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Evaluation of intratesticular chlorhexidine gluconate for chemical contraception in dogs

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Asian pacific Journal of Reproduction 2022年第5期11卷 231-235页

作者： Aeknath Virendra Om Prakash Shrivastava Satya nidhi shukla Manish Kumar shukla Nitin Kumar Bajaj Afroza Khanam Firdous Ahmad Khan Department of Animal Reproduction Gynecology and ObstetricsNanaji Deshmukh Veterinary Science UniversityJabalpur482001Madhya PradeshIndia Department of Animal Reproduction Gynecology and ObstetricsSardar Vallabhbhai Patel UniversityMeerut250110Uttar PradeshIndia Department of Large Animal Medicine and Surgery School of Veterinary MedicineSt.George’s UniversityTrue BlueGrenadaWest Indies

Objective:To investigate the contraceptive effect of intratesticular injection of chlorhexidine gluconate in dogs and compare it with that of zinc gluconate neutralized with ***:Twenty-four sexually mature male mongrel dogs were randomly divided by replicate into four groups(n=6 per group).GroupⅡreceived intra-testicular injection of 2 mL zinc gluconate(10 mg/mL)neutralized with ***Ⅱreceived intratesticular injection of 2 mL chlorhexidine gluconate(5%w/v).GroupⅢreceived intratesticular injection of 2 mL chlorhexidine gluconate(4%w/v).GroupⅣdid not receive any treatment and served as the control *** morphometry was conducted on day 0,7,15 and 30 after *** was collected and evaluated on day 0 and *** were analyzed using repeated measures analysis of ***:There was no difference in the mean values of various parameters between dogs treated with zinc gluconate and those treated with chlorhexidine gluconate at any of the time *** dogs treated with zinc gluconate or chlorhexidine gluconate,there was a significant increase in the testicular morphometric parameters on day 7 followed by a significant reduction thereafter(day 15 and 30).In contrast,there was no change in any of the parameters in the control untreated dogs during the course of the *** to the pre-treatment values,the mean scrotal circumference and the mean paired testicular volume and testicular weight on day 30 were significantly lower in the treated *** samples collected on day 30 from treated dogs were found to be azoospermic,whereas no change in semen quality was observed in the control untreated ***:Intratesticular injection of chlorhexidine gluconate(5%w/v and 4%w/v)is equally as effective as zinc gluconate neutralized with arginine for chemical contraception in dogs.

关键词： Canine Contraception Zinc gluconate Chlorhexidine gluconate Morphometry

An Integrated Analysis of Yield Prediction Models:A Comprehensive Review of Advancements and Challenges

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Computers, Materials & Continua 2024年第7期80卷 389-425页

作者： nidhi Parashar Prashant Johri Arfat Ahmad Khan Nitin Gaur Seifedine Kadry School of Computer Science and Engineering Galgotias UniversityGreater Noida203201India Department of Applied Data Science Noroff University CollegeKristiansand4612Norway Artificial Intelligence Research Center(AIRC) Ajman UniversityAjman346United Arab Emirates MEU Research Unit Middle East UniversityAmman11831Jordan Department of Computer Science College of ComputingKhon Kaen UniversityKhon Kaen40002Thailand

The growing global requirement for food and the need for sustainable farming in an era of a changing climate and scarce resources have inspired substantial crop yield prediction *** learning(DL)and machine learning(ML)models effectively deal with such *** research paper comprehensively analyses recent advancements in crop yield prediction from January 2016 to March *** addition,it analyses the effectiveness of various input parameters considered in crop yield prediction *** conducted an in-depth search and gathered studies that employed crop modeling and AI-based methods to predict crop *** total number of articles reviewed for crop yield prediction using ML,meta-modeling(Crop models coupled with ML/DL),and DL-based prediction models and input parameter selection is *** conduct the research by setting up five objectives for this research and discussing them after analyzing the selected research *** study is assessed based on the crop type,input parameters employed for prediction,the modeling techniques adopted,and the evaluation metrics used for estimatingmodel *** also discuss the ethical and social impacts of AI on ***,various approaches presented in the scientific literature have delivered impressive predictions,they are complicateddue to intricate,multifactorial influences oncropgrowthand theneed for accuratedata-driven ***,thorough research is required to deal with challenges in predicting agricultural output.

关键词： Machine learning crop yield prediction deep learning remote sensing long short-term memory time series prediction systematic literature review

New insights into nitric oxide biosynthesis underpin lateral root development

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Molecular Plant 2024年第5期17卷 691-693页

作者： Kapuganti Jagadis Gupta nidhi Yadav Aprajita Kumari Gary J.Loake National Institute for Plant Genome Research Aruna Asaf Ali MargNew Delhi 110070India Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEH93BF EdinburghUK Centre for Engineering Biology School of Biological SciencesUniversity of EdinburghEH93BF EdinburghUK

In recent years,nitric oxide(NO)has emerged as a key redox signaling molecule in plants functioning in the regulation of key developmental programs and the orchestration of responses to a plethora of environmental cues(Kolbert et al.,2019).The predominant route for the transfer of NO bioactivity is through S-nitrosylation,the addition of an NO moiety to a protein cysteine thiol to form an S-nitrosothiol(Yun et al.,2011).Specificity for this process is established by the structural constraints imposed by tertiary protein structure in gating access to given cysteine redox switches and associated proteins that can either facilitate the addition or removal of the NO moiety at these residues(Umbreen et al.,2018).

关键词： moiety addition redox

Targeting colorectal cancer using dietary flavonols

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Cancer Innovation 2024年第1期3卷 124-132页

作者： Nitin Dubey nidhi Dubey Upendra Bhadoria Kamal Shah Nagendra Singh Chauhan IPS Academy College of Pharmacy IndoreMadhya PradeshIndia School of Pharmacy Devi Ahilya VishwavidyalayaIndoreMadhya PradeshIndia Institute of Pharmaceutical Research GLA UniversityMathuraUttar PradeshIndia Drugs Testing Laboratory Avam Anusandhan Kendra RaipurChhattisgarhIndia

Colorectal cancer is among the well-known forms of cancer and a prominent cause of cancer demises *** vitro experiments reinforced by animal studies,as well as epidemiological studies of human colorectal cancer propose that the growth of this disease can be moderated by eating *** intake including green vegetables and fruits may result in the reduction of colon cancer *** finding suggests that the combinations of dietary nutrients may deliver additive or synergistic effects and might be a powerful method to avoid or eradicate colon cancer beginning and/or *** are one of the most widespread dietary nutrients of the polyphenols-flavonoids and major constituent of Allium and Brassicaceae *** present in vegetables of Allium and Brassicaceae family are kaempferol,myricetin,quercetin,and *** flavonols are claimed to have antiproliferative activity in vivo and in vitro against colorectal *** objective of this review is to summarize the role of flavonols obtained from dietary sources in the prevention and treatment of colorectal cancer.

关键词： isorhamnetin kaempferol myricetin quercetin

Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

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Genes & Diseases 2024年第1期11卷 34-37页

作者： Budhadev Baral Dharmendra Kashyap nidhi Varshney Tarun Prakash Verma Ajay Kumar Jain Debi Chatterji Vinod Kumar Amit Mishra Awanish Kumar Hem Chandra Jha Infection Bioengineering Group Department of Biosciences and Biomedical EngineeringIndian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Choithram Hospital and Research Center IndoreMadhya Pradesh452014India Department of Metallurgy Engineering and Materials Science Indian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Department of Bioscience&Bioengineering Indian Institute of Technology JodhpurNH 65 Nagaur RoadJodhpur DistrictKarwarRajasthan 342037India Department of Biotechnology National Institute of Technology RaipurGE RoadRaipurChhattisgarh 492010India

Persistent gastritis induced by Helicobacter pylori(***)is the strongest known risk factor for gastric cancer(GC).*** is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that *** infection can induce oncogenic properties in AGS cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression.

关键词： H.pylori pylori Helicobacter

Is Regular Probiotic Practice Safe for Management of Sepsis?

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Chinese Journal of Integrative Medicine 2022年第2期28卷 185-192页

作者： Rishabh Kumar Alok Shiomurti Tripathi nidhi Sharma Gaaminepreet Singh Lucy Mohapatra Department of Pharmacology ISF College of PharmacyMoga(Punjab)India Department of Pharmacology Amity Institute of PharmacyAmity UniversityLucknow(UP)India

For decades,the gut has been thought to play an important role in sepsis *** is a serious life-threatening,chronic condition of an infection caused by dysregulated host immune response in most of the intensive care unit *** have dual roles in polymicrobial sepsis *** may induce sepsis in many cases and may prevent its prognosis in many *** evidence from both pre-clinical and clinical studies have demonstrated that probiotic therapy ameliorates various inflammatory mediators such as tumor necrosis factor,interleukin-10(IL-10),IL-6,etc.,in *** addition,probiotic use was also found to reduce the severity of pathological conditions associated with irritable bowel disorder and prevent development of endocarditis in *** contrary,probiotic therapy in neonatal and athymic adult mice fail to provide any beneficial effects on mortality and sepsis-induced ***,in few clinical trials probiotic use was found to aggravate sepsis by promoting inflammatory cascade rather than suppressing *** review discusses various studies regarding the beneficial or harmful effects associated with probiotic therapy in sepsis.

关键词： sepsis probiotics microbial flora immune system

Uncanny valley for interactive social agents:an experimental study

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Virtual Reality & Intelligent Hardware 2022年第5期4卷 393-405页

作者： nidhi MISHRA Manoj RAMANATHAN Gauri TULSULKAR Nadia Magneat THALMANN Institute for Media Innovation Nanyang Technological University637553Singapore Rehabilitation Research Institute of Singapore Nanyang Technological University308232Singapore MIRALab BattelleBuilding A 7Route de DrizeCH-1227 CarougeGenevaSwitzerland

Background The uncanny valley hypothesis states that users may experience discomfort when inter-acting with almost human-like artificial *** in artificial intelligence,robotics,and computer graphics have led to the development of life-like virtual humans and humanoid *** this hypothesis is necessary to check whether they positively or negatively affect the current population,who are highly accustomed to the latest *** In this study,we present a unique evaluation of the uncanny valley hypothesis by allowing participants to interact live with four humanoid robots that have varying levels of *** participant completed a survey questionnaire to evaluate the affinity of each ***,we used deep learning methods to quantify the participants’emotional states using multimodal cues,including visual,audio,and text cues,by recording the participant-robot *** Multi-modal analysis and surveys provided interesting results and insights into the uncanny valley hypothesis.

关键词： Uncanny valley hypothesis Human robot interaction Interactive robots Humanoid robots Virtual humans

Analysis of Cognitive Radio for LTE and 5G Waveforms

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Computer Systems Science & Engineering 2022年第12期43卷 1207-1217页

作者： Ramesh Ramamoorthy Himanshu Sharma A.Akilandeswari nidhi Gour Arun Kumar Mehedi Masud Centre for Artificial Intelligence Chennai Institute of TechnologyChennaiIndia Department of Computer Science and Engineering JECRC UniversityJaipur303905India Institute of ECE Saveetha School of EngineeringChennaiIndia Department of Electronics and Communication Engineering JECRC UniversityJaipur303905India Department of Computer Science College of Computers and Information TechnologyTaif University11099Saudi Arabia

Spectrum sensing is one of the major concerns in reaching an efficientQuality of service (QOS) in the advanced mobile communication system. Theadvanced engineering sciences such as 5G, device 2 device communications(D2D), Internet of things (IoT), MIMO require a large spectrum for better *** frequency division multiplexing (OFDM) is not a choice in advancedradio due to the Cyclic Prefix (CP), wastage of the spectrum, and so on. Hence, itis important to explore the spectral efficient advanced waveform techniques andcombine a cognitive radio (CR) with the 5G waveform to sense the idle spectrum,which overcomes the spectrum issue. The demand for spectrum is ever increasing;however, spectrum is limited and is an acutely scarce resource. To alleviate theissue, techniques like Cognitive Radios (CR) have been devised. However, suchtechniques are non-standardized, and many variations of CR algorithms have beentried and tested. This paper details the several spectrum sensing methods tailoredfor CR. We explain the benefits, uniqueness, and drawbacks of the various techniques to provide a comprehensive review of the scene, including all recent andnovel techniques of CR. Finally, we provided experimental results for the performance of the CR for key 5G and beyond modulation techniques to elaborate thedependency of the CR techniques for CR applications and provide a competitivereview of their performance. Experiments show that the CR integrated withNOMA shows better performance as compared with existing techniques.

关键词： CR Energy detection FBMC NOMA OFDM

Obtaining Crisp Priorities for Triangular and Trapezoidal Fuzzy Judgments

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Computer Systems Science & Engineering 2022年第4期41卷 157-170页

作者： Raman Kumar Goyal Jaskirat Singh nidhi Kalra Anshu Parashar Gagan Singla Sakshi Kaushal Computer Science and Engineering Department Thapar Institute of Engineering and TechnologyPatialaPunjabIndia Computer Science and Engineering University Institute of Engineering and TechnologyPanjab UniversityChandigarhIndia

This paper proposes anoptimal fuzzy-based model for obtaining crisp priorities for Fuzzy-AHP comparison *** judgments cannot be given for real-life situations,as most of these include some level of fuzziness and *** these situations,judgments are represented by the set of fuzzy *** of the fuzzy optimization models derive crisp priorities for judgments repre-sented with Triangular Fuzzy Numbers(TFNs)*** do not work for other types of Triangular Shaped Fuzzy Numbers(TSFNs)and Trapezoidal Fuzzy Numbers(TrFNs).To overcome this problem,a sum of squared error(SSE)based optimization model is *** some other methods,the proposed model derives crisp weights from all of the above-mentioned fuzzy judgments.A fuzzy number is simulated using the Monte Carlo method.A threshold-based constraint is also applied to minimize the deviation from the initial *** Algorithm(GA)is used to solve the optimization *** have also conducted casestudiesto show the proposed approach’s advantages over the *** show that the proposed model outperforms other models to minimize SSE and deviation from initial ***,the proposed model can be applied in various real time scenarios as it can reduce the SSE value upto 29%compared to the existing studies.

关键词： Analytic hierarchy process comparison matrices priority vectors fuzzy judgments triangular fuzzy numbers triangular-shaped fuzzy numbers trapezoidal fuzzy numbers