检索结果-南通市图书馆

Review of Infrared signature suppression systems using optical blocking method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2019年第3期15卷 432-439页

作者： nidhi Baranwal Shripad P. Mahulikar Department of Aerospace Engineering Indian Institute of Technology Bombay Mumbai 400076 India Institute Aerospace Engineering

With rapid advancements in Infra-Red (IR) detection techniques, the range from where the IR-guided missiles are able to lock the target aircraft has increased. To avoid the detection and tracking by modern IR-guided missiles, the aircraft and helicopters also demand progress in its stealth techniques. Hence, study of Infra-Red Signature Suppression (IRSS) systems in aircraft and helicopters has become vital even in design stage. Optical blocking (masking) is one of the effective IRSS techniques used to block the Line- Of-Sight (LOS) of the hot engine parts of the exhaust geometry. This paper reviews the various patents on IR signature suppression systems based on the optical blocking method or a combination of IRSS techniques. The performance penalties generated due to installation of various IRSS methods in aircraft and helicopters are also discussed.

关键词： IR signature suppression Optical blocking Performance penalty IR signature level Engine back-pressure

An Efficient Update Strategy for Content Synchronization in Content-Centric Networking(CCN)

在线全文

学校读者我要写书评

暂无评论

China Communications 2019年第1期16卷 108-118页

作者： nidhi Lal Shishupal Kumar Vijay Kumar Chaurasiya Thapar University IIIT Allahabad

Content-centric Networking(CCN) is progressively flattering the substitutable approach to the Internet architecture through illuminating information(content) dissemination on the Internet with content *** emergent proportion of Internet circulation has expectant adjusting Content-centric architecture to enhance serve the user prerequisites of accessing *** recent years,one of the key aspects of CCN is ubiquitous in-network caching,which has been widely received great attention in research *** foremost shortcoming of in-network caching is that content producers have no awareness about where their content is put in *** routers in CCN have caching capabilities,therefore,each and every content router can cache the content item in its storage *** is problematic in the case in which a producer wishes to update or make the changes in its content *** this paper,we present an approach regarding how to address this issue with a scheme called efficient content update(ECU).Our proposed ECU scheme achieves content update via trifling packets that resemble contemporary CCN communication messages with the use of additional *** measure the performance of ECU scheme by means of simulations and make available a comprehensive exploration of its results.

关键词： content-centric network routing performance caching content delivery

CNTs mediated CD44 targeting;a paradigm shift in drug delivery for breast cancer

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2020年第2期7卷 205-216页

作者： nidhi Jain Singhai Suman Ramteke PI DST WOS-ASchool of Pharmaceutical SciencesRajiv Gandhi Proudyogiki VishwavidyalayaBhopalMadhya PradeshIndia

The breast cancer is one of the most common cancer affecting millions of lives *** the prevalence of breast cancer is worldwide;however,the developing nations are having a comparatively higher percentage of breast cancer cases and associated *** molecular etiology behind breast cancer is complex and involves several regulatory molecules and their downstream *** have demonstrated that the CD44 remains one of the major molecule associated not only in breast cancer but also several other kinds of *** complex structure and functioning of CD44 posed a challenge to develop and deliver precise anti-cancerous drugs against targeted *** are more than 20 isoforms of CD44 reported till date associated with several kinds of tumor in the using breast *** success of any anti-cancerous therapy largely depends on the precise drug delivery system,and in modern days nanotechnology-based drug delivery vehicles are the first choice not only for cancer but several other chronic diseases as *** Carbon nanotubes(CNTs)have shown tremendous scope in delivering the drug by targeting a particular receptor and *** CNTs including both SWCNTs and MWCNTs are a pioneer in drug delivery with higher *** present work emphasized mainly on the potential of CNTs including both SWCNTs and MWCNTs in drug delivery for anti-cancerous *** review provides a comprehensive overview of the development of various CNTs and their validation for effective drug *** work focus on drug delivery approaches for breast cancer,precisely targeting CD44 molecule.

关键词： Anti-cancerous therapy Breast cancer CD44 Delivery Drug Multiwalled carbon nanotubes

Recent advances in the design of biosensors based on novel nanomaterials:An insight

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanotechnology and Precision Engineering 2021年第4期4卷 71-88页

作者： nidhi Chauhan Kirti Saxena Mayukh Tikadar Utkarsh Jain Amity Institute of Nanotechnology(AINT) Amity University Uttar Pradesh(AUUP)Sector-125Noida 201313India

Biosensors have acquired much importance in drug discovery,medical diagnostics,food safety,defense,security,and monitoring of environmental ***,there has been great progress in the potential applications of advanced nanomaterials in *** year there are several advances in sensing techniques that can be attributed to nanomaterials,biorecognition elements,or their related fabrication *** further development of nanotechnology-based sensors provides a wide variety of opportunities to modern *** nanomaterials can provide remarkable optical,electrical,mechanical,and catalytic *** example,transition metals and organic polymers have been used in the fabrication of powerful,sensitive,and precise *** distinctive properties of advanced nanomaterials have been widely incorporated into ***,fabrication techniques also play important roles in the development of these ***,we present a review of some of the advanced nanomaterials that have been widely used over the last few years and discuss their fabrication *** focus of this review is to provide a directional perspective of recently fabricated advanced nanomaterial-based biosensors in the diagnosis of various diseases.

关键词： Biosensors Advanced nanomaterials Transition metals Fabrication of biosensors Fabrication techniques

Gene positioning and genome function

在线全文

学校读者我要写书评

暂无评论

Frontiers in Biology 2014年第4期9卷 255-268页

作者： nidhi VISHNO Jie YAO Department of Cell Biology Yale University School of Medicine New Haven CT 06520 USA

The eukaryotic genome is packaged as chromatin within the three-dimensional nuclear space. Decades of cytological studies have revealed that chromosomes and genes are non-randomly localized within the nucleus and such organizations have important roles on genome function. However, several fundamental questions remain to be resolved. For example, what is required for the preferential localization ofa gene to a nuclear landmark？ What is the mechanism underlying gene repositioning in the nucleus？ How does subnuclear gene positioning regulate gene transcription？ Recent studies have revealed that several factors such as DNA sequence composition, specific regulatory sequences, epigenetic modifications, chromatin remodelers, post-transcriptional regulators and nuclear architectural proteins can influence chromatin dynamics and gene positioning in a gene-specific manner among organisms from yeast to human. In this review, we discuss some recent findings as well as experimental tools to investigate subnuclear gene positioning and to explore its implications in genome functions.

关键词： nucleus transcription gene positioning epigenetics nuclear lamina chromatin

Recent Advances Towards the Development of a Potent Antiviral Against the Hepatitis E Virus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2018年第3期6卷 310-316页

作者： Saumya Anang nidhi Kaushik Milan Surjit Virology Laboratory Vaccine and Infectious Disease Research CentreTranslational Health Science and Technology InstituteNCR Biotech Science Cluster3rd MilestoneFaridabad-Gurgaon ExpresswayFaridabadHaryanaIndia

Hepatitis E virus(HEV)is one of the leading causes of acute viral *** also causes acute liver failure and acute-on-chronic liver failure in many patients,such as those suffering from other infections/liver injuries or organ transplant/chemo-therapy *** widespread sporadic and epidemic incidents,there is no specific treatment against HEV,justifying an urgent need for developing a potent antiviral against *** review summarizes the known antiviral candidates and pro-vides an overview of the potential targets for the development of specific antivirals against HEV.

关键词： Hepatitis E virus HEV antiviral HEV therapy Interferon Ribavirin

Systematic Review on Critical Factors and Their Optimization for Solar Cell Performance Enhancement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 85-98页

作者： nidhi Shukla Satish Kumar Department of Physics Mansarovar Global UniversitySehore 466001India

Solar cells and other renewable energy sources are crucial in today's world where sustainability and environmental consciousness is at *** of this,creating the optimal capacity is a fair aim for the operators of such *** transformation of solar energy into either electricity by means of photovoltaics or into useable fuel by means of photo electrochemical cells remained a primary objective for research organizations and development *** this piece,we will take a look back at the history of solar cells and examine their progression through the *** significant aspects which have an impact on the solar cells' performance are also *** article provides a comprehensive and in-depth overview of the important aspects that affect the solar cells' performance,as well as a discussion of the application of bio-inspired optimization algorithms to improve the parameters of solar *** critical factors and their optimization for solar cell performance enhancement is *** helps identify key performance factors,understand limitations,and challenges,and identify effective optimization *** evaluating trade-offs and synergies,it guides future research and informs industrial applications,leading to more efficient and sustainable solar cell technologies.

关键词： solar energy photovoltaic cells temperature irradiance design optimization

Impacts of Coriaria nepalensis colonization on vegetation structure and regeneration dynamics in a mixed conifer forest of Indian Central Himalaya

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2019年第1期30卷 305-317页

作者： nidhi Rani Mourya Kiran Bargali Surendra Singh Bargali Department of Botany DSB Campus Kumaun University

This study evaluated impacts of Coriaria nepalensis *** on soil characteristics,vegetation structure and composition,regeneration status and expected future compositional changes,biomass and carbon stock in tree species of a mixed conifer forest of Central *** sites(1 ha each in an old landslide area)differing in Coriaria density(low:20 individuals ha^(-1);medium:120 ***^(-1);high:190 ***^(-1))were used to enumerate the tree species.A total of 9 tree species and 2830 individuals were recorded from the three study sites that represented a gradient of Coriaria *** of species varied from 3 to 7 and the individuals from 690 to 1270 per site with lowest numbers at low Coriaria density and highest at medium Coriaria *** number of seedlings increased with increasing Coriaria density,and the sites were unique in their seedling composition,indicating marked temporal *** wise regeneration analysis showed that regeneration was poor at the site with low Coriaria density and good at the high-density site where many species emerged as *** results indicate that the ameliorative effects of Coriaria in terms of soil buildup,and accumulation of nutrients and organic matter helped more species to colonize the *** facilitative ability of Coriaria can be used to restore degraded forest ecosystems of Indian Central Himalaya.

关键词： Basal area Conifer Coriaria Density Facilitation Species richness

Syntheses,characterization,and evaluation of novel non-carboxylic analogues of Gemfibrozil:a bioisosteric approach

在线全文

学校读者我要写书评

暂无评论

Journal of Chinese Pharmaceutical Sciences 2017年第2期26卷 95-105页

作者： nidhi Kala Anand Gaurav Vertika Gautam School of Pharmaceutical Sciences Shobhit UniversityModipuramMeerut 250110lndia Faculty of Pharmaceutical Sciences UCSI UniversityNo.1UCSI HeightsJalan Menara GadingTaman ConnaughtKuala Lumpur 56000Federal Territory of Kuala Lumpur Department of Chemistry Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia

Gemfibrozil is a widely used lipid modifying drug with well-established hypolipidemic and anti-atherosclerotic benefits; however, the presence of a carboxylic acid moiety in its structure is responsible for side effects in the gastrointestinal tract. The principle of bioisosterism was applied to design derivatives replacing the carboxylic acid group. The carboxylic acid group was replaced with bioisoteric groups, such as 1,2,4-triazole-3-thiol and hydroxamic acid. The derivatives were then synthesized, characterized, and evaluated in rats for reduced gastrointestinal irritation and hypolipidemic effects. Gemfibrozil was used as standard for comparison. The derivatives demonstrated less gastric irritation and retained hypolipidemic effects, however the hypolipidemic affects were significantly less than that of Gemfibrozil. The results of this study offers a direction for further research on the application of bioisosterism for the design of new derivatives of Gemfibrozil and other fibric acid derivatives.

关键词： Atherosclerosis Coronary heart disease Fibrates Bioisosterism Hypolipidemic effect Gemfibrozil