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Associations between cardiac arrhythmia,incident disability in activities of daily living and physical performance:the ILSA study

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Journal of Geriatric Cardiology 2020年第3期17卷 127-132,I0002-I0004页

作者： Marianna Noale nicola.veronese Lee Smith Andrea Ungar Stefano Fumagalli Stefania Maggi the Italian Longitudinal Study on Aging Working Group National Research Council(CNR) Neuroscience InstituteAging BranchVia Giustiniani 235128 PaduaItaly Azienda ULSS 3 Serenissima Primary Care DepartmentDistrict 3VeniceItaly The Cambridge Centre for Sport and Exercise Sciences Department of Life SciencesAnglia Ruskin UniversityCambridge CB11PTUK Geriatrics and Intensive Care Unit Department of Experimental and Clinical MedicineUniversity of Florence and AOU CareggiFlorenceItaly 不详

Background Cardiac arrhythmias are common conditions in older ***,there is limited literature on associations between cardiac arrhythmias and physical performance or *** therefore aimed to prospectively investigate associations between cardiac arrhythmias and changes in disability and physical performance during 8 years of follow-up,using data from the Italian Longitudinal Study on Aging(ILSA).Methods Cardiac arrhythmias diagnosis was posed through a screening phase,confirmed by a *** onset of disability in activities of daily living(ADL)and the changes in several physical performance tests during follow-up were considered as ***-adjusted and propensity-score Cox Proportional Hazard models and mixed models were used for exploring associations between cardiac arrhythmia and the outcomes of *** The prevalence of cardiac arrhythmia at baseline was 23.3%.People reporting cardiac arrhythmia at the baseline were significantly older,more frequently male,smokers and reported a higher presence of all medical conditions investigated(hypertension,heart failure,angina,myocardial infarction,diabetes,stroke),but no difference in dementia,Parkinsonism,cognitive or mood *** arrhythmia at baseline was significantly associated with the incidence of disability in ADL(HR=1.23;95%:CI:1.01–1.50;P=0.0478 in propensity score analyses;HR=1.28;95%CI:1.01–1.61;P=0.0401 in fully adjusted models).Cardiac arrhythmia at baseline was also associated with a significant worsening in balance test(P=0.0436).Conclusions The presence of cardiac arrhythmia at baseline was associated with a significant higher risk of disability and of worsening in some physical performance tests,particularly those relating to *** and frequently assessing physical performance in older people affected by cardiac arrhythmia can be important to prevent a loss of physical performance,with further,potential,complications of medical managemen

关键词： Atrial fibrillation Cardiac arrhythmia Disability Physical activity Physical performance

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Empirical assessment of the role of the Sun in climate change using balanced multi-proxy solar records

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Geoscience Frontiers 2023年第6期14卷 191-209页

作者： nicola Scafetta Department of Earth Sciences Environment and GeoresourcesUniversity of Naples Federico IIComplesso Universitario di Monte S.Angelovia Cinthia21Naples 80126Italy

The role of the Sun in climate change is hotly *** studies suggest its impact is significant,while others suggest it is *** Intergovernmental Panel on Climate Change(IPCC)supports the latter view and suggests that nearly 100%of the observed surface warming from 1850–1900 to 2020 is due to anthropogenic ***,the IPCC’s conclusions are based solely on computer simulations made with global climate models(GCMs)forced with a total solar irradiance(TSI)record showing a low multi-decadal and secular *** same models also assume that the Sun affects the climate system only through radiative forcing–such as TSI–even though the climate could also be affected by other solar *** this paper I propose three“balanced”multi-proxy models of total solar activity(TSA)that consider all main solar proxies proposed in scientific *** optimal signature on global and sea surface temperature records is assessed together with those produced by the anthropogenic and volcanic radiative forcing functions adopted by the CMIP6 *** is done by using a basic energy balance model calibrated with a differential multi-linear regression methodology,which allows the climate system to respond to the solar input differently than to radiative forcings alone,and to evaluate the climate’s characteristic time-response as *** proposed methodology reproduces the results of the CMIP6 GCMs when their original forcing functions are applied under similar physical conditions,indicating that,in such a scenario,the likely range of the equilibrium climate sensitivity(ECS)could be 1.4℃to 2.8℃,with a mean of 2.1℃(using the HadCRUT5 temperature record),which is compatible with the low-ECS CMIP6 GCM ***,if the proposed solar records are used as TSA proxies and the climatic sensitivity to them is allowed to differ from the climatic sensitivity to radiative forcings,a much greater solar impact on climate change is found,along with a significant

关键词： Solar activity changes Solar variability climatic impact Global climate change and modeling Equilibrium climate sensitivity

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Impacts and risks of“realistic”global warming projections for the 21st century

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Geoscience Frontiers 2024年第2期15卷 392-416页

作者： nicola Scafetta Department of Earth Sciences Environment and GeoresourcesUniversity of Naples Federico IIComplesso Universitario di Monte S.AngeloVia Vicinale Cupa Cintia2180126 NaplesNAItaly

The IPCC AR6 assessment of the impacts and risks associated with projected climate changes for the 21st century is both alarming and *** to computer projections,global surface temperature may warm from 1.3℃to 8.0℃by 2100,depending on the global climate model(GCM)and the shared socioeconomic pathway(SSP)scenario used for the *** climate-change hazards are estimated to be high and very high if the global surface temperature rises,respectively,more than 2.0℃and 3.0℃above pre-industrial *** studies,however,showed that a substantial number of CMIP6 GCMs run“too hot”because they appear to be too sensitive to radiative forcing,and that the high/extreme emission scenarios SSP3-7.0 and SSP5-8.5 are to be rejected because judged to be unlikely and highly unlikely,***,the IPCC AR6 mostly focused on such alarmistic scenarios for risk *** paper examines the impacts and risks of“realistic”climate change projections for the 21st century generated by assessing the theoretical models and integrating them with the existing empirical knowledge on global warming and the various natural cycles of climate change that have been recorded by a variety of scientists and *** is achieved by combining the SSP2-4.5 scenario(which is the most likely SSP according to the current policies reported by the International Energy Agency)and empirically optimized climate *** to recent research,the GCM macro-ensemble that best hindcast the global surface warming observed from 1980 to 1990 to 2012–2022 should be made up of models that are characterized by a low equilibrium climate sensitivity(ECS)(1.5℃

关键词： Climate change Climate models Shared socioeconomic pathways 21st-century climate projections Impacts and risks assessment

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Prevention of vertical transmission of hepatitis B virus infection

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World Journal of Gastroenterology 2021年第26期27卷 4182-4193页

作者： Piero veronese Icilio Dodi Susanna Esposito Giuseppe Indolfi Department of Medicine and Surgery University of ParmaParma 43121Italy Department of Pediatrics Pietro Barilla Children's HospitalParma 43121Italy Department Neurofarba University of FlorenceFlorence 50129Italy Department Neurofarba Meyer Children's University HospitalFlorence 50129Italy

Hepatitis B virus(HBV)is the leading cause of chronic viral ***,almost two million children younger than 5 years acquire the infection,mostly through vertical or horizontal transmission in early *** transmission of HBV is a high efficacy phenomenon ranging,in the absence of any preventive interventions,from 70%to 90%for hepatitis e antigen positive mothers and from 10%to 40%for hepatitis e antigen-negative *** viraemia is a preeminent risk factor for vertical transmission of *** screening is the first step to prevent vertical transmission of *** B passive and active immunoprophylaxis at birth together with antiviral treatment of highly viraemic mothers are the key strategies for global elimination of HBV *** are needed to promote implementation of birth-dose vaccination and hepatitis B immunoglobulins in low-and middle-income countries where the prevalence of the infection is at the highest.

关键词： Hepatitis B Vertical transmission Hepatitis B vaccine Hepatitis B immune globulin Neonatal immunoprophylaxis Tenofovir alafenamide fumarate

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Effect of template shape on metal nanoimprinting:a dislocation dynamics study

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第10期11卷 722-726页

作者： Lucia nicola Department of Materials Science and Engineering Delft University of Technology

Dislocation dynamics simulations are performed to investigate the effect of template shape on the nanoimprinting of metal layers. To this end, metal thin films are imprinted by a rigid template made of an array of equispaced indenters of various shapes, i.e., rectangular, wedge, and circular. The geometry of the indenters is chosen such that the contact area is approximately the same at the final imprinting depth. Results show that, for all template shapes, the final patterns strongly depend on the dislocation activity, and that each imprint differs from the neighboring ones. Large material pile ups appear between the imprints, such that polishing of the metal layer is suggested for application of the patterns in electronics. Rectangular indenters require the lowest imprinting force and achieve the deepest retained imprints.

关键词： Nanoimprinting Dislocation dynamics Simulations

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Production of metallic iron nanoparticles in a baffled stirred tank reactor: Optimization via computational fluid dynamics simulation

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Particuology 2020年第5期18卷 83-96页

作者： Giorgio Vilardi nicola Verdone Sapienza University of Rome Department of Chemical Engineering Materials EnvironmentVia Eudossiana 1800184RomeItaly

The aim of this work is to optimize iron nanoparticle production in stirred tank reactors equipped with two classical impellers:Rushton and four-pitched blade turbines,which are largely used in batch industrial synthesis and efficient *** main operative parameters of nanoparticle synthesis are the precursor initial concentration,reducing agent/precursor molar ratio,impeller-tank clearance,and impeller rotational *** parameters were varied during the synthesis to find the optimal operating values based on the Fe(0)(%)production,zeta potential,particle size distribution,and powder X-ray diffraction pattern *** found that the optimal operating conditions for nanoparticle production were an impeller velocity of 1500 rpm,initial iron precursor concentration of 20 mM,molar ratio of reducing agent to iron precursor of 3 mol/mol,and impeller clearance of 0.25 and 0.4 times the vessel diameter for Rushton and four-pitched blade impellers,*** these conditions achieved a total conversion of 0.94-0.98 and yielded a product with a unimodal size distribution and average diameters in the range 30-50 *** computational fluid dynamics results agreed with the expectations,and the obtained mixing Damkohler numbers show that the process is mixed controlled.

关键词： Nano zero-valent iron Computational fluid dynamics Turbulence Micromixing Length scale

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Assessing the quality of studies in meta-analyses: Advantages and limitations of the Newcastle Ottawa Scale

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World Journal of Meta-Analysis 2017年第4期5卷 80-84页

作者： Claudio Luchini Brendon Stubbs Marco Solmi nicola.veronese Department of Diagnostics and Public Health University and Hospital Trust of Verona Surgical Pathology Unit Santa Chiara Hospital Physiotherapy Department South London and Maudsley NHS Foundation Trust Health Service and Population Research Department Institute of Psychiatry Psychology and Neuroscience King's College London Faculty of Health Social Care and Education Anglia Ruskin University Department of Neurosciences University of Padova nicola.veronese Institute for Clinical Research and Education in Medicine IREM National Research Council Neuroscience Institute Aging Branch

One of the most important points in the meta-analyses is certainly represented by the assessment of the quality of the studies included in such research. The meta-analyses are considered the highest level of evidence in science. Also for this reason, the quality of the studies included should be accurately evaluated by standardized tools. The overall results of the metaanalysis depend indeed also on a rigorous evaluation of the studies quality. Among all the possible tools for this complex evaluation, the Newcastle Ottawa Scale(NOS) is one of the most used worldwide, above all for observational studies. In this review, we will discuss the strengths and limitation of the NOS, also on the basis of the branch of science in which it has been applied.

关键词： Quality Meta-analysis Newcastle Ottawa Scale

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Personalized surgical management of colorectal cancer in elderly population

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World Journal of Gastroenterology 2014年第14期20卷 3762-3777页

作者： Giampaolo Ugolini Federico Ghignone Davide Zattoni Giacomo veronese Isacco Montroni Department of Medical and Surgical Sciences University of BolognaPoliclinico S. OrsolaMalpighi

Colorectal cancer(CRC)in the elderly is extremely common but only a few clinicians are familiar with the complexity of issues which present in the geriatric *** this phase of the life cycle,treatment is frequently *** the fact that,nowadays,older people tend to be healthier than in previous generations,surgical undertreatment is frequently *** the other hand,surgical overtreatment in the vulnerable or frail patient can lead to unacceptable postoperative outcomes with high mortality or persistent ***,due to the geriatric patient being traditionally excluded from randomized controlled trials for a variety of factors(heterogeneity,frailty,etc.),there is a dearth of evidence-based clinical guidelines for the management of these *** objective of this review was to summarize the most relevant clinical studies available in order to assist clinicians in the management of CRC in the *** than in any other patient group,both surgical and non-surgical management strategies should be carefully individualized in the elderly population affected by *** cure and sphincter preservation are the primary goals,many other variables need to be taken into account,such as maintenance of cognitive status,independence,life expectancy and quality of life.

关键词： Elderly Colorectal cancer Surgery Personalized treatment Geriatric assessment

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How the optical timing system,the longitudinal diagnostics and the associated feedback systems provide femtosecond stable operation at the FERMI free electron laser

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High Power Laser Science and Engineering 2016年第2期4卷 14-28页

作者： Mario Ferianis Enrico Allaria Eugenio Ferrari Giulio Gaio Giuseppe Penco Fabio Rossi Marco veronese Elettra-Sincrotrone Trieste S.C.p.A.

FERMI, the seeded free electron laser(FEL) in operation in Italy, is providing the User Community with unique fully coherent radiation, in the wavelength range 100–4 nm. FERMI is the first FEL fully synchronized by means of optical fibers. The optical timing system ensures an ultra-stable phase reference to its distributed clients. Several femtosecond longitudinal diagnostics verify the achieved performance; the bunch length monitor(BLM) and the bunch arrival monitor(BAM) will be presented in this paper. Feedback systems play a crucial role to guarantee the needed longterm electron beam stability. A real-time infrastructure allows shot-to-shot communication between front-end computers and the servers. Orbit feedbacks are useful in machine tuning, whereas longitudinal feedbacks control electron energy,compression and arrival time. A flexible software framework allows a rapid implementation of heterogeneous multiinput–multi-output(MIMO) longitudinal loops simply by selecting the appropriate sensors and actuators.

关键词： feedback system femtosecond longitudinal diagnostics optical timing

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Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies

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Journal of Sport and Health Science 2021年第3期10卷 290-295页

作者： Pinar Soysal Christopher Hurst Jacopo Demurtas Joseph Firth Reuben Howden Lin Yang Mark A.Tully Ai Koyanagi Petre Cristian Ilie Guillermo F.Lopez-Sanchez Lukas Schwingshackl nicola.veronese Lee Smith Department of Geriatric Medicine Bezmialem Vakif UniversityIstanbul 34093Turkey Institute of Neuroscience Newcastle UniversityNewcastle upon Tyne NE17RUUK Primary Care Department Azienda Usl Toscana Sud EstGrosseto 52100Italy Division of Psychology and Mental Health University of ManchesterManchester M139PLUK College of Health&Human Services University of North Carolina at CharlotteLong BeachCA 90815USA Department of Cancer Epidemiology and Prevention Research Alberta Health ServicesHoly Cross CentreAlbertaT5J 3E4Canada School of Health Sciences Institute of Mental Health SciencesUlster UniversityNewtownabbey BT151EDUK Research and Development Unit Sant Joan de Deu Health ParkCIBER of Mental Health(CIBERSAM)Barcelona 08003Spain ICREA Pg.Lluis Companys 23Barcelona 08010Spain The Queen Elizabeth Hospital King’s Lynn NHS Foundation Trust King’s Lynn PE304ETUK Faculty of Sport Sciences University of MurciaMurcia 30100Spain Institute for Evidence in Medicine Medical CenterUniversity of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79085Germany Neuroscience Institute Aging BranchNational Research CouncilPadua 35122Italy The Cambridge Centre for Sport and Exercise Sciences Anglia Ruskin UniversityCambridge CB11PTUK

Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health ***:An umbrella review of systematic reviews with meta-analyses of observational studies was *** assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess *** graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 ***,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing *** associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as *** further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes.

关键词： Handgrip strength Health outcomes Meta-analysis Umbrella review

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