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Fecal calprotectin in coeliac disease

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World Journal of Gastroenterology 2014年第2期20卷 611-612页

作者： Pietro Capone Antonio Rispo nicola Imperatore nicola Caporaso Raffaella Tortora Gastroenterology Department of Clinical Medicine and SurgeryUniversity "Federico Ⅱ" of Naples80131 NapoliItaly

We would like to share with the readers the results of our experience in 50 celiac disease (CD) patients, enrolled between September 2012 and April 2013, who were referred to our third-level CD Unit. The fecal calprotectin (FC) concentration of 50 adults with newly diagnosed CD was compared to that of a control group of 50 healthy subjects. FC level was determined by enzyme linked immunosorbent assay with diagnostic cut-off of 75 μg/g. In addition, we tried to correlate the FC level with symptoms, histological severity of CD (Marsh grade) and level of tissue transglutaminase antibodies (aTg) in CD patients. Finally, FC level was increased in five CD patients and in four controls (10% vs 8%, P = NS); mean FC concentration of patients and controls were 57.7 (SD ± 29.1) and 45.1 (SD ± 38.4) respectively. Furthermore, no significant correlation was seen between FC levels and symptoms/Marsh grade/aTg. The five CD patients did not show inflammatory lesions (e.g., ulcers, erosions) at upper endoscopy. The four healthy controls with positive FC were followed-up for further six months; in this observational period they did not show clinical signs of any underlying disease. On these bases, we think that FC is not able to investigate the subclinical inflammatory changes of active CD and FC should be considered a useless tool in the diagnostic work-up of uncomplicated CD but it should be accompanied by aTg when ruling out organic disease in patients with irritable bowel syndrome.

关键词： Coeliac disease Calprotectin Bowel inflammation Small bowel

HOW ARE PRODUCT-SERVICE COMBINED OFFERS PROVIDED IN GERMANY AND ITALY?ANALYSIS WITH COMPANY SIZES AND COUNTRIES

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Journal of Systems Science and Systems Engineering 2008年第3期17卷 367-381页

作者： Tomohiko SAKAO nicola NAPOLITANO Massimo TRONCI Erik SUNDIN Mattias LINDAHL Institute for Product Development and Machine Elements Darmstadt University of TechnologyGermany Department of Management and Engineering Linkping UniversitySweden Department of Mechanics and Aeronautics University of Rome"La Sapienza"Italy

A new business concept that offers products and services in a different way of traditional product-sales businesses is getting more attention especially in manufacturing industries. This paper investigates how this new business by means of integration of products and services is achieved in Germany and Italy. In addition, it analyzes the differences according to the company sizes. The results include that this type of business is in many cases motivated by their focus on customers and often consists of physical products and their maintenance. The Italian companies, as opposed to the German ones, often design their physical products specifically for this type of offers. From the analysis based on the size difference, small companies are found to achieve specific design for this type of offers while owning physical products. There do not seem to be any established methods or tools developed to support the development of such offers and within such methods/tools there would be room for more adaptation in form of physical product design.

关键词： Product-service combination functional sales integrated product service engineering service management product design maintenance

Integrating water use systems and soil and water conservation measures into a hydrological model of an Iranian Wadi system

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Journal of Arid Land 2020年第4期12卷 545-560页

作者： Nariman MAHMOODI Jens KIESEL Paul D WAGNER nicola FOHRER Department of Hydrology and Water Resources Management Institute for Natural Resource ConservationKiel UniversityKiel 24118Germany Department of Ecosystem Research Leibniz-Institute of Freshwater Ecology and Inland Fisheries(IGB)Berlin 12489Germany

Water resources are precious in arid and semi-arid areas such as the Wadis of Iran. To sustainably manage these limited water resources, the residents of the Iranian Wadis have been traditionally using several water use systems(WUSs) which affect natural hydrological processes. In this study, WUSs and soil and water conservation measures(SWCMs) were integrated in a hydrological model of the Halilrood Basin in Iran. The Soil and Water Assessment Tool(SWAT) model was used to simulate the hydrological processes between 1993 and 2009 at daily time scale. To assess the importance of WUSs and SWCMs, we compared a model setup without WUSs and SWCMs(Default model) with a model setup with WUSs and SWCMs(WUS-SWCM model). When compared to the observed daily stream flow, the number of acceptable calibration runs as defined by the performance thresholds(Nash-Sutcliffe efficiency(NSE)≥0.68, –25%≤percent bias(PBIAS)≤25% and ratio of standard deviation(RSR)≤0.56) is 177 for the Default model and 1945 for the WUS-SWCM model. Also, the average Kling–Gupta efficiency(KGE) of acceptable calibration runs for the WUS-SWCM model is higher in both calibration and validation periods. When WUSs and SWCMs are implemented, surface runoff(between 30% and 99%) and water yield(between 0 and 18%) decreased in all sub-basins. Moreover, SWCMs lead to a higher contribution of groundwater flow to the channel and compensate for the extracted water by WUSs from the shallow aquifer. In summary, implementing WUSs and SWCMs in the SWAT model enhances model plausibility significantly.

关键词： SWAT model stream flow Wadis multi-metric framework water use systems soil and water conservation measures Halilrood Basin

Wearable devices and IoT applications for symptom detection, infection tracking, and diffusion containment of the COVID-19 pandemic: a survey

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Frontiers of Information Technology & Electronic Engineering 2021年第11期22卷 1413-1442页

作者： Roberto DEFAZIO nicola Ivan GIANNOCCARO Miguel CARRASCO Ramiro VELAZQUEZ Paolo VISCONTI Department of Innovation Engineering University of SalentoLecce73100Italy Facultad de Ingeniería y Ciencias Universidad Adolfo IbáñezPeñalolénSantiago7941169Chile Facultad de Ingeniería Universidad PanamericanaAguascalientes20290Mexico

Until a safe and effective vaccine to fight the SARS-CoV-2 virus is developed and available for the global population, preventive measures, such as wearable tracking and monitoring systems supported by Internet of Things(IoT) infrastructures, are valuable tools for containing the pandemic. In this review paper we analyze innovative wearable systems for limiting the virus spread, early detection of the first symptoms of the coronavirus disease COVID-19 infection, and remote monitoring of the health conditions of infected patients during the quarantine. The attention is focused on systems allowing quick user screening through ready-to-use hardware and software components. Such sensor-based systems monitor the principal vital signs, detect symptoms related to COVID-19 early, and alert patients and medical staff. Novel wearable devices for complying with social distancing rules and limiting interpersonal contagion(such as smart masks) are investigated and analyzed. In addition, an overview of implantable devices for monitoring the effects of COVID-19 on the cardiovascular system is presented. Then we report an overview of tracing strategies and technologies for containing the COVID-19 pandemic based on IoT technologies, wearable devices, and cloud computing. In detail, we demonstrate the potential of radio frequency based signal technology, including Bluetooth Low Energy(BLE), Wi-Fi, and radio frequency identification(RFID), often combined with Apps and cloud technology. Finally, critical analysis and comparisons of the different discussed solutions are presented, highlighting their potential and providing new insights for developing innovative tools for facing future pandemics.

关键词： Wearable devices IoT health-monitoring applications Medical sensors COVID-19 pandemic Symptom detection

Biobanking in the digital pathology era

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Oncology Research 2021年第4期29卷 229-233页

作者： GIUSEPPINA BONIZZI LORENZO ZATTONI nicola FUSCO Biobank for Translational and Digital Medicine Unit Division of PathologyIEOEuropean Institute of Oncology IRCCSUniversity of MilanMilan20141Italy

Digital Pathology is becoming more and more important to achieve the goal of precision *** in whole-slide imaging,software integration,and the accessibility of storage solutions have changed the pathologists’clinical practice,not only in terms of laboratory workﬂow but also for diagnosis and biomarkers *** parallel with the pathology setting advancement,translational medicine is approaching the unprecedented opportunities unrevealed by artiﬁcial intelligence(AI).Indeed,the increased usage of biobanks’datasets in research provided new challenges for AI applications,such as advanced algorithms,and computer-aided *** this scenario,machine learning-based approaches are being propose in order to improve biobanks from biospecimens collection repositories to computational *** date,evidence on how to implement digital biobanks in translational medicine is still *** viewpoint article summarizes the currently available literature that supports the biobanks’role in the digital pathology era,and to provide possible practical applications of digital biobanks.

关键词： Biobank Pathology Digital pathology Biomarkers Translational research

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福田中学

建筑学报 2024年第6期 8-14页

作者：临界工作室陈忱尼古拉·萨拉迪诺吕守拓张佳佳临界工作室

福田中学位于福田区的核心地段,周边数公里内是深圳快速城市化产生的极为多样的城市肌理:东侧远方是中国香港米埔自然保护区湿地和连绵山脉,近处有拥挤的城中村(福田村,少数城中心存留的城中村之一),西侧则是开阔的都市绿轴中心公园,远... 详细信息

福田中学位于福田区的核心地段,周边数公里内是深圳快速城市化产生的极为多样的城市肌理:东侧远方是中国香港米埔自然保护区湿地和连绵山脉,近处有拥挤的城中村(福田村,少数城中心存留的城中村之一),西侧则是开阔的都市绿轴中心公园,远方是CBD天际线;北、东、南三面被百米高层紧贴环绕,仅有西侧与城市街道福田路接驳——福田中学的场地可以被视作补完这片超高密度中心城区的最后一块用地.

关键词：核心地段超高密度天际线快速城市化城市肌理中国香港福田城中村

Electrosorption at metal surfaces from first principles

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npj Computational Materials 2020年第1期6卷 517-526页

作者： nicolas G.Hörmann nicola Marzari Karsten Reuter Chair of Theoretical Chemistry and Catalysis Research Center Technische Universität MünchenGarching 85748Germany Theory and Simulation of Materials(THEOS) and National Centre for Computational Design and Discovery of Novel Materials(MARVEL)École Polytechnique Fédérale de LausanneLausanne 1015Switzerland Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-6Berlin 14195Germany

Electrosorption of solvated species at metal electrodes is a most fundamental class of processes in interfacial ***,we use its sensitive dependence on the electric double layer to assess the performance of ab initio thermodynamics approaches increasingly used for the first-principles description of *** show analytically that computational hydrogen electrode calculations at zero net-charge can be understood as a first-order approximation to a fully grand canonical ***,higher-order terms in the applied potential caused by the charging of the double layer include contributions from adsorbate-induced changes in the work function and in the interfacial *** contributions are essential to yield prominent electrochemical phenomena such as non-Nernstian shifts of electrosorption peaks and non-integer electrosorption *** illustrate this by calculating peak shifts for H on Pt electrodes and electrosorption valencies of halide ions on Ag electrodes,obtaining qualitative agreement with experimental data already when considering only second order *** results demonstrate the agreement between classical electrochemistry concepts and a first-principles fully grand canonical description of electrified interfaces and shed new light on the widespread computational hydrogen electrode approach.

关键词： sorption principles canonical

Predictors of multiple injuries in individual distance runners:A retrospective study of 75,401 entrants in 4 annual races-SAFER XX

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Journal of Sport and Health Science 2022年第3期11卷 339-346页

作者： Sonja Swanevelder nicola Sewry Martin Schwellnus Esme Jordaan Biostatistics Unit South African Medical Research CouncilParow 7575South Africa Sport Exercise Medicine and Lifestyle Institute(SEMLI)Faculty of Health SciencesUniversity of PretoriaPretoria 0081South Africa International Olympic Committee(IOC)Research Centre Pretoria 0081South Africa Emeritus Professor of Sport and Exercise Medicine Faculty of Health SciencesUniversity of Cape TownBellville 7535South Africa Statistics and Population Studies Department University of the Western CapeBellville 7535South Africa

Background There are limited data on factors that predict an increased risk of multiple injuries among distance *** objective of this study was to determine risk factors that are predictive of individual runners with a high annual multiple injury risk(MIR).Methods A retrospective,cross-sectional study at 4 annual(2012-2015)Two Oceans 21.1 km and 56.0 km races in South Africa with 75,401 consenting race ***-related injury data were collected retrospectively through an online pre-race medical screening *** average number of injuries for each runner every year was calculated by taking a runner's race entry history and injury history into account and categorizing entrants into 4 MIR categories(high,intermediate,low,and very low(reference)).Multiple logistic regression modeling(odds ratios)was used to determine whether the following factors were predictive of a high MIR(average>1 injury/year):demographics,training and racing,chronic-disease history(composite chronic disease score(CCDS)),and history of *** Of all entrants,9.2%reported at least 1 injury,and 0.4%of entrants were in the high MIR category;the incidence rate was 2.5 injuries per 10 runner-years(95%confidence interval(95%CI):2.4-2.7).Significant factors predictive of runners in the high MIR category were:running for>20 years:OR=2.0(95%CI:1.3-3.1;p=0.0010);a higher CCDS:OR=2.2(95%CI:2.0-2.4;p20 years and those with multiple chronic diseases or a history of allergies were at higher risk of multiple running-related *** high-risk group can be targeted for further study and possible injury-prevention interventions.

关键词： Allergies Chronic diseases Multiple injuries Risk factors SAFER study

Some insight on the structure/activity relationship of metal nanoparticles in Cu/SiO2 catalysts

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Chinese Journal of Catalysis 2019年第11期40卷 1788-1794页

作者： nicola Scotti Elisabetta Finocchio Claudio Evangelisti Marcello Marelli Rinaldo Psaro Nicoletta Ravasio Federica Zaccheria The Institute of Molecular Science and Technologies (ISTM) CNR Research Centres LabCat via C. Golgi 19 20133 Milano Italy Dip. Ingegneria Civile Chimica e Ambientale (DICCA) Scuola Politecnica Università di Genova Via all'Opera Pia 15 16145 Genova Italy

The activity of two Cu/SiO2 catalysts prepared by the chemisorption hydrolysis technique has been tested in the hydrogenation reaction of 3-methyl-cyclohexanone. Both catalysts were found to be very active at 60 ℃ and 1 atm of H2. Characterization of the materials by FT-IR of adsorbed CO and TEM put in light the presence of well formed Cu cristallites. By assuming a cuboctahedral model we could show that the hydrogenation activity is linked to high coordination sites on the metal particle. A comparison is also reported with a sample prepared by ammonia evaporation that was found to be inactive in the hydrogenation reaction under the same experimental conditions.

关键词： Cu catalysts Metal particle morphology Lewis acid sites Hydrogenation Bifunctional catalysts