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An Integrative Collaborative Project Approach to Climate-Change Resilience and Urban/Regional Sustainability for the Mexico-Lerma-Cutzamala Hydrological Region

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Open journal of Civil Engineering 2022年第1期12卷 101-138页

作者： Timothy j. Downs Morgan Ruelle nigel Brissett Ravi Hanumantha Marisa Mazari-Hiriart Rob Krueger Edward R. Carr International Development Community & Environment (IDCE) Department Clark University Worcester USA Institute of Ecology National Autonomous University of Mexico (UNAM) Ciudad Universitaria Coyoacán Mexico Environmental & Sustainability Studies Worcester Polytechnic Institute (WPI) Worcester USA Humanitarian Response and Development Lab (HURDL) George Perkins Marsh Institute Clark University Worcester USA

In a rapidly urbanizing world, the social, economic, and ecological complexities of cities require conceptual and operational innovations to enhance climate resilience and sustainability. We describe our Integrative Collaborative Project (ICP) approach to co-create climate resilience in the Mexico-Lerma-Cutzamala Hydrological Region (MLCHR). In recent years, it has suffered from frequent natural disasters, and under climate change scenarios, the intensity and frequency of extreme events, including severe floods, droughts, heat waves and landslides are expected to increase. ICPs are framed as socio-technical capacity building enterprises, with networks operating at multiple scales. The approach differs from other integrative efforts, which tend to be top-down with scant civil society co-ownership, and focus on limited aspects like indicators/assessment, or institutional capacity building. We reimagine all operational stages, from creative thinking, through ethos and concept, assessment, planning, project design, implementation and management, and monitoring and evaluation. The design of ICPs is informed by six integrative domains: 1) project ethos, concept, and framing;2) sectors, topics, and issues;3) spatial and temporal scales;4) stakeholder interests, relationships and capacities;5) knowledge types, models and methods;and 6) socio-technical capacities and networks. Empirically, the approach is based on participatory development practices, pilot project work tackling sustainable water and sanitation in Mexico, and a synthesis of rich experiential knowledge spanning 20 years. The theoretical basis considers a pragmatic knowledge frame, socio-technical transitions literature, and education for social transformation. We describe forward-looking operational details of the Pilot ICP for the Mexico-Lerma-Cutzamala Hydrological Region, with our three-university partnership as catalyst, and a new breed of socio-technical enterprise organization as a key partner, engaging

关键词： Climate-Change Resilience Sustainable Development Urban Regional Mexico City

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常见硫化物矿物中不可见金的富集

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黄金地质科技 1991年第4期 63-72页

作者： nigel j.COOK 金洪良

常见硫化物矿物晶格中的金及粒径小于1000埃的分散金均称为不可见金,它们无法用矿相显微镜和扫描电镜测到。离子探针微量分析(次级离子质谱法)表明,12个矿床硫化物矿物颗粒中不可见金的含量为0.5至1000ppm之间。不同矿床,或一个矿床中... 详细信息

常见硫化物矿物晶格中的金及粒径小于1000埃的分散金均称为不可见金,它们无法用矿相显微镜和扫描电镜测到。离子探针微量分析(次级离子质谱法)表明,12个矿床硫化物矿物颗粒中不可见金的含量为0.5至1000ppm之间。不同矿床,或一个矿床中不同矿石相间不可见金含量变化很大。最主要的载金矿物为毒砂和富砷黄铁矿。黄铁矿中金与砷含量呈正相关,表明种促进了金进入黄铁矿晶格。当两种或差别大的毒砂共生时,细粒毒砂更富含不可见金。磁黄铁矿、黄铜矿、斑铜矿、方铅矿和黝铜矿中不可见金的含量通常较低。

关键词：硫化物金富集黄铁矿

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Does Pre-Operative Tranexamic Acid Increase the Incidence of Thromboembolism in Primary Lower Limb Arthroplasty?

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Open journal of Orthopedics 2013年第6期3卷 249-252页

作者： Veenesh Selvaratnam james R. Fountain nigel j. Donnachie Thomas G. Thomas Fintan A. Carroll Wirral University Teaching Hospital NHS Foundation Trust Wirral UK Wirral University Teaching Hospital NHS Foundation Trust Wirral UK.

Introduction: Tranexamic Acid (TA) has been shown to decrease peri-operative bleeding in primary lower limb arthroplasty surgery. There are still concerns with regards to the increased risk of thromboembolic events with the use of TA. The aim of this study was to assess whether the use of pre-operative TA increased the incidence of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) in Total Hip Replacement (THR) and Total Knee Replacement (TKR). Methods: Patients who underwent primary THR or TKR between August 2007 and August 2009 were identified from the databases of three surgeons within the lower limb arthroplasty unit. A retrospective case notes analysis was performed. DVT was diagnosed on Duplex Ultrasound Scan and PE on CT Pulmonary Angiogram. A positive result was a diagnosis of DVT or PE within 3 months of surgery. Results: 701 patients underwent primary THR and TKR over the 2-year period. 320 patients (189 THR, 131 TKR) received TA pre-operatively. 381 patients (190 THR, 191 TKR) did not receive TA prior to surgery. A total of 8 (2.5%) patients who received TA were diagnosed with either a DVT (4) or PE (4) post operatively. In those patients not receiving TA, 6 had a DVT and 4 had a PE, a total of 10 (2.6%). Conclusion: Pre-operative use of Tranexamic Acid in primary THR and TKR does not increase the incidence of DVT and PE.

关键词： Tranexamic Acid DVT PE TKR THR

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Expression analysis of abscisic acid(ABA) and metabolic signalling factors in developing endosperm and embryo of barley

Expression analysis of abscisic acid(ABA) and metabolic sign...

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2013全国植物生物学大会

作者： CHEN Zhiwei HUANG jianhua Nira MUTTUCUMARU Stephen j.POWERS nigel G.HALFORD Biotechnology Research Institute Shanghai Academy of Agricultural Sciences Plant Biology and Crop Science Department Rothamsted Research Computational and Systems Biology Department Rothamsted Research

The expression of genes encoding components of the ABA and metabolic signalling pathway in developing barley endosperm and embryo was *** genes included HvRCAR3547387 and HvRCAR352538(e

关键词： Hordeum vulgare L. abscisic acid(ABA) seed development signalling

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Call for emergency action to limit global temperature increases, restore biodiversity and protect health

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General Psychiatry 2021年第5期34卷 53-55页

作者： Lukoye Atwoli Abdullah H Baqui Thomas Benfield Raffaella Bosurgi Fiona Godlee Stephen Hancocks Richard Horton Laurie Laybourn-Langton Carlos Augusto Monteiro Ian Norman Kirsten Patrick nigel Praities Marcel GM Olde Rikkert Eric j Rubin Peush Sahni Richard Smith Nicholas j Talley Sue Turale Damián Vázquez East African Medical journal NairobiKenya journal of Health Population and NutritionBaltimoreMarylandUSA Danish Medical journal CopenhagenDenmark PLOS Medicine CambridgeUK The BMj LondonUK British Dental journal LondonUK The Lancet LondonUK UK Health Alliance on Climate Change LondonUK Revista de Saúde Pública São PauloBrazil International journal of Nursing Studies LondonUK CMAj OttawaOntarioCanada Pharmaceutical journal LondonUK Dutch journal of Medicine NijmegenThe Netherlands NEjM BostonMassachusettsUSA National Medical journal of India New DelhiIndia Medical journal of Australia NewcastleNew South WalesAustralia International Nursing Review GenevaSwitzerland Pan American journal of Public Health WashingtonDCUSA

Wealthy nations must do much more,much *** United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental *** will meet again at the biodiversity summit in Kunming,China,and the climate conference(Conference of the Parties(COP)26)in Glasgow,*** of these pivotal meetings,we-the editors of health journals worldwide-call for urgent action to keep average global temperature increases below 1.5°C,halt the destruction of nature and protect health.

关键词： action collective faster

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就谢教授及其同僚运用西医术语表达中医概念的回复

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中国中西医结合杂志 2006年第8期26卷 746-748页

作者：魏杰长庚大学中医学院

就《中国中西医结合杂志》〔2005;25(11)∶1046—1049〕关于采用西医名词来英译中医概念,将有助于中医之西传与国际化,笔者的观点与谢教授大有出入,并认为这种翻译方法容易破坏中医概念的完整性及独立性。笔者以风火眼为例,说明此种翻... 详细信息

就《中国中西医结合杂志》〔2005;25(11)∶1046—1049〕关于采用西医名词来英译中医概念,将有助于中医之西传与国际化,笔者的观点与谢教授大有出入,并认为这种翻译方法容易破坏中医概念的完整性及独立性。笔者以风火眼为例,说明此种翻译法的缺陷。并认为对于欲深入了解中医的人,还是直译(仿造)译词较有益,并以丰富例词说明这个论点。

关键词：西医化翻译直译仿造

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混凝土桥梁考虑温度梯度的设计

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中外公路 1980年第6期 13-18页

作者： M.j.nigel PRIESFLEY ,陆楸

本文回顾了预应力及钢筋混凝土桥梁考虑周围温度荷载影响的现状。讨论限于太阳照射于桥面产生的垂直温度梯度。论述了根据当地气象条件预测设计温度梯度的方法,并提出了计算温度应力垂直分布的通用分析方法。实验室及现场试验证实了这... 详细信息

本文回顾了预应力及钢筋混凝土桥梁考虑周围温度荷载影响的现状。讨论限于太阳照射于桥面产生的垂直温度梯度。论述了根据当地气象条件预测设计温度梯度的方法,并提出了计算温度应力垂直分布的通用分析方法。实验室及现场试验证实了这种分析方法的有效性。

关键词：温度梯度极限承载力混凝土桥梁温度荷载温度应力桥面

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A dahlia flower extract has antidiabetic properties by improving insulin function in the brain

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Life Metabolism 2023年第4期2卷 39-50页

作者： Dominik Pretz Philip M.Heyward jeremy Krebs joel Gruchot Charles Barter Pat Silcock Nerida Downes Mohammed Zubair Rizwan Alisa Boucsein julia Bender Elaine j.Burgess Geke Aline Boer Pramuk Keerthisinghe nigel B.Perry Alexander Tups Centre for Neuroendocrinology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Department of Physiology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Maurice Wilkins Centre for Molecular Biodiscovery University of AucklandAuckland 1010New Zealand Department of Medicine University of OtagoWellingtonWellington South 6242New Zealand Centre for Endocrine Diabetes and Obesity Research Wellington Regional HospitalNewtownWellington 6021New Zealand Product Development Research Centre University of OtagoDunedin 9054New Zealand Department of Chemistry The New Zealand Institute for Plant and Food ResearchUniversity of OtagoDunedin 9054New Zealand

Butein,a rare chalcone found in the toxic plant Toxicodendron vernicifluum,has been shown to regulate glucose homeostasis via inhibition of the nuclear factor kappa-B kinase subunit beta(IKKβ)/nuclear factor kappa B(NF-κB)pathway in the ***,we investigated whether the nonpoisonous plant Dahlia pinnata could be a source of butein as a potential treatment for type 2 diabetes(T2D).In mice fed a high-fat diet(HFD)to induce glucose intolerance,an oral *** petal extract improved glucose tolerance at doses of 3.3 mg/kg body weight and 10 mg/kg body ***,this effect was not mediated by butein alone but by butein combined with the closely related flavonoids,sulfuretin and/or ***,the extract improved systemic insulin *** of phosphatidylinositol 3-kinase to block insulin signaling in the brain abrogated the glucoregulatory effect of the orally administered *** extract reinstated central insulin signaling and normalized astrogliosis in the hypothalamus of HFD-fed *** NF-κB reporter zebrafish to determine IKKβ/NF-κB activity,a potent anti-inflammatory action of the extract was found.A randomized controlled crossover clinical trial on participants with predia-betes or T2D confirmed the safety and efficacy of the extract in *** conclusion,we identified an extract from the flower petals of *** as a novel treatment option for T2D,potentially targeting the central regulation of glucose homeostasis as a root cause of the disease.

关键词： inflammation hypothalamus signal transduction neuroendocrine arcuate nucleus

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Uncovering the genetic diversity of Giardia intestinalis in isolates from outbreaks in New Zealand

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Infectious Diseases of Poverty 2022年第3期11卷 27-36页

作者： Paul Ogbuigwe Patrick j.Biggs juan Carlos Garcia-Ramirez Matthew A.Knox Anthony Pita Niluka Velathanthiri nigel P.French David T.S.Hayman School of Veterinary Science Massey UniversityPalmerston NorthManawatu-WanganuiNew Zealand School of Natural Sciences Massey UniversityPalmerston NorthManawatu-WanganuiNew Zealand

Background:Giardia intestinalis is one of the most common causes of diarrhoea worldwide. Molecular techniques have greatly improved our understanding of the taxonomy and epidemiology of this parasite. Co-infection with mixed (sub-) assemblages has been reported, however, Sanger sequencing is sometimes unable to identify shared subtypes between samples involved in the same epidemiologically linked event, due to samples showing multiple dominant subtypes within the same outbreak. Here, we aimed to use a metabarcoding approach to uncover the genetic diversity within samples from sporadic and outbreak cases of giardiasis to characterise the subtype diversity, and determine if there are common sequences shared by epidemiologically linked cases that are missed by Sanger ***:We built a database with 1109 unique glutamate dehydrogenase (gdh) locus sequences covering most of the assemblages of G. intestinalis and used gdh metabarcoding to analyse 16 samples from sporadic and outbreak cases of giardiasis that occurred in New Zealand between 2010 and ***:There is considerable diversity of subtypes of G. intestinalis present in each sample. The utilisation of metabarcoding enabled the identification of shared subtypes between samples from the same outbreak. Multiple variants were identified in 13 of 16 samples, with Assemblage B variants most common, and Assemblages E and A present in mixed ***:This study showed that G. intestinalis infections in humans are frequently mixed, with multiple subtypes present in each host. Shared sequences among epidemiologically linked cases not identified through Sanger sequencing were detected. Considering the variation in symptoms observed in cases of giardiasis, and the potential link between symptoms and (sub-) assemblages, the frequency of mixed infections could have implications for our understanding of host–pathogen interactions.

关键词： DNA sequencing Epidemiology Genetic diversity Giardiasis Metabarcoding

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Call for emergency action to limit global temperature increases, restore biodiversity and protect health

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World journal of Pediatric Surgery 2021年第4期4卷 60-62页

Wealthy nations must do much more,much *** United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental *** will meet again at the biodiversity summit in Kunming,China,and the climate conference(Conference of the Parties(COP)26)in Glasgow,*** of these pivotal meetings,we-the editors of health journals worldwide-call for urgent action to keep average global temperature increases below 1.5℃,halt the destruction of nature and protect health.

关键词： action collective faster

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