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Clinical characteristics of COVID-19 patients who underwent tracheostomy and its effect on outcome:A retrospective observational study

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World Journal of Virology 2022年第6期11卷 477-484页

作者： Yudhyavir Singh Kapil Dev Soni Abhishek Singh nikita Choudhary Fahina Perveen Richa Aggarwal Nishant Patel Shailendra Kumar Anjan Trikha Department of Anesthesiology Pain Medicine and Critical CareAll India Institute of Medical SciencesNew Delhi 110029India Department of Critical and Intensive Care Jai Prakash Narayan Apex Trauma CenterAll India Institute of Medical SciencesNew Delhi 110029India Department of Anesthesia All India Institute of Medical SciencesNew Delhi 110029India

BACKGROUND The exponential rise in Coronavirus disease 2019(COVID-19)cases has resulted in an increased number of patients requiring prolonged ventilatory support and subsequent *** the limited availability of literature regarding the outcomes of COVID-19 patients with tracheostomy,we attempted to study the clinical characteristics and multiple parameters affecting the outcomes in these *** To determine all-cause mortality following tracheostomy and its association with various risk factors in COVID-19 *** This retrospective study included 73 adult COVID-19 patients admitted to the ICU between 1 April,2020 and 30 September,2021 who underwent tracheostomy as a result of acute respiratory failure due to *** data collected included demographics(age,sex),comorbidities,type of oxygen support at admission,severity of COVID-19,complications,and other parameters such as admission to tracheostomy,intubation to tracheostomy,ICU stay,hospital stay,and *** This study included 73 adult patients with an average age of 52±16.67 years,of which 52%were *** average time for admission to tracheostomy was 18.12±12.98 days while intubation to tracheostomy was 11.97±9 *** mortality rate was 71.2%and 28.8%of patients were discharged *** mean duration of ICU and hospital stay was 25±11 days and 28.21±11.60 days,*** age,severe COVID-19,mechanical ventilation,shock and acute kidney injury were associated with poor prognosis;however,early tracheostomy in intubated patients resulted in better *** Patients with severe COVID-19 requiring mechanical ventilation have a poor prognosis but patients with early tracheostomy may benefit with no added *** recommend that the timing of tracheostomy be decided on a case-by-case basis and a well-designed randomised controlled trial should be performed to elucidate the potential benefit of early tracheostomy in such patients.

关键词： COVID-19 Intubation Mechanical ventilation ICU Tracheostomy Oxygen therapy

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Modeling of the Primary Acts of the Interaction between a Cell and an External Mechanical Field

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Applied Mathematics 2019年第7期10卷 527-544页

作者： Irina V. Ogneva Maria A. Usik Nikolay S. Biryukov nikita O. Kremenetskii Yuliya S. Zhdankina Cell Biophysics Laboratory State Scientific Center of the Russian Federation Institute of Biomedical Problems of the Russian Academy of Sciences Moscow Russia I. M. Sechenov First Moscow State Medical University Moscow Russia Ishlinsky Institute for Problems in Mechanics of the Russian Academy of Sciences Moscow Russia

The mechanism of interaction between a cell and an external mechanical field is still poorly understood, and the accumulated diverse experimental data are often scattered. Therefore, the aim of this work was to systematize the experimental data in a mathematical model of the interaction between a cell and an external mechanical field based on standard kinetic equations and Fick’s diffusion equation. Assuming that the cortical cytoskeleton proteins play a key role in cell mechanosensitivity, we compared the results of mathematical modeling and experimental data concerning the content of cytoskeletal proteins at the early stages of a mechanical field change. In addition, the proposed mathematical model suggests the dynamics of changes of a key transcription factor, which is necessary for the expression of certain genes encoding cytoskeletal proteins.

关键词： Cell Mechanosensititvity Kinetic Equations Cortical Cytoskeleton

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民机复合材料等同性验证方法及二类错误控制研究

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航空制造技术 2020年第21期63卷 70-79页

作者：涂圣余音吕新颖 nikita Kalutskiy 上海交通大学航空航天学院飞行器先进结构与材料试验中心上海200240 莫斯科航空学院机身应力试验室莫斯科125080

在民用复合材料飞机的制造和适航审定过程中,复合材料等同性验证在新材料替代原材料后的适航认证方面发挥重要作用。基于复合材料等同性的验证原理,针对控制复合材料性能的关键参数,研究了等同性的验证方法。运用假设检验的方法,推导了... 详细信息

在民用复合材料飞机的制造和适航审定过程中,复合材料等同性验证在新材料替代原材料后的适航认证方面发挥重要作用。基于复合材料等同性的验证原理,针对控制复合材料性能的关键参数,研究了等同性的验证方法。运用假设检验的方法,推导了复合材料等同性中第二类错误的理论分析方法,并提出和讨论了降低犯第二类错误概率的措施。研究表明:通常利用统计检验来比较新材料与原材料在关键性能上的差异程度以判定材料是否等同;在目前的复合材料等同性检验中,除了注意第一类错误的控制,更应该重视危害性更大的第二类错误;而增大试验样本数量能够有效降低犯第二类错误的概率;针对复合材料在民用飞机中的应用位置和受力情况来控制犯第二类错误的概率,选择等同性试验样本数量,以达到在等同性验证中既控制第二类错误又降低验证成本的目的。

关键词：适航验证复合材料等同性验证假设检验第二类错误复合材料应用位置

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Basal cisternostomy for traumatic brain injury: A case report of unexpected good recovery

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Chinese Journal of Traumatology 2022年第5期25卷 302-305页

作者： Manuel De Jesus Encarnacion Ramirez Rossi Evelyn Barrientos Castilo Anton Vorobiev nikita Kiselev Amaya Alvarez Aquino Ibrahim E.Efe Department of Neurosurgery Russian People's Friendship University MoscowRussia Department of Neurosurgery Municipal HospitalPodolskRusia Department of Neurosurgery International Center for Neurological Restoration HavanaCuba Charite-Universitatsmedizin Berlin Corporate Member of Freie Universitat BerlinHumbold-Universitat zu BerlinAnd Berlin Institute of HealthBerlinGermany

In subarachnoid hemorrhage following traumatic brain injury (TBI), the high intracisternal pressure drives the cerebrospinal fluid into the brain parenchyma, causing cerebral edema. Basal cisternostomy involves opening the basal cisterns to atmospheric pressure and draining cerebrospinal fluid in an attempt to reverse the edema. We describe a case of basal cisternostomy combined with decompressive craniectomy. A 35-year-old man with severe TBI following a road vehicle accident presented with acute subdural hematoma, Glasgow coma scale score of 6, fixed pupils and no corneal response. Opening of the basal cisterns and placement of a temporary cisternal drain led to immediate relaxation of the brain. The patient had a Glasgow coma scale score of 15 on postoperative day 6 and was discharged on day 10. We think basal cisternostomy is a feasible and effective procedure that should be considered in the management of TBI.

关键词： Basal cisternostomy Cerebral edema Decompressive craniectomy Neurotrauma Traumatic brain injury

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沙虫

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世界建筑导报 2014年第2期29卷 99-101页

作者：马可.卡萨格兰 nikita Wu

沙虫是坐落在比利时韦德市沿岸沙丘上的有机建构/空间/创造体。建筑有机的拱形外壳是用柳条编织而成的,总长45米,宽10米,高度则各不相同。沙虫弯曲的形态与比利时小镇上的沙丘融为一体。以作品和环境持续交互的＂当地知识＂为依据,这座... 详细信息

沙虫是坐落在比利时韦德市沿岸沙丘上的有机建构/空间/创造体。建筑有机的拱形外壳是用柳条编织而成的,总长45米,宽10米,高度则各不相同。沙虫弯曲的形态与比利时小镇上的沙丘融为一体。以作品和环境持续交互的＂当地知识＂为依据,这座高大的景观装置,是一件自由游走于建筑及环境艺术之间的作品。建筑师卡萨格兰及其年轻建筑师团队历I],-J4周，与当地专家共同研究柳条材料，并讨论出“弱建筑”的命题，意思是“通过灵活和有机性设计成为与自然相融合的人工建筑”。

关键词：室内面积环境艺术韦德萨格 artist 自然相 relaxation 有机性人工建筑 visitors

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Blood–brain barrier and laser technology for drug brain delivery

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Journal of Innovative Optical Health Sciences 2017年第5期10卷 27-38页

作者： Oxana V.Semyachkina-Glushkovskaya Arkady S.Abdurashitov Elena I.Saranceva Eketerina G.Borisova Alexander A.Shirokov nikita V.Navolokin Saratov State University 83 Astrakhanskaya Str.Saratov 410012 Russia Institute of Electronics Bulgarian Academy of Sciences TsarigradskoChaussee 72 Sofia 1784Bulgaria Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences 13 Prospekt EntuziastovSaratov 410049Russia Saratov State Medical University Saratov 410010 Russia

Here,we discuss an important problem in medicine as development of efctive strategies for brain drug *** problem is related to the blood-brain barrier(BBB),which is a“customs”controlling the entrance of different molecules from blood into the brain protecting the normal function of central nervous system(CNS).We show three interfaces of anatomical side of BBB and two functional types of BBB一physical and transporter *** this protective mechanism is essential for health of CNS,it also creates a hindrance to the entry of drugs into the *** BBB was discovered over 100 years ago but till now,there is no efective methods for brain drug *** ane more than 70 approaches for overcoming BBB incuding physical,chenical and biological techniques but all of these tools have limitation to be widely used in clinical practice due to invasi venes,challenge in performing,very costly or lim-itation of drug *** therapy(PDT)is usual clinical method of surgical navigation for the resection of brain tumor and anti-cancer ***,the application of PDT is considered as a potential promising tool for brain drug delivery via opening of ***,we show the first sucoessful experimental results in this field discussing the adventures and disadv antages of PDT-related BBB disruption as well as altematives to overcome these limitations and possi ble mechanisms with new pathways for brain clearance via gly mphatic and lymphatic systems.

关键词： Blood-brain barrier laser technologies photodynamic therapy brain drug delivery

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Novel materials for solid oxide fuel cells cathodes and oxygen separation membranes:Fundamentals of oxygen transport and performance

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Carbon Resources Conversion 2020年第1期3卷 112-121页

作者： Vladislav A.Sadykov Ekaterina M.Sadovskaya nikita F.Eremeev Elena Yu.Pikalova Nina M.Bogdanovich Elena A.Filonova Tamara A.Krieger Yulia E.Fedorova Alexey V.Krasnov Pavel I.Skriabin Anton I.Lukashevich Robert Steinberger-Wilckens Izaak C.Vinke Federal Research Center Boreskov Institute of Catalysis SB RAS 630090 NovosibirskRussia Novosibirsk State University 630090 NovosibirskRussia Institute of High Temperature Electrochemistry UB RAS 620137 YekaterinburgRussia Ural Federal University 620002 YekaterinburgRussia University of Birmingham EdgbastonBirmingham B152TTUK Forschungszentrum Jülich GmbH 52425 JülichGermany

In the field of modern hydrogen energy,obtaining pure hydrogen and syngas and then being able to use them for green energy production are significant *** solid oxide fuel cells(SOFC)and catalytic membranes for oxygen separation as well as materials for these devices is one of the most likely ways to solve these *** this work,the authors’recent studies in this field are reviewed;the fundamentals of developing materials for SOFC cathodes and oxygen separation membranes’permselective layers based on research of their oxygen mobility and surface reactivity are ***-Popper phases Ln_(2-x)Ca_(x)NiO_(4+δ)(LnCNO)and perovskite-fluorite nanocomposites PrNi_(0.5)Co_(0.5)O_(3-δ)-Ce_(0.9)Y_(0.1)O_(2-δ)(PNC-YDC)were studied by isotope exchange of oxygen with C_(18)O_(2)and^(18)O_(2)in flow and closed *** LnCNO a high oxygen mobility was shown(D*~10^(-7)cm^(2)/s at 700℃),being provided by the cooperative mechanism of oxygen migration involving both regular and highly-mobile interstitial *** PNC-YDC dominated a wide fast diffusion channel via fluorite phase and interphases due to features of the redistribution of cations resulting in superior oxygen mobility(D*~10^(-8)cm^(2)/s at 700℃).After optimization of composition and nanodomain structure of these materials,as cathodes of SOFC they provided a high power density,while for asymmetric supported oxygen separation membranes-a high oxygen permeability.

关键词： Solid oxide fuel cells Oxygen separation membranes Oxygen mobility Perovskites Nanocomposites Ruddlesden-Popper phases

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A new quantum speed-meter interferometer: measuring speed to search for intermediate mass black holes

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Light(Science & Applications) 2018年第1期7卷 940-948页

作者： Stefan L.Danilishin Eugene Knyazev nikita V.Voronchev Farid Ya.Khalili Christian Gräf Sebastian Steinlechner Jan-Simon Hennig Stefan Hild Institut für Theoretische Physik Leibniz Universität Hannover and Max-Planck-Institut für Gravitationsphysik(Albert-Einstein-Institut)Callinstraße 38D-30167 HannoverGermany SUPA School of Physics and AstronomyUniversity of GlasgowGlasgow G128QQUnited Kingdom M.V.Lomonosov Moscow State University Faculty of PhysicsMoscow 119991Russia Institut für Laserphysik und Zentrum für Optische Quantentechnologien der Universität Hamburg Luruper Chaussee 14922761 HamburgGermany

The recent discovery of gravitational waves(GW)by Advanced LIGO(Laser Interferometric Gravitational-wave Observatory)has impressively launched the novel field of gravitational astronomy and allowed us to glimpse exciting objects about which we could previously only *** sensitivity improvements at the low-frequency end of the detection band of future GW observatories must rely on quantum non-demolition(QND)methods to suppress fundamental quantum fluctuations of the light fields used to readout the GW *** we present a novel concept of how to turn a conventional Michelson interferometer into a QND speed-meter interferometer with coherently suppressed quantum back-action *** use two orthogonal polarizations of light and an optical circulator to couple *** carry out a detailed analysis of how imperfections and optical loss influence the achievable *** find that the proposed configuration significantly enhances the low-frequency sensitivity and increases the observable event rate of binary black-hole coalescences in the range of 102103Mby a factor of up to~300.

关键词： quantum allowed coherent

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Nanodiamond-Based Tests Systems for Biochemical Determination of Glucose and Cholesterol

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Journal of Biomaterials and Nanobiotechnology 2013年第3期4卷 242-246页

作者： nikita O. Ronzhin Alexey V. Baron Ekaterina S. Mamaeva Alexey P. Puzyr Vladimir S. Bondar Institute of Biophysics SB RAS Krasnoyarsk Russia Siberian Federal University Krasnoyarsk Russia.

Model test-systems for biochemical determination of glucose and cholesterol are designed by covalent coupling of enzymes to the surface of modified nanodiamonds (MND). In both cases after immobilization on MND the enzymes exhibit activity and catalyze the formation of a colored product in the chain of successive enzymatic reactions of oxidative azocoupling (Н2О2—4-aminoantipyrine—phenol). Produced MND-enzymes complexes: function in DI water and various buffers, over a wide range of temperature and pH, provide for the linear product yield over a broad concentration range of analyzed substances, make possible to test cholesterol and glucose in vitro many times, exhibit functional activity after long storage at + 4°C.

关键词： Nanodiamond Test-System Glucose Cholesterol

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Modification in Atmospheric Refractivity and GPS Based TEC as Earthquake Precursors

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Positioning 2014年第2期5卷 46-52页

作者： Sheetal P. Karia Kamlesh N. Pathak Kunvar S. Yadav nikita P. Chaudhary Nilesh C. Patel. Ranjan Jana Applied Physics Department S. V. National Institute of Technology Surat India

The present paper reports the modification in GPS TEC (total electron content) and atmospheric refractivity prior to the Iran earthquake that had occurred on 16 April 2013 in Iran (28.10°N, 62.05°E). The analysis of GPS-based TEC from two GPS receivers, Surat (21.16°N, 72.78°E) and Lucknow (26.91°N, 80.95°E ) and results of atmospheric refractivity profile for radiosonde observation stations (Shiraz, Iran and Delhi, India) around the fault line are presented in this paper. It is seen that atmospheric refractivity gets modified from 8 to 6 days prior to the earthquake at Shiraz, Iran and Delhi, India. The GPS TEC showed variations a few days prior to the earthquake. We conclude that in search of precursory signatures for an earthquake, both GPS TEC and refractivity are important parameters.

关键词： Total Electron Content Refractivity Earthquake

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