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Estimation of boswellic acids in herbal formulations containing Boswellia serrata extract and comprehensive characterization of secondary metabolites using UPLC-Q-Tof-MS^e

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Journal of Pharmaceutical Analysis 2019年第6期9卷 414-422页

作者： Kumar Katragunta Bandi Siva niharika kondepudi PRRao Vadaparthi Nadendla Rama Rao Ashok Kumar Tiwari Katragadda Suresh Babu Centre for Natural Products and Traditional Knowledge CSIR-Indian Institute of Chemical TechnologyHyderabad500007India Chalapathi Institute of Pharmaceutical Sciences LamGuntur522034India College of Pharmaceutical Sciences Acharya Nagarjuna UniversityNagarjuna NagarGuntur522510India

Boswellia serrata is a widely used herb in Indian systems of medicine and is well known for its potential medicinal properties.A chromatographic method was developed for the analysis and quanti cation of six boswellic acid marker compounds,i.e.,keto boswellic acid(1),3-O-Acetyl 11-keto-boswellic acid(2),-b Boswellic acid(3),-Boswellic acid(4),3-O-Acetyl--boswellic acid(5)and 3-O-Acetyl--boswellic acid b(6)in commercial herbal products containing *** as an *** UPLCbwith Q-Tof-MS/MS makes the better identi cation of secondary metabolites and adulterants in the herbal formulations containing *** in rapid time using fragmentation approach than the traditional *** this study quanti cation of boswellic acids with UPLC-PDA method was performed as per the pharmacopeia ***,minor phytochemical constituenBoswellia serrata is a widely used herb in Indian systems of medicine and is well known for its potential medicinal properties.A chromatographic method was developed for the analysis and quantification of six boswellic acid marker compounds,i.e.,keto boswellic acid(1),3-O-Acetyl 11-keto b-boswellic acid(2),ɑ-Boswellic acid(3),b-Boswellic acid(4),3-O-Acetyl-ɑ-boswellic acid(5)and 3-O-Acetyl-b-boswellic acid(6)in commercial herbal products containing *** as an *** UPLC with Q-Tof-MS/MS makes the better identification of secondary metabolites and adulterants in the herbal formulations containing *** in rapid time using fragmentation approach than the traditional *** this study quantification of boswellic acids with UPLC-PDA method was performed as per the pharmacopeia ***,minor phytochemical constituents were identified and characterized with the help of LC-Q-Tof-MS/MS fragmentation data and various isoforms of boswellic acids and tirucallic acids in *** oleo-gum-resin extract were *** were identi ed and characterized with the help of LC-Q-Tof-MS/MS

关键词： Boswellia serrata Herbal formulations Quantification UPLC-Q-tof-MSe Boswellic acids Tirucallic acids

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Performance Evaluation of Deep Dense Layer Neural Network for Diabetes Prediction

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Computers, Materials & Continua 2023年第7期76卷 347-366页

作者： niharika Gupta Baijnath Kaushik Mohammad Khalid Imam Rahmani Saima Anwar Lashari Department of Computer Science and Engineering Shri Mata Vaishno Devi UniversityKatraJ&KIndia College of Computing and Informatics Saudi Electronic UniversityRiyadhSaudi Arabia

Diabetes is one of the fastest-growing human diseases worldwide and poses a significant threat to the population’s longer *** prediction of diabetes is crucial to taking precautionary steps to avoid or delay its *** this study,we proposed a Deep Dense Layer Neural Network(DDLNN)for diabetes prediction using a dataset with 768 instances and nine *** also applied a combination of classical machine learning(ML)algorithms and ensemble learning algorithms for the effective prediction of the *** classical ML algorithms used were Support Vector Machine(SVM),Logistic Regression(LR),Decision Tree(DT),K-Nearest Neighbor(KNN),and Naïve Bayes(NB).We also constructed ensemble models such as bagging(Random Forest)and boosting like AdaBoost and Extreme Gradient Boosting(XGBoost)to evaluate the performance of prediction *** proposed DDLNN model and ensemble learning models were trained and tested using hyperparameter tuning and K-Fold cross-validation to determine the best parameters for predicting the *** combined ML models used majority voting to select the best outcomes among the *** efficacy of the proposed and other models was evaluated for effective diabetes *** investigation concluded that the proposed model,after hyperparameter tuning,outperformed other learning models with an accuracy of 84.42%,a precision of 85.12%,a recall rate of 65.40%,and a specificity of 94.11%.

关键词： Diabetes prediction hyperparameter tuning k-fold validation machine learning neural network

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Diagnosis of process faults and sensor faults in a class of nonlinear uncertain systems

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Journal of Systems Engineering and Electronics 2011年第1期22卷 22-32页

作者： niharika Sonti Department of Electrical Engineering Wright State University

This paper presents a fault diagnosis method for process faults and sensor faults in a class of nonlinear uncertain *** fault detection and isolation architecture consists of a fault detection estimator and a bank of adaptive isolation estimators,each corresponding to a particular fault *** thresholds for fault detection and isolation are *** detectability conditions characterizing the class of process faults and sensor faults that are detectable by the presented method are derived.A simulation example of robotic arm is used to illustrate the effectiveness of the fault diagnosis method.

关键词： fault detection fault isolation fault detectability robustness sensor bias process faults.

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Effects of the type of forest alteration on gross nitrogen mineralization in soils of southern India

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Journal of Forestry Research 2021年第4期32卷 1689-1697页

作者： niharika Sharma Sanjeev Kumar Geosciences Division Physical Research LaboratoryAhmedabadGujarat 380009India

Change in land-use practices can result in major shifts in the cycling of various elements,particularly nitrogen(N),which is prone to anthropogenic *** quantifying these shifts,accurate measurements of rates of biogeochemical transformations of N are *** used the(^(15)N) isotope dilution technique to understand the effects of the types of forest alteration on(N) transformation rates by comparing gross N mineralization and ammonium(NH_(4)^(+)) consumption rates in soils of a managed forest,an unmanaged forest,and a rubber plantation in Kerala,***,nitrate(NO_3~-) dominated soils of the managed and unmanaged forests,whereas soils in the rubber plantation showed relatively higher NH_(4)^(+) *** N(TN) and total organic carbon(TOC) concentrations were the highest under the rubber canopy(TN:1.49±0.02 mg N g^(-1);TOC:7.96±0.86 mg C g^(-1)).In soils of all three forest types,gross N mineralization rates were higher compared to NH_(4)^(+) consumption *** high TN and TOC concentrations,the rates of gross N mineralization and NH_(4)^(+) consumption were considerably lower in the rubber plantation(mineralization:1.08±0.08 mg N kg^(-1)d^(-1);consumption:0.85±0.09 mg N kg^(-1) d^(-)) compared to the managed(mineralization:3.71±0.35 mg N kg^(-1) d^(-1);consumption:2.20±1.41 mg N kg^(-1) d^(-1)) and unmanaged(mineralization:2.20±1.07 mg N kg^(-1) d^(-1);consumption:1.39±0.27 mg N kg^(-1) d^(-1)) *** lower NH_(4)^(+) consumption rates in the rubber plantation led to significantly higher(p<0.05) residence time of NH_(4)^(+)(~4 days) compared to the managed and unmanaged forests(<2 days),possibly contributing to acidification of rubber soils(pH~4.8).These results together suggest that replacement of naturally grown forests with a mono-cropped plantation such as rubber negatively impact rates of N transformation processes in tropical soils and imply that change in tree species composition of naturally grown forests can adve

关键词： Nitrogen Mineralization Forest soils Rubber plantation Land-use change

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Turnaround times for molecular testing of pediatric viral cerebrospinal fluid samples in United Kingdom laboratories

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World Journal of Clinical Pediatrics 2022年第3期11卷 289-294页

作者： Siba Prosad Paul Varathagini Balakumar Arangan Kirubakaran Jothilingam niharika Paul Anthony Heaton Paul Christopher Turner Department of Paediatrics Yeovil District HospitalYeovil BA214ATSomersetUnited Kingdom School of Medicine Cardiff UniversityCardiff CF144XNUnited Kingdom Department of Paediatrics Hillingdon HospitalUxbridge UB83NNUnited Kingdom Department of Medical Microbiology Torbay HospitalTorquay TQ27AAUnited Kingdom

BACKGROUND Rapid molecular testing has revolutionized the management of suspected viral meningitis and encephalitis by providing an etiological diagnosis in<90 min with potential to improve outcomes and shorten inpatient ***,use of molecular assays can vary *** To evaluate current practice for molecular testing of pediatric cerebrospinal fluid(CSF)samples across the United Kingdom using a structured *** A structured telephone questionnaire survey was conducted between July and August *** was collected on the availability of viral CSF nucleic acid amplification testing(NAAT),criteria used for testing and turnaround times including the impact of the coronavirus disease 2019 *** Of 196/212(92%)microbiology laboratories responded;63/196(32%)were excluded from final analysis as they had no on-site microbiology laboratory and outsourced their *** 133 Laboratories included in the study,47/133(35%)had onsite facilities for viral CSF *** currently undertaking onsite NAAT(n=47)had much faster turnaround times with 39 centers(83%)providing results in≤24 h as compared to those referring samples to neighboring laboratories(5/86;6%).CONCLUSION Onsite/near-patient rapid NAAT(including polymerase chain reaction)is recommended wherever possible to optimize patient management in the acute setting.

关键词： Cerebrospinal fluid Nucleic acid amplification testing Questionnaire survey Turnaround times Viral studies

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WNT/β-catenin signaling in urothelial carcinoma of bladder

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World Journal of Nephrology 2019年第5期8卷 83-94页

作者： Minal Garg niharika Maurya Department of Biochemistry University of Lucknow

Urothelial carcinoma of bladder is the second most prevalent genitourinary *** is a highly heterogeneous disease as it represents a spectrum of neoplasms,including non-muscle invasive bladder cancer(NMIBC),muscle invasive bladder cancer(MIBC)and metastatic ***-wide approaches and candidate gene analysis suggest that malignant transformation of the bladder is multifactorial and a multitude of genes are involved in the development of MIBC or NMIBC *** signaling is being examined to control and maintain balance between stemness and differentiation in adult stem cell *** to its participation in urothelial development and maintenance of adult urothelial tissue homeostasis,the components of Wnt signaling are reported as an important diagnostic and prognostic markers as well as novel therapeutic ***/epigenetic alterations in the key molecules of Wnt/β-catenin canonical pathway have been linked with tumorigenesis,development of drug resistance and enhanced *** review extends our understanding on the functions of key regulatory molecules of canonical Wnt/β-catenin pathway in urothelial tumorigenesis by inducing cancer stem cell phenotype(UCSCs).UCSCs may be responsible for tumor heterogeneity,high recurrence rates and complex biological behavior of bladder ***,understanding the role of UCSCs and the regulatory mechanisms that are responsible for high relapse rates and metastasis could help to develop pathway inhibitors and augment current *** implications in the treatment of urothelial carcinoma of bladder by targeting this pathway primarily in UCSCs as well as in bulk tumor population that are responsible for high relapse rates and metastasis may facilitate potential therapeutic avenues and better prognosis.

关键词： Chemoresistance Therapeutic approaches Urothelial carcinoma of bladder Urothelial cancer stem cells Wnt/β-catenin

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Lung cancer metastasis to the gastrointestinal system:An enigmatic occurrence

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World Journal of Gastrointestinal Oncology 2017年第3期9卷 129-134页

作者： Kanthi Rekha Badipatla niharika Yadavalli Trupti Vakde Masooma Niazi Harish K Patel Division of Gastro-enterology Department of MedicineBronx Lebanon Hospita CenterAffiliated to Icahn School of Medicine at Mount Sinai Bronx Department of Medicine Bronx Lebanon Hospital CenterAffiliated to Icahn School of Medicine at Mount Sinai Division of Pulmonary and Critical Care Department of MedicineBronx Lebanon Hospital CenterAffiliated to Icahn School of Medicine at Mount Sinai Department of Pathology Bronx Lebanon Hospital CenterAffiliated to Icahn School of Medicine at Mount Sinai

Adenocarcinoma of the lung infrequently metastasizes to the gastrointestinal tract. We report a rare case of a 65-year-old male with no respiratory symptoms diagnosed with adenocarcinoma of the lung by histopathological examination of metastatic sites which included an ulcer in the gastric body and a mass in the rectum. Metastatic disease also involved the liver as well. Patient was treated with systemic chemotherapy but unfortunately expired five months after the diagnosis was made.

关键词： Lung cancer Gastrointestinal metastasis

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Preparation of NiFe_2O_4 nanopowder via EDTA precursor and study of its properties

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Particuology 2012年第1期10卷 29-34页

作者： Amit B.Rajput Subhenjit Hazra niharika B.Krishna Pavani Chavali Sneha Datla Narendra Nath Ghosh Nano-Materials Lab Department of Chemistry BITS-Pilani K.K. Birla Goa Campus

An ethylene diamine tetra acetic acid （EDTA） precursor-based chemical method is reported for prepar- ing single-phase nickel ferrite （NiFe204） nanopowder. The synthesized powder was characterized by thermogravimetric analysis, differential scanning calorimetric analysis, X-ray diffraction, particle size analysis and scanning electron microscopy. DC electrical resistivity and magnetic property of the synthesized NiFe204 were measured by using a two-probe method and a vibrating sample magnetometer respectively. The DC resistivity behaviour of the NiFe204 nanopowder was correlated with the change of microstructure, during sintering. This EDTA precursor-based method is capable of producing nanos- tructured single-phase NiFe204 powder at a comparatively low calcination temperature and offers the potential of a simple and cost-effective route, including the preparation of other ferrite nanoparticles.

关键词： Magnetic materialsChemical synthesisX-ray diffractionMagnetic properties

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Cardiovascular sequelae in post-COVID-19 patients with moderate to severe CT severity score: A follow-up study

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Journal of Acute Disease 2023年第5期12卷 198-203页

作者： niharika Agarwal Anamika Goyal Nikhil Pursnani Garima Kanaujia Akanksha Semwal Prabhat Agrawal Abhishek Raj Department of Medicine S.N.Medical CollegeAgraUttar PradeshIndia Department of Paediatrics S.N.Medical CollegeAgraUttar PradeshIndia

Objective:To study cardiovascular sequelae of post-COVID-19 patients with moderate to severe computed tomography(CT)severity ***:A prospective,non-randomized,observational study was conducted on 100 post-COVID-19 patients with moderate to severe CT severity scores from January 2021 to December ***-nine were male[mean age(54.1±12.2)years]and 41 were female[mean age(46.9±15.1)years].Patients with previous cardiovascular disease,previous chronic lung disease,and pre-existing primary or secondary pulmonary hypertension were *** were examined,and serial electrocardiogram and 2D echocardiography were performed to detect any cardiovascular ***:Post-COVID-19 patients had persistent symptoms,the most common being fatigue(59%).Most of these symptoms were relieved on follow-up.A rise in systolic,diastolic blood pressure,and pulse rate was *** electrocardiographic evaluation revealed ST-T segment changes,sinus tachycardia,ventricular hypertrophy,and arrhythmias among a considerable number of *** echocardiography,left ventricular diastolic dysfunction was most common(43%).Pulmonary hypertension,as evidenced by elevated pulmonary artery systolic pressure,was seen in 15%of ***:The present findings reveal an increased incidence of cardiovascular complications after recovery from COVID-19 infection in those without pre-existing cardiovascular or chronic lung disease.

关键词： Cardiovascular outcomes Arrhythmia Heart failure Post acute-sequale Long COVID-19

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Change in Internal Energy and Enthalpy of Spinning Black Holes in XRBs and AGN Using Spin Parameter a* = 0.9

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International Journal of Astronomy and Astrophysics 2017年第1期7卷 38-44页

作者： Dipo Mahto Alok Ranjan niharika Kumari Department of Physics Marwari College T. M. B. University Bhagalpur India Department of Physics T. M. B. University Bhagalpur India

In the present research work, we have proposed a model for the change in the internal energy and enthalpy of the spinning black holes using first law of black holes in the case of spin parameter a*=0.9 and calculated ... 详细信息

关键词： Surface Gravity Enthalpy Spinning Black Holes and AGN

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