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第12届生物毒素研究及医药应用学术大会

作者： Yu Song Zheng Fan Zhenhuan Zhao Wei Hong Zhengyang Zeng nicolai e.savaskan Wenxin Li Yingliang Wu Zhijian Cao State Key Laboratory of Virology College of Life Sciences Wuhan University Department of Neurosurgery University Hospital erlangen Friedrich-Alexander University (FAU)of erlangen-Nürnberg

A new peptide precursor,termed Sj7170,was characterized from the venomous gland cDNA library of the scorpion ***7170 was deduced to be a 62 amino acid peptide cross-linked by five disulfide *** recombinant Sj7170 peptide（rSj7170）with a chromatographic purity was produced by prokaryotic expression *** inhibition assay in vitro and in vivoshowed that rSj7170 specifically inhibited the activity of α-chymotrypsin at micromole *** addition,Sj7170 not only promoted cell proliferation and colony formation by up-regulating the expression of cyclinD1 in vitro,but also enhanced tumor growth in nude ***,Sj7170 accelerated cellular migration and invasion by increasing the expression of the transcription factor Snail and then inducing the epithelial-mesenchymal ***,Sj7170 changed cell morphology and cytoskeleton of U87 cells by GTPase *** together,Sj7170 is a unique dual-functional peptide:a specific α-chymotrypsin inhibitor and a potent tumorigenesis/*** work not only opens an avenue of developing new modulators of tumorigenesis/metastasis from serine protease inhibitors,but also strengthens the functional link between protease inhibitors and tumor *** brain tumors are hallmarked by fast proliferation and their ability to destruct the brain microenvironment for their growth *** chemotherapeutic strategies are currently lacking which combat this deadly disease *** glioma-specific chloride ion channel（GCC）represents a specific target for therapy and Chlorotoxin（CTX）,a peptide derived from scorpion venom has been shown to be efficacious and specific in blocking glioma CI- channel ***,we report on one new derivative（termed CA4） based on the CTX peptide sequence with high potency against glioma cell ***4 is effective in reducing glioma cell proliferation and cell ***,we found that CA4 and CTX are selective and s

关键词： Scorpion venom peptide Serine protease inhibitor Glioblastoma Antiviral peptide HBV HCV endosomal escape Signal pathway

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An Analytic Method for Interval Bimatrix Games

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Journal of Mathematics and System Science 2016年第2期6卷 66-71页

作者： G. Selin savaskan Aykut OR Yakup HACI Department of Mathematics Canakkale Onsekiz Mart University Canakkale 17200 Turkey

This paper deals with rnxn two-person non-zero sum games with interval pay-offs. An analytic method for solving such games is given. A pair of Nash equilibrium is found by using the method. The analytic method is effective to find at least one Nash equilibrium （N.e） for two-person bimatrix games. Therefore, the analytic method for two-person bimatrix games is adapted to interval bimatrix games.

关键词： Bimatrix game Nash equilibrium interval payoff interval matrix

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Year-round cooling and thermal stabilization of water-saturated soils under engineering structures

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Research in Cold and Arid Regions 2017年第3期9卷 258-260页

作者： Vladimir Moiseev nicolai Vasiliev Tatyana Komarova Olga Komarova Department of Mathematics Emperor Alexander I St.Petersburg State Transport University Static Research of Soils Laboratory B.E.Vedeneev VNIIG JSC DISIST Scientific Center

We consider the problem of year-round cooling of water-saturated soil to freezing temperatures in order to convert it into a state of permafrost.A new soil-cooling apparatus is *** apparatus is to be made in modular form and connected to passive-active thermal piles(thermosyphons).The estimated capacity of one apparatus allows simultaneous use of up to 1,000 thermal piles for ground *** apparatus is based on natural sources of energy:solar radiation and wind;and it can be used for soil *** approach can prevent thawing of soft soils under railways and roads,as well as under buildings or structures,in an area of more than tens of *** apparatus has no mechanical moving parts and can operate for a long time in stand-alone mode without staff involvement.

关键词： thermopiles frozen soil preventing of thawing the apparatus for cooling

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evaluation of soil erosion risk and identification of soil cover and management factor (C) for RUSLe in european vineyards with different soil management

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International Soil and Water Conservation Research 2020年第4期8卷 337-353页

作者： M.Biddoccu G.Guzmán G.Capello T.Thielke P.Strauss S.Winter J.G.Zaller A.nicolai D.Cluzeau D.Popescu C.Bunea A.Hoble e.Cavallo J.A.Gómez Institute for Agricultural and earthmoving Machines(IMAMOTeR) National Research Council of Italy(CNR)TorinoItaly Institute for Sustainable Agriculture CSICCordobaSpain Institute for Land and Water Management Research Federal Agency for Water ManagementPetzenkirchenAustria Institute of Plant Protection and Institute of Integrative Nature Conservation Research University of Natural Resources and Life SciencesViennaAustria Institute of Zoology University of Natural Resources and Life Sciences ViennaViennaAustria UniversitéRennes 1 Station Biologique de PaimpontUMR 6553 EcoBio35380PaimpontFrance SC JIDVeI SRI Research DepartmentJidveiRomania University of Agriculture Science and Veterinary Medicine Cluj NapocaRomania

Vineyards show some of the largest erosion rates reported in agricultural areas in *** rates vary considerably under the same land use,since erosion processes are highly affected by climate,soil,topography and by the adopted soil management *** also shows differences in the effect of same conservation practices on reducing soil erosion from conventional,bare soil based,*** Revised Universal Soil Loss equation(RUSLe)is commonly adopted to estimate rates of water erosion on cropland under different forms of land use and management,but it requires proper value of soil cover and management(C)factors in order to obtain a reliable evaluation of local soil erosion *** this study the ORUSCAL(Orchard RUSle CALibration)is used to identify the best calibration strategy against long-term experimental ***,ORUSCAL is used in order to apply the RUSLe technology from farm based information across different european wine-growing *** results suggest that the best strategy for calibration should incorporate the soil moisture sub-factor(Sm)to provide better soil loss *** C factor,whose average values ranged from 0.012 to *** a large spatial variability due to coupling with local climate and specific local *** comparison across the five wine-growing regions indicates that for the soil protection management,permanent cover crop is the best measure for accomplishing sustainable erosion rates across the studied *** and temporary cover crops,that are used in areas of limited water resources to prevent competition with vines,failed to achieve sustainable erosion rates,that still need to be *** raises the need for a careful use of C values developed under different environmental conditions.

关键词： Vineyard erosion Soil management RUSLe europe

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托普索合成氨技术综述

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化肥设计 2014年第3期52卷 5-7页

作者： Stephanie Michelle King nicolai Petersen Ib Dybkjr 托普索贸易(北京)有限公司北京100020

回顾了合成氨发展的百年历程;介绍了托普索公司发明的侧烧管式转化炉、径向流动氨合成塔以及氨合成催化剂等合成氨工艺技术;展望了合成氨工艺技术的发展前景。

关键词：托普索合成氨:综述

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Assembly of Oligoglycine Layers on Mica Surface

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Journal of Biomaterials and Nanobiotechnology 2011年第1期2卷 91-97页

作者： Svetlana V. Tsygankova Alexander A. Chinarev Alexander B. Tuzikov Ilya S. Zaitsev Nikolai Severin Alexey A. Kalachev Jurgen P. Rabe nicolai V. Bovin 不详

Assembly of [Gly7-NHCH2-]4C, [Gly7-NHCH2-]3C CH3 and [Gly4NH(CH2)5-]2 peptides on mica surface in aqueous so-lution was studied. The peptides are capable of forming atomically smooth (2.65-4.3 nm in height) layers assembled as polyglycine II. Monomers in the layers are situated normally to the surface. Formation of analogous flat 2D structures also takes place in solution but much more slowly than on mica surface, i.e. negatively charged surface plays an active role promoting the assembly.

关键词： Self-Assembling Oligoglycine Scanning Force Microscopy Monolayers

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Time evolution of stimulated Raman scattering and two-plasmon decay at laser intensities relevant for shock ignition in a hot plasma

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High Power Laser Science and engineering 2019年第3期7卷 142-155页

作者： G.Cristoforetti L.Antonelli D.Mancelli S.Atzeni F.Baffigi F.Barbato D.Batani G.Boutoux F.D'Amato J.Dostal R.Dudzak e.Filippov Y.J.Gu L.Juha O.Klimo M.Krus S.Malko A.S.Martynenko Ph.nicolai V.Ospina S.Pikuz O.Renner J.Santos V.T.Tikhonchuk J.Trela S.Viciani L.Volpe S.Weber L.A.Gizzi National Institute of Optics CNRPisa and FlorenceItaly York Plasma Physics Institute University of YorkHe slingtonYorkUK Universite de Bordeaux CNRSCEACELIATalenceFrance Donostia International Physics Center(DiPC) Donostia/San SebastianBasque CountrySpain Dipartimento SBAI Universita di Roma La SapienzaRomaItaly National Research Nuclear University MePhl MoscowRussia CeA DAMDIFArpajonFrance Department of Radiation and Chemical Physics Institute of Physics of the CASPragueCzech Republic Laser Plasma Department Institute of Plasma Physics of the CASPragueCzech Republic Joint Institute for High Temperature RAS MoscowRussia eLI-Beamlines Institute of Physics of the CASPragueCzech Republic FNSPe Czech Technical University in PraguePragueCzech Republic Universidad de Salamanca Ctr Laseres PulsadosSalamancaSpain Centro de Laseres Pulsados(CLPU) VillamayorSalamancaSpain

Laser–plasma interaction(LPI)at intensities 1015–1016 W·cm^-2 is dominated by parametric instabilities which can be responsible for a significant amount of non-collisional absorption and generate large fluxes of high-energy nonthermal *** a regime is of paramount importance for inertial confinement fusion(ICF)and in particular for the shock ignition *** this paper we report on an experiment carried out at the Prague Asterix Laser System(PALS)facility to investigate the extent and time history of stimulated Raman scattering(SRS)and two-plasmon decay(TPD)instabilities,driven by the interaction of an infrared laser pulse at an intensity^1.2×1016 W·cm^-2 with a^100μm scalelength plasma produced from irradiation of a flat plastic *** laser pulse duration(300 ps)and the high value of plasma temperature(~4 ke V)expected from hydrodynamic simulations make these results interesting for a deeper understanding of LPI in shock ignition *** results show that absolute TPD/SRS,driven at a quarter of the critical density,and convective SRS,driven at lower plasma densities,are well separated in time,with absolute instabilities driven at early times of interaction and convective backward SRS emerging at the laser peak and persisting all over the tail of the ***-scattering SRS,driven at low plasma densities,is also clearly *** results are compared to fully kinetic large-scale,two-dimensional ***-in-cell results,beyond reproducing the framework delineated by the experimental measurements,reveal the importance of filamentation instability in ruling the onset of SRS and stimulated Brillouin scattering instabilities and confirm the crucial role of collisionless absorption in the LPI energy balance.

关键词： plasma simulations shock ignition stimulated Raman scattering two-plasmon decay

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Collisionless shock acceleration of protons in a plasma slab produced in a gas jet by the collision of two laser-driven hydrodynamic shockwaves

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Matter and Radiation at extremes 2024年第2期9卷 12-25页

作者： J.-R.Marquès L.Lancia P.Loiseau P.Forestier-Colleoni M.Tarisien e.Atukpor V.Bagnoud C.Brabetz F.Consoli J.Domange F.Hannachi P.Nicolaï M.Salvadori B.Zielbauer LULI CNRSÉcole PolytechniqueCEASorbonne UniversitéInstitut Polytechnique de Paris91128 Palaiseau CedexFrance CeA DAMDIF91297 Arpajon CedexFrance UniversitéParis-Saclay CEALMCE91680 Bruyères-le-ChatelFrance CeNBG CNRS-IN2P3Universitéde Bordeaux33175 Gradignan CedexFrance GSI Helmholtzzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany University of Darmstadt Schloßgartenstr.764289 DarmstadtGermany eNeA Fusion and Technologies for Nuclear Safety Department C.R.FrascatiVia Enrico Fermi 45FrascatiRomeItaly CeLIA Universitéde Bordeaux–CNRS–CEA33405 TalenceFrance UniversitéParis-Saclay CEALIDYL91191 Gif-sur-YvetteFrance

We have recently proposed a new technique of plasma tailoring by laser-driven hydrodynamic shockwaves generated on both sides of a gas jet[Marquès et al.,*** 28,023103(2021)].In a continuation of this numerical work,we study experimentally the influence of the tailoring on proton acceleration driven by a high-intensity picosecond laser in three cases:without tailoring,by tailoring only the entrance side of the picosecond laser,and by tailoring both sides of the gas *** tailoring,the acceleration is transverse to the laser axis,with a low-energy exponential spectrum,produced by Coulomb *** the front side of the gas jet is tailored,a forward acceleration appears,which is significantly enhanced when both the front and back sides of the plasma are *** forward acceleration produces higher-energy protons,with a peaked spectrum,and is in good agreement with the mechanism of collisionless shock acceleration(CSA).The spatiotemporal evolution of the plasma profile is characterized by optical shadowgraphy of a probe *** refraction and absorption of this beam are simulated by post-processing 3D hydrodynamic simulations of the plasma *** with the experimental results allows estimation of the thickness and near-critical density of the plasma slab produced by tailoring both sides of the gas *** parameters are in good agreement with those required for CSA.

关键词： acceleration hydrodynamic collision

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评价定量PeT/MR影像标志物鉴别克罗恩病炎性狭窄和纤维性狭窄

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国际医学放射学杂志 2016年第3期 303-303页

作者： O.A.Catalano M.S.Gee e.nicolai F.Selvaggi G.Pellino A.Cuocolo 蒋小露 Department of Radiology University of Naples “Parthenope”

摘要目的回顾性评价PeT/MR在克罗恩病病人中鉴别炎性狭窄和纤维性狭窄的应用价值。方法该回顾性研究已通过伦理审查委员会的批准,并取得病人的知情同意。19例克罗恩病病人进行了PeT/MRI肠道成像检查,这些病人都经过术后病理已证实存在... 详细信息

摘要目的回顾性评价PeT/MR在克罗恩病病人中鉴别炎性狭窄和纤维性狭窄的应用价值。方法该回顾性研究已通过伦理审查委员会的批准,并取得病人的知情同意。19例克罗恩病病人进行了PeT/MRI肠道成像检查,这些病人都经过术后病理已证实存在肠道狭窄。2名放射学医师和1名核医学医师共同评估肠壁的PeT/MR影像标志物,包括以

关键词：炎性狭窄克罗恩病局限性回肠炎肠炎纤维性 PeT/MR 标志物 MR

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脾对比增强复合谐波超声检查对于提高霍奇金淋巴瘤病人的分期准确性:前瞻性研究

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国际医学放射学杂志 2009年第4期32卷 387-387页

作者： M. Picardi A. Soricelli F. Pane P. Zeppa e. nicolai M. De Laurentiis 李瑞利（译）沈文（校） Departments of Biochemistry and Medical Biotechnology Histopathology and Oncology Federico H University Medical School and Fondazione SDN Naples Italy. 不详

目的前瞻性比较对比增强复合谐波超声（US）、CT、18-氟脱氧葡萄糖正电子发射断层显像（FDG—PeT）对初诊霍奇金淋巴瘤病人脾结节样浸润的检出效果。方法经机构审查委员会批准，病人知情同意后，在对连续100例霍奇金淋巴瘤病人进行治疗... 详细信息

目的前瞻性比较对比增强复合谐波超声（US）、CT、18-氟脱氧葡萄糖正电子发射断层显像（FDG—PeT）对初诊霍奇金淋巴瘤病人脾结节样浸润的检出效果。方法经机构审查委员会批准，病人知情同意后，在对连续100例霍奇金淋巴瘤病人进行治疗前分期，探查脾是否受累时，前瞻性比较复合谐波超声（33例病人静脉注射微泡对比剂）与CT、FDG—PeT的检查结果。以上影像学手段发现恶性结节的提示征象时认为是淋巴瘤浸润；对于存在争议的病灶，

关键词：霍奇金淋巴瘤对比增强脾结节脱氧葡萄糖正电子发射断层显像超声谐波复合前瞻性比较

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