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Music therapy and pediatric palliative care:songwriting with children in the end-of-life

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World Journal of Pediatrics 2022年第10期18卷 695-699页

作者： Filippo Giordano Chiara Rutigliano Mariagrazia Baroni Massimo Grassi Paola Muggeo nicola santoro Department of Emergency and Organ Transplants University of Bari Aldo MoroPiazza G.Cesare 1170124BariItaly Section of Pediatric Hematology-Oncology University Hospital of BariBariItaly Hospice Madonna Dell’Uliveto AlbineaREItaly

Children's needs in pediatric palliative care(PPC)are complex and are determined by age,the course of the disease,family structure,and cultural background[1].The child's family system also has multiple needs which mus... 详细信息

关键词： pediatric assessed palliative

Cardiovascular dysfunction and vitamin D status in childhood acute lymphoblastic leukemia survivors

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World Journal of Pediatrics 2019年第5期15卷 465-470页

作者： Paola Muggeo Vito Michele Rosario Muggeo Paola Giordano Maurizio Delvecchio Maria Altomare Chiara Novielli Marco Matteo Ciccone Gabriele D'Amato Maria Felicia Faienza nicola santoro Department of Pediatric Oncology and Hematology University Hospital of PoliclinicoPiazza G.Cesare 1170124 BariItaly Department of Economical Business and Statistical SciencesUniversity of PalermoPalermoItaly Department of Biomedicine and Human Oncology Pediatric SectionUniversity"A.Moro"BariItaly Pediatric and Neonatology Unit Mother and Children Health Care Department"Madonna delle Grazie"HospitalASL MateraMateraItaly Cardiovascular Diseases Section Department of Emergency and Organ TransplantationUniversity"A.Moro"BariItaly Neonatal Intensive Care Unit Di Venere HospitalBariItaly

Background Vitamin D(25-OHD)has a role in bone health after treatment for cancer.25-OHD deficiency has been associated with risk factors for cardiovascular disease,but no data focusing on this topic in childhood cancer survivors have been *** investigated the 25-OHD status in children treated for acute lymphoblastic leukemia(ALL),and evaluated its influence on vascular *** 25-OHD levels were evaluated in 52 ALL survivors and 40 matched healthy *** were grouped according to 25-OHD level(<20 ng/m or≥20 ng/ml).Auxological parameters,biochemical and hemostatic markers of endothelial function(AD,HMW-AD,ET-1,vWFAg,TAT,D-dimers,Fbg,and hs-CRP),ultrasound markers of vascular endothelial function(flow-mediated dilatation,FMD,common carotid intima-media thickness,C-IMT,and antero-posterior diameter of infra-renal abdominal aorta,APAO)were evaluated in the *** Cases showed higher prevalence of 25-OHD deficiency than controls(p=0.002).In univariate analysis via mean comparisons,25-OHD deficient(<20 ng/ml)patients showed higher C-IMT values compared to the 25-OHD non-deficient(≥20 ng/ml)group(P=0.023).Significant differences were also found for ET-1(P=0.035)and AD-HMW(P=0.015).In the multiple regression models controlling for some confounders,25-OHD still was associated with C-IMT(P=0.0163),ET-1(P=0.0077),and AD-HMW(P=0.0008).Conclusions Childhood ALL survivors show higher prevalence of 25-OHD deficiency as compared to *** 25-OHD levels appear to be linked to indicators of endothelial and vascular *** monitoring of 25-OHD balance may help to prevent cardiovascular diseases in childhood ALL survivors,characterized by high cardiovascular risk.

关键词： Acute lymphoblastic leukemia Cardiovascular disease C-IMT Vascular ultrasound studies Vitamin D

Pediatric non-alcoholic fatty liver disease:New insights and future directions

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World Journal of Hepatology 2014年第4期6卷 217-225页

作者： Pierluigi Marzuillo Emanuele Miraglia del Giudice nicola santoro Department of women and children and General and Specialized Surgery Seconda Università degli Studi di Napoli Department of Pediatrics Yale University School of Medicine

One of the most common complications of childhood obesity is the non-alcoholic fatty liver disease(NAFLD),which is the most common form of liver disease in *** is defined by hepatic fat infiltration > 5% hepatocytes,as assessed by liver biopsy,in the absence of excessive alcohol intake,viral,autoimmune and drug-induced liver *** encompasses a wide spectrum of liver diseases ranging from simple steatosis to non-alcoholic steatohepatitis,which,in turn,can evolve into cirrhosis and end stage liver *** and insulin resistance are the main risk factors for pediatric *** fact,NAFLD is strongly associated with the clinical features of insulin resistance especially the metabolic syndrome,prediabetes and type 2 diabetes mellitus(T2D).In particular,it has been clearly shown in obese youth that the prevalence of metabolic syndrome,pre-diabetes and type 2 diabetes increaseswith NAFLD severity *** that not all of the obese patients develop NAFLD suggests that the disease progression is likely to depend on complex interplay between environmental factors and genetic ***,a non-synonymous SNP(rs738409),characterized by a C to G substitution encoding an isoleucine to methionine substitution at the amino acid position 148 in the patatin like phospholipase containing domain 3 gene(PNPLA3),has been associated with hepatic steatosis in a multiethnic cohort of adults as well as in *** important polymorphisms that acts with PNPLA3 to convey susceptibility to fatty liver in obese youths is the rs1260326 polymorphism in the glucokinase regulatory *** pharmacological approach in NAFLD children poorly adherent to or being unresponsive/partially responsive to lifestyle changes,is aimed at acting upon specific targets involved in the *** are some therapeutic approaches that are being studied in *** article reviews the current knowledge regarding the pediatric fatty liver disease,t

关键词： Non alcoholic fatty liver disease PNPLA3 Obesity Insulin resistance Glucokinase regulatory protein Fructose

Iatrogenic calcinosis cutis in a child affected by Acute Lymphoblastic Leukemia

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Case Reports in Clinical Medicine 2014年第1期3卷 13-17页

作者： Teresa Perillo Giampaolo Arcamone Domenico Bonamonte Michele Pascone nicola santoro Department of Dermatology Policlinico Hospital Bari Italy Department of Pediatric Oncology Policlinico Hospital University of Studies Bari Italy Department of Plastic Surgery Policlinico Hospital Bari Italy

Iatrogenic calcinosis cutis is a rare disorder that can be due to the intravenous administration of calcium or phosphate-containing infusions such as calcium gluconate or calcium chloride with extravasation. Fortunately, the course of calcinosis cutis is benign in immunocompetent children. The treatment remains supportive therapy. After about 6 months, there is no evidence of tissue calcification. We describe a 4-year-old girl with Acute Lymphoblastic Leukemia (ALL) who developed severe calcinosis cutis in the left humerus after extravasation of calcium gluconate during the treatment for the tumor-lysissyndrome-related hypocalcaemia. Surgical debridement and local wound care were not successful, and so a temporary suspension of chemotherapy was necessary to achieve complete healing of the lesion. Notwithstanding this complication, her ALL is in complete hematological remission after 8 months from the diagnosis. No functional or sensitive impairment due to the cutis has persisted.

关键词： Calcinosis Cutis Treatment Immunocompromised Leukemia

From the liver to the heart: Cardiac dysfunction in obese children with non-alcoholic fatty liver disease

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World Journal of Hepatology 2017年第2期9卷 69-73页

作者： Anna Di Sessa Giuseppina Rosaria Umano Emanuele Miraglia del Giudice nicola santoro Department of Woman and Child and General and Specialized Surgery Seconda Università degli Studi di Napoli Department of Pediatrics Yale University School of Medicine

In the last decades the prevalence of non-alcoholic fatty liver disease(NAFLD) has increased as a consequence of the childhood obesity world epidemic. The liver damage occurring in NAFLD ranges from simple steatosis to steatohepatitis, fibrosis and cirrhosis. Recent findings reported that fatty liver disease is related to early atherosclerosis and cardiac dysfunction even in the pediatric population. Moreover, some authors have shown an association between liver steatosis and cardiac abnormalities, including rise in left ventricular mass, systolic and diastolic dysfunction and epicardial adipose tissue thickness. In this editorial, we provide a brief overview of the current knowledge concerning the association between NAFLD and cardiac dysfunction.

关键词： Cardiac dysfunction Non-alcoholic fatty liver disease atherosclerosis Children Cardiovascular risk

Music therapy in children affected by brain tumors

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World Journal of Pediatric Surgery 2021年第3期4卷 44-45页

作者： Filippo Giordano Raffaella Messina Anna Riefolo Chiara Rutigliano Teresa Perillo Massimo Grassi nicola santoro Francesco Signorelli School of Medicine University of BariBariItaly Department of Basic Medical Sciences Neurosciences and Sense OrgansDivision of NeurosurgeryUniversity of BariBariPugliaItaly Anesthesia and Intensive Care Unit Azienda Ospedaliero-Universitaria Consorziale Policlinico di BariBariPugliaItaly Pediatric Hemathology-Oncology Policlinico di Bari Ospedale Giovanni XXIIIBariPugliaItaly

Children affected by brain tumors experi-ence significant levels of anxiety,nervousness,and fear regarding surgery,especially in the preoperative *** operating room can be an intimidating environment for them,and preoperative anxiety can adversely affect postoperative pain.1 Interest is growing in finding non-pharmacological means that may be used to reduce these symptoms.

关键词： tumors surgery dating

Magnetic resonance diffusion tensor imaging and fibertracking diffusion tensor tractography in the management of spinal astrocytomas

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World Journal of Clinical Cases 2016年第1期4卷 1-4页

作者： Alessandro Landi Valeria Palmarini Alessandro D'Elia nicola Marotta Maurizio Salvati Antonio santoro Roberto Delfini Department of Neurology and Psychiatry Division of NeurosurgeryUniversity of Rome "Sapienza"

Some specially imaging of magnetic resonance imaging,the diffusion-weighted imaging(DWI),the diffusion tensor imaging and fractional anisotropy(FA),are useful to described,detect,and map the extent of spinal cord *** measurements may are used to predicting the outcome of patients who have spinal cord *** tracking enable to visualizing the integrity of white matter tracts surrounding some lesions,and this information could be used to formulating a differential diagnosis and planning biopsies or *** this article,we will describe the current uses for DWI and fiber tracking and speculate on others in which we believe these techniques will be useful in the future.

关键词： Fiber tracking diffusion tensor imaging Surgery Magnetic resonance diffusion tensor imaging Intramedullary astrocytomas Spinal cord tumors Radiology

Intrahepatic Cholangiocarcinoma and Thermal Ablation:Long-term Results of An Italian Retrospective Multicenter Study

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 287-292页

作者： Antonio Giorgio Pietro Gatti Luca Montesarchio Bruno santoro Andrea Dell’Olio nicola Crucinio Carmine Coppola Ferdinando Scarano Fabio De Biase Emanuela Cirac Stefano Semeraro Valentina Giorgio Liver Unit and Interventional Ultrasound Unit Athena Clinical InstitutePiedimonte Matese(CE)Italy Internal Medicine Unit Brindisi General HospitalBrindisiItaly General Surgery Unit Polla General HospitalPolla(SA)Italy Department of Radiology Bisceglie Hospital-ASL BATBisceglieItaly Gastroenterology Unit Foggia General HospitalFoggiaItaly Department of Internal Medicine Hepatology Interventional UnitGragnano HospitalGragnano(NA)Italy Internal Medicine Unit Ostuni HospitalOstuni(BR)Italy Fondazione Policlinico A.Gemelli IRCCS Department of Woman and Child Health and Public HealthLargo A GemelliRomaItaly

Background and Aims: Despite resection being considered the treatment of choice for intrahepatic cholangiocarcinoma(ICC),percutaneous thermal ablation can be an alter-native treatment for patients unfit for *** aim was to compare long-term results of percutaneous sonographi-cally-guided radiofrequency ablation(RFA)with high-powered microwave ablation(MWSA)in treatment of ***: Results of 71 ICC patients with 98 nodules treated with RFA(36 patients)or MWSA(35 patients)between January 2008 and June 2018 in 5 Interventional Ultrasound centers of Southern Italy were retrospectively ***-mulative overall survival curves were calculated with the Ka-plan-Meyer method and differences with the log-rank *** possible factors affecting survival were ***: Overall survival of the entire series was 88%,65%,45%and 34%at 12,36,60 and 80 months,*** treated with MWSA survived longer than pa-tients treated with RFA(p 4 cm,no significant difference was ***-free sur-vival and progression-free survival were better in the MWSA group compared to the RFA group(p < 0.005).Diameter of nodules and MWSA were independent factors predicting a better *** major complications were ***: MWSA is superior to RFA in treating ICC unfit for surgery,achieving better long-term survival in small(≤3 cm)ICC nodules as well as nodules up to 4 cm of neo-plastic tumors and should replace RFA.

关键词： Intrahepatic cholangiocarcinoma Thermal ablation Microwaves Radiofrequency Percutaneous treatment

Litchi-derived platinum groupmetal-free electrocatalysts for oxygen reduction reaction and hydrogen evolution reaction in alkalinemedia

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SusMat 2023年第2期3卷 248-262页

作者： Seyed Ariana Mirshokraee Mohsin Muhyuddin Roberto Lorenzi Giorgio Tseberlidis Carmelo Lo Vecchio Vincenzo Baglio Enrico Berretti Alessandro Lavacchi Carlo santoro Department of Materials Science University of Milano-BicoccaMilanoItaly Istituto di Tecnologie Avanzate per l’Energia“nicola Giordano”(ITAE) Consiglio Nazionale delle Ricerche(CNR)Via Salita S.MessinaItaly Istituto di Chimica Dei Composti OrganoMetallici(ICCOM) Consiglio Nazionale Delle Ricerche(CNR)Sesto FiorentinoFirenzeItaly

Within the framework of the circular economy,the waste litchi’s skins were upgraded and transformed into electrocatalysts for oxygen reduction reaction(ORR)and hydrogen evolution reaction(HER).The waste litchi’s skins were pyrolyzed,activated,and then used as carbon support for fabricating metal–nitrogen–carbons(M–N–Cs)which belong to a promising class of platinum group metal-free *** activated char was functionalized with transition metal(Fe,Ni,and Co)-phthalocyanine(Pc)in monometallic and bimetallic fashion by subjecting it to a thermal treatment at 600 and 900◦*** samples functionalized at 900℃ showed higher performance for HER due to the formation of metal nanoparticles,whereas the samples functionalized at 600℃ showed higher performance for ***,sample Ni–Co 900 had an overpotential of−0.38 V for HER,while the sample Fe 600 was the most active electrocatalyst for ORR by demonstrating the onset potential of∼0.9 V(a half-wave potential of∼0.81 V)with the least production of unwanted peroxide anion.

关键词： circular economy hydrogen evolution reaction oxygen reduction reaction PGM-free electrocatalyst