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Quantitative evaluation of LAL productivity of colloidal nanomaterials:Which laser pulse width is more productive,ergonomic,and economic?

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Chinese Physics b 2022年第7期31卷 23-33页

作者： Alena Nastulyavichus nikita Smirnov Sergey Kudryashov P.N.Lebedev Physical Institute of the Russian Academy of Sciences MoscowRussia

Near-IR(wavelength≈1μm)laser ablation of bulk,chemically-inert gold in water was compared for different laser pulse width in broad the range of 300 fs–100 ns,comparing a number of key ablation characteristics:mass loss,singleshot crater volume and extinction coefficient of the generated colloidal solutions taken in the spectral ranges of interband transitions and localized plasmon *** to related air-based ablation results,at the given fluences laser ablation in the liquid resulted in the maximum ablation yield per unit energy and maximum NP yield per pulse and per unit energy for the picosecond lasers,occurring at subcritical peak pulse powers for laser *** self-focusing effect was demonstrated to yield in incomplete,effectively weaker focusing in the water filaments of ultrashort laser pulses with supercritical peak powers,comparing to linear(geometrical)focusing at sub-critical peak *** the other,nanosecondpulse extreme the high ablation yield per pulse,but low ablation yield per unit energy and low NP yield per pulse and per unit energy were related to strong ablation plasma screening,providing mass removal according to the well-established scaling relationships for *** comparison of the ablation and nanoparticle generation efficiency versus the broad fs–ns laser pulse width range was enabled in terms of productivity,economicity,and ergonomicity,using the proposed universal quantitative criteria.

关键词： laser ablation of gold in liquid ablated mass critical power for self-focusing filamentation

Mathematical modeling of icing process of the outer surface of the hull for a marine vessel

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Journal of Hydrodynamics 2023年第2期35卷 232-239页

作者： Konstantin Koshelev Andrey Osipov Sergei Strijhak nikita Tryaskin ISP RAS MoscowRussia Saint-Petersburg State Marine Technical University Saint-PetersburgRussia

The task of studying the process of icing is important due to the operation of large ships and fishing vessels in the seas of the Arctic *** this paper the ice accretion simulation for fishing vessel has been done at different Reynolds and Froude numbers.A hybrid approach was used for modeling:first,the approach based on Reynolds-averaged Navier-Stokes(RANS)model and volume of fluid(VOF)method with interDyMFoam solver was used for ship modelling in waves,second,RANS model and Euler-Lagrangian approach with iceFoam solver for ice accretion process modelling for ship with hull was *** k-ωSST turbulence model with wall functions was used for the RANS *** the help of the interDyMFoam solver,the position of water jet and liquid droplets in space were determined during the movement of the ship and taking into account the waves in the *** the help of iceFoam solver,the process of ice accretion on the surface of the vessel was *** calculations were run for different number Reynolds,*** analysis of mesh convergency was *** distribution of ice thickness and water film on the ship’s surface is *** simulations were performed on a high-performance cluster in parallel mode.

关键词： Ship sea safety climate movement modelling turbulence model water spray droplets velocity ice film mass

The morphological changes in the internal organs of laboratory animals after prolonged oral administration of gold nanoparticles

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Journal of Innovative Optical Health Sciences 2016年第4期9卷 74-84页

作者： Alla b.bucharskaya Galina N.Maslyakova Svetlana S.Pakhomy Olga V.Zlobina Irina O.bugaeva nikita A.Navolokin boris N.Khlebtsov Vladimir A.bogatyrev Nikolai G.Khlebtsov Valery V.Tuchin Saratov State Medical University n.a.V.I.Razumovsky 410012 Saratov Russia Institute of biochemistry and Physiology of Plants and Microorganisms RAS 410049 Saratov Russia Research-Educational Institute of Optics and biophotonics Saratov National Research State University 410012 Saratov Russia Institute of Precision Mechanics and Control RAS 410028 Saratov Russia Interdisciplinary Laboratory of biophotonics Tomsk National Research State University 634050 TomskRussia

Recently gold nanoparticles(GNPs)have been actively studied as photot hermal converters,drug carriers,and imaging agents in a wide range of applications in cancer diagnosis and ther *** prolonged peroral administration of GNPs in a range of sizes was performed to investigate the morphological changes and their reversibility in the internal organs of laboratory *** this study,GNP's with average diameters of 2 nm,15 nm and 50nm were administered during 30 days,and the reversibility of morphological changes was investigated 14 days after *** the prolonged administration of GNPs,the severity of morphological changes in the liver,kidney,spleen and lymph nodes depended on the nanoparticle ***,50 nm nano-particles caused the most pronounced dystrophic and necrobiotic effects,whereas the smallest 2 nm nanoparticles caused proliferative *** importantly,the development of patho-logical processes was reversible,as evidenced by the gradual restoration of the organ structure at 14 days after the end of GNPs administration.

关键词： Gold nanoparticles prolonged peroral administration morphological changes reversibility.

Alterations of morphology of lymphoid organs and peripheral blood indicators under the influence of gold nanoparticles in rats

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Journal of Innovative Optical Health Sciences 2016年第1期9卷 47-56页

作者： Alla b.bucharskaya Svetlana S.Pakhomy Olga V.Zlobina Galina N.Maslyakova Olga V.Matveeva Irina O.bugaeva nikita A.Navolokin boris N.Khlebtsov Vladimir A.bogatyrev Nikolai G.Khlebtsov Valery V.Tuchin Saratov State Medical University 112 B.Kazach'ya str.Saratov 410012Russia Institute of biochemistry and Physiology of Plants and Microorganisms RAS 13 Entuziastov Prospekt.Saratov 410049Russia Saratov State University 83 Astrakhanskaya str.Saratov 410012Russia§Institute of Precise Mechanics and Control of Russian Academy of Sciences 24Rabochaya str.Saratov 410028Russia Interdisciplinary Laboratory of biophotonics Tomsk State University 36 Lenina str.Tomsk 634050Russia

At present,gold nanoparticles(GNPs)are widely used in biomedical applications such as cancer diagnostics and ***,the potential toxicity hazards of these nanomaterials and human safety concerns are gaining significant ***,we report the effects of prolonged peroral administration of GNPs with different sizes(2,15 and 50 nm)on morphological changes in lymphoid organs and indicators of peripheral blood of laboratory *** experiment was conducted on 24 white mongrel male rats weighing 180–220 g,gold nanospheres sizes 2,15 and 50nm were administered orally for 15 days at a dosage of 190g/kg of animal body *** GNPs were conjugated with polyethylene glycol to increase their biocompatibility and *** size-dependent decrease of the number of neutrophils and lymphocytes was noted in the study of peripheral blood,especially pronounced after administration of GNPs with size of 50 *** stimulation of myelocytic germ of hematopoiesis was recorded at morphological study of the bone *** signs of strengthening of the processes of differentiation and maturation of cellular elements were found in lymph nodes,which were showed as the increasing number of immunoblasts and large *** quantitative changes of cellular component morphology of lymphoid organs due to activation of migration,proliferation and di®erentiation of immune cells indicate the presence of immunostimulation effect of GNPs.

关键词： Gold nanoparticles lymphoid organs morphological changes bone marrow examination

Optical in vivo and ex vivo imaging of glioma cells migration via the cerebral vessels:Prospective clinical application of the beta2-adrenoreceptors blockade for glioma treatment

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Journal of Innovative Optical Health Sciences 2018年第4期11卷 98-107页

作者： Olga Pavlova Alexander Shirokov Alexander Fomin nikita Navolokin Andrey Terskov Alexander Khorovodov Anton Namykin Alexey Pavlov Valery Tuchin Oxana Semyachkina-Glushkovskaya Interdisciplinary Center of Critical Technologies in Medicine Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Institute of biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences13 Entuziastov Ave.Saratov 410049Russia Saratov State Medical University 112 bolshaya Kazachia Str. Saratov 410012Russia Department of Optics and biophotonics Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Yuri Gagarin State Technical University of Saratov 77 Politechnicheskaya Str. Saratov 410054Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control of RAS 24 Rabochaya Str.Saratov 410028Russia Laboratory of biophotonics Tomsk State University 36 Lenin's Ave.Tomsk 634050Russia

Malignant gliomas are highly invasive tumors that 1use the cerebral vessels for invasion due to high vascular fragility of the blood--brain barrier(bbb).On one hand,glioma is characterized by the bbb disruption,on the other hand,drug brain delivery via the bbb is a big challenge in glioma *** limited information about vascular changes associated with glioma growth is a reason of slow progress in prevention of glioma ***,we present in vrivo and er vrivo study of the bbb disruption and glioma cells(GCs)migration in rats using fuorescence and confocal *** uncovered a local breach in the bbb in the main tumor mass but not within the border of normal and malignant cells,where the bbb was impermeable for high weight *** migr ation of GCs were observed via the cerebral vessels with the intact bbb that was associated with macrophages *** mechanisms underlying glioma progression remain umknown but there is an evidence that the sympathetic nervous system(SNS)via activation of vascular beta2-adrenoreceptors(b2-ADRs)can play an important role in tumor *** results clearly show an increase in the expression of vascular b2-ADRs and production of the beta arrestin-1-co-factor of b2-ADRs signaling pathway in rats with *** blockade of b2-ADRs reduces the bbb disruption,macrophages infiltration,GCs migration and increases survival *** data suggest that the blockade of b2-ADRs may be a novel adjuvant therapeutic strategy to reduce glioma progression and prevent metastasis。

关键词： Glioma macrophages blood-brain barrier beta-2 adrenoreceptors bet a arrestin-1

MET inhibitor tepotinib antagonizes multidrug resistance mediated by AbCG2 transporter:In vitro and in vivo study

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Acta Pharmaceutica Sinica b 2022年第5期12卷 2609-2618页

作者： Zhuo-Xun Wu Qiu-Xu Teng Yuqi Yang nikita Acharekar Jing-Quan Wang Min He Sabesan Yoganathan Jun Lin Jian Wang Zhe-Sheng Chen Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Department of Anesthesiology Stony Brook University Health Sciences CenterStony BrookNY 11794USA Department of Radiotherapy the Afﬁliated Jiangyin People’s Hospital of Nantong UniversityJiangyin 214400China

Overexpression of AbCG2 transporter in cancer cells has been linked to the development of multidrug resistance(MDR), an obstacle to cancer therapy. Our recent study uncovered that the MET inhibitor,tepotinib, is a potent reversal agent for AbCb1-mediated MDR. In the present study, we reported for the first time that the MET inhibitor tepotinib can also reverse AbCG2-mediated MDR in vitro and in vivo by directly binding to the drug-binding site of AbCG2 and reversibly inhibiting AbCG2 drug efflux activity, therefore enhancing the cytotoxicity of substrate drugs in drug-resistant cancer cells. Furthermore, the AbCb1/AbCG2 double-transfected cell model and AbCG2 gene knockout cell model demonstrated that tepotinib specifically inhibits the two MDR transporters. In mice bearing drug-resistant tumors, tepotinib increased the intratumoral accumulation of AbCG2 substrate drug topotecan and enhanced its antitumor effect. Therefore, our study provides a new potential of repositioning tepotinib as an AbCG2 inhibitor and combining tepotinib with substrate drugs to antagonize AbCG2-mediated MDR.

关键词： MET inhibitor Tepotinib Multidrug resistance AbCG2 transporter Reversal agent Combination treatment Chemotherapy In vivo study

Recent advances in laser self-injection locking to high-Q microresonators

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Frontiers of physics 2023年第2期18卷 89-130页

作者： nikita M.Kondratiev Valery E.Lobanov Artem E.Shitikov Ramzil R.Galiev Dmitry A.Chermoshentsev nikita Yu.Dmitriev Andrey N.Danilin Evgeny A.Lonshakov Kirill N.Min’kov Daria M.Sokol Steevy J.Cordette Yi-Han Luo Wei Liang Junqiu Liu Igor A.bilenko Directed Energy Research Centre Technology Innovation InstituteAbu DhabiUnited Arab Emirates Russian Quantum Center MoscowRussia Skolkovo Institute of Science and Technology SkolkovoRussia Moscow Institute of Physics and Technology DolgoprudnyMoscow RegionRussia Faculty of Physics Lomonosov Moscow State UniversityMoscowRussia Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China International Quantum Academy Shenzhen 518048China Key Laboratory of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Hefei National Laboratory University of Science and Technology of ChinaHefei 230026China

The stabilization and manipulation of laser frequency by means of an external cavity are nearly ubiquitously used in fundamental research and laser applications. While most of the laser light transmits through the cavity, in the presence of some back-scattered light from the cavity to the laser, the self-injection locking effect can take place, which locks the laser emission frequency to the cavity mode of similar frequency. The self-injection locking leads to dramatic reduction of laser linewidth and noise. Using this approach, a common semiconductor laser locked to an ultrahigh-Q microresonator can obtain sub-Hertz linewidth, on par with state-of-the-art fiber lasers. Therefore it paves the way to manufacture high-performance semiconductor lasers with reduced footprint and cost. Moreover, with high laser power, the optical nonlinearity of the microresonator drastically changes the laser dynamics, offering routes for simultaneous pulse and frequency comb generation in the same microresonator. Particularly, integrated photonics technology, enabling components fabricated via semiconductor CMOS process, has brought increasing and extending interest to laser manufacturing using this method. In this article, we present a comprehensive tutorial on analytical and numerical methods of laser self-injection locking, as well a review of most recent theoretical and experimental achievements.

关键词： self-injection locking laser stabilization microresonator nonlinearity single-frequency lasing multi-frequency lasing

Evidence for Non-existence of Oscillations in Photofield Emission Current in Gallium Arsenide

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材料科学与工程（中英文A版） 2022年第3期12卷 94-96页

作者： R.K.Thapa nikita Chhetri Condensed Matter Theory Research Laboratory Physics DepartmentSikkim Alpine UniversityNamchi 737126SikkimIndia Department of Physics Sikkim Alpine UniversityKamrang 737126NamchiIndia Department of Physics North Bengal UniversitySiliguri 734013DarjeelingW.B.India

We have shown here the results of PFEC(photofield emission current)calculated for GaAs(gallium arsenide).We have used the initial state wavefunctions derived using the Kronig-Penney potential model for evaluating the *** have found that PFEC is not oscillatory as obtained by Modinos and Klient,[Solid State Commun.50,651(1984)],but it is an exponential function.

关键词： Photofield emission matrix element Kronig-Penney potential model density of state.

The optical tweezer of skyrmions

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npj Computational Materials 2020年第1期6卷 484-490页

作者： Xi-Guang Wang Levan Chotorlishvili Vitalii K.Dugaev Arthur Ernst Igor V.Maznichenko nikita Arnold Chenglong Jia Jamal berakdar Ingrid Mertig Józef barnaś School of Physics and Electronics Central South University410083 ChangshaChina Institut für Physik Martin-Luther Universität Halle-Wittenberg06099 HalleSaaleGermany Department of Physics and Medical Engineering Rzeszów University of Technology35-959 RzeszówPoland Institute for Theoretical Physics Johannes Kepler UniversityAltenberger Straße 694040 LinzAustria Max Planck Institute of Microstructure Physics Weinberg 206120 HalleSaaleGermany Soft Materials Lab Linz Institute of Technology LITJohannes Kepler University LinzAltenberger Straße 694040 LinzAustria Department of Soft Matter Physics Institute for Experimental PhysicsJohannes Kepler UniversityAltenberger Straße 694040 LinzAustria Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou University730000 LanzhouChina Faculty of Physics Adam Mickiewicz University61-614 PoznańPoland

In a spin-driven multiferroic system,the magnetoelectric coupling has the form of effective dynamical Dzyaloshinskii–Moriya(DM)***,it is confirmed,for instance,for Cu_(2)OSeO_(3),that the DM interaction has an essential role in the formation of skyrmions,which are topologically protected magnetic *** skyrmions are very robust and can be manipulated through an electric *** external electric field couples to the spin-driven ferroelectric polarization and the skyrmionic magnetic texture emerged due to the DM *** this work,we demonstrate the effect of optical *** a particular configuration of the external electric fields it is possible to trap or release the skyrmions in a highly controlled *** functionality of the proposed tweezer is visualized by micromagnetic simulations and model analysis.

关键词： interaction field instance