Blood–brain barrier and laser technology for drug brain delivery

作     者：Oxana V.Semyachkina-Glushkovskaya Arkady S.Abdurashitov Elena I.Saranceva Eketerina G.Borisova Alexander A.Shirokov Nikita V.Navolokin 

作者机构：Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Institute of Electronics Bulgarian Academy of Sciences TsarigradskoChaussee 72Sofia 1784Bulgaria Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences 13Prospekt EntuziastovSaratov 410049Russia Saratov State Medical University Saratov 410010Russia 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2017年第10卷第5期

页      面：27-38页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0808[工学-电气工程] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 10[医学] 

基　　金：supported by Grant of Russian Science Foundation No.17-15-01263 

主　　题：Blood-brain barrier laser technologies photodynamic therapy brain drug delivery 

摘      要：Here,we discuss an important problem in medicine as development of efctive strategies for brain drug *** problem is related to the blood-brain barrier(BBB),which is a“customscontrolling the entrance of different molecules from blood into the brain protecting the normal function of central nervous system(CNS).We show three interfaces of anatomical side of BBB and two functional types of BBB一physical and transporter *** this protective mechanism is essential for health of CNS,it also creates a hindrance to the entry of drugs into the *** BBB was discovered over 100 years ago but till now,there is no efective methods for brain drug *** ane more than 70 approaches for overcoming BBB incuding physical,chenical and biological techniques but all of these tools have limitation to be widely used in clinical practice due to invasi venes,challenge in performing,very costly or lim-itation of drug *** therapy(PDT)is usual clinical method of surgical navigation for the resection of brain tumor and anti-cancer ***,the application of PDT is considered as a potential promising tool for brain drug delivery via opening of ***,we show the first sucoessful experimental results in this field discussing the adventures and disadv antages of PDT-related BBB disruption as well as altematives to overcome these limitations and possi ble mechanisms with new pathways for brain clearance via gly mphatic and lymphatic systems.