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Comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

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Journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： melissa A.Stephen Chris R.Burke Jennie E.Pryce nicole.m.steele Peter R.Amer Susanne meier Claire V.C.Phyn Dorian J.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae Centre for Genetics and Breeding-massey University RuakuraHamilton 3214New Zealand Agriculture Victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGEP4),which generally coincides with onset of puberty,as an example *** We produced AGEP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** Credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(EBVs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： Cattle Gibbs sampler markov-chain monte Carlo(mCmC) Puberty

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Impact of sex on the outcomes of deceased donor liver transplantation

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World Journal of Transplantation 2024年第1期14卷 120-129页

作者： Oya m Andacoglu Isabel S Dennahy nicole C mountz Luisa Wilschrey Arzu Oezcelik Division of Transplantation and Advanced Hepatobiliary Surgery University of UtahSalt Lake CityUT 84112United States Department of Surgery University of EssenEssen D-45122Germany Department of Surgery The University of Oklahoma Health Sciences CenterOklahoma CityOK 73117United States Department of Surgery University of Oklahoma College of MedicineOklahoma CityOK 73117United States

BACKGROUND Data examining the impact of sex on liver transplant(LT)outcomes are *** is clear that further research into sex-related differences in transplant patients is necessary to identify areas for *** of these differences may help to identify specific areas of focus to improve on the organ matching process,as well as the peri-and post-operative care of these *** To utilize data from a high-volume Eurotransplant center to compare characteristics of male and female patients undergoing liver transplant and assess association between sex-specific variables with short-and long-term post-transplant *** A retrospective review of the University of Essen’s transplant database was performed with collection of baseline patient characteristics,transplant-related data,and short-term *** of these data were made with Shapiro-Wilk,mann-Whitney U,χ2 and Bonferroni tests applied where appropriate.A P value ofmic liver disease(P=0.001).Female patients were more likely to have received an organ from a female donor with a higher donor risk index score,and as a high urgency offer(all Pmale and female recipients were also significantly *** multivariate hazard regression analysis,recipient lab-model for End-Stage Liver Disease score and donor cause of death were associated with long-term outcomes in ***-operative diagnosis of hepatocellular carcinoma,age at time of listing,duration of surgery,and units transfused during surgery,were associated with long-term outcomes in *** of complications was associated with long-term outcomes in both *** survival was similar in both males and females;however,when stratified by age,females<50 y

关键词： Liver transplant Outcomes Survival Peri-and post-operative care

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A Golden Touch in the Design of multifunctional Porphyrin metallacages:Host-Guest Chemistry for Drug-Target Interactions

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CCS Chemistry 2024年第7期6卷 1662-1671页

作者： Tamara Rodríguez-Prieto Darren Wragg nicole Heiduk mihyun Park nicole Strittmatter Roland A.Fischer Angela Casini Guillermo moreno-Alcántar Chair of medicinal and Bioinorganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Professorship for Analytical Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Chair of Inorganic and metalOrganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München munich Data Science Institute(mDSI) Technical University of Munich85748 Garching b.München

The use of three-dimensional self-assembled metallacages(mCgs)as multimodal drug platforms holds great ***,the synthesis of mCgs with increased complexity and functionality is a great challenge since understanding of the interaction of mCgs with biological targets is still *** this context,this work reports on the integration of a gold(III)porphyrin scaffold into a prismatic mCg structure and explores its application for multimodal therapy of cancer in vitro,namely enabling both photodynamic therapy and *** experimental approaches with a state-of-the-art metadynamics theoretical study,we discovered that the gold cage shows unprecedented host-guest interaction-driven selective stabilization of guanine-quadruplex(G4)structures-validated anticancer drug targets-disclosing a new mechanism to pursue in the design of supramolecular drugs.

关键词： gold metallacages porphyrins G4stabili-zation host-guestchemistry anticanceragents

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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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Journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso myriam Filion Spencer J.Allen Stephanie m.Ntoukas Gordon J.Bell Jessica mcNeil Qinggang Wang margaret L.mcNeely Jeff K.Vallance Lin Yang S.nicole Culos-Reed Leanne Dickau John R.mackey Christine m.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(pmptom(pmultiple symptoms(pmonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

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HLTV年度最佳NO.20--Twistzz:保持简单

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电子竞技 2024年第3期 77-79页

作者： nicole 不详

随着2023年末钟声的敲响,HLTV按惯例以每天一位的速度公布了他们每年为CS:GO选手排名的年度最佳选手Top20榜单。截止2024年1月13日,榜单上的Top20选手已经全部揭晓。ZywOo、NiKo、ropz成为了2023年Top20的第1、2、3名,m0NESY、Spinx、Su... 详细信息

随着2023年末钟声的敲响,HLTV按惯例以每天一位的速度公布了他们每年为CS:GO选手排名的年度最佳选手Top20榜单。截止2024年1月13日,榜单上的Top20选手已经全部揭晓。ZywOo、NiKo、ropz成为了2023年Top20的第1、2、3名,m0NESY、Spinx、SunPayus紧随其后。

关键词： HLT 选手 yw

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C19mC miRNA-520G induces SP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma

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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh marian T.Smallin Nino mtchedlidze Isha Godwin marco Napoli nicole Hackel manali S.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden R.Baldwin Suehelay Acevedo-Acevedo Yifeng Gao michelle A.Reiser Keiran S.m.Smalley Elsa R.Flores Andrew S.Brohl Department of molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA molecular medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Saveetha medical College ChennaiTamil Nadu 602105India Tumor Biology Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sarcoma Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

SP100 is an antiviral protein that restricts the productive stage of human papillomavirus(HPV)and multiple other viruses,and viruses in turn block sUmO-1-mediated stabilization of SP100 and promotes its degradation(Table S1).Interferon(IFN)signaling could still produce more SP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of SP100 to achieve persistent infection in hosts.

关键词： SP100 melanoma stabilization

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A Glassy Carbon Electrode modified with Cellulose Nanofibrils from Ammophila arenaria for the Sensitive Detection of L-Trytophan

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Journal of Sensor Technology 2024年第3期14卷 35-50页

作者： Sondes Bourigua Feriel Boussema Zayneb Jebali Houcine Barhoumi Hatem majdoub Abderrazak maaref nicole Jaffrezic-Renault Laboratory of Advanced materials and Interfaces Faculty of Sciences University of Monastir Monastir Tunisia Institute of Analytical Sciences University of Lyon Villeurbanne France

L-tryptophan is an essential amino acid for human health. Nanofibrillated cellulose (NFC) from marram grass (Ammophila arenaria) extracted from plants harvested in the center of Tunisia was used for the first time for the modification of a glassy carbon electrode (GCE), for the sensitive detection of L-tryptophan (Trp). After spectroscopic and morphological characterization of the extracted NFC, the GC electrode modification was monitored through cyclic voltammetry. The NFC-modified electrode exhibited good analytical performance in detecting Trp with a wide linear range between 7.5 × 10−4 mm and 10−2 mm, a detection limit of 0.2 µm, and a high sensitivity of 140.0 µA∙mm−1. Additionally, the NFC/GCE showed a good reproducibility, good selectivity versus other amino acids, uric acid, ascorbic acid, and good applicability to the detection of Trp in urine samples.

关键词： Nanofibrillated Cellulose Chitosan Chemically modified Glassy Carbon Electrode Electrochemical Detection L-Tryptophan

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Controlling Heat Transfer for the manufacturing of High molecular Weight Polyisobutylene via Formation of micelles

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Chinese Journal of Polymer Science 2019年第9期37卷 898-902页

作者： Szilard Csihony nicole Janssen Klaus mühlbach Advanced materials & Systems

An alternative cationic polymerization method is developed to produce high molecular weight polyisobutylene (Hm-PIB) with molecular weights above 5×10^5g/mol. The method involves micelle formation via functionalized low molecular weight polyisobutylene (Lm-PIB) in non-polar solvent. One end of Lm-PIB is modified with an imidazolium-containing ionic group, which together with the anion (eg. Al2Cl7) works as Lewis acid. While the monomer isobutylene dissolves readily in non-polar solvent, polymerization can occur only within the micelle, which affords stable Hm-PIB particles. Hm-PIB with a molecular weight (mW) close to 1 × 10^6 g/mol was produced successfully with the described method.

关键词： Cationic polymerization High molecular weight polyisobutylene micelle

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Telomeres:Linking stress and survival,ecology and evolution

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Current Zoology 2010年第6期56卷 714-727页

作者： mark F.HAUSSmANN nicole m.mARCHETTO Department of Biology Bucknell University

Telomeres are protective structures at the ends of eukaryotic chromosomes. The loss of telomeres through cell division and oxidative stress is related to cellular aging, organismal growth and disease. In this way, telomeres link molecular and cellular mechanisms with organismal processes, and may explain variation in a number of important life-history traits. Here, we discuss how telomere biology relates to the study of physiological ecology and life history evolution. We emphasize current knowledge on how telomeres may relate to growth, survival and lifespan in natural populations. We finish by examining interest- ing new connections between telomeres and the glucocorticoid stress response. Glucocorticoids are often employed as indices of physiological condition, and there is evidence that the glucocorticoid stress response is adaptive. We suggest that one way that glucocorticoids impact organismal survival is through elevated oxidative stress and telomere loss. Future work needs to establish and explore the link between the glucocorticoid stress response and telomere shortening in natural populations. If a link is found, it provides an explanatory mechanism by which environmental perturbation impacts life history trajectories [Current Zoology 56 （6）： 714-727, 2010].

关键词： Corticosterone Stress Survival Telomeres

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The role of cellular and molecular neuroimmune crosstalk in gut immunity

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Cellular & molecular Immunology 2023年第11期20卷 1259-1269页

作者： Daping Yang nicole Almanzar Isaac m.Chiu Department of Immunology Harvard Medical SchoolBostonMA02115USA

The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune *** two systems critically coordinate the sensations of and adaptations to dietary,microbial,and damaging stimuli from the external and internal microenvironment during tissue homeostasis and *** brain receives and integrates ascending sensory signals from the gut and transduces descending signals back to the gut via autonomic *** regulate intestinal immune responses through the action of local axon reflexes or through neuronal circuits via the gut-brain *** neuroimmune crosstalk is critical for gut homeostatic maintenance and disease *** this review,we discuss the roles of distinct types of gut-innervating neurons in the modulation of intestinal mucosal *** will focus on the molecular mechanisms governing how different immune cells respond to neural signals in host defense and *** also discuss the therapeutic potential of strategies targeting neuroimmune crosstalk for intestinal diseases.

关键词： Neuroimmunology Neuroimmune Host defense Gut Sensory

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