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High T_(g) Polymer Insulator Yields Organic Photovoltaic Blends with Superior Thermal Stability at 150℃

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Chinese Journal of Chemistry 2021年第9期39卷 2570-2578页

作者： Fei Chen Ying Zhang Qi Wang Mengyuan Gao nigel Kirby Zhongxiang Peng Yunfeng Deng Miaomiao Li Long Ye School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Australian Synchrotron ClaytonVictoria 3168Australia Tianjin Key Laboratory of Molecular Optoelectronic Science Tianjin Universityand Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin 300072China State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhouGuangdong 510640China

Record-breaking organic solar cells(OSCs)based on blends of polymer donors and small molecule acceptors often show undesirable degradati on,which severely precludes their practical *** n,we demonstrate a facile and cost-effective approach to con struct thermally stable OSCs at 150℃ by incorporating a small amount of a polymer insulator polyacenaphthylene(PAC)with high glass-transition temperature over 230℃ into polymer:acceptor *** model PTB7-Th:EH-IDTBR blend with 10 wt%PAC maintained above 85%of its initial efficiency upon continuous heating at 150℃ for over 800 h,while the efficiency of the blend without PAC sharply dropped by 70%after-300 *** to high miscibility with acceptors,PAC confines the motion of the acceptor molecules and suppresses the acceptor crystallization at elevated temperatures,leading to significantly improved ***,the effectiveness of this blending approach was also validated in many other OSC systems,showing great potential for achieving high-performance thermally stable electronics.

关键词： Energy conversion Thin films Polymer insulator Thermal stability Crystal growth

Prostate cancer： diagnosis and staging

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Asian Journal of Andrology 2009年第1期11卷 74-80页

作者： nigel Borley Mark R. Feneley Department of Urology University College Hospitals London NW1 2BU UK

Prostate cancer represents an increasing health burden. The past 20 years, with the introduction of prostate-specific antigen （PSA）, has seen prostate cancer move increasingly from a condition that presented with locally advanced disease or metastases to one that is found upon screening. More is also known about the pathology ofpre-malignant lesions. Di- agnosis relies on trans-rectal ultrasound （TRUS） to obtain biopsies from throughout the prostate, but TRUS is not useful for staging. Imaging for staging, such as magnetic resonance imaging or computed tomography, still has a low accuracy compared with pathological specimens. Current techniques are also inaccurate in identifying lymph node and bony me- tastases. Nomograms have been developed from the PSA, Gleason score and clinical grading to help quantify the risk of extra-capsular extension in radical prostatectomy specimens. Improved clinical staging modalities are required for more reliable prediction of pathological stage and for monitoring of response to treatments.

关键词： diagnosis imaging prostate cancer PSA staging

Strange metallicity and high-T_(c) superconductivity:quantifying the paradigm

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Science Bulletin 2022年第10期67卷 985-987页

作者： nigel E.Hussey Caitlin Duffy H.H.Wills Physics Laboratory University of BristolBristol BS81TLUK HFML-FELIX and Institute for Molecules and Materials Radboud UniversityNijmegen 6525EDNetherlands

A key goal of superconductivity research is to identify the mechanism by which electrons *** to the pairing mechanism lie in the resistive behavior(that is itself governed by electrons scattering off impurities and dy... 详细信息

关键词：物理规律 governed 高温超导

Selective embolization for bleeding visceral artery pseudoaneurysms in patients with pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2010年第6期9卷 634-638页

作者： Harsheet Sethi Praveen Peddu Andreas Prachalias Pauline Kane John Karani Mohamed Rela nigel Heaton Department of Hepatobiliary Surgery Institute ofLiver Studies Kings College London School of Medicine at Kings College Hospital Department of Hepatobiliaryand Interventional Radiology Institute ofLiver StudiesKings College London School of Medicine at Kings College Hospital

BACKGROUND:Pancreatitis is associated with arterial complications in 4%-10%of patients,with untreated mortality approaching 90%.Timely intervention at a specialist center can reduce the mortality to 15%.We present a single institution experience of selective embolization as first line management of bleeding pseudoaneurysms in pancreatitis. METHODS:Sixteen patients with pancreatitis and visceral artery pseudoaneurysms were identified from searches of the records of interventional angiography from January 2000 to June *** visceral artery aneurysms and pseudoaneurysms arising as a result of post-operative pancreatic or biliary leak were excluded from the study. RESULTS:In 50%of the patients,bleeding complicated the initial presentation of *** was the offending agent in 10 patients,gallstones in 3,trauma,drug-induced and idiopathic pancreatitis in one *** 16 patients had a contrast CT scan and 15 underwent coeliac axis angiography. The pseudoaneurysms ranging from 0.9 to 9.0 cm affected the splenic artery in 7 patients:hepatic in 3,gastroduodenal and right gastric in 2 each,and left gastric and pancreatico-duodenal in 1 *** patient developed spontaneous thrombosis of the *** patients had effective coil embolization of the *** patient needed surgical exclusion of the pseudoaneurysm following difficulty in accessing the coeliac axis *** were no episodes of re-bleeding and no in-hospital mortality. CONCLUSIONS:Pseudoaneurysms are unrelated to the severity of pancreatitis and major hemorrhage can occur irrespective of their ***-existent portal hypertension and sepsis increase the risk of *** and selective coil embolization is a safe and effective way to arrest the hemorrhage.

关键词： pseudoaneurysm embolization acute pancreatitis chronic pancreatitis vascular complications

Novel en-bloc resection of locally advanced hilar cholangiocarcinoma: the Rex recess approach

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 93-97页

作者： Mohamed Rela Rajesh Rajalingam Vivekanandan Shanmugam Adrian O' Sullivan Mettu S Reddy nigel Heaton Institute of Liver Studies King's College Hospital Institute of Liver Surgery and Transplantation Global Hospital and Health City

Loco-regional recurrence after potentially curative resection remains a problem in hilar cholangiocarcinoma. Hilar dissection risks local spillage of tumor cells leading to suboptimal disease free survival. We have developed a new technique of radical resection for hilar cholangiocarcinoma based on the distinctive anatomy of the Rex recess of the liver, which has been assessed in two patients with locally advanced hilar cholangiocarcinoma. This technique included a right hepatectomy with en-bloc resection of the hepatoduodenal ligament and portal venous reconstruction to the left portal vein at the Rex recess. Both patients had R0 resection and have been disease-free for 26 and 38 months, respectively.

关键词： cholangiocarcinoma vascular resection no-touch technique Rex recess

RU486 Reversal of Cortisol Repression of 1,25-Dihydroxyvitamin D<sub>3</sub>Induction of the Human Osteocalcin Promoter

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Open Journal of Endocrine and Metabolic Diseases 2013年第1期3卷 55-62页

作者： nigel A. Morrison School of Medical Science Griffith University Gold Coast Campus Gold Coast Australia

In conditions of corticosteroid excess, such as Cushing’s syndrome, a reduction in serum osteocalcin is observed and bone loss occurs. The human osteocalcin gene is induced by 1,25-dihydroxyvitamin D3 derivatives and repressed by glucocorticoids. In this paper we show that cortisol, a natural glucocorticoid, represses both basal and vitamin D induced activity of the human osteocalcin promoter. Furthermore, we address the specific question as to whether the anti-progestin anti-glucocorticoid RU486 is able to antagonize the inhibitory effect of cortisol on osteocalcin gene expression. We show that RU486 has agonist activity alone, in that it is able to repress the basal promoter activity of the osteocalcin gene and antagonist activity, reversing incompletely the cortisol mediated repression of 1,25-dihydroxyvitamin D3 induction.

关键词： RU486 Osteocalcin Vitamin D Glucocorticoid

A machine learning driven 3D+1D model for efficient characterization of proton exchange membrane fuel cells

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Energy and AI

Energy and AI 2024年第3期17卷 281-294页

作者： Yuwei Pan Haijun Ruan Billy Wu Yagya N.Regmi Huizhi Wang nigel P.Brandon Department of Earth Science and Engineering Imperial College LondonLondon SW72AZUK Dyson School of Design Engineering Imperial College LondonLondon SW72AZUK Centre for E-Mobility and Clean Growth Coventry UniversityCoventry CV15FBUK Manchester Fuel Cell Innovation Centre Department of Natural SciencesManchester Metropolitan UniversityManchester M15GDUK Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

The computational demands of 3D continuum models for proton exchange membrane fuel cells remain substantial. One prevalent approach is the hierarchical model combining a 2D/3D flow field with a 1D sub-model for the catalyst layers and membrane. However, existing studies often simplify the 1D domain to a linearized 0D lumped model, potentially resulting in significant errors at high loads. In this study, we present a computationally efficient neural network driven 3D+1D model for proton exchange membrane fuel cells. The 3D sub-model captures transport in the gas channels and gas diffusion layers and is coupled with a 1D electrochemical sub-model for microporous layers, membrane, and catalyst layers. To reduce computational intensity of the full 1D description, a neural network surrogates the 1D electrochemical sub-model for coupling with the 3D domain. Trained by model-generated large synthetic datasets, the neural network achieves root mean square errors of less than 0.2%. The model is validated against experimental results under various relative humidities. It is then employed to investigate the nonlinear distribution of internal states under different operating conditions. With the neural network operating at 0.5% of the computing cost of the 1D sub-model, the hybrid model preserves a detailed and nonlinear representation of the internal fuel cell states while maintaining computational costs comparable to conventional 3D+0D models. The presented hybrid data-driven and physical modeling framework offers high accuracy and computing speed across a broad spectrum of operating conditions, potentially aiding the rapid optimization of both the membrane electrode assembly and the gas channel geometry.

关键词： Proton exchange membrane fuel cell Hierarchical model Neural network Hybrid model

Ruptured hepatocellular carcinoma following chemoembolization:a western experience

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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 49-51页

作者： Narendra Battula Parthi Srinivasan Mansoor Madanur Srinivas Prabhu Chava Oliver Priest Mohamed Rela nigel Heaton Institute of Liver Studies King's College Hospital Denmark Hill London SE5 9RS UK

BACKGROUND: Transcatheter arterial chemoembolization (TACE) is a recommended first line therapy for unresectable hepatocellular carcinoma (HCC). Serious complications such as neutropenic sepsis and hepatic decompensation are well known, but rupture of HCC following TACE is a rare and potentially fatal complication. The aim of this study was to identify the incidence of ruptured HCC following TACE and the associated risk factors. METHODS: A retrospective analysis was performed using our liver database with 'chemoembolization', 'ruptured HCC' covering the patients who received chemoembolization from January 1995 to December 2005. There were no exclusions. RESULTS: A total of 294 patients received chemoemboliza- tion in 530 sessions during the 10-year period. Of these, 2 ruptured following treatment (incidence 0.68%). The mean age was 65 years and the interval between the treatment and rupture was 2 and 24 days. The common factors were male sex, large tumor size (range 11-13 cm), and exophytic tumor growth. One patient died 2 days after rupture with hepatic decompensation while the second is alive after a 6-month follow up without tumor recurrence. CONCLUSIONS: Ruptured HCC following TACE is a rare but serious complication. Large tumor size, male sex, and exophytic growth of tumor may be predisposing factors for rupture.

关键词： life-threatening complications chemoembolization rupture carcinoma, hepatocellular ruptured hepatocellular tumor

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社交媒体可早期警示病毒暴发

英国医学杂志中文版 2016年第2期19卷 70-71页

作者： nigel Hawkes 马岩伦敦北京协和医学院卫生部老年医学研究所

英国食品标准局（FSA）资助的一个项目发现，根据那些生病的推特（Twitter）客在推特上的标签追踪到诺如病毒（noro virus）暴发。

关键词：社交媒体病毒治疗方法医学研究