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PCR-RFLP Methodology to Identify <i>Nocardia</i>Isolates in Cuba

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Advances in Microbiology 2015年第10期5卷 724-729页

作者： Yaxsier de Armas Carlos Manuel Fernández Raúl Díaz nicolas bioni stefano Gustavo Wissmann Enrique José Calderón Institute of Tropical Medicine Pedro Kour Havana Cuba Hospital de Clínicas de Porto Alegre Federal University of Rio Grande do Sul Porto Alegre Brazil Department of Internal Medicine Center of Biomedical Research Network in Epidemiology and Public Health Virgen del Rocío University Hospital Seville Spain

Nocardiosis diagnosis is a major challenge. The clinical features and radiological findings are nonspecific. Traditionally, Nocardia identification is based on colonial and microscopical morphology and biochemical tests. However, molecular biology techniques allow a better characterization of species and biotypes. PCR-RFLP of the 65-kDa heat shock protein (HSP) gene provides a rapid, sensitive, and time and labor-efficient method for this proposal. Using this technique, six of eight isolates tested were identified as Nocardia asteroides type VI. PCR-RFLP of the 65-kDa HSP gene could be very useful for determining the incidence of this pathogen in different population groups and its association with susceptibility/resistance profiles to the drugs of choice for treatment. This work is the first molecular detection of Nocardia species in Cuba.

关键词： Nocardia PCR-RFLP Cuba Molecular Identification 65-kDa HSP Gene

GEOEssential–mainstreaming workflows from data sources to environment policy indicators with essential variables

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International Journal of Digital Earth 2020年第2期13卷 322-338页

作者： Anthony Lehmann stefano Nativi Paolo Mazzetti Joan Maso Ivette Serral Daniel Spengler Aidin Niamir Ian McCallum Pierre Lacroix Petros Patias Denisa Rodila nicolas Ray Grégory Giuliani enviroSPACE Institute for Environmental SciencesUniversity of GenevaGenevaSwitzerland Dpt.F.-A.Forel for Environment and Water Sciences Faculty of SciencesUniversity of GenevaGenevaSwitzerland National Research Council of Italy–Institute of Atmospheric Pollution Research Sesto Fiorentino(FI)Italy CREAF Grumets research group CREAF.Edifici C.Universitat Autònoma de BarcelonaBellaterraSpain Remote Sensing Section Helmholtz Center Potsdam GFZ German Research Center for GeosciencesPotsdamGermany Senckenberg Biodiversity and Climate Research Institute Senckenberg Gesellschaft für NaturforschungFrankfurt am MainGermany International Institute for Applied Systems Analysis LaxenburgAustria GRID-Geneva Institute for Environmental SciencesUniversity of GenevaGenevaSwitzerland School of Surveying Engineering Aristotle University of ThessalonikiThessalonikiGreece GeoHealth Group Institute of Global HealthFaculty of MedicineUniversity of GenevaGenevaSwitzerland

When defining indicators on the environment,the use of existing initiatives should be a priority rather than redefining indicators each *** an Information,Communication and Technology perspective,data interoperability and standardization are critical to improve data access and exchange as promoted by the Group on Earth *** is following an end-user driven approach by defining Essential Variables(EVs),as an intermediate value between environmental policy indicators and their appropriate data *** international to local scales,environmental policies and indicators are increasingly percolating down from the global to the local *** scientific business processes for the generation of EVs and related indicators can be formalized in workflows specifying the necessary logical *** this aim,GEOEssential is developing a Virtual Laboratory the main objective of which is to instantiate conceptual workflows,which are stored in a dedicated knowledge base,generating executable *** interpret and present the relevant outputs/results carried out by the different thematic workflows considered in GEOEssential(***,ecosystems,extractives,night light,and food-water-energy nexus),a Dashboard is built as a visual *** is a valuable instrument to track progresses towards environmental policies.

关键词： SDGs environmental policies essential variables earth observation knowledge base workflows virtual research environment

Real-time mechanical characterization of DNA degradation under therapeutic X-rays and its theoretical modeling

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Microsystems & Nanoengineering 2016年第1期2卷 9-17页

作者： Grégoire Perret Thomas Lacornerie Fabio Manca stefano Giordano Momoko Kumemura nicolas Lafitte Laurent Jalabert Mehmet C.Tarhan Eric F.Lartigau Fabrizio Cleri Hiroyuki Fujita Dominique Collard LIMMS/CNRS-IIS UMI 2820 Institute of Industrial ScienceThe University of Tokyo4-6-1 Komaba Meguro KuTokyo 153-8505Japan IEMN UMR8520CNRSAvenue PoincaréCitéScientifiqueBP 60069Villeneuve d’AscqCedex 59652France CNRS/IIS/COL/Lille 1 SMMiL-E project CNRS Délégation Nord-Pas de Calais et Picardie2 rue de CanonniersLilleCedex 59046France Centre Oscar Lambret Universitéde LilleDépartement Universitaire de RadiothérapieCentre Oscar LambretLille 59000France Institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan

The killing of tumor cells by ionizing radiation beams in cancer radiotherapy is currently based on a rather empirical understanding of the basic mechanisms and effectiveness of DNA damage by *** contrast,the mechanical behaviour of DNA encompassing sequence sensitivity and elastic transitions to plastic responses is much better understood.A novel approach is proposed here based on a micromechanical Silicon Nanotweezers *** instrument allows the detailed biomechanical characterization of a DNA bundle exposed to an ionizing radiation beam delivered here by a therapeutic linear particle accelerator(LINAC).The micromechanical device endures the harsh environment of radiation beams and still retains molecular-level detection *** this study,the first real-time observation of DNA damage by ionizing radiation is *** DNA bundle degradation is detected by the micromechanical device as a reduction of the bundle stiffness,and a theoretical model provides an interpretation of the *** first real-time observations pave the way for both fundamental and clinical studies of DNA degradation mechanisms under ionizing radiation for improved tumor treatment.

关键词： biomechanical measurements DNA damage microfluidic radiotherapy real-time Silicon Nanotweezers

The Giant Radio Array for Neutrino Detection(GRAND):Science and design

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Science China(Physics,Mechanics & Astronomy) 2020年第1期63卷 1-43页

作者： Jaime Alvarez-Muniz Rafael Alves Batista Aswathi Balagopal V. Julien Bolmont Mauricio Bustamante Washington Carvalho Jr. Didier Charrier Ismael Cognard Valentin Decoene Peter B.Denton Sijbrand De Jong Krijn D.De Vries Ralph Engel Ke Fang Chad Finley stefano Gabici Quan Bu Gou Jun Hua Gu Claire Guépin Hong Bo Hu Yan Huang Kumiko Kotera Sandra Le Coz Jean-Philippe Lenain Guo Liang Léü Olivier Martineau-Huynh Miguel Mostafá Fabrice Mottez Kohta Murase Valentin Niess Foteini Oikonomou Tanguy Pierog Xiang Li Qian Bo Qin Duan Ran nicolas Renault-Tinacci Markus Roth Frank G.Schroder Fabian Schüssler Cyril Tasse Charles Timmerman Matías Tueros Xiang Ping Wu Philippe Zarka Andreas Zech B.Theodore Zhang Jian Li Zhang Yi Zhang Qian Zheng Anne Zilles Departamento de Fisica de Particulas&lnstituto Galego de Fisica de Altas Enerxias Universidad de Santiago de CompostelaSantiago de Compostela 15782Spain Instituto de Astronomia Geofisica e Ciencias AtmosfericasUniversidade de Sao PauloSao Paulo-SP 05508-090Brazil Department of Physics-Astrophysics University of OxfordDWBOxford 0X13RHUK Institute of Experimental Particle Physics(ETP) Karlsruhe Institute of Technology(KIT)Karlsru he D-76021Germany Laboratoire de Physique Nucleeaire et de Hautes Energies(LPNHE) Sorbonne UniversiteUniversite Paris DiderotSorbonne Paris CiteCNRS place Jussieu F-75252Paris Cedex 5France Niels Bohr International Academy and DARK Niels Bohr InstituteCopenhagen 2100Denmark Discovery Center Niels Bohr InstituteCopenhagen 2100Denmark Center for Cosmology and AstroParticle Physics(CCA.PP)&Department of Physics Ohio State UniversityColumbus OH 43210USA Universidade de Santiago de Compostela Santiago de Compostela 15782Spain 0SUBATECH Institut Mines-Telecom Atlantique-CNRS/IN2P3-Universite de NantesNantes 44300France Laboratoire de Physique et Chimie de KEnvironnement et de VEspace LPC2E CNRS-Universite d'Orleans Orleans F-45071France Station de Radioastronomie de Nancay Observatoire de ParisCNRS/INSU F-18330 NangayFrance Sorbonne Universite UMR 7095Institut d'Astrophysique de Paris98 bis bd AragoParis 75014France Institute for Mathematics Astrophysics and Particle Physics(IMAPP)Radboud UniversiteitNijmegen 6500Netherlands Nationaal Instituut voor Kemfysica en Hoge Energie Fysica(NIKHEF) Amsterdam NL-1009Netherlands IIHE/ELEM Vrije Universiteit BrusselPleinlaan 2Brussels 1050Belgium Institute for Nuclear Physics(IKP) Karlsruhe Institute of Technology(KIT)Karlsruhe D-76021Germany Einstein Fellow Stanford UniversityStanford CA 94305USA Department of Astronomy University of MarylandCollege Park MD 20742-2421USA Joint Space-Science Institute College Park MD 20742-2421USA Oskar Klein Centre Stockholm UniversityStockholm SE-10691Sweden Department of Phy

The Giant Radio Array for Neutrino Detection(GRAND)is a planned large-scale observatory of ultra-high-energy(UHE)cosmic particles,with energies exceeding 10~8 Ge *** goal is to solve the long-standing mystery of the origin of UHE cosmic *** do this,GRAND will detect an unprecedented number of UHE cosmic rays and search for the undiscovered UHE neutrinos and gamma rays associated to them with unmatched *** will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHE particles in the *** design is modular:20 separate,independent sub-arrays,each of 10000 radio antennas deployed over 10000 km^2.A staged construction plan will validate key detection techniques while achieving important science goals *** we present the science goals,detection strategy,preliminary design,performance goals,and construction plans for GRAND.

关键词： radio telescopes neutrinos in astronomical observations cosmic rays in astronomical observations radiowave radiation:sources galactic and extragalactic cosmic rays:galactic and extragalactic

The Giant Radio Array for Neutrino Detection(GRAND):Science and design

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Science China(Physics,Mechanics & Astronomy) 2020年第1期Mechanics & Astronomy) .卷 5-47页

作者： Jaime álvarez-Mu?iz Rafael Alves Batista Aswathi Balagopal V. Julien Bolmont Mauricio Bustamante Washington Carvalho Jr. Didier Charrier Isma?l Cognard Valentin Decoene Peter B.Denton Sijbrand De Jong Krijn D.De Vries Ralph Engel Ke Fang Chad Finley stefano Gabici Quan Bu Gou Jun Hua Gu Claire Guépin Hong Bo Hu Yan Huang Kumiko Kotera Sandra Le Coz Jean-Philippe Lenain Guo Liang Léü Olivier Martineau-Huynh Miguel Mostafá Fabrice Mottez Kohta Murase Valentin Niess Foteini Oikonomou Tanguy Pierog Xiang Li Qian Bo Qin Duan Ran nicolas Renault-Tinacci Markus Roth Frank G.Schr ?der Fabian Schüssler Cyril Tasse Charles Timmerman Matías Tueros Xiang Ping Wu Philippe Zarka Andreas Zech B.Theodore Zhang Jian Li Zhang Yi Zhang Qian Zheng Anne Zilles Departamento de Física de Partículas & Instituto Galego de Física de Altas Enerxías Universidad de Santiago de Compostela Instituto de Astronomia Geofísica e Ciências Atmosféricas Universidade de S?o Paulo Department of Physics—Astrophysics University of Oxford DWB Institute of Experimental Particle Physics (ETP) Karlsruhe Institute of Technology (KIT) Laboratoire de Physique Nucléeaire et de Hautes Energies (LPNHE) Sorbonne Université Université Paris Diderot Sorbonne Paris Cité Niels Bohr International Academy and DARK Niels Bohr Institute Discovery Center Niels Bohr Institute Center for Cosmology and Astro Particle Physics (CCAPP) & Department of Physics Ohio State University Universidade de Santiago de Compostela SUBATECH Institut Mines-Telecom Atlantique – CNRS/IN2P3 – Université de Nantes Laboratoire de Physique et Chimie de l’Environnement et de l’Espace LPC2E CNRS-Université d’Orléans Station de Radioastronomie de Nan?cay Observatoire de Paris Sorbonne Université UMR 7095 Institut d’Astrophysique de Paris Institute for Mathematics Astrophysics and Particle Physics (IMAPP) Radboud Universiteit Nationaal Instituut voor Kernfysica en Hoge Energie Fysica (NIKHEF) IIHE/ELEM Vrije Universiteit Brussel Institute for Nuclear Physics (IKP) Karlsruhe Institute of Technology (KIT) Einstein Fellow Stanford University Department of Astronomy University of Maryland Joint Space-Science Institute Oskar Klein Centre Stockholm University Department of Physics Stockholm University Astro Particule et Cosmologie (APC) Université Paris Diderot CNRS/IN2P3 CEA/Irfu Observatoire de Paris Institute of High Energy Physics Chinese Academy of Sciences National Astronomical Observatories Chinese Academy of Sciences School of Physical Science and Technology Xinjiang University Center for Particle and Gravitational Astrophysics Pennsylvania State University Department of Physics Pennsylvania State University Department of Astronomy & Astrophysics Pennsylvania State University LUTH Observatoire de Paris

The Giant Radio Array for Neutrino Detection（GRAND） is a planned large-scale observatory of ultra-high-energy（UHE） cosmic particles, with energies exceeding 10～8 Ge V. Its goal is to solve the long-standing mystery of the origin of UHE cosmic rays. To do this, GRAND will detect an unprecedented number of UHE cosmic rays and search for the undiscovered UHE neutrinos and gamma rays associated to them with unmatched sensitivity. GRAND will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHE particles in the atmosphere. Its design is modular: 20 separate, independent sub-arrays, each of 10000 radio antennas deployed over 10000 km2. A staged construction plan will validate key detection techniques while achieving important science goals early. Here we present the science goals, detection strategy, preliminary design, performance goals, and construction plans for GRAND.

关键词： radio telescopes neutrinos in astronomical observations cosmic rays in astronomical observations radiowave radiation: sources galactic and extragalactic cosmic rays

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

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JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and University of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector

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