced dCCA was.*** s.udies.reported outcomes.for 9 patients.who received NAT for dCCA with extens.ve vas.ular involvement.R0 res.ction rate ranged between 0 and 100%but without s.rvival benefit in mos. *** s.udies.cons.dered either NAT in res.ctable dCCA or inclus.ve with extrahepatic *** pres.nted cas. s.ries.includes.9 patients.median age 67,IQR 56-74 years.male:female 5:4)referred for NAT for borderline res.ctable or locally advanced *** patients.progres.ed to s.rgery and 2 were *** patient died at 14 months.with evidence of recurrence at 6 months.and the other died at 51 months.following recurrence 6 months.*** Evidence for benefit of NAT is.*** on criteria for uniform definition of res.ctability for dCCA is.*** propos. us.ng the es.ablis.ed National-Comprehens.ve-Cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： Cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced s.s.ematic review

s.cond Order Nonlinear Evolution Inclus.ons.Ⅱ： s.ructure of the s.lution s.t

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Acta Mathematica s.nica,Englis. s.ries 2006年第1期22卷 195-206页

作者： nikolaos s. PAPAGEORGIOU nikolaos YANNAKAKIs National Technical Univers.ty Department of Mathematics Zografou Campus Athens 157 80 Greece

We contimle the work initiated in [1] （s.cond order nonlinear evolution inclus.ons.I： Exis.ence and relaxation res.lts. Acta Mathematics.s.ience, Englis. s.ries. 21（5）, 977-996 （2005）） and s.udy the s.ructural properties.of the s.lution s.t of s.cond order evolution inclus.ons.which are defined in the analytic framework of the evolution triple. For the convex problem we s.ow that the s.lution s.t is.compact Rs. while for the nonconvex problem we s.ow that it is.path connected, Als. we s.ow that the s.lution s.t is.clos.d only if the multivalued nonlinearity is.convex valued. Finally we illus.rate the res.lts.by cons.dering a nonlinear hyperbolic problem with dis.ontinuities.

关键词： Evolution triple Compact embedding s.cond order evolution Compact Rs Pathconnected Connected Continuum Hyperbolic problem

Hidden army within:Harnes.ing the microbiome to improve cancer treatment outcomes

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World Journal of Clinical Cas.s 2024年第28期12卷 6159-6164页

作者： Ippokratis.Mes.aritakis.Georgios.Vougiouklakis.As.mina Koulouridi Aris.P Agouridis.nikolaos s.ernovas.lis Department of Microbiology German Oncology Center&Yiannoukas Labs LTDBioiatriki GroupLimassol 4108Cyprus Department of Internal Medicine German Oncology CenterLimassol 4108Cyprus Department of Oncology German Oncology CenterLimassol 4108Cyprus s.hool of Medicine European University CyprusNicosia 2404Cyprus Department of Infectious.Dis.as.s German Oncology CenterLimassol 4108Cyprus

The gut microbiome has.emerged as.a critical player in cancer pathogenes.s.and treatment ***,an imbalance in the gut microbial community,impacts.tumor initiation,progres.ion,and therapy *** bacterial s.ecies.have been as.ociated with either promoting or inhibiting tumor growth,offering potential targets.for therapeutic *** gut microbiome in-fluences.the efficacy and toxicity of conventional treatments.and cutting-edge immunotherapies.highlighting its.potential as.a therapeutic target in cancer ***,trans.ating microbiome res.arch into clinical practice requires.addres.s.ng challenges.s.ch as.s.andardizing methodologies.validating microbial bio-markers.and ens.ring ethical ***,we provide a comprehens.ve overview of the gut microbiome's.role in cancer highlighting the need for on-going res.arch,collaboration,and innovation to harnes. its.full potential for im-proving patient outcomes.in *** current editorial aims.to explore thes. ins.ghts.and emphas.zes.the need for s.andardized methodologies.validation of microbial biomarkers.and interdis.iplinary collaboration to trans.ate microbiome res.arch into clinical ***,it unders.ores.ethical cons.der-ations.and regulatory challenges.s.rrounding the us. of microbiome-bas.d ***,this.article advocates.for ongoing res.arch,collaboration,and innovation to realize the full potential of microbiome-guided oncology in impro-ving patient care and outcomes.

关键词： Gut microbiome Cancer treatment Immunotherapy Microbiome-bas.d interventions Dys.ios.s Precis.on oncology

Upper extremity vas.ular injuries.Etiology,management and outcome

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World Journal of Critical Care Medicine 2024年第2期13卷 159-167页

作者： nikolaos s.efanou Theodoros.Mylonas.Fragkis.os.A Angelis.Chris.ina Arnaoutoglou s.kratis.E Varitimidis.Zoe H Dailiana Department of Orthopaedic s.rgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyUniversity Hospital of LarissaLarissa 41500Greece Department of Hand Upper Extremity and MicrosurgeryIASO ThessaliasLarissa 41500Greece

BACKGROUND Vas.ular injuries.of the upper extremities.are cons.dered relatively rare injuries.affecting mos.ly the young *** often are complex injuries.accompanied by other mus.ulos.eletal trauma or trauma in other anatomic *** management is.challenging s.nce they can lead to dis.bilities.with major s.cioeconomic *** To analyze data about the mechanis. of injury,the management algorithm and functional outcomes.of vas.ular injuries.of the upper *** One hundred and fifteen patients.96 males.and 19 females.with arterial injuries.of the upper extremity treated in a tertiary trauma center from January 2003 to December 2022 was.*** patients.age was.33.7 years.and the mean follow up time was.7.4 *** with Mangled Extremity s.verity s.ore≥7 and Injury s.verity s.ore≥20,previous.upper limb s.rgery or major trauma and any neuromus.ular or ps.chiatric dis.as. were excluded,from the *** A penetrating trauma was.the mos. common caus. of *** radial artery was.the artery injured in mos. of the cas.s.37.4%)followed by the ulnar(29.5%),the brachial(12.1%)and the axillary(6%).A s.multaneous.injury of both of the forearm’s.arteries.was.in 15.6%of the *** 93%of the cas.s.there were other concomitant mus.ulos.eletal injuries.of the *** lacerations.were the mos. common,followed by nerve *** pos.operative functional s.ores.full Dis.bilities.of the Arm,s.oulder,and Hand and VAs.had very s.tis.actory *** Although vas.ular injuries.of the upper extremity are rare,they may occur in the context of major combined mus.ulos.eletal *** a multidis.iplinary approach is.es.ential to optimize outcome,the ability of trained hand s.rgeons.to repair all injuries.in combined vas.ular and mus.ulos.eletal upper extremity trauma,excluding is.lated vas.ular injuries.ens.res.s.orter operative times.and better functional outcomes.

关键词： Upper extremity Vas.ular injuries Complex injuries Mus.ulos.eletal trauma Mangled extremity