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Diabetes-induced changes in cardiac voltage-gated ion channels

World Journal of Diabetes 2021年第1期12卷 1-18页

作者： nihal ozturk Serkan Uslu Semir Ozdemir Department of Biophysics Akdeniz University Faculty of MedicineAntalya 07058Turkey

Diabetes mellitus affects the heart through various mechanisms such as microvascular defects,metabolic abnormalities,autonomic dysfunction and incompatible immune ***,it can also cause functional and structural changes in the myocardium by a disease known as diabetic cardiomyopathy(DCM)in the absence of coronary artery *** DCM progresses it causes electrical remodeling of the heart,left ventricular dysfunction and heart *** changes in the diabetic heart contribute significantly to the incidence of arrhythmias and sudden cardiac death in diabetes mellitus *** recent studies,significant changes in repolarizing K+currents,Na+currents and L-type Ca^(2+)currents along with impaired Ca^(2+ )homeostasis and defective contractile function have been identified in the diabetic *** addition,insulin levels and other trophic factors change significantly to maintain the ionic channel expression in diabetic *** are many diagnostic tools and management options for DCM,but it is difficult to detect its development and to effectively prevent its *** this review,diabetes-associated alterations in voltage-sensitive cardiac ion channels are comprehensively assessed to understand their potential role in the pathophysiology and pathogenesis of DCM.

关键词： Diabetes Action potential Cardiac ion channels L-type Ca^(2+)channels Potassium channels Sodium channels

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Trace elements in diabetic cardiomyopathy:An electrophysiological overview

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World Journal of Diabetes 2013年第4期4卷 92-100页

作者： nihal ozturk Yusuf Olgar Semir Ozdemir Department of Biophysics Akdeniz University Faculty of Medicine

There is a growing body of evidence that Diabetes Mellitus leads to a specific cardiomyopathy apart from vascular disease and bring about high morbidity and mortality throughout the *** clinical and experimental studies have extensively demonstrated that this cardiomyopathy causes impaired cardiac performance manifested by early diastolic and late systolic *** impaired cardiac performance most probably have emerged upon the expression and activity of regulatory proteins such as Na+/Ca2+exchanger,sarcoplasmic reticulum Ca2+-ATPase,ryanodine receptor and *** years many therapeutic strategies have been recommended for treatment of diabetic ***,inorganic elements have been suggested to have anti-diabetic effects due to their suggested ability to regulate glucose homeostasis,reduce oxidative stress or suppress *** findings have shown that trace elements exert many biological effects including insulin-mimetic or antioxidant activity and in this manner they have been recommended as potential candidates for treatment of diabetes-induced cardiac complications,an effect based on their modes of *** of these trace elements are known to play an essential role as component of enzymes and thus modulate the organ function in physiological and pathological ***,they can also manipulate redox state of the channels via antioxidant properties and thus contribute to the regulation of [Ca2+]i homeostasis and cardiac ion *** account of little information about some trace elements,we discussed the effect of vanadium,selenium,zinc and tungstate on diabetic heart complications.

关键词： Diabetic cardiomyopathy Electrophysiology Trace elements Insulin-mimetic Antioxidant

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