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前庭体征的分类及检查方法:眼震及眼震样眼动Bárány学会国际前庭疾病分类委员会共识文件

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神经损伤与功能重建 2020年第12期15卷 683-698页

作者：焉双梅(译) 凌霞(译) 司丽红(译) 常丽英(审校) 杨旭(审校) Scott DZEggers Alexandre Bisdorff Michael von Brevern David SZee Ji-Soo Kim nicolas perez-fernandez Miriam SWelgampola Charles CDella Santinahand David ENewman-Toker 航天中心医院(北京大学航天临床医学院)神经内科湖北文理学院附属医院襄阳市中心医院神经内科美国明尼苏达州罗切斯特市梅奥诊所神经内科卢森堡埃施Emile Mayrisch医疗中心神经内科德国柏林大学附属夏洛特医院神经内科&私立神经内科美国马里兰州巴尔的摩约翰霍普金斯大学医学院神经内科韩国首尔国立大学盆唐医院首尔国立大学医学院神经内科西班牙马德里纳瓦拉大学耳鼻喉科澳大利亚悉尼大学中心临床学院皇家阿尔弗雷德王子医院临床神经科学研究所美国马里兰州巴尔的摩约翰霍普金斯大学医学院耳鼻咽喉头颈外科

本文介绍了Bárány学会国际前庭疾病分类委员会制定的各种类型眼震和眼震样眼动的分类和定义,用于前庭及神经系统疾病患者的评估,以利于临床工作及科学研究中对这些体征的识别和交流。文中对眼震多种属性和影响因素的相关术语进行了描... 详细信息

本文介绍了Bárány学会国际前庭疾病分类委员会制定的各种类型眼震和眼震样眼动的分类和定义,用于前庭及神经系统疾病患者的评估,以利于临床工作及科学研究中对这些体征的识别和交流。文中对眼震多种属性和影响因素的相关术语进行了描述和定义。首先基于临床现象学对眼震相关的复杂术语进行了系统整理,同时也进一步对其相关的解剖学、病理生理学和病因学进行描述,并对眼震和与其相鉴别的其他多种眼震样眼动(如扫视侵扰/扫视振荡)特征进行了总结。

关键词：眼震前庭疾病神经系统疾病病理生理学病因学科学研究解剖学扫视

The Deep Thioredoxome in Chlamydomonas reinhardtii： New Insights into Redox Regulation

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Molecular Plant 2017年第8期10卷 1107-1125页

作者： Maria Esther perez-perez Adeline Mauries Alexandre Maes nicolas J. Tourasse Marion Hamon Stephane D. Lemaire Christophe H. Marchand Institut de Biologie Physico-Chimique UMR8226 CNRS Sorbonne Universit6s UPMC Univ Paris 06 13 rue Pierre et Marie Curie 75005 Paris France Institut de Biologie Physico-Chimique Plateforme de Proteomique FRC550 CNRS 13 rue Pierre et Marie Curie 75005 Paris France Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas (CSIC)-Universidad de Sevilla Seville Spain ARNA Laboratory INSERM U1212 CNRS UMR5320 Universite Bordeaux 2 Bordeaux France

Thiol-based redox post-translational modifications have emerged as important mechanisms of signaling and regulation in all organisms, and thioredoxin plays a key role by controlling the thiol-disulfide status of target proteins. Recent redox proteomic studies revealed hundreds of proteins regulated by glutathio- nylation and nitrosylation in the unicellular green alga Chlamydomonas reinhardtii, while much less is known about the thioredoxin interactome in this organism. By combining qualitative and quantitative proteomic analyses, we have comprehensively investigated the Chlamydomonas thioredoxome and 1188 targets have been identified. They participate in a wide range of metabolic pathways and cellular pro- cesses. This study broadens not only the redox regulation to new enzymes involved in well-known thiore- doxin-regulated metabolic pathways but also sheds light on cellular processes for which data supporting redox regulation are scarce （aromatic amino acid biosynthesis, nuclear transport, etc）. Moreover, we char- acterized 1052 thioredoxin-dependent regulatory sites and showed that these data constitute a valuable resource for future functional studies in Chlamydomonas. By comparing this thioredoxome with proteomic data for glutathionylation and nitrosylation at the protein and cysteine levels, this work confirms the existence of a complex redox regulation network in Chlamydomonas and provides evidence of a tremendous selectivity of redox post-translational modifications for specific cysteine residues.

关键词： Chlamydomonas reinhardtii disulfide bond isotope-coded affinity tag redox proteomics redox regulation thioredoxin targets

Thermoelectric properties of silicon and recycled silicon sawing waste

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Journal of Materiomics 2019年第1期5卷 15-33页

作者： Ran He Wieland Heyn Felix Thiel nicolas perez Christine Damm Darius Pohl Bernd Rellinghaus Christian Reimann Maximilian Beier Jochen Friedrich Hangtian Zhu Zhifeng Ren Kornelius Nielsch Gabi Schierning Leibniz-Institut für Festk€orper-und Werkstoffforschung Dresden 01069DresdenGermany Institute of Materials Science Technische Universit€at Dresden01069DresdenGermany Dresden Center for Nanoanalysis Technische Universit€at Dresden01062DresdenGermany Fraunhofer Institut für Integrierte Systeme und Bauelementetechnologie 91058ErlangenGermany Department of Physics and TcSUH University of HoustonHoustonTX77204USA

Large-scale-applicable thermoelectric materials should be both self-sustaining,in order to survive longterm duty cycles,and *** all classes of known thermoelectric materials,these criteria reduce the available candidate pool,leaving silicon as one of the remaining *** we first review the thermoelectric properties of various silicon-related materials with respect to their morphologies and *** then report the thermoelectric properties of silicon sawing wastes recycled from silicon wafer *** obtain a high power factor of~32 mWcm1 K2 at 1273 K with 6%phosphorus substitution in the Si crystal,a value comparable to that of phosphorus-doped silicongermanium *** work suggests the large-scale thermoelectric applicability of recycled silicon that would otherwise contribute to the millions of tons of industrial waste produced by the semiconductor industry.

关键词： Silicon Thermoelectric Nanostructure Power factor Sawing waste

Evolution and impact of cellulose architecture during enzymatic hydrolysis by fungal cellulases

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Advances in Bioscience and Biotechnology 2013年第12期4卷 1095-1109页

作者： Marie Chauve Loic Barre Sandra Tapin-Lingua Denilson da Silva perez Dominique Decottignies Serge perez nicolas Lopes Ferreira IFP Energies Nouvelles Rueil-MalmaisonFrance IFP Energies Nouvelles Rond-Point de l’Echangeur de SolaizeSolaizeFrance FCBA Pole NMADomaine UniversitaireGrenobleFrance ESRF Rue Jules HorowitzGrenobleFrance Centre de Recherches sur les Macromolecules Vegetales CNRSAffiliated with Universite de GrenobleGrenobleFrance

The enzymatic hydrolysis of cellulose is still considered as a main limiting step of the biological production of biofuels from ligno-cellulosic biomass. Glycoside hydrolases from Trichoderma reesei are currently used to produce fermentable glucose units from degradation of cellulose packed in a complex assembly of cellulose microfibrils. The present work describes the structural evolution of two prototypical samples of cellulose (a micro-crystalline cellulose and a bleached sulfite pulp) over 5 length scale orders of magnitude. The results were obtained through wide angle, small angle and ultra-small angles synchrotron X-ray scattering, completed by Small Angle Neutron Scattering and particle size analyzers. These structural evolutions were followed as a function of enzymatic conversion. The results show that whereas there is no change at the nanometer scale, drastic changes occur at micron. The observed decrease of the size of the cellulose particles is accompanied by a smoothing of the crystalline surfaces that can be explained by a two-step mechanism of the enzymatic hydrolysis.

关键词： Cellulose Cellulase Trichoderma reesei Synchrotron X-Ray Scattering Neutron Scattering Particle Size

基于冷热水试验和头脉冲试验的梅尼埃病患者的前庭诱发肌源性电位检查

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基于冷热水试验和头脉冲试验的梅尼埃病患者的前庭诱发肌源性电位...

Description of a Propulsion Unit Used in Guiding a Walking Machine by Recognizing a Three-point Bordered Path

中国中西医结合学会眩晕病专业委员会第二次学术大会暨河南...

作者： nicolas perez Raquel MANRIQUE Lorea ARBIZU Maria Victoria UCAR 纳瓦拉大学耳鼻喉科

最近有假说认为,梅尼埃病(MD)患者冷热水试验(CAL)、视频-头脉冲试验(vHIT)之间的不一致提示水平半规管中内淋巴积水。在本研究中我们基于CAL和vHIT的结果将MD分类,评估了他们的前庭诱发肌源性电位(VEMP)改变。我们收集了诊断为单侧病...

最近有假说认为,梅尼埃病(MD)患者冷热水试验(CAL)、视频-头脉冲试验(vHIT)之间的不一致提示水平半规管中内淋巴积水。在本研究中我们基于CAL和vHIT的结果将MD分类,评估了他们的前庭诱发肌源性电位(VEMP)改变。我们收集了诊断为单侧病变的肯定的梅尼埃病患者,所有患者患耳和健侧耳的vHIT试验均正

关键词：

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Chinese Journal of Mechanical Engineering 2016年第6期29卷 1157-1166页

作者： NUNEZ-ALTAMIRANO Diego A JUAREZ-CAMPOS Ignacio MARQUEZ-perez Lucia FLORES-DIAZ Ociel School of Mechanical Engineering Universidad Michoacana de San Nicolas de Hidalgo Morelia Michoacan Mexico

A reconfigurable propulsion unit based on the Peaucellier-Lipkin mechanism has the ability to describe exact straight or curved paths depending on the selected ratio between the lengths of two of its links. The Peaucellier-Lipkin mechanism with one degree of freedom is transformed into a more sophisticated parallel kinematic chain by including four more degrees of freedom. The resulting propulsion unit is able to adapt its kinematic structure and reach instant centers of rotation, in accordance with the presence of three points that border a geometric path. A laser sensor mounted on the body of the machine detects each point. Once the machine has detected the exact location of the border of the road, it walks along a curve parallel to that border. Although the proposed research describes only one propulsion unit or leg, the methodology can be applied to all the legs of the walking machine. The novel 5-DOF leg is able to reach different centers of rotation, providing either the concave or convex arcs that satisfy the basic principle of displacement of walking machines.

关键词： Propulsion unit Peaucellier-Lipkin walking machine straight line mechanism.

Diagnosis of Developmental Dysplasia of the Hip Using Sound Transmission in Neonates

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Health 2014年第18期6卷 2510-2516页

作者： nicolas Padilla-Raygoza Diana Medina-Alvarez Ma Laura Ruiz-Paloalto Teodoro Cordova-Fraga Modesto Antonio Sosa-Aquino Aaron Huetzin perez-Olivas Department of Nursing and Obstetrics Division of Health Sciences and Engineering Campus Celaya Salvatierrra University of Guanajuato Celaya Mexico Department of Clinical Nursing Division of Health Sciences and Engineering Campus Celaya Salvatierrra University of Guanajuato Celaya Mexico Department of Engineering Physics Division of Engineering Science Campus Leon University of Guanajuato Leon Mexico

The developmental dysplasia of the hip disease is in 1% of newborns, and it is a risk factor for dislocation of the hip;only 1 from 7000 newborns develops dislocation of the hip. Newborns were selected from public and private hospitals in Celaya, Guanajuato. Parents were asked to sign informed consent. Clinical maneuvers were applied for diagnosis of developmental dysplasia of the hip, on three consecutive occasions, two by the same investigator and the third by a different observer: Ortolani, Barlow, Piston, Galeazzi, Peter Baden, the comparative sound transmission test, and comparative sound transmission with extension/flexion test were applied. The diagnosis was confirmed with ultrasound of hip, technique Graf, I healthy hip, II functionally immature, III subluxation, and IV dislocation. Sample size was 8 affected hips and 56 healthy hips. Kappa for intra observer and inter observer reliability were measured;the validity was measured by sensitivity, specificity, positive and negative predictive values, using the ultrasound diagnosis as the gold standard. The sample consisted of 78 neonates hips with female’s predominance. With comparative sound transmission test was obtained Kappa intra observer 0.80, Kappa inter observer 0.93, sensitivity 45.45%, specificity 96.27%, positive predictive value 66.67% and negative predictive value 91.49%;with comparative sound transmission with extension/flexion, was 0.83, 0.92, 72.73%, 95.52%, 72.73%, and 95.52%, respectively. The tests compared the sound transmission help better diagnose developmental dysplasia disease of the hip.

关键词： Sound Transmission Newborns Developmental Dysplasia of Hip

Validity and Reliability of a Measuring Device Based on Sound Transmission for Diagnosis of Hip Dysplasia in Newborns

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Advances in Bioscience and Biotechnology 2014年第10期5卷 831-837页

作者： nicolas Padilla-Raygoza Rosalina Diaz-Guerrero Ma. Laura Ruiz-Paloalto Teodoro Cordova-Fraga Modesto Antonio Sosa-Aquino Aaron Huetzin perez-Olivas Department of Nursing and Obstetrics Division of Health Sciences and Engi-neering Campus Celaya Salvatierra University of Guanajuato Celaya Mexico Department of Clinical Nursing Division of Health Sciences and Engineering Campus Celaya Salvatierra University of Guanajuato Celaya Mexico Department of Physical Engineering Division of Sciences and Engineering Campus Leon University of Guanajuato Leon Mexico

Sound transmission has been used for diagnosis of hip dysplasia in newborns and infants with tunning fork and sthetoscope. The study aims to identify the validity of a device based on sound transmission. Male and female newborns from Celaya, Gto, ranging from 4 to 28-day-old were selected for the study. The sound transmission device was used both, in bilateral assessment (compared sound transmission) and on each hip separately (sound transmission with extension/flexion). In the first application if the sound is lower by a digit, there is a hip unhealthy. In the second application if the sound is increased by a digit, there is also an alteration of the hip. A hip ultrasound was applied using the Graf technique as a gold standard. Sensitivity, specificity and predictive values were calculated to identify validity. The intra-observer and inter-observer Kappa Test was applied to identify reliability. The hips of 103 newborns were assessed, obtaining a sensitivity of 60.9%, and a specificity of 92%;it should be a positive predictive value of 51.9% and a negative predictive value of 95% for the compared sound transmission test. In the sound transmission test with extension/flexion, the values were 82.6%, 96.2%, 73.1% and 97.8% for sensitivity, specificity, positive predictive value and negative predictive value, respectively. The result of the intra-observer kappa was 0.80 and the inter-observer was 0.70 for the compared sound transmission. The intra-observer Kappa was 0.88 and the inter-observer was 0.78 for the compared sound transmission test with extension/flexion. The device for sound transmission is valid and reliable for the diagnosis of dysplastic development hip disease in newborns.

关键词： Validity Reliability Sound Transmission Dysplasia of the Hip