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Validation and performance of three scoring systems for predicting primary non-function and early allograft failure after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 463-471页

作者： Yu nie Jin-bo Huang shu-Jiao He Hua-Di Chen Jun-Jun Jia Jing-Jing Li Xiao-shun He Qiang Zhao General surgery Center Department of Hepatobiliary Surgery IIResearch Center for Artificial Organ and Tissue EngineeringGuangzhou Clinical Research and Transformation Center for Artificial LiverInstitute of Regenerative MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510515China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology Guangzhou 510080China Guangdong Provincial International Cooperation base of science and Technology Guangzhou 510080China Division of Hepatobiliary Pancreatic surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

background: Primary non-function(PNF) and early allograft failure(eAF) after liver transplantation(LT) seriously affect patient outcomes. In clinical practice, effective prognostic tools for early identifying recipients at high risk of PNF and eAF were urgently needed. Recently, the Model for early Allograft Function(MeAF), PNF score by King's College(King-PNF) and balance-and-Risk-Lactate(bAR-Lac) score were developed to assess the risks of PNF and eAF. This study aimed to externally validate and compare the prognostic performance of these three scores for predicting PNF and eAF. Methods: A retrospective study included 720 patients with primary LT between January 2015 and December 2020. MeAF, King-PNF and bAR-Lac scores were compared using receiver operating characteristic(ROC) and the net reclassification improvement(NRI) and integrated discrimination improvement(IDI) analyses. Results: Of all 720 patients, 28(3.9%) developed PNF and 67(9.3%) developed eAF in 3 months. The overall early allograft dysfunction(eAD) rate was 39.0%. The 3-month patient mortality was 8.6% while 1-year graft-failure-free survival was 89.2%. The median MeAF, King-PNF and bAR-Lac scores were 5.0(3.5–6.3),-2.1(-2.6 to-1.2), and 5.0(2.0–11.0), respectively. For predicting PNF, MeAF and King-PNF scores had excellent area under curves(AUCs) of 0.872 and 0.891, superior to bAR-Lac(AUC = 0.830). The NRI and IDI analyses confirmed that King-PNF score had the best performance in predicting PNF while MeAF served as a better predictor of eAD. The eAF risk curve and 1-year graft-failure-free survival curve showed that King-PNF was superior to MeAF and bAR-Lac scores for stratifying the risk of eAF. Conclusions: MeAF, King-PNF and bAR-Lac were validated as practical and effective risk assessment tools of PNF. King-PNF score outperformed MeAF and bAR-Lac in predicting PNF and eAF within 6 months. bAR-Lac score had a huge advantage in the prediction for PNF without post-transplant variables. Proper use

关键词： Primary non-function early allograft failure Risk predicting model Liver transplantation

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speed limit effect during lane change in a two-lane lattice model under V2X environment

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Chinese Physics b 2024年第3期33卷 718-722页

作者：金灿彭光含聂方彦 College of Physical science and Technology Guangxi Normal UniversityGuilin 541004China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004China Information and Modern education Technology Center Hunan University of Arts and ScienceChangde 415000China Computer and Information engineering College Guizhou University of CommerceGuiyang 550014China

speed limit measures are ubiquitous due to the complexity of the road environment,which can be supplied with the help of vehicle to everything(V2X)communication ***,the influence of speed limit on traffic system will be investigated to construct a two-lane lattice model accounting for the speed limit effect during the lane change process under V2X ***,the stability condition and the mKdV equation are closely associated with the speed limit effect through theory ***,the evolution of density and hysteresis loop is simulated to demonstrate the positive role of the speed limit effect on traffic stability in the cases of strong reaction intensity and high limited speed.

关键词： traffic flow lattice model speed limit

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slip rate and interseismic coupling along the Moxi-shimian segment of the Xianshuihe fault, eastern Qinghai-Xizang Plateau

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Geodesy and Geodynamics 2024年第4期15卷 338-351页

作者： Xinyu Zhao Gang Liu Zhaosheng nie Wei Xiong Wei Chen Mu Lin Dijin Wang Qi Li Jiansheng Yu Dongzhen Wang Pengfei Yu Institute of seismology China Earthquake AdministrationWuhan 430071China Key Laboratory of earthquake Geodesy.China earthquake Administration Wuhan 430071China state Key Laboratory of Geodesy and earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China

On september 5,2022,the Luding M6.8 earthquake occurred in the Moxi-shimian segment of the Xianshuihe fault,coinciding with the historical ruptured zone of the 1786 Moxi *** seis-mogenic environment provides a foundation for comprehending the mechanism of the earthquake and its future *** the Moxi-shimian segment,we establish a series of near-field Global Navigation satellite systems(GNss)stations to enhance the spatial resolution of observational data for the inversion of the interseismic kinematic *** this study,with an elastic screw dislocation model con-strained by GNss observations,the slip rate of the Moxi-shimian segment is estimated to be 10.9±1.0 mm/yr,while the locking depth is 15.7±6.2 ***,we utilize a block-dislocation model to invert the interseismic fault coupling along the Kangding-Moxi-shimian *** result indicates a gradual deepening of the locking depth along the section from Kangding to *** coseismic rupture of the 2022 event occurred within the high coupling regions in the Kangding-Moxi-shimian segment,which indicates that the rupture kinematics in this event might be controlled by the interseismic *** seismic moment accumulated within the ruptured zone of the Luding earthquake since 1786 ranges in[1.42-3.40]×10^(19) N-m,which is significantly greater than the seismic moment released during the 2022 *** a result,we infer that the Luding earthquake released only a portion of the accumulated energy within the original rupture zone since 1786,indicating that the 2022 event has not caused a complete rupture in the Moxi-shimian ***,there remains a substantial seismic hazard in this area.

关键词： Moxi-shimian segment of Xianshuihe fault Luding earthquake Global positioning system Interseismic kinematic parameters

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blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

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Neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés berardo Cristian R.bacaglio bárbara b.báez Rubén sambuelli Kazim A.sheikh Pablo H.H.Lopez Laboratorio de Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química biológica-Centro de Investigaciones en Química biológica de Córdoba(CIQUIbIC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICeT) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of Neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-barrèsyndrome,mostly related to halted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon *** effects involve the activation of the small GTPase Rho A/ROCK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stablished inhibitors of axon regeneration described so *** aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632,a selective pharmacological inhibitor of ROCK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of *** with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous *** contrast,the same dose showed toxic effects on the regeneration of myelinated ***,scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only ***,these findings confirm the in vivo participation of Rho A/ROCK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-GD1a/GT1b monoclonal *** findings open the possibility of therapeutic pharmacological intervention targeting Rho A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-barrésyndrome nerve repair ROCK Y-27632

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Clinical features of gastroesophageal reflux disease and erosive esophagitis:Insights from patients undergoing esophagogastroduodenoscopy in resource-limited ethiopia

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World Journal of Gastroenterology 2024年第34期30卷 3883-3893页

作者： Firehiwot A Mengistie Abate b shewaye Abel T Tasamma Zekarias s Ayalew Department of Internal Medicine Addis Ababa UniversityAddis Ababa 1176Addis AbabaEthiopia Department of Internal Medicine Rheum Rheumatology and Internal Medicine Specialty ClinicAddis Ababa 1000Addis AbabaEthiopia Division of Gastroenterology and Hepatology Department of Internal MedicineAdera Medical and Surgical CenterAddis Ababa 1000Addis AbabaEthiopia

bACKGROUND Gastroesophageal reflux disease(GeRD)is a common disease worldwide with varying clinical presentations and risk *** data for Africa is lacking,but an increasing trend is expected due to demographic and epidemiological *** endoscopic studies for general gastrointestinal disorders have shown some patients with erosive esophagitis(ee),no studies in ethiopia have investigated the clinical characteristics,risk factors,and severity of GeRD using esophagogastroduodenoscopy(eGD).AIM To assess the clinical features of GeRD in ethiopian patients who underwent eGD and determine the severity and risk factors of *** We conducted a multicenter,retrospective cross-sectional study of 221 patients diagnosed with GeRD and endoscopic findings of ee at Trauma Associated severe Hemorrhage and Amniotic Membrane stem Cell between January 2019 and August *** were collected from electronic medical records and phone call *** used descriptive statistics and binary logistic regression analysis with sPss version 26 to identify the association between variables with a statistical significance set at P valuee mean±sD age of the patients was 44.8(±15.9)years,with a male-to-female ratio of 1.6:*** most commonly reported symptom was epigastric pain(80.5%),followed by heartburn(43%).Los Angeles(LA)-A ee was diagnosed in 71.1%of patients,followed by LA-b(14.9%),LA-C(7.7%),and LA-D(5.9%).Multivariate analysis showed that age 50 or above,presence of bleeding,and endoscopic findings of duodenitis/duodenopathy were significantly associated with severe ee(Pstricture and barrett’s esophagus were observed in 4.5%and 1.36%of patients with ee,*** Most of the patients had milder ee with fewer ***,severe ee was more prevalent in older patients and those with duodenitis/duodenopathy.

关键词： Gastroesophageal reflux disease erosive esophagitis Hiatal hernia esophagogastroduodenoscopy Heart burn

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Deep Learning shows Promise for seasonal Prediction of Antarctic sea Ice in a Rapid Decline scenario

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Advances in Atmospheric sciences 2024年第8期41卷 1569-1573页

作者： Xiaoran DONG Yafei nie Jinfei WANG Hao LUO Yuchun GAO Yun WANG Jiping LIU Dake CHeN Qinghua YANG school of Atmospheric sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China earth and Climate Center Earth and Life InstituteUniversitécatholique de LouvainLouvain-la-Neuve 1348Belgium Frontier science Center for Deep Ocean Multispheres and earth system(FDOMes) Physical Oceanography LaboratoryOcean University of ChinaQingdao 266100China

The rapidly changing Antarctic sea ice has garnered significant interest. To enhance the prediction skill for sea ice and respond to the sea Ice Prediction Network-south's latest call, this study presents the reforecast results of Antarctic sea-ice area and extent from December to June of the coming year with a Convolutional Long short-Term Memory(Conv LsTM)Network. The reforecast experiments demonstrate that Conv LsTM captures the interannual and interseasonal variability of Antarctic sea ice successfully, and performs better than the european Centre for Medium-Range Weather Forecasts. based on this, we present the prediction from December 2023 to June 2024, indicating that the Antarctic sea ice will remain at lows, but may not create a new record low. This research highlights the promising application of deep learning in Antarctic sea-ice prediction.

关键词： deep learning Antarctic sea ice seasonal prediction

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A systematic scoping review of study methodology for randomized controlled trials investigating probiotics in athletic and physically active populations

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Journal of sport and Health science 2024年第1期13卷 61-71页

作者： Alex e.Mohr David b.Pyne Geovana silva Fogaça Leite Deborah Akins Jamie Pugh College of Health solutions Arizona State UniversityPhoenixAZ 85004USA Research Institute for sport and exercise University of CanberraCanberraACT 2617Australia Laboratory of Functional Fermented Food Faculty of Pharmaceutical SciencesUniversity of São PauloSão Paulo 05508-030Brazil Research Institute for sport and exercise sciences Liverpool John Moores UniversityLiverpool L33AFUK

background:The purported ergogenic and health effects of probiotics have been a topic of great intrigue among researchers,practitioners,and the lay public *** has also been an increased research focus within the realm of sports science and exercise medicine on the athletic gut ***,compared to other ergogenic aids and dietary supplements,probiotics present unique study *** objectives of this systematic scoping review were to identify and characterize study methodologies of randomized controlled trials investigating supplementation with probiotics in athletes and physically active ***:Four databases(MeDLINe,CINAHL,Cochrane CeNTRAL,and Cochrane Database of systematic Reviews)were searched for randomized controlled studies involving healthy athletes or physically active *** intervention with probiotics and inclusion of a control and/or placebo group were *** peer-reviewed articles in english were considered,and there were no date *** were extracted and presented in tabular form to detail study protocols,characteristics,and *** in randomized controlled trials was determined with the Rob 2.0 ***:A total of 45 studies were included in the review,with 35 using a parallel group design and 10 using a cross-over *** half the studies used a single probiotic and the other half a multi-strain *** probiotic dose ranged from 2×10^(8)to 1×10^(11)colony forming units daily,and the length of intervention was between 7 and 150 *** than half the studies directly assessed gastrointestinal symptoms,gut permeability,or the gut *** sex ratio of participants was heavily weighted toward males,and only 3 studies exclusively investigated ***-level adverse events were reported in only 2 studies,although the methodology of reporting varied *** risk of bias was generally low,although details on randomization were lacking in some s

关键词： exercise experimental methodology Gastrointestinal symptoms Gut microbiota Probiotic supplementation

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effect of gas components on the postdischarge temporal behavior of OH and O of a non-equilibrium atmospheric pressure plasma driven by nanosecond voltage pulses

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Plasma science and Technology 2024年第5期26卷 72-81页

作者：王兰萍聂兰兰卢新培 state Key Laboratory of Advanced electromagnetic engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China

OH radicals and O atoms are two of the most important reactive species of non-equilibrium atmospheric pressure plasma(NAPP),which plays an important role in applications such as plasma ***,experimental studies on how the gas content affects the postdischarge temporal evolutions of OH and O in the noble gas ns-NAPP are very *** this work,the effect of the percentages of O_(2),N_(2),and H_(2)O on the amounts of OH and O productions and their post-discharge temporal behaviors in ns-NAPP is investigated by laser-induced fluorescence(LIF)*** results show that the productions of OH and O increase and then decrease with the increase of O_(2)*** OH and O densities reach their maximum when about 0.8%O_(2)is *** increase of the O_(2)concentration results in a decrease of the initial densities of both OH and O,and leads to their faster *** increase of N_(2)percentage also results in the increase and then decrease of the OH and O densities,but the change is ***,when the H_(2)O concentration is increased from 100 to 3000 ppm,the initial OH density increases slightly,but the OH density decays much faster,while the initial density of O decreases with the increase of the H_(2)O *** analysis,it is found that OH and O are mainly produced through electron collisional dissociation.O(^(1)D)is critical for OH generation.O_(3)accelerates the consumption processes of OH and O at high O_(2)*** addition of H_(2)O in the NAPP considerably enhances the electronegativity,while it decreases the overall plasma reactivity,accelerates the decay of OH,and reduces the O atom density.

关键词： O atom OH radical post-discharge temporal behavior laser-induced fluorescence

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Observing strain glass transition in Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)high entropy alloy with elinvar effect

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Journal of Materials science & Technology 2024年第1期168卷 16-23页

作者： Kaichao Zhang Kai Wang bin Wang Chao Lv Jiaxing Zheng Guanqi Li Yu Fu Wenlong Xiao Qingqing Cai Xutao nie Yingfeng shao Huilong Hou Xinqing Zhao school of Materials science and engineering Beihang UniversityBeijing 100191China China Aerodynamics Research and Development Center Mianyang 621000China state Key Laboratory of Nonlinear Mechanics Chinese Academy of SciencesInstitute of MechanicsBeijing 100190China Tianmushan Laboratory(Zhejiang Provincial Laboratory for Aviation) Hangzhou 310000China

exploring the phase transition of high entropy alloys(HeAs)with multiple major elements is of great importance for understanding the underlying physical *** martensitic phase tran-sition has been frequently reported in HeAs,however,nanoscale microstructural phase evolution has not been investigated to the same ***,we have prepared the Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)HeA and investi-gated the strain glass transition and its associated properties using dynamic mechanical analysis and mi-crostructure *** have found that the elastic modulus in Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)HeA deviates from Wachtman’s equation and observed the elinvar effect in the form of temperature-independent mod-ulus in the temperature range from 150 K to 450 K and frequency-dependence modulus around 220 *** strain glass transition has been evidenced in Ti_(33)Nb_(15)Zr_(25)Hf_(25)O_(2)HeA by the formation and growth of nano-sized domains during in-situ transmission electron microscopy(TeM)cooling,and substantiated by the broken ergodicity during zero-field-cooling/*** strain glass transition is believed to account for the elinvar effect,where the modulus hardening of nano-sized domains compensates dynam-ically with the modulus softening of the transformable matrix.

关键词： High entropy alloys strain glass transition elinvar effect Microstructural evolution Nanodomains

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From VIb‑to Vb‑Group Transition Metal Disulfides:structure engineering Modulation for superior electromagnetic Wave Absorption

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Nano-Micro Letters 2024年第2期16卷 218-257页

作者： Junye Cheng Yongheng Jin Jinghan Zhao Qi Jing bailong Gu Jialiang Wei shenghui Yi Mingming Li Wanli nie Qinghua Qin Deqing Zhang Guangping Zheng Renchao Che Department of Materials science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China school of Materials science and engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China school of Materials science and engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Department of Mechanical engineering Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China

The laminated transition metal disulfides(TMDs),which are well known as typical two-dimensional(2D)semiconductive materials,possess a unique layered structure,leading to their wide-spread applications in various fields,such as catalysis,energy storage,sensing,*** recent years,a lot of research work on TMDs based functional materials in the fields of electromagnetic wave absorption(eMA)has been carried ***,it is of great significance to elaborate the influence of TMDs on eMA in time to speed up the *** this review,recent advances in the development of electromagnetic wave(eMW)absorbers based on TMDs,ranging from the VIb group to the Vb group are *** compositions,microstructures,electronic properties,and synthesis methods are presented in ***,the modulation of structure engineering from the aspects of heterostructures,defects,morphologies and phases are systematically summarized,focusing on optimizing impedance matching and increasing dielectric and magnetic losses in the eMA materials with tunable eMW absorption *** as well as the challenges are also identified to guide the design of new TMDs based dielectric eMA materials with high performance.

关键词： Transition metal disulfides electromagnetic wave absorption Impedance matching structure engineering modulation

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