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Impact of gut microbiome in the development and treatment of pancreatic cancer:Newer insights

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World Journal of Gastroenterology 2023年第25期29卷 3984-3998页

作者： Ayrton I Bangolo Chinmay Trivedi Ishan Jani Silvanna Pender Hirra Khalid Budoor Alqinai Alina Intisar Karamvir Randhawa Joseph Moore nicoleta De Deugd Shaji Faisal SuchithBoodgere Suresh Parva Gopani Vignesh K Nagesh Tracy Proverbs-Singh Simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Gastrointestinal Malignancies John Theurer Cancer CenterHackensackNJ 07601United States

The gut microbiome plays an important role in the variation of pharmacologic *** aspect is especially important in the era of precision medicine,where understanding how and to what extent the gut microbiome interacts with drugs and their actions will be key to individualizing *** impact of the composition of the gut microbiome on the efficacy of newer cancer therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell treatment has become an active area of *** adenocarcinoma(PAC)has a poor prognosis even in those with potentially resectable disease,and treatment options are very *** studies have concluded that there is a synergistic effect for immunotherapy in combination with cytotoxic drugs,in the treatment of PAC.A variety of commensal microbiota can affect the efficacy of conventional chemotherapy and immunotherapy by modulating the tumor microenvironment in the treatment of *** review will provide newer insights on the impact that alterations made in the gut microbial system have in the development and treatment of PAC.

关键词： Pancreatic cancer Gut microbiome Chemotherapy Dysbiosis Intratumoral microbiome Gut flora

Complex Target Volume Delineation and Treatment Planning in Radiotherapy for Malignant Pleural Mesothelioma (MPM)

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2020年第3期9卷 125-140页

作者： Aaron Innocent Bogmis Adrian Raducu Popa Daniela Adam Violeta Ciocâltei nicoleta Alina Guraliuc Florin Ciubotaru Ion-Christian Chiricuță Department of Electricity Solid State Physics & Biophysics Faculty of Physics University of Bucharest Bucharest Romania Amethyst Radiotherapy Center Otopeni Romania

Introduction: Radiotherapy alone or combined with surgery and/or chemotherapy is being investigated in the treatment of malignant pleural mesothelioma (MPM). This study aimed to simulate a Volumetric Modulated Arc Therapy (VMAT) treatment of a patient with MPM. Materials and Methods: CT images from a patient with intact lungs were imported via DICOM into the Pinnacle3 treatment planning (TP) system (TPS) and used as a model for MPM to delineate organs at risk (OAR) and both clinical and planning target volumes (CTV and PTV) with a margin of 5 mm. Elekta Synergy with 6 MV photons and 80 leafs MLCi2 was employed. VMAT plans were generated using two coplanar arcs with gantry rotation angles of 178° - 182°, the collimator angles of each arc were set to 90°, Octavius® 4D 729 was employed for quality assurance while the calculated and measured doses were compared using VeriSoft. Results: A TP was achieved. The Gamma volume analysis with criteria of 3 mm distance to agreement and 3% dose difference yielded the gamma passing rate = 99.9%. The reference isodose was 42.75 Gy with the coverage constraints for the PTV D95 and V95 = 95.0% of 45 Gy. The remaining dosimetric parameters met the recommendations from the clinically acceptable guidelines for the radiotherapy of MPM. Conclusion: Using well-defined TV and VMAT, a consistent TP compared to similar ones from publications was achieved. We obtained a high agreement between the 3D dose reconstructed and the dose calculated.

关键词： Malignant Pleural Mesothelioma Radiation Therapy Radiotherapy Volumetric Modulated Arc Therapy VMAT Target Volume Delineation Treatment Planning CTV PTV

Pheochromocytoma and stress cardiomyopathy:Insight into pathogenesis

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World Journal of Cardiology 2017年第3期9卷 255-260页

作者： Sahil Agrawal Jamshid Shirani Lohit Garg Amitoj Singh Santo Longo Angelita Longo Mark Fegley Lauren Stone Muhammad Razavi nicoleta Radoianu Sudip Nanda Department of Cardiology St.Luke’s University Health NetworkBethlehemPA 18015United States

AIM To investigate the occurrence of cardiomyopathy(CMP)in a cohort of patients with histologically proven pheochromocytoma(pheo),and to determine if catecholamine excess was causative of the left ventricular(LV)*** A retrospective chart review spanning years 1998through 2014 was undertaken and patients with a diagnosis of pheo confirmed with histopathologic examination were *** electrocardiograms and cardiac imaging studies were *** echocardiography(TTE),ventriculography or single positron emission computed tomography imaging was evaluated and if significant abnormalities[left ventricular hypertrophy(LVH)or LV dysfunction]were noted in the pre operative period a follow up post-operative study was also *** analysis using logistic regression was used to investigate independent predictors for outcomes of interest,LV dysfunction and *** We identified 18 patients with diagnosis of pheo confirmed on *** age was 54.3±19.3years and 11(61.1%)patients were females.50%of such patients had either resistant hypertension or labile blood pressures during hospitalization,which had raised suspicion for a *** imaging studies were available for 12(66.7%)patients at the time of inclusion into study and preceding the adrenalectomy.7(58.3%)patients with a TTE available for review had mild or more severe LVH while 3(25%)patients had LV dysfunction of presumably acute *** a multivariate analysis,elevated catecholamine levels as assessed by urinary excretion of metabolites was not an independent predictor of development of LV systolic dysfunction or of presence of LVH on *** female patients with a preceding history of hypertension had marked LV hypertrophy and systolic anterior motion of the mitral *** of the QTc interval was noted in 5(27.8%)patients but no acute arrhythmias were observed in any *** This study adds to the growing body of literature on the

关键词： Pheochromocytoma Cardiomyopathy Stress

使用计算机对下塔尔克乌砂岩组中浊积岩（罗马尼亚东喀尔巴阡山）的马尔科夫链分析

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沉积与特提斯地质 1995年第2期16卷 66-70页

作者： nicoleta Badescu(Geological Institute of Romania, Caransebes 1, 78344 Bucharest, Romania) 罗马尼亚地质研究所

如复理石沉积那样的垂向连续型韵律序列的研究能揭示有关生成过程和沉积区域的重要信息。无论不同岩性的垂向组合是否随机的，甚至没有沉积层序的优选次序，也能进行马尔科夫链分析这样的统计分析。此类分析适用于下塔尔克乌砂岩组（罗... 详细信息

如复理石沉积那样的垂向连续型韵律序列的研究能揭示有关生成过程和沉积区域的重要信息。无论不同岩性的垂向组合是否随机的，甚至没有沉积层序的优选次序，也能进行马尔科夫链分析这样的统计分析。此类分析适用于下塔尔克乌砂岩组（罗马尼亚东喀尔巴吁山）的复理石沉积，注意这些沉积物保存的发生程序并给以储存，而那些沉积物（至少被研究的层段）是浊流作用的产物，这些浊积物堆积在水道化沉积亚环境（诸如水道化的中深海扇之类）具良好分带的沉积区中。

关键词：马尔科夫链浊积岩罗马尼亚计算机复理石沉积砂岩沉积物类分析沉积区垂向

Circulating microparticles and micro RNAs as players in atherosclerosis

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World Journal of Hematology 2013年第2期2卷 16-19页

作者： nicoleta Alexandru Adriana Georgescu Petru Poni Institute of Macromolecular Chemistry R-6600 Iasi Romania Department of Pathophysiology and Pharmacology Institute of Cellular Biology and Pathology Nicolae Simionescu of Romanian Academy 050568 Bucharest Romania

Microparticles(MPs) are extracellular membrane vesicles released from normal, apoptotic and pathological cells following a process of detachment from cells of origin. MPs are typically defined by their size, exposure of phosphatidylserine, the expression of surface antigens, proteins and genetic material, originating from their donor cells, and as important vehicles of intercellular communication across numerous biological processes. MPs contain the major source of systemic RNA including micro RNA(mi RNA) of which aberrant expression appears to be associated with stage and progression of atherosclerosis. The involvement and influence of mi RNA during the onset and progression of atherosclerotic disease have generated a lot of inter-est in assessing the feasibility of therapeutic regulation of mi RNAs to manipulate them with a special focus on cardiovascular disease. We speculate on the future de velopments of MPs which contain mi RNA as new thera peutic targets for proliferative vascular diseases such as atherosclerosis.

关键词： Microparticles MicroRNA Atherosclerosis

Insurance Accounting in Romania

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Economics World 2018年第3期6卷 242-247页

作者： Varteiu Daniel Petru Vilijencova nicoleta Daian Daniela University 1st of December 1918 Alba IuliaRomania

The permanent existence of risks under all forms and in all domains of activity,supposes the closing of insurance policies between natural and legal persons,having the quality of insurant respectively specialized institutions,having the quality of insurer,which assumes the risk production in return for the payment of some insurance premiums from the beneficiaries of the insurance *** the development of the insurance policies in Romania is Law No.32/2000 concerning the insurance activity and surveying insurances with their subsequent modifications and *** companies keep a double-entry accounting with the help of specific accounts to the insurance activities and draw up annual financial reports which include balance sheet,profit and loss account,the report of own capital modifications,the report of treasury flux,and the explanatory notes to financial reports.

关键词： accounting insurances insurant insurer

Complex Target Volume Delineation and Treatment Planning in Radiotherapy for Malignant Pleural Mesothelioma (MPM)

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