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Alterations of morphology of lymphoid organs and peripheral blood indicators under the influence of gold nanoparticles in rats

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Journal of Innovative Optical Health Sciences 2016年第1期9卷 47-56页

作者： Alla B.Bucharskaya Svetlana S.Pakhomy Olga v.Zlobina Galina N.Maslyakova Olga v.Matveeva Irina O.Bugaeva nikita A.Navolokin Boris N.Khlebtsov vladimir A.Bogatyrev Nikolai G.Khlebtsov valery v.Tuchin Saratov State Medical University 112 B.Kazach'ya str.Saratov 410012Russia Institute of Biochemistry and Physiology of Plants and Microorganisms RAS 13 Entuziastov Prospekt.Saratov 410049Russia Saratov State University 83 Astrakhanskaya str.Saratov 410012Russia§Institute of Precise Mechanics and Control of Russian Academy of Sciences 24Rabochaya str.Saratov 410028Russia Interdisciplinary Laboratory of Biophotonics Tomsk State University 36 Lenina str.Tomsk 634050Russia

At present,gold nanoparticles(GNPs)are widely used in biomedical applications such as cancer diagnostics and ***,the potential toxicity hazards of these nanomaterials and human safety concerns are gaining significant ***,we report the effects of prolonged peroral administration of GNPs with different sizes(2,15 and 50 nm)on morphological changes in lymphoid organs and indicators of peripheral blood of laboratory *** experiment was conducted on 24 white mongrel male rats weighing 180–220 g,gold nanospheres sizes 2,15 and 50nm were administered orally for 15 days at a dosage of 190g/kg of animal body *** GNPs were conjugated with polyethylene glycol to increase their biocompatibility and *** size-dependent decrease of the number of neutrophils and lymphocytes was noted in the study of peripheral blood,especially pronounced after administration of GNPs with size of 50 *** stimulation of myelocytic germ of hematopoiesis was recorded at morphological study of the bone *** signs of strengthening of the processes of differentiation and maturation of cellular elements were found in lymph nodes,which were showed as the increasing number of immunoblasts and large *** quantitative changes of cellular component morphology of lymphoid organs due to activation of migration,proliferation and di®erentiation of immune cells indicate the presence of immunostimulation effect of GNPs.

关键词： Gold nanoparticles lymphoid organs morphological changes bone marrow examination

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The morphological changes in the internal organs of laboratory animals after prolonged oral administration of gold nanoparticles

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Journal of Innovative Optical Health Sciences 2016年第4期9卷 74-84页

作者： Alla B.Bucharskaya Galina N.Maslyakova Svetlana S.Pakhomy Olga v.Zlobina Irina O.Bugaeva nikita A.Navolokin Boris N.Khlebtsov vladimir A.Bogatyrev Nikolai G.Khlebtsov valery v.Tuchin Saratov State Medical University n.a.v.I.Razumovsky 410012 Saratov Russia Institute of Biochemistry and Physiology of Plants and Microorganisms RAS 410049 Saratov Russia Research-Educational Institute of Optics and Biophotonics Saratov National Research State University 410012 Saratov Russia Institute of Precision Mechanics and Control RAS 410028 Saratov Russia Interdisciplinary Laboratory of Biophotonics Tomsk National Research State University 634050 TomskRussia

Recently gold nanoparticles(GNPs)have been actively studied as photot hermal converters,drug carriers,and imaging agents in a wide range of applications in cancer diagnosis and ther *** prolonged peroral administration of GNPs in a range of sizes was performed to investigate the morphological changes and their reversibility in the internal organs of laboratory *** this study,GNP's with average diameters of 2 nm,15 nm and 50nm were administered during 30 days,and the reversibility of morphological changes was investigated 14 days after *** the prolonged administration of GNPs,the severity of morphological changes in the liver,kidney,spleen and lymph nodes depended on the nanoparticle ***,50 nm nano-particles caused the most pronounced dystrophic and necrobiotic effects,whereas the smallest 2 nm nanoparticles caused proliferative *** importantly,the development of patho-logical processes was reversible,as evidenced by the gradual restoration of the organ structure at 14 days after the end of GNPs administration.

关键词： Gold nanoparticles prolonged peroral administration morphological changes reversibility.

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NMR Imaging of Heavy Crude Oil for Softening Detection under Pleat Treatment

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材料科学与工程（中英文A版） 2011年第4X期1卷 545-551页

作者： Morozov Evgeny v. Martyanov Oleg N. volkov nikita v Falaleev Oleg v. Kirensky Institute of Physics SB RAS Krasnoyarsk 660036 Russia Special designing and technological bureau "Nauka" KSC SB RAS Krasnoyarsk 660049 Russia Boreskov Institute of Catalysis SB RAS Novosibirsk 630090 Russia

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Facile Synthesis of Amino Acid Decorated Water-Soluble Fullerene Derivatives with Anti-influenza Activity

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Chinese Journal of Chemistry 2023年第15期41卷 1803-1808页

作者： valeriya S.Bolshakova Ekaterina O.Sinegubova Yana L.Esaulkova Alexander S.Peregudov Ekaterina A.Khakina nikita A.Slesarenko Alexander F.Shestakov vladimir v.Zarubaev Pavel A.Troshin Olga A.Kraevaya Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry of RAS Academician Semenov ave.1Chernogolovka142432Russia Higher Chemical College of RAS D.1.Mendeleev University of Chemical Technology of RussiaMiusskaya square 9Moscow125047Russia St.Petersburg Pasteur Institute Mira st.14St.Petersburg197101Russia A.N.Nesmeyanov Institute of Organoelement compounds of RAS Vavylova St.28B-334Moscow119991Russia National Research University Higher School of Economics Vavylova St.7Moscow101000Russia Department of Fundamental Physics&Chemical Engineering M.V.Lomonosov Moscow State UniversityLeninskie Gory 1/51Moscow119991Russia Zhengzhou Research Institute Harbin Institute of TechnologyLongyuan East 7th 26Jinshui DistrictZhengzhouHenan 450003China Harbin Institute of Technology West Dazhi Street 92Nan Gang DistrictHarbinHeilongjiang 150001China

Comprehensive Summary Herein,we present a facile synthesis of amide-type water-soluble fullerene derivatives decorated with five residues of amino *** compared to the previously developed approaches,the proposed method enables usage of a broad range of amino acids,including those unstable under Friedel-Crafts reaction ***,it is fully tolerant to the nature of the sixth addend X in C60R5X precursor compounds and allows one to obtain fullerene derivatives with X=Cl,H,*** synthesized amide-type water-soluble fullerene derivatives demonstrated promising antiviral activities against rimantadine-resistant influenzaА/Puerto Rico/8/34(Н1N1)virus in vitro.

关键词： Fullerenes Amino acids Regioselectivity Water-solublel Influenza Antiviral

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中国早白垩世反鸟类一新科(Bohaiornithidae ***.)（英文）

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古脊椎动物学报 2014年第1期52卷 31-76页

作者：王敏周忠和邹晶梅 nikita v.ZELENKOv 中国科学院古脊椎动物与古人类研究所脊椎动物演化与人类起源重点实验室北京100044 中国科学院大学北京100049 俄罗斯科学院Borissiak古生物研究所莫斯科117997

依据3件近乎完整的骨骼化石,记述了辽宁建昌早白垩世湖相地层九佛堂组反鸟类的两个新属种:马氏副渤海鸟(Parabohaiornis martini *** ***.)和库氏长爪鸟(Longusunguis kurochkini *** ***.)。这两个新属种与此前报道的渤海鸟(Bohaiornis... 详细信息

依据3件近乎完整的骨骼化石,记述了辽宁建昌早白垩世湖相地层九佛堂组反鸟类的两个新属种:马氏副渤海鸟(Parabohaiornis martini *** ***.)和库氏长爪鸟(Longusunguis kurochkini *** ***.)。这两个新属种与此前报道的渤海鸟(Bohaiornis)、神七鸟(Shenqiornis)、齿槽鸟(Sulcavis)和周鸟(Zhouornis)具有一些独特的形态特征,包括吻端粗壮、牙齿粗大并近似锥形、叉骨上升支的末端明显膨大、胸骨的后外侧突向外侧强烈偏转、跗蹠骨粗短、第三脚趾具有很长的爪子。对包含有大量中生代鸟类和形态特征的矩阵进行了系统发育分析,其结果显示这两个新属种与上述的这些反鸟构成了一个单系类群,基于此建立了一个新科——渤海鸟科。渤海鸟科包括6个属,代表了目前已知的反鸟类中多样性最丰富的一个类群,进一步增加了我们对于反鸟类高阶分类单元之间亲缘关系的认识。渤海鸟科强壮的吻端和脚爪表明其占据了不同于其他早白垩世反鸟的生态位。

关键词：早白垩世热河生物群 .反鸟类 Bohaiornis Shenqiornis Sulcavis Zhouornis

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Sparse representation for machine learning the properties of defects in 2D materials

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npj Computational Materials 2023年第1期9卷 1186-1195页

作者： nikita Kazeev Abdalaziz Rashid Al-Maeeni Ignat Romanov Maxim Faleev Ruslan Lukin Alexander Tormasov A.H.Castro Neto Kostya S.Novoselov Pengru Huang Andrey Ustyuzhanin Institute for Functional Intelligent Materials National University of Singapore4 Science Drive 2117544 SingaporeSingapore Constructor University Bremen gGmbH Campus Ring 1Bremen 28759Germany HSE University Myasnitskaya Ulitsa20101000 MoscowRussia Innopolis University Universitetskaya St1InnopolisRepublic of Tatarstan 420500Russia Centre for Advanced 2D Materials National University of Singapore6 Science Drive 2117546 SingaporeSingapore

Two-dimensional materials offer a promising platform for the next generation of(opto-)electronic devices and other high technology *** of the most exciting characteristics of 2D crystals is the ability to tune their properties via controllable introduction of ***,the search space for such structures is enormous,and ab-initio computations prohibitively *** propose a machine learning approach for rapid estimation of the properties of 2D material given the lattice structure and defect *** method suggests a way to represent configuration of 2D materials with defects that allows a neural network to train quickly and *** compare our methodology with the state-of-the-art approaches and demonstrate at least 3.7 times energy prediction error ***,our approach is an order of magnitude more resource-efficient than its contenders both for the training and inference part.

关键词： properties defects prediction

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Terahertz technology in intraoperative neurodiagnostics:A review

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Opto-Electronic Advances 2023年第5期6卷 41-67页

作者： nikita v.Chernomyrdin Guzel R.Musina Pavel v.Nikitin Irina N.Dolganova Anna S.Kucheryavenko Anna I.Alekseeva Yuye Wang Degang Xu Qiwu Shi valery v.Tuchin Kirill I.Zaytsev Prokhorov General Physics Institute of the Russian Academy of Sciences Moscow 119991Russia Bauman Moscow State Technical University Moscow 105005Russia Institute for Regenerative Medicine Sechenov UniversityMoscow 119991Russia Institute of Solid State Physics of the Russian Academy of Sciences Chernogolovka 142432Russia Research Institute of Human Morphology Moscow 117418Russia School of Precision Instrument and Optoelectronic Engineering Tianjin UniversityTianjin 300000China College of Materials Science and Engineering Sichuan UniversityChengdu 610000China Science Medical Center Saratov State UniversitySaratov 410012Russia Institute of Precision Mechanics and Control FRC"Saratov Scientific Centre of the Russian Academy of Sciences"Saratov 410028Russia

Terahertz(THz)technology offers novel opportunities in biology and medicine,thanks to the unique features of THzwave interactions with tissues and *** them,we particularly notice strong sensitivity of THz waves to the tissue water,as a medium for biochemical reactions and a main endogenous marker for THz spectroscopy and *** of the brain have an exceptionally high content of *** factor,along with the features of the structural organization and biochemistry of neuronal and glial tissues,makes the brain an exciting subject to study in the THz *** this paper,progress and prospects of THz technology in neurodiagnostics are overviewed,including diagnosis of neurodegenerative disease,myelin deficit,tumors of the central nervous system(with an emphasis on brain gliomas),and traumatic brain *** and applied challenges in study of the THz-wave–brain tissue interactions and development of the THz biomedical tools and systems for neurodiagnostics are discussed.

关键词： THz technology THz spectroscopy and imaging superresolution imaging biophotonics brain neurodiagnosis tumor glioma neurodegenerative diseases brain injury light scattering

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The role of wild goose(Anser) populations of Russia and theTibet Plateau in the spread of the avian influenza virus

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Chinese Birds 2011年第3期2卷 140-146页

作者： Mariya v.SIvAY nikita Y.SILKO Kirill A.SHARSHOv Aleksander v.PROKUDIN 李来兴杨敏操胜 Aleksander M.SHESTOPALOv Novosibirsk State University Pirogova Street 2630090NovosibirskRussia State Research Center of virology and Biotechnology Rospotrabnadzora 630559KoltsovoRussia Scientific Research Institute of Agriculture of Utmost North Siberian Branch of Russian Agricultural Academy NorilskRussia 中国科学院西北高原生物研究所

Wild birds of the orders Anseriformes and Charadriiformes represent a natural reservoir of low pathogenic avian influenza(LPAI) viruses(family Orthomyxoviridae).Wild geese(order Anseriformes)relating to waterfowls undertake extensive migration flights reaching thousands of *** of the avian influenza virus(AIv) from wild geese is quite low or *** aims of this study are to monitor the AIv in different wild goose species,nesting on Russian territory and the Tibet Plateau and to analyze the derived data for the purpose of determining the role of these wild bird species in spreading *** our study 3245 samples from nine wild goose species in nine regions of Russia and on the territory of the Tibet Plateau(the Xizang Autonomous Region) were tested and no AIv were *** study shows the non-essential role of wild geese in the spread of the AIv over long distances and reaches theconclusion that geese are probably not natural reservoirs for the primary ***,further inquiry of AIv in wild goose populations is *** of wild geese and AIv ecology will allow us to obtainmore information about pathogen-host relationships and to make arrangements for the maintenance ofwild goose populations.

关键词： avian influenza virus wild geese Russia Tibet Plateau

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Highly efficient transient stimulated Raman scattering on secondary vibrational mode of BaWO_(4) crystal due to its constructive interference with self-phase modulation

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Chinese Optics Letters 2023年第3期21卷 113-117页

作者： Igor Kinyaevskiy valeri Kovalev Pavel Danilov nikita Smirnov Sergey Kudryashov Andrey Koribut Andrey Ionin P.N.Lebedev Physical Institute of the Russian Academy of Sciences Moscow 119991Russia

An exceptionally high stimulated Raman scattering[SRS]conversion efficiency to the first Stokes component associated with the secondary[low-frequency and low intensity]vibrational mode v2[~330 cm^[-1]]was observed in a BaWO4 crystal in a highly transient regime of *** effect takes place in the range of pump pulse energy from~0.1 to~0.5μJ with maximum energy conversion efficiency up to 35%at 0.2μ*** nature of the observed effects is explained by interference of SRS and self-phase modulation,where the latter is related to a noninstantaneous orientational Kerr nonlinearity in the BaWO4 crystal.

关键词： stimulated Raman scattering secondary vibrational mode self-phase modulation ultrashort laser pulses transient phenomena

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Modeling of the Primary Acts of the Interaction between a Cell and an External Mechanical Field

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Applied Mathematics 2019年第7期10卷 527-544页

作者： Irina v. Ogneva Maria A. Usik Nikolay S. Biryukov nikita O. Kremenetskii Yuliya S. Zhdankina Cell Biophysics Laboratory State Scientific Center of the Russian Federation Institute of Biomedical Problems of the Russian Academy of Sciences Moscow Russia I. M. Sechenov First Moscow State Medical University Moscow Russia Ishlinsky Institute for Problems in Mechanics of the Russian Academy of Sciences Moscow Russia

The mechanism of interaction between a cell and an external mechanical field is still poorly understood, and the accumulated diverse experimental data are often scattered. Therefore, the aim of this work was to systematize the experimental data in a mathematical model of the interaction between a cell and an external mechanical field based on standard kinetic equations and Fick’s diffusion equation. Assuming that the cortical cytoskeleton proteins play a key role in cell mechanosensitivity, we compared the results of mathematical modeling and experimental data concerning the content of cytoskeletal proteins at the early stages of a mechanical field change. In addition, the proposed mathematical model suggests the dynamics of changes of a key transcription factor, which is necessary for the expression of certain genes encoding cytoskeletal proteins.

关键词： Cell Mechanosensititvity Kinetic Equations Cortical Cytoskeleton

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